Synthesis and biological evaluation of novel N,N′-bis- methylenedioxybenzyl-alkylenediamines as bivalent anti-Alzheimer disease ligands

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 26, Issue 5, 2011, Pages 706-711

  Luo, Wen ^a   Li, Yan Ping ^a   Tan, Jia Heng ^a   Gu, Lian Quan ^a   Huang, Zhi Shu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

amyloid aggregation; Alzheimer's disease; Cholinesterase; Inhibitors; Synthesis

Indexed keywords

ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; CHOLINESTERASE; CURCUMIN; DIAMINE DERIVATIVE; LIGAND; N1,N3 BIS[(7 METHOXYBENZO[D][1,3]DIOXOL 5Y L)METHYL]PROPANE 1,3 DIAMINE; N1,N9 BIS[(7NMETHOXYBENZO[D][1,3]DIOXOL 5 YL)METHYL]NONANE 1,9 DIAMINE; RIVASTIGMINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CELL ASSAY; CELL VIABILITY; CLINICAL EVALUATION; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DETERMINATION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; BENZOPHENONES; CELLS, CULTURED; CURCUMIN; DIAMINES; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; METHYLENE CHLORIDE;

EID: 80052852029     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.3109/14756366.2010.548329     Document Type: Article

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