메뉴 건너뛰기




Volumn 14, Issue 8, 2010, Pages 855-868

Targeting YAP and Hippo signaling pathway in liver cancer

Author keywords

Hippo pathway; Liver cancer; Molecular therapeutics; YAP oncogene

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ALPHA FETOPROTEIN; AMG 479; BORTEZOMIB; CARBOPLATIN; CGP 6984; CGP 69846A; CP 751871; DACHSOUS PROTEIN; EXPANDED PROTEIN; HIPPO PROTEIN; HOMOTHORAX PROTEIN; KIBRA PROTEIN; MERLIN; MICRORNA; NEUROFIBROMIN; PACLITAXEL; PDZ PROTEIN; PROTEIN; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; TAMOXIFEN; TEASHIRT PROTEIN; TRANSCRIPTION FACTOR; TRICHOSTATIN A; UNCLASSIFIED DRUG; UNINDEXED DRUG; YES ASSOCIATED PROTEIN; YORKIE PROTEIN;

EID: 77954770827     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728222.2010.499361     Document Type: Review
Times cited : (87)

References (145)
  • 1
    • 77954313699 scopus 로고    scopus 로고
    • Yorkie: The final destination of Hippo signaling
    • published online 7 May 2010, doi:10.1016/j.tcb.2010.04.005
    • Oh H, Irvine KD. Yorkie: the final destination of Hippo signaling. Trends Cell Biol 2010: published online 7 May 2010, doi:10.1016/j.tcb.2010.04.005
    • (2010) Trends Cell Biol
    • Oh, H.1    Irvine, K.D.2
  • 3
    • 33747591465 scopus 로고    scopus 로고
    • Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon
    • Overholtzer M, Zhang J, Smolen GA, et al. Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci USA 2006;103:12405-12410
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 12405-12410
    • Overholtzer, M.1    Zhang, J.2    Smolen, G.A.3
  • 4
    • 33745253109 scopus 로고    scopus 로고
    • Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
    • Zender L, Spector MS, Xue W, et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 2006;125:1253-1267
    • (2006) Cell , vol.125 , pp. 1253-1267
    • Zender, L.1    Spector, M.S.2    Xue, W.3
  • 5
    • 35948961118 scopus 로고    scopus 로고
    • Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
    • Zhao B, Wei X, Li W, et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev 2007;21:2747-2761
    • (2007) Genes Dev , vol.21 , pp. 2747-2761
    • Zhao, B.1    Wei, X.2    Li, W.3
  • 6
    • 34548636132 scopus 로고    scopus 로고
    • Elucidation of a universal size-control mechanism in Drosophila and mammals
    • Dong J, Feldmann G, Huang J, et al. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 2007;130:1120-1133
    • (2007) Cell , vol.130 , pp. 1120-1133
    • Dong, J.1    Feldmann, G.2    Huang, J.3
  • 7
    • 0028902594 scopus 로고
    • The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation
    • Justice RW, Zilian O, Woods DF, et al. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev 1995;9:534-46
    • (1995) Genes Dev , vol.9 , pp. 534-548
    • Justice, R.W.1    Zilian, O.2    Woods, D.F.3
  • 8
    • 0037162714 scopus 로고    scopus 로고
    • Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines
    • Tapon N, Harvey KF, Bell DW, et al. Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 2002;110:467-478
    • (2002) Cell , vol.110 , pp. 467-478
    • Tapon, N.1    Harvey, K.F.2    Bell, D.W.3
  • 9
    • 0036926950 scopus 로고    scopus 로고
    • Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila
    • Kango-Singh M, Nolo R, Tao C, et al. Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development 2002;129:5719-5730
    • (2002) Development , vol.129 , pp. 5719-5730
    • Kango-Singh, M.1    Nolo, R.2    Tao, C.3
  • 10
    • 0042733354 scopus 로고    scopus 로고
    • The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis
    • Harvey KF, Pfleger CM, Hariharan IK. The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 2003;114:457-67
    • (2003) Cell , vol.114 , pp. 457-467
    • Harvey, K.F.1    Pfleger, C.M.2    Hariharan, I.K.3
  • 11
    • 0141505119 scopus 로고    scopus 로고
    • The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila
    • Pantalacci S, Tapon N, Leopold P. The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. Nat Cell Biol 2003;5:921-927
    • (2003) Nat Cell Biol , vol.5 , pp. 921-927
    • Pantalacci, S.1    Tapon, N.2    Leopold, P.3
  • 12
    • 0141616617 scopus 로고    scopus 로고
    • Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway
    • Udan RS, Kango-Singh M, Nolo R, et al. Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol 2003;5:914-920
    • (2003) Nat Cell Biol , vol.5 , pp. 914-920
    • Udan, R.S.1    Kango-Singh, M.2    Nolo, R.3
  • 13
    • 0042232429 scopus 로고    scopus 로고
    • Hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts
    • Wu S, Huang J, Dong J, Pan D. Hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell 2003;114:445-456
