Effect of Feeding Blends of Fusarium Mycotoxin-Contaminated Grains Containing Deoxynivalenol and Fusaric Acid on Growth and Feed Consumption of Immature Swine

Journal of Animal Science

Volumn 75, Issue 8, 1997, Pages 2184-2191

  Smith, Trevor K ^a,b   McMillan, Ewen G ^a   Castillo, Jorge B ^a  

^a Shur Gain Research   (Canada)

^b UNIVERSITY OF GUELPH   (Canada)

Author keywords

Fusaric Acid; Pigs; Synergism; Trichothecenes; Vomitoxin

Indexed keywords

FUSARIUM; HORDEUM VULGARE SUBSP. VULGARE; SUS SCROFA; TRITICUM AESTIVUM; ZEA MAYS;

FUSARIC ACID; MYCOTOXIN; TRICHOTHECENE DERIVATIVE; VOMITOXIN;

AGING; ANIMAL; ANIMAL FOOD; ARTICLE; BARLEY; CEREAL; CHEMISTRY; DRUG EFFECT; DRUG POTENTIATION; EATING; FEMALE; FUSARIUM; GROWTH, DEVELOPMENT AND AGING; MAIZE; MALE; METABOLISM; PHYSIOLOGY; RANDOMIZATION; STANDARD; SWINE; WEIGHT GAIN; WHEAT;

AGING; ANIMAL FEED; ANIMALS; CEREALS; DRUG SYNERGISM; EATING; FEMALE; FUSARIC ACID; FUSARIUM; HORDEUM; MALE; MYCOTOXINS; RANDOM ALLOCATION; SWINE; TRICHOTHECENES; TRITICUM; WEIGHT GAIN; ZEA MAYS;

EID: 0031201771     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/1997.7582184x     Document Type: Article

References (35)

