Glycogen synthase kinase 3 involvement in the excessive proinflammatory response to LPS in patients with decompensated cirrhosis

Journal of Hepatology

Volumn 55, Issue 4, 2011, Pages 784-793

  Coant, Nicolas ^a,b   Simon Rudler, Marika ^a   Gustot, Thierry ^a,c   Fasseu, Magali ^a   Gandoura, Sonia ^a   Ragot, Kévin ^d   Abdel Razek, Waël ^e   Thabut, Dominique ^a   Lettéron, Philippe ^a,b   Ogier Denis, Eric ^a,b   Ouziel, Romy ^c   Devière, Jacques ^c   Lizard, Gérard ^d   Tellier, Zéra ^f   Lebrec, Didier ^a,b,e   Moreau, Richard ^a,b,e  

^a CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c ERASME HOSPITAL   (Belgium)

^d Chu   (France)

^e BEAUJON HOSPITAL   (France)

^f Laboratoire Franais du Fractionnement et des Biotechnologies   (France)

Author keywords

AKT; Alcohol; Cirrhosis; Glycogen synthase kinase 3; Innate immunity; Lipopolysaccharides

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3BETA; INTERLEUKIN 10; INTERLEUKIN 12P40; LIPOPOLYSACCHARIDE; LITHIUM CHLORIDE; MESSENGER RNA; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DECOMPENSATED LIVER CIRRHOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; INCUBATION TIME; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADJUVANTS, IMMUNOLOGIC; ADULT; AGED; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLYCOGEN SYNTHASE KINASE 3; HEPATITIS; HUMANS; INDOLES; INTERLEUKIN-10; INTERLEUKIN-12; LIPOPOLYSACCHARIDES; LITHIUM CHLORIDE; LIVER CIRRHOSIS; MALE; MALEIMIDES; MIDDLE AGED; MONOCYTES; PROTO-ONCOGENE PROTEINS C-AKT; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 80052950765     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.12.039     Document Type: Article

References (49)