    • (2003) Cell , vol.114 , pp. 445-456
    • Wu, S.1    Huang, J.2    Dong, J.3    Pan, D.4
  • 14
    • 14844297327 scopus 로고    scopus 로고
    • Control of cell proliferation and apoptosis by mob as tumor suppressor, mats
    • Lai ZC, Wei X, Shimizu T, et al. Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Cell 2005;120:675-685
    • (2005) Cell , vol.120 , pp. 675-685
    • Lai, Z.C.1    Wei, X.2    Shimizu, T.3
  • 15
    • 23744458034 scopus 로고    scopus 로고
    • The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP
    • Huang J, Wu S, Barrera J, et al. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell 2005;122:421-434
    • (2005) Cell , vol.122 , pp. 421-434
    • Huang, J.1    Wu, S.2    Barrera, J.3
  • 16
    • 67349136817 scopus 로고    scopus 로고
    • In vivo analysis of Yorkie phosphorylation sites
    • Oh H, Irvine KD. In vivo analysis of Yorkie phosphorylation sites. Oncogene 2009;28:1916-1927
    • (2009) Oncogene , vol.28 , pp. 1916-1927
    • Oh, H.1    Irvine, K.D.2
  • 17
    • 40849086201 scopus 로고    scopus 로고
    • SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila
    • Goulev Y, Fauny JD, Gonzalez-Marti B, et al. SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila. Curr Biol 2008 18:435-441
    • (2008) Curr Biol , vol.18 , pp. 435-441
    • Goulev, Y.1    Fauny, J.D.2    Gonzalez-Marti, B.3
  • 18
    • 42049116586 scopus 로고    scopus 로고
    • The Hippo growth-regulatory pathway
    • Wu S, Liu Y, Zheng Y, et al. The Hippo growth-regulatory pathway. Dev Cell 2008;14:388-398
    • (2008) Dev Cell , vol.14 , pp. 388-398
    • Wu, S.1    Liu, Y.2    Zheng, Y.3
  • 19
    • 70349624119 scopus 로고    scopus 로고
    • Transcription factor choice in the Hippo signaling pathway: Homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc
    • Peng HW, Slattery M, Mann RS. Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal disc. Genes Dev 2009;23:2307-2319
    • (2009) Genes Dev , vol.23 , pp. 2307-2319
    • Peng, H.W.1    Slattery, M.2    Mann, R.S.3
  • 20
    • 33747159113 scopus 로고    scopus 로고
    • The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila
    • Thompson BJ, Cohen SM. The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila. Cell 2006;126:767-774
    • (2006) Cell , vol.126 , pp. 767-774
    • Thompson, B.J.1    Cohen, S.M.2
  • 21
    • 33749242966 scopus 로고    scopus 로고
    • The bantam microRNA is a target of the hippo tumor-suppressor pathway
    • Nolo R, Morrison CM, Tao C, et al. The bantam microRNA is a target of the hippo tumor-suppressor pathway. Curr Biol 2006;16:1895-1904
    • (2006) Curr Biol , vol.16 , pp. 1895-1904
    • Nolo, R.1    Morrison, C.M.2    Tao, C.3
  • 22
    • 30344445706 scopus 로고    scopus 로고
    • The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis
    • Hamaratoglu F, Willecke M, Kango-Singh M, et al. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol 2006;8:27-36
    • (2006) Nat Cell Biol , vol.8 , pp. 27-36
    • Hamaratoglu, F.1    Willecke, M.2    Kango-Singh, M.3
  • 23
    • 76249093838 scopus 로고    scopus 로고
    • Kibra is a regulator of the Salvador/ Warts/Hippo signaling network
    • Genevet A, Wehr MC, Brain R, et al. Kibra is a regulator of the Salvador/ Warts/Hippo signaling network. Dev Cell 2010;18:300-308
    • (2010) Dev Cell , vol.18 , pp. 300-308
    • Genevet, A.1    Wehr, M.C.2    Brain, R.3
  • 24
    • 33750611115 scopus 로고    scopus 로고
    • Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway
    • Bennett FC, Harvey KF. Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway. Curr Biol 2006;16:2101-2110
    • (2006) Curr Biol , vol.16 , pp. 2101-2110
    • Bennett, F.C.1    Harvey, K.F.2
  • 25
    • 33750624298 scopus 로고    scopus 로고
    • The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway
    • Silva E, Tsatskis Y, Gardano L, et al. The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway. Curr Biol 2006;16:2081-2089
    • (2006) Curr Biol , vol.16 , pp. 2081-2089
    • Silva, E.1    Tsatskis, Y.2    Gardano, L.3
  • 26
    • 33750614445 scopus 로고    scopus 로고
    • The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size
    • Willecke M, Hamaratoglu F, Kango-Singh M, et al. The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Curr Biol 2006;16:2090-2100
    • (2006) Curr Biol , vol.16 , pp. 2090-2100
    • Willecke, M.1    Hamaratoglu, F.2    Kango-Singh, M.3
  • 27
    • 0025748166 scopus 로고
    • The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily
    • Mahoney PA, Weber U, Onofrechuk P, et al. The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily. Cell 1991;67:853-868
    • (1991) Cell , vol.67 , pp. 853-868
