Assessment of the potential of a boron-fructose additive in counteracting the toxic effect of Fusarium mycotoxins

British Journal of Nutrition

Volumn 106, Issue 3, 2011, Pages 398-407

  Taranu, Ionelia ^a   Marin, Daniela E ^a   Manda, Gina ^b   Motiu, Monica ^a   Neagoe, Ionela ^b   Tabuc, Cristina ^a   Stancu, Mariana ^a   Olteanu, Margareta ^a  

^a Institutul National de Cercetare Dezvoltare pentru Biologie si Nutritie Animala Bucharest   (Romania)

^b VICTOR BABES NATIONAL INSTITUTE OF PATHOLOGY   (Romania)

Author keywords

Decontaminating agents; Fusarium toxins; Immune response; Pigs

Indexed keywords

BORON; FRUCTOSE; FUMONISIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 1BETA; INTERLEUKIN 8; MYCOTOXIN; TUMOR NECROSIS FACTOR ALPHA; VOMITOXIN; ZEARALENONE; ANTIDOTE; BORIC ACID; CALCIUM FRUCTOBORATE; CYTOKINE; DRUG DERIVATIVE; FOOD ADDITIVE; IMMUNOGLOBULIN; TRICHOTHECENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL TISSUE; ARTICLE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; FUSARIUM; GRANULOCYTE; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; LYMPHOCYTE SUBPOPULATION; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; RESPIRATORY BURST; SWINE; ANIMAL; BIOSYNTHESIS; BLOOD; BODY WEIGHT; DIET SUPPLEMENTATION; DRUG EFFECT; FOOD CONTAMINATION; IMMUNITY; MAIZE; METABOLISM; MONONUCLEAR CELL; PHYSIOLOGY; SOYBEAN; T LYMPHOCYTE SUBPOPULATION;

ANIMALIA; FUSARIUM; FUSARIUM SP.; SUIDAE; SUS; ZEA MAYS;

ANIMAL FEED; ANIMALS; ANTIDOTES; BODY WEIGHT; BORATES; BORON; CELL PROLIFERATION; CYTOKINES; DIETARY SUPPLEMENTS; FOOD ADDITIVES; FOOD CONTAMINATION; FRUCTOSE; FUSARIUM; GRANULOCYTES; IMMUNITY; IMMUNOGLOBULINS; LEUKOCYTES, MONONUCLEAR; RESPIRATORY BURST; SOYBEANS; SWINE; T-LYMPHOCYTE SUBSETS; TRICHOTHECENES; ZEA MAYS;

EID: 80052886018     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114511000341     Document Type: Article

References (53)

