Synthesis and biological evaluation of 2-pyridyl-substituted pyrazoles and imidazoles as transforming growth factor-β type 1 receptor kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 14, 2010, Pages 4228-4232

  Dewang, Purushottam M ^a   Kim, Dae Kee ^a  

^a Ewha Womans University   (South Korea)

Author keywords

ALK5 inhibitor; Cell based luciferase reporter assays; TGF

Indexed keywords

3 (3 (6 METHYLPYRIDIN 2 YL) 4 (QUINOLIN 6 YL) 1H PYRAZOLE 1 CARBOTHIOAMIDO)BENZAMIDE; 4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; IMIDAZOLE DERIVATIVE; PROTEIN TYROSINE KINASE INHIBITOR; PYRAZOLE DERIVATIVE; SB 505124; SB 525334; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

CELL LINE; HUMANS; IMIDAZOLES; PROTEIN-SERINE-THREONINE KINASES; PYRAZOLES; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA;

EID: 77953873137     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.05.032     Document Type: Article

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