    • Mahoney, P.A.1    Weber, U.2    Onofrechuk, P.3
  • 28
    • 6944253410 scopus 로고    scopus 로고
    • Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling
    • Cho E, Irvine KD. Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling. Development 2004;131:4489-4500
    • (2004) Development , vol.131 , pp. 4489-4500
    • Cho, E.1    Irvine, K.D.2
  • 29
    • 77953127131 scopus 로고    scopus 로고
    • Four-jointed modulates growth and planar polarity by reducing the affinity of dachsous for fat
    • Brittle AL, Repiso A, Casal J, et al. Four-jointed modulates growth and planar polarity by reducing the affinity of dachsous for fat. Curr Biol 2010;20:803-810
    • (2010) Curr Biol , Issue.20 , pp. 803-810
    • Brittle, A.L.1    Repiso, A.2    Casal, J.3
  • 30
    • 77953324959 scopus 로고    scopus 로고
    • Modulation of FAt: Dachsous binding by the cadherin domain kinase four-jointed
    • Simon MA, Xu A, Ishikawa HO, Irvine KD. Modulation of FAt: dachsous binding by the cadherin domain kinase four-jointed. Curr Biol 2010;20:811-817
    • Curr Biol , vol.2010 , Issue.20 , pp. 811-817
    • Simon, M.A.1    Xu, A.2    Ishikawa, H.O.3    Irvine, K.D.4
  • 31
    • 33746410714 scopus 로고    scopus 로고
    • Dachs: An unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila
    • Mao Y, Rauskolb C, Cho E, et al. Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila. Development 2006;133:2539-2551
    • (2006) Development , vol.133 , pp. 2539-2551
    • Mao, Y.1    Rauskolb, C.2    Cho, E.3
  • 32
    • 33749125438 scopus 로고    scopus 로고
    • Delineation of a fat tumor suppressor pathway
    • Cho E, Feng Y, Rauskolb C, et al. Delineation of a fat tumor suppressor pathway. Nat Genet 2006;38:1142-1150
    • (2006) Nat Genet , vol.38 , pp. 1142-1150
    • Cho, E.1    Feng, Y.2    Rauskolb, C.3
  • 33
    • 0034033896 scopus 로고    scopus 로고
    • The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation
    • McCartney BM, Kulikauskas RM, LaJeunesse DR, Fehon RG. The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation. Development 2000;127:1315-1324
    • (2000) Development , vol.127 , pp. 1315-1324
    • McCartney, B.M.1    Kulikauskas, R.M.2    Lajeunesse, D.R.3    Fehon, R.G.4
  • 34
    • 33845426464 scopus 로고    scopus 로고
    • The Drosophila RASSF homolog antagonizes the hippo pathway
    • Polesello C, Huelsmann S, Brown NH, Tapon N. The Drosophila RASSF homolog antagonizes the hippo pathway. Curr Biol 2006;16:2459-2465
    • (2006) Curr Biol , vol.16 , pp. 2459-2465
    • Polesello, C.1    Huelsmann, S.2    Brown, N.H.3    Tapon, N.4
  • 35
    • 76249125346 scopus 로고    scopus 로고
    • The WW domain protein Kibra acts upstream of Hippo in Drosophila
    • Baumgartner R, Poernbacher I, Buser N, et al. The WW domain protein Kibra acts upstream of Hippo in Drosophila. Dev Cell 2010;18:309-316
    • Dev Cell , vol.2010 , Issue.18 , pp. 309-316
    • Baumgartner, R.1    Poernbacher, I.2    Buser, N.3
  • 36
    • 76249109900 scopus 로고    scopus 로고
    • Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded
    • Yu J, Zheng Y, Dong J, et al. Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Dev Cell 2010;18:288-299
    • Dev Cell , vol.2010 , Issue.18 , pp. 288-299
    • Yu, J.1    Zheng, Y.2    Dong, J.3
  • 37
    • 77950485564 scopus 로고    scopus 로고
    • Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms
    • Grzeschik NA, Parsons LM, Allott ML, et al. Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. Curr Biol 2010;20:573-581
    • Curr Biol , vol.2010 , Issue.20 , pp. 573-581
    • Grzeschik, N.A.1    Parsons, L.M.2    Allott, M.L.3
  • 38
    • 77950478873 scopus 로고    scopus 로고
    • Crumbs regulates Salvador/ Warts/Hippo signaling in Drosophila via the FERM-domain protein expanded
    • Robinson BS, Huang J, Hong Y, Moberg KH. Crumbs regulates Salvador/ Warts/Hippo signaling in Drosophila via the FERM-domain protein expanded. Curr Biol 2010;20:582-590
    • Curr Biol , vol.2010 , Issue.20 , pp. 582-590
    • Robinson, B.S.1    Huang, J.2    Hong, Y.3    Moberg, K.H.4
  • 39
    • 0032954260 scopus 로고    scopus 로고
    • Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity
    • Tao W, Zhang S, Turenchalk GS, et al. Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat Genet 1999;21:177-181
    • (1999) Nat Genet , vol.21 , pp. 177-181
    • Tao, W.1    Zhang, S.2    Turenchalk, G.S.3
  • 40
    • 33748308721 scopus 로고    scopus 로고
    • Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation
    • Callus BA, Verhagen AM, Vaux DL. Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. FEBS J 2006;273:4264-4276
    • (2006) FEBS J , vol.273 , pp. 4264-4276