1. Smith TK, McMillan EG & Castillo JB (1997) Effect of feeding blends of Fusarium mycotoxin-contaminated grains containing deoxynivalenol and fusaric acid on growth and feed consumption of immature swine. J Anim Sci 75, 2184-2191. (Pubitemid 127443343)
2. Agence Francaise de Securite Alimentaire-AFSA (2009) Report: Evaluation des risques liés à la présence de mycotoxines dans la châne alimentaire (Report: Assessment of Risk Associated with the Presence of Mycotoxins in the Food Chain). http://www.afssa.fr/index.htm.
3. Pestka JJ & Smolinski AT (2005) Deoxynivalenol: toxicology and potential effects on humans. J Toxicol Environ Health B Crit Rev 8, 39-69. (Pubitemid 40066025)
4. Lillehoj EB (1983) Effect of environmental and cultural factors on aflatoxin contamination of developing corn kernels. In Aflatoxins and Aspergillus flavus in Corn, pp. 27-34 [UL Diener, RL Asquith and JW Dickens, editors]. Aubum University. Southern Cooperative Series Bulletin 279. Auburn, AL: Alabama Agricultural Experiment Station.
5. Bhatnagar D, Lillehoj EB, Bennett JW, et al. (1991) Biological detoxification of mycotoxins. In Mycotoxin and Animal Food, Chapter 36, pp. 815-826. Boca Raton, FL: CRC Press.
6. Kabak B, Dobson ADW & Işl V (2006) Strategies to prevent mycotoxin contamination of food and animal feed: a review. Crit Rev Food Sci Nutr 46, 593-619. (Pubitemid 44601413)
7. Bata A & Lasztity R (1999) Detoxification of mycotoxin-contaminated food and feed by microorganisms. Trends Food Sci Technol 10, 223-228.
8. Karlovsky P (1999) Biological detoxification of fungal toxins and its use in plant breeding, feet, and food production. Nat Toxins 7, 1-23. (Pubitemid 29397223)
9. Avantaggiato G, Havenaar R & Visconti A (2007) Assessment of the multi-mycotoxin-binding efficacy of a carbon/aluminosilicate-based product in an in vitro gastrointestinal model. J Agric Food Chem 55, 4810-4819. (Pubitemid 46960910)
10. Bata A & Lasztity R (1999) Detoxification of mycotoxin-contaminated food and feed by microorganisms. Trends Food Sci Technol 10, 223-228.
11. Döll S, Gericke S, Dänicke S, et al. (2005) The efficacy of a modified aluminosilicate as a detoxifying agent in Fusarium toxin contaminated maize containing diets for piglets. J Anim Physiol Anim Nutr 89, 342-358. (Pubitemid 41335793)
12. The European Food Safety Authority (EFSA) Journal (2009) Review of Mycotoxin-detoxifying Agents used as Feed Additives: Mode of Action, Efficacy and Feed/food Safety. Scientific Report Q-2009-00839. http://www.efsa.europa.eu/ en/scdocs/scdoc/22e.htm
13. The European Food Safety Authority (EFSA) Journal (2005) Opinion of the Scientific Panel on Additives and Products or Substances Used in Animal Feed on a Request from the Commission on the Safety of the Product "Biomin BBSH 797" for Piglets, Pigs for Fattening and Chickens for Fattening. http://www.efsa.europa.eu
14. Galvano F, Piva A, Ritieni A, et al. (2001) Dietary strategies to counteract the effects of mycotoxins: a review. J Food Prot 64, 120-131. (Pubitemid 32102905)
15. Pié S, Lallès JP, Blazy F, et al. (2004) Weaning is associated with an upregulation of expression of inflammatory cytokines in the intestine of piglets. J Nutr 134, 641-647. (Pubitemid 38298510)
16. EC/576 (2006) European Commission recommendation on the presence of deoxynivalenol, zearalenone, ochratoxin A, T-2 and HT-2 and fumonisins in products intended for animal feeding. Official J European Union I, 229/7-229/9.
17. Rotaru P, Scorei R, Harabor A, et al. (2010) Thermal analysis of a calcium fructoborate sample. Thermochim Acta 506, 8-13.
18. The Romanian Standardized Association (ASRO) Standardized Bulletin (2010) SR ISO 6496/2001. http://www.asro.ro
19. The Romanian Standardized Association (ASRO) Standardized Bulletin (2010) SR EN ISO 5983-2/2009. http://www. asro.ro
20. The Romanian Standardized Association (ASRO) Standardized Bulletin (2010) SR ISO 6492/2001. http://www.asro.ro
21. The Romanian Standardized Association (ASRO) Standardized Bulletin (2010) SR EN ISO 6865/2002. http://www. asro.ro
22. The Romanian Standardized Association (ASRO) Standardized Bulletin (2010) SR EN ISO 2171/2010. http://www. asro.ro
23. Marin DE, Taranu I, Pascale F, et al. (2006) Sex-related differences in the immune response of weanling piglets exposed to low doses of fumonisin extract. Br J Nutr 95, 1-9.
24. Etienne M (2007) Effets biologiques et physiologiques d'une mycotoxine, le déoxynivalénol (DON), chez le porc (Biological and physiological effects of deoxynivalenol (DON), a mycotoxin, in the pig). Journées Rech Porcine 39, 407-418.
25. Grosjean F, Callu P, Pinton P, et al. (2003) Quantification des effets de la consommation de déoxynivalénol (DON) par le porcelet sevré (Quantification of the effects of deoxynivalenol consumption by weaned piglets). Journées Rech Porcine 35, 443-450.
26. Swamy HVLN, Smith TK, MacDonald EJ, et al. (2002) Effects of feeding a blend of grains naturally contaminated with mycotoxins Fusarium on swine performance, brain regional neurochemistry, and serum chemistry and the efficacy of a polymeric glucomannan mycotoxin adsorbent. J Anim Sci 80, 3257-3267. (Pubitemid 41138366)
27. Foster BC, Trenholm HL, Friend DW, et al. (1986) Evaluation of different sources of deoxynivalenol (vomitoxin) fed to swine. Can J Anim Sci 66, 1149-1154.
28. Friend DW, Trenholm HL, Elliot JI, et al. (1982) Effect of feeding vomitoxin-contaminated wheat to pigs. Can J Anim Sci 62, 1211-1222.