1. 1 and fusaric acid measured by injection into fertile chicken egg. Mycopathologia 129:29-35.
2. Burmeister, H. R., M. D. Grove, D. Peterson, D. Weisleder, and R. D. Plattner. 1985. Isolation and characterization of two new fusaric acid analogs from Fusarium moniliforme NRRL 13,163. Appl. Environ. Microbiol. 50:311-314.
3. Carson, M. S., and T. K. Smith. 1983. Role of bentonite in prevention of T-2 toxicosis in rats. J. Anim. Sci. 57:1498-1506.
4. Cavan, K. R., E. J. MacDonald, and T. K. Smith. 1988. Potential for dietary amino acid precursors of neurotransmitters to overcome neurochemical changes in acute T-2 toxicosis in rats. J. Nutr. 118:901-907.
5. Chaouloff, F., D. Laude, D. Merino, B. Serrurrier, and J. L. Elghozi. 1986. Peripheral and central short-term effects of fusaric acid, a DBH inhibitor, on tryptophan and serotonin metabolism in the rat. J. Neural Transm. 65:219-232.
6. Cote, L. M., V. R. Beasley, P. M. Bratich, S. P. Swanson, H. L. Shivaprasad, and W. B. Buck. 1985. Sex-related reduced weight gains in growing swine fed diets containing deoxynivalenol. J. Anim. Sci. 61:942-950.
7. Davis, N. D., J. W. Dickens, R. L. Freie, P. B. Hamilton, O. L. Shotwell, T. D. Wyllie, and J. F. Fulkerson. 1980. Protocols for surveys, sampling, post-collection handling, and analysis of grain samples involved in mycotoxin problems. J. Assoc. Off. Anal. Chem. 63:95-102.
8. Dowd, P. F. 1988. Toxicological and biochemical interactions of the fungal metabolites fusaric acid and kojic acid with xenobiotics in Heliothis zea (F.) and Spodoptera furgiperda (J. E. Smith). Pestic. Biochem. Physiol. 32:123-134.
9. Forsell, J. H., M. F. Witt, J.-H. Tai, R. Jensen, and J. J. Pestka. 1986. Effects of 8-week exposure of the B6C3F1 mouse to dietary deoxynivalenol (vomitoxin) and zearalenone. Food Chem. Toxicol. 24:213-219.
10. Forsyth, D. M., T. Yoshizawa, N. Morooka, and J. Tuite. 1977. Emetic and refusal activity of deoxynivalenol to swine. Appl. Environ. Microbiol. 34:547-552.
11. Friend, D. W., H. L. Trenholm, B. K. Thompson, P. S. Fiser, and K. E. Hartin. 1986. Effect of feeding diets containing deoxynivalenol (vomitoxin)-contaminated wheat or corn on the feed consumption, weight gain, organ weight and sexual development of male and female pigs. Can. J. Anim. Sci. 66:765-775.
12. 1 present in Fusarium moniliforme culture material and T-2 toxin on turkey poults. Poult. Sci. 74:306-313.
13. Leathwood, P. D. 1987. Tryptophan availability and serotonin synthesis. Proc. Nutr. Soc. 46:143-156.
14. Matsui, Y., and M. Watanabe. 1988. Quantitative analysis of fusaric acid in the cultural filtrate and soybean plants inoculated with Fusarium oxysporum var. redolens. J. Rakuno Gakuen Univ. Nat. Sci. 13:159-167.
15. Meloche, J. L., and T. K. Smith. 1995. Altered tissue amino acid metabolism in acute T-2 toxicosis. Proc. Soc. Exp. Biol. Med. 210:260-265.
16. NRC. 1988. Nutrient Requirements of Swine (9th Ed.). National Academy Press, Washington, DC.
17. Ostle, R., and R. W. Mensing. 1975. Statistics in Research (3rd Ed.). Iowa State University Press, Ames.
18. Pollmann, D. S., B. A. Kock, L. M. Seitz, H. E. Mohr, and G. A. Kennedy. 1985. Deoxynivalenol-contaminated wheat in swine diets. J. Anim. Sci. 60:239-247.
19. Porter, J. K., C. W. Bacon, E. M. Wray, and W. M. Hagler. 1995. Fusaric acid in Fusarium moniliforme cultures, corn, and feeds toxic to livestock and the neurochemical effects in the brain and pineal gland of rats. Nat. Toxins 3:91-100.
20. Prelusky, D. B. 1993. The effect of low-level of deoxynivalenol on neurotransmitter levels measured in pig cerebral spinal fluid. J. Environ. Sci. Health 628:731-761.
21. Prelusky, D. B., R. G. Gerdes, K. L. Underhill, B. A. Rotter, P. Y. Jui, and H. L. Trenholm. 1994. Effects of low-level dietary deoxynivalenol on haematological and clinical parameters of the pig. Nat. Toxins 2:97-104.
22. Prelusky, D. B., J. M. Yeung, B. K. Thompson, and H. L. Trenholm. 1992. Effect of deoxynivalenol on neurotransmitters in discrete regions of swine brain. Arch. Environ. Contam. Toxicol. 22: 36-40.
23. Rotter, B. A., D. B. Prelusky, and J. J. Pestka. 1996. Toxicology of deoxynivalenol (vomitoxin). J. Toxicol. Environ. Health 48: 1-34.
24. Rotter, B. A., B. K. Thompson, M. Lessard, H. L. Trenholm, and H. Tryphonas. 1994. Influence of low-level exposure to Fusarium mycotoxins on selected immunological and hematological parameters in young swine. Fundam. Appl. Toxicol. 23: 117-124.
25. Rotter, R. G., B. K. Thompson, D. B. Prelusky, K. E. Hartin, and J. D. Miller. 1992. A preliminary examination of the potential interactions between deoxynivalenol (DON) and other selected Fusarium metabolites in growing pigs. Can. J. Anim. Sci. 72: 107-116.
26. Rotter, B. A., B. K. Thompson, D. B. Prelusky, and H. L. Trenholm. 1991. Evaluation of potential interactions involving trichothecene mycotoxins using the chick embryotoxicity bioassay. Arch. Environ. Contam. Toxicol. 21:621-624.
27. SAS. 1987. SAS User's Guide: Statistics. SAS Inst. Inc., Cary, NC.
28. Smith, T. K. 1980. Influence of dietary fiber, protein and zeolite on zearalenone toxicosis in rats and swine. J. Anim. Sci. 50: 278-285.
29. Smith, T. K., and E. J. MacDonald. 1991. Effect of fusaric acid on brain regional neurochemistry and vomiting behavior in swine. J. Anim. Sci. 69:2044-2049.
30. Smith, T. K., and M. G. Sousadias. 1993. Fusaric acid content of swine feedstuffs. J. Agric. Food Chem. 41:2296-2298.
31. Steel, R.G.D., and J. H. Torrie. 1980. Principles and Procedures of Statistics: A Biometrical Approach (2nd Ed.). McGraw-Hill Publishing Co., New York.
32. Trenholm, H. L., W. P. Cochrane, H. Cohen, J. I. Elliott, E. R. Farnworth, D. W. Friend, R.M.G. Hamilton, J. R. Standish, and B. K. Thompson. 1983. Survey of vomitoxin contamination of 1980 Ontario winter wheat crop: Results of survey and feeding trials. J. Assoc. Off. Anal. Chem. 66:92-97.
33. Trenholm, H. L., B. C. Foster, L. L. Charmley, B. K. Thompson, K. E. Hartin, R. W. Coppock, and M. A. Albassam. 1994. Effects of feeding diets containing Fusarium (naturally) contaminated wheat or pure deoxynivalenol (DON) in growing pigs. Can. J. Anim. Sci. 74:361-364.
34. Wannemacher, R. W., D. L. Bunner, and H. A. Neufeld. 1991. Toxicity of trichothecenes and other related mycotoxins in laboratory animals. In: J. E. Smith and R. S. Henderson (Ed.) Mycotoxins and Animal Foods. p 500. CRC Press, Boca Raton, FL.
35. Young, J. C. 1986. Reduction in levels of deoxynivalenol in contaminated corn by chemical and physical treatments. J. Agric. Food Chem. 34:465-467.