    • Callus, B.A.1    Verhagen, A.M.2    Vaux, D.L.3
  • 41
    • 16444373346 scopus 로고    scopus 로고
    • The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
    • Chan EH, Nousiainen M, Chalamalasetty RB, et al. The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene 2005;24:2076-2086
    • (2005) Oncogene , vol.24 , pp. 2076-2086
    • Chan, E.H.1    Nousiainen, M.2    Chalamalasetty, R.B.3
  • 42
    • 40149111984 scopus 로고    scopus 로고
    • MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation
    • Praskova M, Xia F, Avruch J. MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol 2008;18:311-321
    • (2008) Curr Biol , vol.18 , pp. 311-321
    • Praskova, M.1    Xia, F.2    Avruch, J.3
  • 43
    • 41949138130 scopus 로고    scopus 로고
    • Tumor suppressor LATS1 is a negative regulator of oncogene YAP
    • Hao Y, Chun A, Cheung K, et al. Tumor suppressor LATS1 is a negative regulator of oncogene YAP. J Biol Chem 2008;283:5496-5509
    • (2008) J Biol Chem , vol.283 , pp. 5496-5509
    • Hao, Y.1    Chun, A.2    Cheung, K.3
  • 44
    • 41149098966 scopus 로고    scopus 로고
    • TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway
    • Lei QY, Zhang H, Zhao B, et al. TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway. Mol Cell Biol 2008;28:2426-2436
    • (2008) Mol Cell Biol , vol.28 , pp. 2426-2436
    • Lei, Q.Y.1    Zhang, H.2    Zhao, B.3
  • 45
    • 58149478523 scopus 로고    scopus 로고
    • Identification of Fat4 as a candidate tumor suppressor gene in breast cancers
    • Qi C, Zhu YT, Hu L, Zhu Y-J. Identification of Fat4 as a candidate tumor suppressor gene in breast cancers. Int J Cancer 2009;124:793-798
    • (2009) Int J Cancer , vol.124 , pp. 793-798
    • Qi, C.1    Zhu, Y.T.2    Hu, L.3    Zhu, Y.-J.4
  • 46
    • 48649109725 scopus 로고    scopus 로고
    • Merlin is a potent inhibitor of glioma growth
    • Lau YK, Murray LB, Houshmandi SS, et al. Merlin is a potent inhibitor of glioma growth. Cancer Res 2008;68(14):5733-5742
    • (2008) Cancer Res , vol.68 , Issue.14 , pp. 5733-5742
    • Lau, Y.K.1    Murray, L.B.2    Houshmandi, S.S.3
  • 47
    • 33846702026 scopus 로고    scopus 로고
    • Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac
    • Morrison H, Sperka T, Manent J, et al. Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac. Cancer Res 2007;67:520-527
    • (2007) Cancer Res , vol.67 , pp. 520-527
    • Morrison, H.1    Sperka, T.2    Manent, J.3
  • 48
    • 73349136609 scopus 로고    scopus 로고
    • Hippo pathway-dependent and -independent roles of RASSF6
    • Ikeda M, Kawata A, Nishikawa M, et al. Hippo pathway-dependent and -independent roles of RASSF6. Sci Signal 2009;2(90):ra59
    • (2009) Sci Signal , vol.2 , Issue.90
    • Ikeda, M.1    Kawata, A.2    Nishikawa, M.3
  • 49
    • 69249217720 scopus 로고    scopus 로고
    • RASSF2 associates with and stabilizes the proapoptotic kinase MST2
    • Cooper WN, Hesson LB, Matallanas D, et al. RASSF2 associates with and stabilizes the proapoptotic kinase MST2. Oncogene 2009;28:2988-2998
    • (2009) Oncogene , vol.28 , pp. 2988-2998
    • Cooper, W.N.1    Hesson, L.B.2    Matallanas, D.3
  • 50
    • 0028997651 scopus 로고
    • Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain
    • Sudol M, Bork P, Einbond A, et al. Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain. J Biol Chem 1995;270:14733-14741
    • (1995) J Biol Chem , vol.270 , pp. 14733-14741
    • Sudol, M.1    Bork, P.2    Einbond, A.3
  • 51
    • 0028283579 scopus 로고
    • Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product
    • Sudol M. Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product. Oncogene 1994;9:2145-2152
    • (1994) Oncogene , vol.9 , pp. 2145-2152
    • Sudol, M.1
  • 52
    • 0042858208 scopus 로고    scopus 로고
    • WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus
    • Komuro A, Nagai M, Navin NE, Sudol M. WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. J Biol Chem 2003;278:33334-33341
    • (2003) J Biol Chem , vol.278 , pp. 33334-33341
    • Komuro, A.1    Nagai, M.2    Navin, N.E.3    Sudol, M.4
  • 53
    • 0029099161 scopus 로고
    • The WW domain of Yes-associated protein binds aproline-rich ligand that differs from the consensus established for Src homology 3-binding modules
    • Chen HI, Sudol M. The WW domain of Yes-associated protein binds aproline-rich ligand that differs from the consensus established for Src homology 3-binding modules. Proc Natl Acad Sci USA 1995;92:7819-7823
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7819-7823
    • Chen, H.I.1    Sudol, M.2
  • 54
    • 0027988814 scopus 로고
    • The WW domain: A signalling site in dystrophin?