29. Armstrong TA, Flowers WL, Spears JW, et al. (2002) Longterm effects of boron supplementation on reproductive characterstics and bone mechanical properties in gilts. J Anim Sci 80, 154-161.
30. Armstrong TA & Spears JW (2003) Effect of boron supplementation of pig diets on the production of tumor necrosis factor-alpha and interferon-gamma. J Anim Sci 81, 2552-2561. (Pubitemid 38571659)
31. Gutzwiller A, Czegledi L, Stoll P, et al. (2007) Effects of Fusarium toxins on growth, humoral immune response and internal organs in weaner pigs, and the efficacy of apple pomace as an antidote. J Anim Physiol Anim Nutr 91, 432-438. (Pubitemid 47382871)
32. Wetscherek W, Huber H & Lew J (1998) Einsatz von mit Mycotoxinen kontaminiertern Mais und von Detoxifikationsmitteln in der Schweinemast (Use of corn contaminated with mycotoxins and detoxifying in pigs). Proc Soc Nutr Physiol 7, 93.
33. Swamy HVLN, Smith TK, Cotter PF, et al. (2002) Effects of feeding blends of grains naturally contaminated with Fusarium mycotoxins on production and metabolism in broilers. Poult Sci 81, 966-975. (Pubitemid 39622712)
34. Oswald IP, Marin DE, Bouhet S, et al. (2005) Immunotoxicological risk of mycotoxins for domestic animals. Food Add Contam 22, 354-360. (Pubitemid 40723770)
35. Pestka JJ, Zhou HR, Moon Y, et al. (2004) Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes: unravelling a paradox. Toxicol Lett 153, 61-73. (Pubitemid 39165750)
36. Meky FA, Hardie LJ, Evans SW, et al. (2001) Deoxynivalenolinduced immunomodulation of human lymphocyte proliferation and cytokine production. Food Chem Toxicol 39, 827-836. (Pubitemid 32575250)
37. Grosjean F, Pinton P, Callu P, et al. (2007) Effets de la consommation par le porcelet sevré d'aliment contenant du blé naturellement fusarié (Effects of consumption of diet including Fusarium naturally contaminated wheat in weaned piglets). Journees Rech. Porcine 39, 427-428.
38. Goyarts T, Danicke S, Tiemann U, et al. (2006) Effect of the Fusarium toxin deoxynivalenol (DON) on IgA, IgM and IgG concentrations and proliferation of porcine blood lymphocytes. Toxicol In vitro 20, 858-867.
39. Pinton P, Accensi F & Beauchamp E (2006) Effets de la consommation d'aliment naturellement contaminé par du déoxynivalénol (DON) sur la réponse vaccinale du porc (Effects of consumption of naturally contaminated feed by deoxynivalenol (DON) on the vaccinal immune response in pigs). Journées Rech Porcine 38, 399-406.
40. Rotter BA, Prelusky DB & Pestka JJ (1996) Toxicology of deoxynivalenol (vomitoxin). J Toxicol Environ Health 48, 1-34.
41. Accensi F, Pinton P, Callu P, et al. (2006) Ingestion of low doses of deoxynivalenol does not affect haematological, biochemical, or immune responses of piglets. J Anim Sci 84, 1935-1942. (Pubitemid 44033983)
42. Danicke S, Valenta H, Klobasa F, et al. (2004) Effects of graded levels of Fusarium toxin contaminated wheat in diets for fattening pigs on growth performance, nutrient digestibility, deoxynivalenol balance and clinical serum characteristics. Arch Anim Nutr 58, 1-17. (Pubitemid 38597301)
43. Doll S, Danicke S, Ueberschar KH, et al. (2003) Effects of graded levels of Fusarium toxin contaminated maize in diets for female weaned piglets. Arch Anim Nutr 57, 311-334.
44. Swamy HVLN, Smith TK, MacDonald EJ, et al. (2003) Effects of feeding a blend of grains naturally contamined with Fusarium mycotoxins on growth and immunological measurements of starter pigs, and the efficacy of a polymeric glucomannan mycotoxin adsorbent. J Anim Sci 81, 2792-2803. (Pubitemid 38571624)
45. Girish CK, Smith TK, Boermans HJ, et al. (2010) Effects of dietary Fusarium mycotoxins on intestinal lymphocyte subset populations, cell proliferation and histological changes in avian lymphoid organs. Food Chem Toxicol 48, 3000-3007.
46. Pinton P, Royer E, Accensi F, et al. (2004) Effets zootechniques et immunitaires de la consommation d'aliment naturellement contaminé par du déoxynivalénol (DON) chez le porc en phase de croissance ou de finition (Effects of feeding growing or finishing pigs with deoxynivalenol (DON) natually contaminated feed on growth performance and immunological status). Journées Rech Porcine 36, 301-308.
47. Grosjean F, Taranu I, Skiba F, et al. (2002) Comparaisons de blés fusariés naturellement à des blés sains, dans l'alimentation du porcelet sevré (Comparisons of different naturally Fusarium-contaminated wheats with uncontaminated wheats in weaned piglet diets). Journées Rech Porcine 34, 333-339.
48. Scorei RI, Ciofrangeanu C, Ion R, et al. (2010) In vitro effects of calcium fructoborate upon production of inflammatory mediators by LPS-stimulated RAW 264.7 macrophages. Biol Trace Elem Res 135, 334-344.
49. Scorei R, Cimpoiasu VM & Iordachescu D (2005) In vitro evaluation of the antioxidant activity of calcium fructoborate. Biol Trace Elem Res 107, 127-134.
50. Luo D & Eckhert CD (2000) Boron responsive human genes. FASEB J 14, A478.
51. Hunt CD & Idso JP (1999) Dietary boron as physiological regulator of the normal inflammatory response: a review and current reaserch progress. J Trace Elem Exo Med 12, 221-223.
52. Nielsen FH (1997) Boron in human and animal nutrition. Plant Soil 193, 199-208. (Pubitemid 27392922)
53. Nielsen FH (1994) Biochemical and physiologic consequences of boron deprivation in humans. Environ Health Perspect 102, Suppl. 7, 59-63.