1. T. Gustot, F. Durand, D. Lebrec, J.L. Vincent, and R. Moreau Severe sepsis in cirrhosis Hepatology 50 2009 2022 2033
2. R. Moreau, A. Hadengue, T. Soupison, P. Kirstetter, M.F. Mamzer, and M. Assous Clinical, hemodynamic and metabolic characteristics and ICU outcome of septic shock in patients with cirrhosis Crit Care Med 20 1992 746 750
3. J.L. Vincent, Y. Sakr, C.L. Sprung, V.M. Ranieri, K. Reinhart, and H. Gerlach Sepsis Occurrence in Acutely Ill Patients Investigators. Sepsis in European intensive care units: results of the SOAP study Crit Care Med 34 2006 344 353 (Pubitemid 43145611)
4. K.A. Tazi, I. Biche, V. Paradis, C. Guichard, I. Laurendeau, and D. Dargre In vivo altered unfolded protein response and apoptosis in livers from lipopolysaccharide-challenged cirrhotic rats J Hepatol 46 2007 1075 1088 (Pubitemid 46680360)
5. O. Le Moine, A. Marchant, D. De Groote, C. Azar, M. Goldman, and J. Deviere Role of defective monocyte interleukin-10 release in tumor necrosis factor-alpha overproduction in alcoholics cirrhosis Hepatology 22 1995 1436 1439
6. B. Byl, I. Roucloux, A. Crusiaux, E. Dupont, and J. Devire Tumor necrosis factor α and interleukin 6 plasma levels in infected cirrhotic patients Gastroenterology 104 1993 1492 1497 (Pubitemid 23235425)
7. K.A. Tazi, J.J. Quioc, V. Saada, M. Bezeaud, D. Lebrec, and R. Moreau Upregulation of TNF-alpha production signaling pathways in monocytes from patients with advanced cirrhosis: possible role of Akt and IRAK-M J Hepatol 45 2006 280 289 (Pubitemid 44026567)
8. K.A. Tazi, J.J. Quioc, W. Abdel-Razek, Z. Tellier, C. Guichart, and E. Ogier-Denis Protein array technology to investigate cytokine production by monocytes from patients with advanced alcoholic cirrhosis: an ex vivo pilot study Hepatol Res 39 2009 706 715
9. A. Galbois, D. Thabut, K.A. Tazi, M. Rudler, M.S. Mohammadi, and D. Bonnefont-Rousselot Ex vivo effects of high-density lipoprotein exposure on the lipopolysaccharide-induced inflammatory response in patients with severe cirrhosis Hepatology 49 2009 175 184
10. J.R. Woodgett Molecular cloning and expression of glycogen synthase kinase-3/factor A EMBO J 9 1990 2431 2438
11. M. Martin, K. Rehani, R.S. Jope, and S.M. Michalek Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3 Nat Immunol 6 2005 777 784 (Pubitemid 43090463)
12. K. Rehani, H. Wang, C.A. Garcia, D.F. Kinane, and M. Martin Toll-like receptor-mediated production of IL-1Ra is negatively regulated by GSK3 via the MAPK ERK1/2 J Immunol 182 2009 547 553
13. G. Weintz, J.V. Olsen, K. Fruhauf, M. Niedzielska, I. Amit, and J. Jantsch The phosphoproteome of toll-like receptor-activated macrophages Mol Syst Biol 6 2010 371
14. X. Hu, P.K. Paik, J. Chen, A. Yarilina, L. Kockeritz, and T.T. Lu IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins Immunity 24 2006 563 574 (Pubitemid 43728157)
15. M. Ohtani, S. Nagai, S. Kondo, S. Mizuno, K. Nakamura, and M. Tanabe Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells Blood 112 2008 635 643
16. K.P. Hoeflich, J. Luo, E.A. Rubie, M.S. Tsao, O. Jin, and J.R. Woodgett Requirement for glycogen kinase-3beta in cell survival and NF-kappaB activation Nature 406 2000 86 90 (Pubitemid 30460216)
17. K. MacAulay, B.W. Doble, S. Patel, T. Hansotia, E.M. Sinclair, and D.J. Drucker Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism Cell Metab 6 2007 329 337 (Pubitemid 47450185)
18. D.A. Vignali Multiplexed particle-based flow cytometric assays J Immunol methods 243 2000 243 255
19. K.L. Kellar, and M.A. Iannone Multiplexed microsphere-based flow cytometric assays Exp Hematol 30 2002 1227 1237 (Pubitemid 35287575)
20. R. Varro, R. Chen, H. Sepulveda, and J. Apgar Bead-based multianalyte flow immunoassays: the cytometric bead array system Methods Mol Biol 378 2007 125 152
21. E.B. Cook, J.L. Stahl, L. Lowe, R. Chen, E. Morgan, and J. Wilson Simultaneous measurement of six cytokines in a single sample of human tears using microparticle-based flow cytometry: allergics vs. non-allergics J Immunol Methods 254 2001 109 118 (Pubitemid 32530752)
22. C. Prunet, T. Montange, A. Véjux, A. Laubriet, J.F. Rohmer, and J.M. Riedinger Multiplexed flow cytometric analyses of pro- and anti-inflammatory cytokines in the culture media of oxysteral-treated human monocytic cells and in the sera of atherosclerotic patients Cytometry A 69 2006 359 373 (Pubitemid 44651349)
23. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 2001 402 408 (Pubitemid 34164012)
24. J. Deviere, J. Content, C. Denys, P. Vandenbussche, L. Schandene, and J. Wybran Excessive in vitro bacterial lipopolysaccharide-induced monokines in cirrhosis Hepatology 11 1990 628 634 (Pubitemid 20151741)
25. M.P. Coghlan, A.A. Culbert, D.A.E. Cross, S.L. Corcoran, J.W. Yates, and N.J. Pearce Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription Chem Biol 7 2000 793 803