    • Bork P, Sudol M. The WW domain: A signalling site in dystrophin? Trends Biochem Sci 1994;19:531-533
    • (1994) Trends Biochem Sci , vol.19 , pp. 531-533
    • Bork, P.1    Sudol, M.2
  • 55
    • 32644436068 scopus 로고    scopus 로고
    • Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73
    • Hoshino M, Qi M-L, Yoshimura N, et al. Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73. J Cell Biol 2006;172:589-604
    • (2006) J Cell Biol , vol.172 , pp. 589-604
    • Hoshino, M.1    Qi, M.-L.2    Yoshimura, N.3
  • 56
    • 73549095761 scopus 로고    scopus 로고
    • A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCFbeta-TRCP
    • Zhao B, Li L, Tumaneng K, et al. A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCFbeta-TRCP. Genes Dev 2010;24:72-85
    • Genes Dev , vol.2010 , Issue.24 , pp. 72-85
    • Zhao, B.1    Li, L.2    Tumaneng, K.3
  • 57
    • 17744380191 scopus 로고    scopus 로고
    • TAZ: A novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins
    • Kanai F, Marignani PA, Sarbassova D, et al. TAZ: A novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J 2000;19:6778-6791
    • (2000) EMBO J , vol.19 , pp. 6778-6791
    • Kanai, F.1    Marignani, P.A.2    Sarbassova, D.3
  • 58
    • 65449154339 scopus 로고    scopus 로고
    • Nuclear localization and pro-apoptotic signaling of YAP2 require intact PDZ-binding motif
    • Oka T, Sudol M. Nuclear localization and pro-apoptotic signaling of YAP2 require intact PDZ-binding motif. Genes Cells 2009;14:607-615
    • (2009) Genes Cells , vol.14 , pp. 607-615
    • Oka, T.1    Sudol, M.2
  • 59
    • 37349005990 scopus 로고    scopus 로고
    • Yes-associated protein (YAP) is a critical mediator of c-Jun-dependent apoptosis
    • Danovi SA, Rossi M, Gudmundsdottir K, et al. Yes-associated protein (YAP) is a critical mediator of c-Jun-dependent apoptosis. Cell Death Differ 2008;15:217-219
    • (2008) Cell Death Differ , vol.15 , pp. 217-219
    • Danovi, S.A.1    Rossi, M.2    Gudmundsdottir, K.3
  • 60
    • 21044442524 scopus 로고    scopus 로고
    • The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA damage
    • Strano S, Monti O, Pediconi N, et al. The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA damage. Mol Cell 2005;18:447-459
    • (2005) Mol Cell , vol.18 , pp. 447-459
    • Strano, S.1    Monti, O.2    Pediconi, N.3
  • 61
    • 33947382284 scopus 로고    scopus 로고
    • The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73
    • Levy D, Adamovich Y, Reuven N, Shaul Y. The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73. Cell Death Differ 2007;14:743-751
    • (2007) Cell Death Differ , vol.14 , pp. 743-751
    • Levy, D.1    Adamovich, Y.2    Reuven, N.3    Shaul, Y.4
  • 62
    • 61349089170 scopus 로고    scopus 로고
    • EGR-1 forms a complex with YAP-1 and upregulates Bax expression in irradiated prostate carcinoma cells
    • Zagurovskaya M, Shareef MM, Das A, et al. EGR-1 forms a complex with YAP-1 and upregulates Bax expression in irradiated prostate carcinoma cells. Oncogene 2009;28:1121-1131
    • (2009) Oncogene , vol.28 , pp. 1121-1131
    • Zagurovskaya, M.1    Shareef, M.M.2    Das, A.3
  • 63
    • 0035805487 scopus 로고    scopus 로고
    • Physical interaction with Yes-associated protein enhances p73 transcriptional activity
    • Strano S, Munarriz E, Rossi M, et al. Physical interaction with Yes-associated protein enhances p73 transcriptional activity. J Biol Chem 2001;276:15164-15173
    • (2001) J Biol Chem , vol.276 , pp. 15164-15173
    • Strano, S.1    Munarriz, E.2    Rossi, M.3
  • 64
    • 1842457741 scopus 로고    scopus 로고
    • Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription
    • Zaidi SK, Sullivan AJ, Medina R, et al. Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription. EMBO J 2004;23:790-799
    • (2004) EMBO J , vol.23 , pp. 790-799
    • Zaidi, S.K.1    Sullivan, A.J.2    Medina, R.3
  • 65
    • 55549120557 scopus 로고    scopus 로고
    • Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors
    • Teplyuk NM, Galindo M, Teplyuk VI, et al. Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors. J Biol Chem 2008;283:27585-27597
    • (2008) J Biol Chem , vol.283 , pp. 27585-27597
    • Teplyuk, N.M.1    Galindo, M.2    Teplyuk, V.I.3
  • 66
    • 0035873391 scopus 로고    scopus 로고
    • TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/ Yes-associated protein localized in the cytoplasm
    • Vassilev A, Kaneko KJ, Shu H, et al. TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/ Yes-associated protein localized in the cytoplasm. Genes Dev 2001;15:1229-1241
