Synthesis and biological evaluation of 1-(4′-Indolyl and 6′-Quinolinyl) indoles as a new class of potent anticancer agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 3623-3629

  Lai, Mei Jung ^a   Chang, Jang Yang ^b,c   Lee, Hsueh Yun ^a   Kuo, Ching Chuan ^b   Lin, Mei Hsiang ^a   Hsieh, Hsing Pang ^b   Chang, Chi Yen ^b   Wu, Jian Sung ^b   Wu, Su Ying ^b   Shey, Kuang Shing ^d   Liou, Jing Ping ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^d CHENG HSIN GENERAL HOSPITAL   (Taiwan)

Author keywords

Anti mitotic agent; Inhibition of tubulin polymerization

Indexed keywords

1 (4' INDOLYL AND 6' QUINOLINYL) INDOLE DERIVATIVE; 1 BENZOFURAN 5 YL 4,5,6 TRIMETHOXY 1H INDOLE DERIVATIVE; 2 METHOXY 5 (4,5,6 TRIMETHOXY INDOL 1 YL) PHENOL DERIVATIVE; 2 METHOXY 5 (4,5,6 TRIMETHOXY INDOL 1 YL) PHENYLAMINE DERIVATIVE; 4 (4,5,6 TRIMETHOXY INDOL 1 YL) QUINOLINE DERIVATIVE; 4,5,6 TRIMETHOXY 1 (4 METHOXY PHENYL) 1H INDOLE DERIVATIVE; 4,5,6 TRIMETHOXY 1' METHYL 1'H [1,5']BIINDOLYL DERIVATIVE; 4,5,6 TRIMETHOXY 10' METHYL 1'H [1,4']BIINDOLYL DERIVATIVE; 4,5,6,6' TETRAMETHOXY 1' METHYL 1'H [1,3']BIINDOLYL DERIVATIVE; 5 (4,5,6 TRIMETHOXY INDOL 1 YL) QUINOLINE DERIVATIVE; 5 METHOXY 2 (4,5,6 TRIMETHOXY INDOL 1 YL) PHENYLAMINE DERIVATIVE; 6 (4,5,6 TRIMETHOXY INDOL 1 YL) QUINAZOLINE DERIVATIVE; 6 (4,5,6 TRIMETHOXY INDOL 1 YL) QUINOLINE DERIVATIVE; 6 METHOXY 2 (4,5,6 TRIMETHOXY INDOL 1 YL) QUINOLINE DERIVATIVE; ANTINEOPLASTIC AGENT; COLCHICINE; DIMETHYL [4 (4,5,6 TRIMETHOXY INDOL 1 YL) PHENYL] AMINE DERIVATIVE; INDOLE DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN 1; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MICROTUBULE; PROTEIN BINDING; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TUBULIN;

EID: 80052932683     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.04.065     Document Type: Article

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