Quinolinyl and quinolinyl N-oxide chalcones: Synthesis, antifungal and cytotoxic activities

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4448-4456

  De Carvalho Tavares, Luciana ^a   Johann, Susana ^b,c   Maria De Almeida Alves, Tânia ^c   Guerra, Juliana Correia ^b   Maria De Souza Fagundes, Elaine ^b   Cisalpino, Patrícia Silva ^b   Bortoluzzi, Adailton J ^a   Caramori, Giovanni F ^a   De Mattos Piccoli, Rafael ^a   Braibante, Hugo T S ^d   Braibante, Mara E F ^d   Pizzolatti, Moacir G ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

^d FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

Antifungal activity; Cytotoxic activity; Quinolinyl chalcones; Quinolinyl N oxide chalcones

Indexed keywords

1 (4 BROMOPHENYL) 3 (1 OXIDE 6 QUINOLINYL) 2 PROPEN 1 ONE; 1 (4 BROMOPHENYL) 3 (6 QUINOLINYL) 2 PROPEN 1 ONE; 1 (4 CHLOROPHENYL) 3 (1 OXIDE 6 QUINOLINYL) 2 PROPEN 1 ONE; 1 (4 CHLOROPHENYL) 3 (6 QUINOLINYL) 2 PROPEN 1 ONE; 1 (4 FLUOROPHENYL) 3 (1 OXIDE 6 QUINOLINYL) 2 PROPEN 1 ONE; 1 (4 FLUOROPHENYL) 3 (6 QUINOLINYL) 2 PROPEN 1 ONE; 1 (4 METHOXYPHENYL) 3 (1 OXIDE 6 QUINOLINYL) 2 PROPEN 1 ONE; 1 (4 METHOXYPHENYL) 3 (6 QUINOLINYL) 2 PROPEN 1 ONE; 1 (4 METHYLPHENYL) 3 (1 OXIDE 6 QUINOLINYL) 2 PROPEN 1 ONE; 1 (4 METHYLPHENYL) 3 (6 QUINOLINYL) 2 PROPEN 1 ONE; 1 (4 NITROPHENYL) 3 (1 OXIDE 6 QUINOLINYL) 2 PROPEN 1 ONE; 1 (4 NITROPHENYL) 3 (6 QUINOLINYL) 2 PROPEN 1 ONE; 1 PHENYL 3 (6 QUINOLINYL) 2 PROPEN 1 ONE; 3 (1 OXIDE 6 QUINOLINYL) 1 PHENYL 2 PROPEN 1 ONE; 6 (3 OXO 3 PHENYL 1 PROPEN 1 YL) 1 METHYLQUINOLINIUM IODIDE; 6 [3 (4 BROMOPHENYL) 3 OXO 1 PROPEN 1 YL] 1 METHYLQUINOLINIUM IODIDE; 6 [3 (4 CHLOROPHENYL) 3 OXO 1 PROPEN 1 YL] 1 METHYLQUINOLINIUM IODIDE; 6 [3 (4 FLUOROPHENYL) 3 OXO 1 PROPEN 1 YL] 1 METHYLQUINOLINIUM IODIDE; 6 [3 (4 METHOXYPHENYL) 3 OXO 1 PROPEN 1 YL] 1 METHYLQUINOLINIUM IODIDE; 6 [3 (4 METHYLPHENYL) 3 OXO 1 PROPEN 1 YL] 1 METHYLQUINOLINIUM IODIDE; 6 [3 (4 NITROPHENYL) 3 OXO 1 PROPEN 1 YL] 1 METHYLQUINOLINIUM IODIDE; AMPHOTERICIN B; ANTIFUNGAL AGENT; CHALCONE DERIVATIVE; COTRIMOXAZOLE; CYTOTOXIC AGENT; QUINOLINYL CHALCONE DERIVATIVE; QUINOLINYL N OXIDE CHALCONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; BREAST CANCER; CANCER GROWTH; CANCER SURVIVAL; CANDIDA; CELL STRAIN HL 60; CONTROLLED STUDY; CRYPTOCOCCUS GATTII; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; KIDNEY CANCER; LEUKEMIA CELL; LEUKEMIA CELL LINE; MELANOMA; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PARACOCCIDIOIDES BRASILIENSIS;

ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHALCONES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; QUINOLINES; SPECTROPHOTOMETRY, INFRARED;

EID: 80052926752     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.07.019     Document Type: Article

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