    • (2001) Genes Dev , vol.15 , pp. 1229-1241
    • Vassilev, A.1    Kaneko, K.J.2    Shu, H.3
  • 67
    • 68049142436 scopus 로고    scopus 로고
    • Transcriptional output of the Salvador/warts/hippo pathway is controlled in distinct fashions in Drosophila melanogaster and mammalian cell lines
    • Zhang X, Milton CC, Humbert PO, Harvey KF. Transcriptional output of the Salvador/warts/hippo pathway is controlled in distinct fashions in Drosophila melanogaster and mammalian cell lines. Cancer Res 2009;69:6033-6041
    • (2009) Cancer Res , vol.69 , pp. 6033-6041
    • Zhang, X.1    Milton, C.C.2    Humbert, P.O.3    Harvey, K.F.4
  • 68
    • 76149134716 scopus 로고    scopus 로고
    • Structural basis of YAP recognition by TEAD4 in the hippo pathway
    • Chen L, Chan SW, Zhang X, et al. Structural basis of YAP recognition by TEAD4 in the hippo pathway. Genes Dev 2010;24:290-300
    • Genes Dev , vol.2010 , Issue.24 , pp. 290-300
    • Chen, L.1    Chan, S.W.2    Zhang, X.3
  • 69
    • 76149138881 scopus 로고    scopus 로고
    • Structural insights into the YAP and TEAD complex
    • Li Z, Zhao B, Wang P, et al. Structural insights into the YAP and TEAD complex. Genes Dev 2010;24:235-240
    • Genes Dev , vol.2010 , Issue.24 , pp. 235-240
    • Li, Z.1    Zhao, B.2    Wang, P.3
  • 70
    • 59149088576 scopus 로고    scopus 로고
    • Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein
    • Zhao B, Kim J, Ye X, et al. Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein. Cancer Res 2009;69:1089-1098
    • (2009) Cancer Res , vol.69 , pp. 1089-1098
    • Zhao, B.1    Kim, J.2    Ye, X.3
  • 71
    • 47549095853 scopus 로고    scopus 로고
    • TEAD mediates YAP-dependent gene induction and growth control
    • Zhao B, Ye X, Yu J, et al. TEAD mediates YAP-dependent gene induction and growth control. Genes Dev 2008;22:1962-1971
    • (2008) Genes Dev , vol.22 , pp. 1962-1971
    • Zhao, B.1    Ye, X.2    Yu, J.3
  • 72
    • 67649770134 scopus 로고    scopus 로고
    • TEADs mediate nuclear retention of TAZ to promote oncogenic transformation
    • Chan SW, Lim CJ, Loo LS, et al. TEADs mediate nuclear retention of TAZ to promote oncogenic transformation. J Biol Chem 2009;284:14347-14358
    • (2009) J Biol Chem , vol.284 , pp. 14347-14358
    • Chan, S.W.1    Lim, C.J.2    Loo, L.S.3
  • 73
    • 23644431709 scopus 로고    scopus 로고
    • TAZ, a transcriptional modulator of mesenchymal stem cell differentiation
    • Hong JH, Hwang ES, McManus MT, et al. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 2005;309:1074-1078
    • (2005) Science , vol.309 , pp. 1074-1078
    • Hong, J.H.1    Hwang, E.S.2    McManus, M.T.3
  • 74
    • 53849087493 scopus 로고    scopus 로고
    • Expression of Yes-associated protein in common solid tumors
    • Steinhardt AA, Gayyed MF, Klein AP, et al. Expression of Yes-associated protein in common solid tumors. Hum Pathol 2008;39:1582-1589
    • (2008) Hum Pathol , vol.39 , pp. 1582-1589
    • Steinhardt, A.A.1    Gayyed, M.F.2    Klein, A.P.3
  • 75
    • 72549090299 scopus 로고    scopus 로고
    • YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic Hedgehog-driven neural precursor proliferation
    • Fernandez-L A, Northcott PA, Dalton J, et al. YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic Hedgehog-driven neural precursor proliferation. Genes Dev 2009;23:2729-2741
    • (2009) Genes Dev , vol.23 , pp. 2729-2741
    • Fernandez-L, A.1    Northcott, P.A.2    Dalton, J.3
  • 76
    • 36549074631 scopus 로고    scopus 로고
    • YAP1 increases organ size and expands undifferentiated progenitor cells
    • Camargo FD, Gokhale S, Johnnidis JB, et al. YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol 2007;17:2054-2060
    • (2007) Curr Biol , vol.17 , pp. 2054-2060
    • Camargo, F.D.1    Gokhale, S.2    Johnnidis, J.B.3
  • 77
    • 70349295967 scopus 로고    scopus 로고
    • Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma
    • Xu MZ, Yao TJ, Lee NP, et al. Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma. Cancer 2009;115:4576-4585
    • (2009) Cancer , vol.115 , pp. 4576-4585
    • Xu, M.Z.1    Yao, T.J.2    Lee, N.P.3
  • 78
    • 77953197857 scopus 로고    scopus 로고
    • Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancer
    • Published online 10 March 2010, doi; 10.1111/j.1349-7006.2010.01511
    • Wang Y, Dong Q, Zhang Q, et al. Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancer. Cancer Sci 2010: published online 10 March 2010, doi; 10.1111/j.1349-7006.2010. 01511
    • (2010) Cancer Sci
    • Wang, Y.1    Dong, Q.2    Zhang, Q.3