26. P.S. Klein, and D.A. Melton A molecular mechanism for the effect of lithium on development Proc Natl Acad Sci USA 93 1996 8455 8459 (Pubitemid 26269579)
27. G. Trinchieri Interleukin-12 and the regulation of innate resistance and adaptive immunity Nat Rev Immunol 3 2003 133 146 (Pubitemid 37328691)
28. E. Rodionova, M. Conzelmann, E. Maraskovsky, M. Hess, M. Kirsch, and T. Giese GSK-3 mediates differentiation and activation of proinflammatory dendritic cells Blood 109 2007 1584 1592 (Pubitemid 46239592)
29. J.M. Beaulieu, S. Marion, R.M. Rodriguiz, I.O. Medvedev, T.D. Sotnikova, and V. Ghisi A beta-arrestin 2 signaling complex mediates lithium action on behavior Cell 132 2008 125 136
30. C.C. Kumar, and V. Madison AKT crystal structure and AKT-specific inhibitors Oncogene 24 2005 7493 7501 (Pubitemid 41637989)
31. K.M. Nicholson, and N.G. Anderson The protein kinase B/Akt signaling pathway in human malignancy Cell Signal 14 2002 381 395 (Pubitemid 34214843)
32. J. Brognard, E. Sierecki, T. Gao, and A.C. Newton PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signalling by regulating distinct Akt isoforms Mol Cell 25 2007 917 931 (Pubitemid 46436532)
33. H.E. Wasmuth, D. Kunz, E. Yagmur, A. Timmer-Stranghöner, D. Vidacek, and E. Siewert Patients with acute on chronic liver failure display "sepsis-like" immune paralysis J Hepatol 42 2005 195 201 (Pubitemid 40143465)
34. A. Androulidaki, D. Iliopoulos, A. Arranz, C. Doxaki, S. Schworer, and V. Zacharioudaki The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs Immunity 31 2009 220 231
35. B.K. Verma, M. Fogarasi, and G. Szabo Down-regulation of tumor necrosis factor alpha activity by acute ethanol treatment in human peripheral blood monocytes J Clin Immunol 13 1993 8 22 (Pubitemid 23047992)
36. G. Szabo, S. Chavan, P. Mandrekar, and D. Catalano Acute alcohol consumption attenuates interleukin-8 (IL-8) and monocytes cheoattractant peptide-1 (MCP-1) induction in response to ex vivo stimulation J Clin Immunol 19 1999 67 76 (Pubitemid 29113334)
37. G. Szabo, P. Mandrekar, L. Girouard, and D. Catalano Regulation of human monocyte functions by acute ethanol treatment: decreased tumor necrosis factor-alpha, interleukin-1 beta and elevated interleukin-10, and transforming growth factor-beta production Alcohol Clin Exp Res 20 1996 900 907 (Pubitemid 26282325)
38. P. Mandrekar, S. Bala, D. Catalano, K. Kodys, and G. Szabo The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes J Immunol 183 2009 1320 1327
39. H. Ma, L. Yu, E.A. Byra, N. Hu, K. Kitagawa, and K.I. Nakayama Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: role of protein phosphatase J Mol Cell Cardiol 49 2010 322 329
40. L. Gobejishvili, S. Barve, S. Joshi-Barve, S. Uriarte, Z. Song, and C. McClain Chronic ethanol-mediated decrease in cAMP primes macrophages to enhanced LPS-inducible NF-kappaB activity and TNF expression: relevance to alcoholic liver disease Am J Physiol Gastrointest Liver Physiol 291 2006 G681 688
41. L. Gobejishvili, S. Barve, S. Joshi-Barve, and C. McClain Enhanced PDE4B expression augments LPS-inducible TNF expression in ethanol-primed monocytes: relevance to alcoholic liver disease Am J Physiol Gastrointest Liver Physiol 295 2008 G718 724
42. Bala S, Marcos M, Kodys K, Csak T, Catalano D, Mandrekar P, et al. Upregulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor alpha (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease. J Biol Chem 2010 [Epub ahead of print.
43. A. Albillos, L. Herza Ad Ade, E. Reyes, J. Monserrat, L. Munoz, and M. Nieto Tumor necrosis factor-alpha expression by activated monocytes and altered T-cell homeostasis in ascetic alcoholic cirrhosis: amelioration with norfloxacin J Hepatol 40 2004 624 631 (Pubitemid 38367784)
44. T.K. Mao, Z.X. Lian, C. Selmi, Y. Ichiki, P. Ashwood, and A.A. Ansari Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis Hepatology 42 2005 802 808 (Pubitemid 41401117)
45. E. Foy, K. Li, C. Wang, R. Sumpter Jr, M. Ikeda, and S.M. Lemon Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease Science 300 2003 1145 1148 (Pubitemid 36583099)
46. K. Li, E. Foy, J.C. Ferreon, M. Nakamura, A.C. Ferreon, and M. Ikeda Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptator protein TRIF Proc Natl Acad Sci USA 102 2005 2992 2997 (Pubitemid 40299904)
47. H. Chung, T. Watanabe, M. Kudo, and T. Chiba Hepatitis C virus core protein induces homotolerance and cross-tolerance to Toll-like receptor ligands by activation of Toll-like receptor 2 J Infect Dis 202 2010 853 861
48. K. Visvanathan, N.A. Skinner, A.J. Thompson, S.M. Riordan, V. Sozzi, and R. Edwards Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein Hepatology 45 2007 102 110 (Pubitemid 46150869)
49. S.I. Grivennikov, A.V. Tumanov, D.J. Liepinsh, A.A. Kruglov, B.I. Marakusha, and A.N. Shakhov Distinct and nonredundant in vivo functions of TNF produced by T cells and macrophages/neutrophils: protective and deleterious effects Immunity 22 2005 93 104 (Pubitemid 40143454)