Assessment of the multi-mycotoxin-binding efficacy of a carbon/aluminosilicate-based product in an in vitro gastrointestinal model

Journal of Agricultural and Food Chemistry

Volumn 55, Issue 12, 2007, Pages 4810-4819

  Avantaggiato, Gluseppina ^a   Havenaar, Robert ^b   Visconti, Angelo ^a  

^a INSTITUTE OF SCIENCES OF FOOD PRODUCTION   (Italy)

^b TNO   (Netherlands)

Author keywords

Aflatoxins; Fumonisins, deoxynivalenol; Mycotoxin binders; Mycotoxin detoxification; Mycotoxins; Ochratoxins; Zearalenone

Indexed keywords

ALUMINOSILICIC ACID; ALUMINUM SILICATE; CARBON; MYCOTOXIN; UNCLASSIFIED DRUG;

ADSORPTION; ANIMAL; ANIMAL FOOD; ARTICLE; BINDING SITE; BIOLOGICAL MODEL; GASTROINTESTINAL TRACT; GASTROINTESTINAL TRANSIT; METABOLISM; PH; PHYSIOLOGY; STOMACH EMPTYING; SWINE;

ADSORPTION; ALUMINUM SILICATES; ANIMAL FEED; ANIMALS; BINDING SITES; CARBON; GASTRIC EMPTYING; GASTROINTESTINAL TRACT; GASTROINTESTINAL TRANSIT; HYDROGEN-ION CONCENTRATION; MODELS, BIOLOGICAL; MYCOTOXINS; SWINE;

ANIMALIA; SUS;

EID: 34250762536     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf0702803     Document Type: Article

References (31)