  • 79
    • 43149110395 scopus 로고    scopus 로고
    • The hippo pathway i human upper gastrointestinal dysplasia and carcinoma: A novel oncogenic pathway
    • Lam-Himlin DM, Daniels JA, Gayyed MF, et al. The hippo pathway i human upper gastrointestinal dysplasia and carcinoma: A novel oncogenic pathway. Int J Gastrointest Cancer 2006;37:103-109
    • (2006) Int J Gastrointest Cancer , vol.37 , pp. 103-109
    • Lam-Himlin, D.M.1    Daniels, J.A.2    Gayyed, M.F.3
  • 80
    • 54049121368 scopus 로고    scopus 로고
    • Yes-associated protein (YAP) functions a a tumor suppressor in breast
    • Yuan M, Tomlinson V, Lara R, et al. Yes-associated protein (YAP) functions a a tumor suppressor in breast. Cell Death Differ 2008;15:1752-1759
    • (2008) Cell Death Differ , vol.15 , pp. 1752-1759
    • Yuan, M.1    Tomlinson, V.2    Lara, R.3
  • 81
    • 55749104705 scopus 로고    scopus 로고
    • Kpm/Lats2 is linked to chemosensitivity of leukemic cells through the stabilization of p73
    • Kawahara M, Hori T, Chonabayashi K, et al. Kpm/Lats2 is linked to chemosensitivity of leukemic cells through the stabilization of p73. Blood 2008;112:3856-3866
    • (2008) Blood , vol.112 , pp. 3856-3866
    • Kawahara, M.1    Hori, T.2    Chonabayashi, K.3
  • 82
    • 0037249343 scopus 로고    scopus 로고
    • Akt phosphorylates the Yes-associated protein YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis
    • Basu S, Totty NF, Irwin MS, et al. Akt phosphorylates the Yes-associated protein YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. Mol Cell 2003;11:11-23
    • (2003) Mol Cell , vol.11 , pp. 11-23
    • Basu, S.1    Totty, N.F.2    Irwin, M.S.3
  • 83
    • 34047250808 scopus 로고    scopus 로고
    • RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network
    • Guo C, Tommasi S, Liu L, et al. RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network. Curr Biol 2007;17:700-705
    • (2007) Curr Biol , vol.17 , pp. 700-705
    • Guo, C.1    Tommasi, S.2    Liu, L.3
  • 84
    • 34748812613 scopus 로고    scopus 로고
    • RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein
    • Matallanas D, Romano D, Yee K, et al. RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. Mol Cell 2007;27:962-975
    • (2007) Mol Cell , vol.27 , pp. 962-975
    • Matallanas, D.1    Romano, D.2    Yee, K.3
  • 85
    • 55549098921 scopus 로고    scopus 로고
    • Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP)
    • Oka T, Mazack V, Sudol M. Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP). J Biol Chem 2008;283:27534-27546
    • (2008) J Biol Chem , vol.283 , pp. 27534-27546
    • Oka, T.1    Mazack, V.2    Sudol, M.3
  • 86
    • 77954772169 scopus 로고    scopus 로고
    • JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis
    • Tomlinson V, Gudmundsdottir K, Luong P, et al. JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis. Cell Death and Dis 2010;1(2):e29
    • (2010) Cell Death and Dis , vol.1 , Issue.2
    • Tomlinson, V.1    Gudmundsdottir, K.2    Luong, P.3
  • 87
    • 77954784171 scopus 로고    scopus 로고
    • C-Abl phosphorylation of DeltaNp63alpha is critical for cell viability
    • Yuan M, Luong P, Hudson C, et al. c-Abl phosphorylation of DeltaNp63alpha is critical for cell viability. Cell Death and Dis 2010;1(1):e16
    • (2010) Cell Death and Dis , vol.1 , Issue.1
    • Yuan, M.1    Luong, P.2    Hudson, C.3
  • 88
    • 0032907439 scopus 로고    scopus 로고
    • Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction
    • St John MA, Tao W, Fei X, et al. Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. Nat Genet 1999;21:182-186
    • (1999) Nat Genet , vol.21 , pp. 182-186
    • John Ma, S.1    Tao, W.2    Fei, X.3
  • 89
    • 0036800399 scopus 로고    scopus 로고
    • Molecular alterations of h-warts/ LATS1 tumor suppressor in human soft tissue sarcoma
    • Hisaoka M, Tanaka A, Hashimoto H. Molecular alterations of h-warts/ LATS1 tumor suppressor in human soft tissue sarcoma. Lab Invest 2002;82:1427-1435
    • (2002) Lab Invest , vol.82 , pp. 1427-1435
    • Hisaoka, M.1    Tanaka, A.2    Hashimoto, H.3
  • 90
    • 33751019980 scopus 로고    scopus 로고
    • Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma
    • Jiang Z, Li X, Hu J, et al. Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. Neurosci Res 2006;56:450-458
    • (2006) Neurosci Res , vol.56 , pp. 450-458
    • Jiang, Z.1    Li, X.2    Hu, J.3
  • 91
    • 0034546548 scopus 로고    scopus 로고
    • Molecular analysis of the h-warts/ LATS1 gene in human breast cancer
