Antiulcerogenic activity of peptide concentrates obtained from hydrolysis of whey proteins by proteases from Cynara cardunculus

International Dairy Journal

Volumn 21, Issue 12, 2011, Pages 934-939

  Tavares, T G ^a,d   Monteiro, K M ^b   Possenti, A ^b   Pintado, M E ^a   Carvalho, J E ^b   Malcata, F X ^c,d  

^a UNIVERSIDADE CATÓLICA PORTUGUESA   (Portugal)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c UNIVERSITY INSTITUTE OF MAIA   (Portugal)

^d INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

ABSOLUTE ETHANOL; AQUEOUS EXTRACTS; BODY WEIGHT; CYNARA CARDUNCULUS; CYTOPROTECTION; DOSE RESPONSE; GASTRIC INJURY; GASTRIC MUCOSA; ORAL ADMINISTRATION; SINGLE-DOSE; WHEY PROTEIN CONCENTRATE; WHEY PROTEINS;

ETHANOL; HYDROLYSIS; NITRIC OXIDE; SOLVENT EXTRACTION;

PEPTIDES;

CYNARA CARDUNCULUS;

EID: 80052879121     PISSN: 09586946     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.idairyj.2011.06.004     Document Type: Article

References (47)

1. Abdel-Salam D.M.E., Czimmer J., Debreceni A., Szolesanyi J., Mózsik G. Gastric mucosal integrity: gastric mucosal blood flow and microcirculation. An overview. Journal of Physiology 2001, 95:105-127.
2. Adibi S.A., Morse E.L. Intestinal transport of dipeptides in man: relative importance of hydrolysis and intact absorption. Journal of Clinical Investigation 1971, 50:2266-2275.
3. Allen A., Flemstrom G., Garner A., Kivilaakso E. Gastroduodenal mucosal protection. Physiological Reviews 1993, 73:823-857.
4. Barocelli E., Chiavarini M., Ballabeni V., Barlocco D., Vianello P., dal Piaz V., et al. Study of the antisecretory and antiulcer mechanisms of a new indenopirydazinone derivative in rats. Pharmacological Research 1997, 35:487-492.
5. Barros R.M., Extremina C.I., Gonçalves I.C., Braga B.O., Balcão V.M., Malcata F.X. Hydrolysis of α-lactalbumin by cardosin A immobilized on highly activated supports. Enzyme and Microbial Technology 2003, 33:908-916.
6. Barros R.M., Ferreira C.A., Silva S.V., Malcata F.X. Quantitative studies on the enzymatic hydrolysis of milk proteins brought about by cardosins precipitated by ammonium sulfate. Enzyme and Microbial Technology 2001, 29:541-547.
7. Barros R.M., Malcata F.X. Modelling the kinetics of whey protein hydrolysis brought about by enzymes from Cynara cardunculus. Journal of Agricultural and Food Chemistry 2002, 50:4347-4356.
8. Barros R.M., Malcata F.X. A kinetic model for hydrolysis of whey proteins by cardosin A extracted from Cynara cardunculus. Food Chemistry 2004, 88:351-359.
9. Barros R.M., Malcata F.X. Molecular characterization of peptides released from β-lactoglobulin and α-lactalbumin via cardosins A and B. Journal of Dairy Science 2006, 89:483-494.
10. Boirie Y., Dangin M., Gachon P., Vasson M.P., Maubois J.L., Beaufrère B. Slow and fast dietary proteins differently modulate postprandial protein accretion. Proceedings of the National Academy of Sciences of the United States of America 1997, 94:14930-14935.
11. Clare D.A., Swaisgood H.E. Bioactive milk peptides: a prospectus. Journal of Dairy Science 2000, 83:1187-1195.
12. Clemente A. Enzymatic protein hydrolysates in human nutrition. Trends in Food Science and Technology 2000, 11:254-262.
13. Elliot S.N., Msknight W., Cirino G., Wallance J.L. A nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats. Gastroenterology 1995, 109:524-530.
14. FitzGerald R.J., Murray B.A., Walsh D.J. Hypotensive peptides from milk proteins. Journal of Nutrition 2004, 134:980-988.
15. Gamberini M.T., Skorupa L.A., Souccar C., Lapa A.J. Inhibition of gastric secretion by a water extract from Baccharis triptera, Mart. Memórias do Instituto Oswaldo Cruz 1991, 86(Suppl.):137-139.
16. Gauthier S.F., Pouliot Y., Saint-Sauveur D. Immunomodulatory peptides obtained by the enzymatic hydrolysis of whey proteins. International Dairy Journal 2006, 16:1315-1323.
17. Gill H.S., Rutherford K.J., Cross M.L. Bovine milk: a unique source of immunomodulatory ingredients for functional foods. Functional foods II - Claims and evidence 2000, 82-90. Royal Society of Chemistry Press, Cambridge, UK. J. Buttriss, M. Saltmarsh (Eds.).
18. Grimble R.F., Grimble G.K. Immunonutrition: role of sulfur amino acids, related amino acids, and polyamines. Nutrition 1998, 14:605-610.
19. Konturek S.J. Mechanisms of gastroprotection. Scandinavian Journal of Gastroenterology 1990, 25:15-28.
20. Konturek S.J., Pawlik W. Physiology and pharmacology of prostaglandins. Digestive Diseases and Sciences 1986, 31:6S-19S.
21. Korhonen H. Milk-derived bioactive peptides: from science to applications. Journal of Functional Foods 2009, 1:177-187.
22. Lamas E.M., Barros R.M., Balcão V.M., Malcata F.X. Hydrolysis of whey proteins by proteases extracted from Cynara cardunculus and immobilized onto highly activated supports. Enzyme and Microbial Technology 2000, 28:642-652.