1. CAST (Council for Agricultural Science and Technology). Mycotoxins: Risks in Plant, Animal, and Human Systems; Task Force Report 139; Ames, IA, 2003.
2. Speijers, G. J.; Speijers, M. H. Combined toxic effects of mycotoxins. Toxicol. Lett. 2004, 153, 91-98.
3. Harvey, R. B.; Huff, W. E.; Kubena, L. F.; Phillips, T. D. Evaluation of diets contaminated with aflatoxin and ochratoxin fed to growing pigs. Am. J. Vet. Res. 1989, 50, 1400-1405.
4. 1-containing culture material, deoxynivalenol-contaminated wheat, or their combination on growing barrows. Am. J. Vet. Res. 1996, 57, 1790-1794.
5. Smith, T. K.; McMillan, E. G.; Castillo. J. B. Effect of feeding blends of Fusarium mycotoxin-contaminated grains containing deoxynivalenol and fusaric acid on growth and feed consumption of immature swine. J. Anim. Sci. 1997, 75, 2184-2191.
6. Ramos, A. J.; Fink-Gremmels, J.; Hernandez, E. Prevention of toxic effects of mycotoxins by means of non-nutritive adsorbent compounds. J. Food Prot. 1996, 59, 631-641.
7. Phillips, T. D. Dietary clay in the chemoprevention of aflatoxin-induced disease. Toxicol. Sci. 1999, 52, 118-126.
8. Chestnut, A. B.; Anderson, P. D.; Cochran, M. A.; Fribourg, H. A.; Gwinn, K. D. Effects of hydrated sodium calcium alumino-silicate on fescue toxicosis and mineral absorption. J. Anim. Sci. 1992, 70, 2838-2846.
9. Diaz, D. E.; Smith, T. K. Mycotoxin sequestering agents: practical tools for the neutralisation of mycotoxins. In The Mycotoxin Blue Book; Diaz, D. E., Ed.; Nottingham University Press: Nottingham, U.K., 2005; pp 323-338.
10. Avantaggiato, G.; Havenaar, R.; Visconti, A. Assessing the zearalenone-binding activity of adsorbent materials during passage through a dynamic in vitro gastrointestinal model. Food Chem. Toxicol. 2003, 41, 1283-1290.
11. Avantaggiato, G.; Havenaar, R.; Visconti, A. Evaluation of the intestinal absorption of deoxynivalenol and nivalenol by an in vitro gastrointestinal model, and the binding efficacy of activated carbon and other adsorbent materials. Food Chem. Toxicol. 2004, 42, 817-824.
12. Avantaggiato, G.; Solfrizzo, M.; Visconti, A. Recent advances on the use of adsorbent materials for detoxification of Fusarium mycotoxins. Food Addit. Contam. 2005, 22, 379-388.
13. Minekus, M.; Marteau, P.; Havenaar, R.; Huis in't Veld, J. H. J. A multi compartmental dynamic computer-controlled model simulating the stomach and small intestine. Altern. Lab. Anim. 1995, 23, 197-209.
14. Zeijdner, E. E.; Avantaggiato, G.; Sidler, S.; Escribano, F.; Visconti, A.; Havenaar, R. The use of a dynamic in vitro model of the gastrointestinal tract (TIM) in studying mycotoxin adsorbents. In Meeting the Mycotoxin Menace; Barug, D., Van Egmond, H. P., Lopez-Garcia, R., Van Osenbruggen, T., Visconti, A., Eds.; Wageningen Academic Publishers: Wageningen, The Netherlands, 2004; pp 281-293.
15. 1 in cattle feed: collaborative study. J. AOAC Int. 2003, 86, 1179-1186.
16. Entwisle, A. C.; Williams, A. C.; Mann, P. J.; Slack, P. T.; Gilbert, J. Liquid chromatographic method with immunoaffinity column cleanup for determination of ochratoxin A in barley: collaborative study. J. AOAC Int. 2000, 83, 1377-1383.
17. Visconti, A.; Pascale, M. Determination of zearalenone in corn by means of immunoaffinity clean-up and high-performance liquid chromatography with fluorescence detection. J. Chromatogr. A 1998, 815, 133-140.
18. Pascale, M.; Visconti, A.; Avantaggiato, G.; Pronczuk, M.; Chelkowski J. Mycotoxin contamination of maize hybrids after infection with Fusarium proliferatum. J. Sci. Food Agric. 1999, 79, 2094-2098.
19. Bauer, J. Moglichkeiten zur Entgiftung mycotoxin-haltiger Futtermittel. Monatsh. Veterinaermed. 1994, 49, 175-181.
20. Galvano, F.; Pietri, A.; Bertuzzi, T.; Piva, A.; Chies, L.; Galvano, M. Activated carbons: In vitro affinity for ochratoxin A and deoxynivalenol and relation of adsorption ability to physicochemical parameters. J. Food Prot. 1998, 61, 469-475.
21. 1 and relation of adsorption ability to physicochemical parameters. J. Food Prot. 1997, 60, 985-991.
22. Phillips, T. D.; Clement, B. A.; Kubena, L. F.; Harvey, R. B. Detection and detoxification of aflatoxins. Prevention of aflatoxicosis and aflatoxin residues with hydrated sodium calcium aluminosilicate. Vet. Hum. Toxicol. 1990, 32, 15-19.
23. Lawlor, P. G.; Lynch, P. B. Mycotoxins in pig feeds 2: clinical aspects. Ir. Vet. J. 2001, 54, 172-176.
24. Ramos, A. J.; Hernandez, E.; Plà-Delfina, J. M.; Merino, M. Intestinal absorption of zearalenone and in vitro study of non-nutritive sorbent materials. Int. J. Pharm 1996, 128, 129-137.
25. Döll, S.; Dänicke, S.; Ueberschär, K. H.; Valenta, H.; Schnurrbusch, U.; Ganter, M.; Klobasa, F.; Flachowsky, G. Effects of graded levels of Fusarium toxin contaminated maize in diets for female weaned piglets. Arch. Tierernahr. 2003, 57, 311-334.
26. Afriyie-Gyawu, E.; Wiles, M. C.; Huebner, H. J.; Richardson, M. B.; Fickey, C.; Phillips, T. D. Prevention of zearalenone-induced hyperestrogenism in prepubertal mice. J. Toxicol. Environ. Health, A 2005, 68, 353-368.
27. Underhill, K. L.; Rotter, B. A.; Thompson, B. K.; Prelusky, D. B.; Trenholm, H. L. Effectiveness of cholestyramine in the detoxification of zearalenone as determined in mice. Bull. Environ. Contam. Toxicol. 1995, 54, 128-134.
28. Solfrizzo, M.; Visconti, A.; Avantaggiato, G.; Torres, A.; Chulze, S. In vitro and in vivo studies to assess the effectiveness of cholestyramine as a binding agent for fumonisins. Mycopathologia 2001, 151, 147-153.
29. Madhyastha, M. S.; Frohlich, A. A.; Marquardt, R. R. Effect of dietary cholestyramine on the elimination pattern of ochratoxin A in rats. Food Chem. Toxicol. 1992, 30, 709-714.
30. Roth, A.; Chakor, K.; Creppy, E. E.; Kane, A.; Roschenthaler, R.; Dirheimer, G. Evidence for an enterohepatic circulation of ochratoxin A in mice. Toxicology 1988, 48, 293-308.
31. Kerkadi, A.; Barriault. C.; Tuchweber, B.; Frohlich, A. A.; Marquardt, R. R.; Bouchard, G.; Yousef, I. M. Dietary cholestyramine reduces ochratoxin A-induced nephrotoxicity in the rat by decreasing plasma levels and enhancing fecal excretion of the toxin. J. Toxicol. Environ. Health, A 1998, 53, 231-250.