A facile four-component sequential protocol in the expedient synthesis of novel 2-aryl-5-methyl-2,3-dihydro-1H-3-pyrazolones in water and their antitubercular evaluation

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4530-4536

  Gunasekaran, Pethaiah ^a   Perumal, Subbu ^a   Yogeeswari, Perumal ^b   Sriram, Dharmarajan ^b  

^a MADURAI KAMARAJ UNIVERSITY   (India)

^b BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

naphthol; Antimycobacterial activity; Methyl acetatoacetate; Multi component; Phenylhydrazines; Pyrazolones; Sequential

Indexed keywords

2 (4 CHLOROPHENYL) 4 [(4 CHLOROPHENYL)(2 HYDROXY 1 NAPHTHYL)METHYL] 5 METHYL 2,3DIHYDRO 1H 3 PYRAZOLONE; 2 (4 FLUOROPHENYL) 4 (2 HYDROXY 1 NAPHTHYL)[4 (NITROMETHYL)PHENYL]METHYL 5 METHYL 2,3 DIHYDRO 1H 3 PYRAZOLONE; 2 (4 FLUOROPHENYL) 4 [(2 HYDROXY 1 NAPHTHYL)(3 NITROPHENYL)METHYL] 5 METHYL 2,3 DIHYDRO 1H 3 PYRAZOLONE; 2 (4 FLUOROPHENYL) 4 [(2 HYDROXY 1 NAPHTHYL)(4 METHYLPHENYL)METHYL] 5 METHYL 2,3 DIHYDRO 1H 3 PYRAZOLONE; 2 (4 FLUOROPHENYL) 4 [(2 HYDROXY 1 NAPHTHYL)(PHENYL)METHYL] 5 METHYL 2,3 DIHYDRO 1H 3 PYRAZOLONE; 2 (4 FLUOROPHENYL) 4 [(4 FLUOROPHENYL)(2-HYDROXY 1 NAPHTHYL)METHYL] 5 METHYL 2,3 DIHYDRO 1H 3 PYRAZOLONE; 4 (2 HYDROXY 1-NAPHTHYL)[4 (NITROMETHYL)PHENYL]METHYL 5 METHYL 2 PHENYL 2,3 DIHYDRO 1H 3 PYRAZOLONE; 4 [(2 HYDROXY 1 NAPHTHYL)(2 NITROPHENYL)METHYL] 5 METHYL 2 PHENYL 2,3 DIHYDRO 1H 3 PYRAZOLONE; 4 [(2 HYDROXY 1 NAPHTHYL)(4 ISOPROPYLPHENYL)METHYL] 5 METHYL 2 PHENYL 2,3 DIHYDRO 1H 3 PYRAZOLONE; 4 [(2 HYDROXY 1 NAPHTHYL)(4 METHOXYPHENYL)METHYL] 5 METHYL 2 PHENYL 2,3 DIHYDRO 1H 3 PYRAZOLONE; 4 [(2 HYDROXY 1 NAPHTHYL)(4 METHYLPHENYL)METHYL] 5 METHYL 2 PHENYL 2,3 DIHYDRO 1H 3 PYRAZOLONE; 4 [(2 HYDROXY 1 NAPHTHYL)(PHENYL)METHYL] 5 METHYL 2 PHENYL 2,3 DIHYDRO 1H 3 PYRAZOLONE; 4 [(2,4 DICHLOROPHENYL)(2 HYDROXY 1 NAPHTHYL)METHYL] 2 (4 FLUOROPHENYL) 5 METHYL 2,3 DIHYDRO 1H 3 PYRAZOLONE; 4 [(4 CHLOROPHENYL)(2 HYDROXY 1 NAPHTHYL)METHYL] 2 (4 FLUOROPHENYL) 5 METHYL 2,3 DIHYDRO 1H 3 PYRAZOLONE; 4 [(4 CHLOROPHENYL)(2 HYDROXY 1 NAPHTHYL)METHYL] 5 METHYL 2 PHENYL 2,3 DIHYDRO 1H 3 PYRAZOLONE; CIPROFLOXACIN; ETHAMBUTOL; PYRAZOLONE DERIVATIVE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

AGAR DILUTION; ARTICLE; DRUG ACTIVITY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; ONE POT SYNTHESIS;

ANTITUBERCULAR AGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; PYRAZOLONES; WATER;

EID: 80052916066     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.07.029     Document Type: Article

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