23. Lee Y.M., Skurk T., Hennig M., Hauner H. Effect of a milk drink supplemented with whey peptides on blood pressure in patients with mild hypertension. European Journal of Nutrition 2007, 46:21-27.
24. Matsumoto H., Shimokawa Y., Ushida Y., Toida T., Hayasawa H. New biological function of bovine α-lactalbumin: protective effect against ethanol- and stress-induced gastric mucosal injury in rats. Bioscience, Biotechnology and Biochemistry 2001, 65:1104-1111.
25. Meisel H. Biochemical properties of peptides encrypted in bovine milk proteins. Current Medicinal Chemistry 2005, 12:1905-1919.
26. Meisel H., FitzGerald R.J. Biofunctional peptides from milk proteins: mineral binding and cytomodulatory effects. Current Pharmaceutical Design 2003, 9:1289-1295.
27. Melo J.R.C., Castro J.P., Lanna J.C.B.D., Guimarães J.T., Sobrinho J.M.D.L. Anatomia do estômago e anatomia do desenvolvimento. Gastroenterologia Clínica 1993, Vol. 1:449-459. Guanabara Koogan, Rio de Janeiro, Brazil. R. Dani, L.P. Castro (Eds.).
28. Mezzaroba L.F.H., Carvalho J.E., Ponezi A.N., Antônio M.A., Monteiro K.M., Possenti A., et al. Antiulcerative properties of bovine α-lactalbumin. International Dairy Journal 2006, 16:1005-1012.
29. Miller T.A. Protective effects of prostaglandins against gastric mucosa damage: current knowledge and proposed mechanisms. American Journal of Physiology 1983, 245:G601-G623.
30. Nishida K., Ohta Y., Ishiguro I. Role of gastric mucosal constitutive and inducible nitric oxide synthases in the development of stress-induced gastric mucosal lesions in rats. Biochemistry and Biophysical Research Communications 1997, 236:275-279.
31. Pacheco M.T.B., Bighetti E.A., Antônio M., Carvalho J.E., Possenti A., Sgarbieri V.C. Antiulcerogenic activity of fraction and hydrolyzate obtained from whey protein concentrate. Brazilian Journal of Food Technology, III JIPCA 2006, 15-22.
32. Qiu B.S., Pfeiffer C.J., Cho C.H. Effects of chronic nitric oxide synthase inhibition in cold-restraint and ethanol-induced gastric mucosal damage in rats. Digestion 1996, 57:60-66.
33. Robert A. Cytoprotection by prostaglandins. Gastroenterology 1979, 77:761-767.
34. Rosaneli C.F., Bighetti A.E., Antônio M.A., Carvalho J.E., Sgarbieri V.C. Efficacy of a whey protein concentrate on the inhibition of stomach ulcerative lesions caused by ethanol ingestion. Journal of Medicinal Food 2002, 5:221-228.
35. Rosaneli C.F., Bighetti A.E., Antônio M.A., Carvalho J.E., Sgarbieri V.C. Protective effect of bovine milk whey protein concentrate on the ulcerative lesions caused by subcutaneous administration of indomethacin. Journal of Medicinal Food 2004, 7:309-314.
36. Roseiro M.L.B. Ewe's milk cheesemaking in Portugal using a vegetable rennet (a review). Sheep Dairy News 1991, 8:65-80.
37. Schmidt D.G., Meijer R.J., Slangen C.J., van Beresteijn E.C. Raising the pH of the pepsin-catalysed hydrolysis of bovine whey proteins increases the antigenicity of the hydrolysates. Clinical and Experimental Allergy 1995, 25:1007-1017.
38. Sgarbieri V.C. Food protein and peptides presenting specific protection to human health (a review). Food for health in the Pacific Rim 1999, 335-352. Food and Nutrition Press, Trumbull, CT, USA. J.R. Whitaker, N.F. Sholmaker, R.P. Singh (Eds.).
39. Szabo S., Nagy L., Pevebani M. Glutathione, protein sulfhydryls and cysteine proteinases in gastric mucosal injury and protection. Clinica Chimica Acta 1992, 206:95-105.
40. Szabo S., Trier J.S., Frankel P.W. Sulfhydryl compounds may mediate gastric cytoprotection. Science 1981, 214(4517):201-202.
41. Terano A. Mechanistic aspects of gastric cytoprotection: a review. Gastroenterologia Japonica 1992, 27:267-275.
42. Ushida Y., Shimokawa Y., Toida T., Matsui H., Takase M. Bovine α-lactalbumin stimulates mucus metabolism in gastric mucosa. Journal of Dairy Science 2007, 90:541-546.
43. Veríssimo P., Faro C., Moir A.J., Lin Y., Tang J., Pires E. Purification, characterization and partial amino acid sequencing of two new aspartic proteinases from fresh flowers of Cynara cardunculus L. European Journal of Biochemistry 1996, 235:762-768.
44. Virtanen T., Pihlanto A., Akkanen S., Korhonen H. Development of antioxidant activity in milk whey during fermentation with lactic acid bacteria. Journal of Applied Microbiology 2007, 102:106-115.
45. Wilson D.E. Role of prostaglandins in gastroduodenal mucosal protection. Journal of Clinical Gastroenterology 1991, 13:S65-S71.
46. Yamamoto N., Ejiri M., Mizuno S. Biogenic peptides and their potential use. Current Pharmaceutical Design 2003, 9:1345-1355.
47. Zhang G.F., Zhang M.A., Chen Y.R., Wang L. The roles of endothelin and nitric oxide in gastric mucosa injuries in rats with endotoxemia. World Chinese Journal of Digestology 2000, 8(Suppl. 8):24.