    • Morinaga N, Shitara Y, Yanagita Y, et al. Molecular analysis of the h-warts/ LATS1 gene in human breast cancer. Int J Oncol 2000;17:1125-1129
    • (2000) Int J Oncol , vol.17 , pp. 1125-1129
    • Morinaga, N.1    Shitara, Y.2    Yanagita, Y.3
  • 92
    • 14644420898 scopus 로고    scopus 로고
    • Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers
    • Takahashi Y, Miyoshi Y, Takahata C, et al. Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers. Clin Cancer Res 2005;11:1380-1385
    • (2005) Clin Cancer Res , vol.11 , pp. 1380-1385
    • Takahashi, Y.1    Miyoshi, Y.2    Takahata, C.3
  • 93
    • 85047699404 scopus 로고    scopus 로고
    • LATS1 tumor suppressor regulates G2/M transition and apoptosis
    • Xia H, Qi H, Li Y, et al. LATS1 tumor suppressor regulates G2/M transition and apoptosis. Oncogene 2002;21:1233-1241
    • (2002) Oncogene , vol.21 , pp. 1233-1241
    • Xia, H.1    Qi, H.2    Li, Y.3
  • 94
    • 0035807242 scopus 로고    scopus 로고
    • Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G2/M arrest or apoptosis
    • Yang X, Li DM, Chen W, Xu T. Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G2/M arrest or apoptosis. Oncogene 2001;20(45):6516-6523
    • (2001) Oncogene , vol.20 , Issue.45 , pp. 6516-6523
    • Yang, X.1    Li, D.M.2    Chen, W.3    Xu, T.4
  • 95
    • 35148841871 scopus 로고    scopus 로고
    • Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma
    • Seidel C, Schagdarsurengin U, Blumke K, et al. Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma. Mol Carcinog 2007;46:865-871
    • (2007) Mol Carcinog , vol.46 , pp. 865-871
    • Seidel, C.1    Schagdarsurengin, U.2    Blumke, K.3
  • 97
    • 70350502865 scopus 로고    scopus 로고
    • Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene
    • Zhou D, Conrad C, Xia F, et al. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell 2009;16:425-438
    • (2009) Cancer Cell , vol.16 , pp. 425-438
    • Zhou, D.1    Conrad, C.2    Xia, F.3
  • 98
    • 76549124517 scopus 로고    scopus 로고
    • Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
    • Lu L, Li Y, Kim SM, et al. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci USA 2010;107:1437-1442
    • Proc Natl Acad Sci USA , vol.2010 , Issue.107 , pp. 1437-1442
    • Lu, L.1    Li, Y.2    Kim, S.M.3
  • 99
    • 76549127712 scopus 로고    scopus 로고
    • Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
    • Song H, Mak KK, Topol L, et al. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci USA 2010;107:1431-1436
    • Proc Natl Acad Sci USA , vol.2010 , Issue.107 , pp. 1431-1436
    • Song, H.1    Mak, K.K.2    Topol, L.3
  • 100
    • 33645050117 scopus 로고    scopus 로고
    • Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis
    • Oh HJ, Lee KK, Song SJ, et al. Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis. Cancer Res 2006;66:2562-2569
    • (2006) Cancer Res , vol.66 , pp. 2562-2569
    • Oh, H.J.1    Lee, K.K.2    Song, S.J.3
  • 101
    • 64249116807 scopus 로고    scopus 로고
    • The human WW45 protein enhances MST1-mediated apoptosis in vivo
    • Luo X, Li Z, Yan Q, et al. The human WW45 protein enhances MST1-mediated apoptosis in vivo. Int J Mol Med 2009;23:357-362
    • (2009) Int J Mol Med , vol.23 , pp. 357-362
    • Luo, X.1    Li, Z.2    Yan, Q.3
  • 102
    • 42449101282 scopus 로고    scopus 로고
    • A crucial role of WW45 in developing epithelial tissues in the mouse
    • Lee JH, Kim TS, Yang TH, et al. A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J 2008;27:1231-1242
    • (2008) EMBO J , vol.27 , pp. 1231-1242
    • Lee, J.H.1    Kim, T.S.2    Yang, T.H.3
  • 103
    • 77952336576 scopus 로고    scopus 로고
    • The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis
    • Lee KP, Lee JH, Kim TS, et al. The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis. Proc Natl Acad Sci USA 2010;107:8248-8253
    • Proc Natl Acad Sci USA , vol.2010 , Issue.107 , pp. 8248-8253
    • Lee, K.P.1    Lee, J.H.2    Kim, T.S.3
  • 105
    • 33847206401 scopus 로고    scopus 로고
    • The Salvador-Warts-Hippo pathway - An emerging tumour-suppressor network
    • Harvey K, Tapon N. The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network. Nat Rev Cancer 2007;7:182-191
    • (2007) Nat Rev Cancer , vol.7 , pp. 182-191
    • Harvey, K.1    Tapon, N.2
  • 106
    • 77950626836 scopus 로고    scopus 로고
    • MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties
    • Liu AM, Poon RT, Luk JM. MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties. Biochem Biophys Res Commun 2010;394:623-627
    • Biochem Biophys Res Commun , vol.2010 , Issue.394 , pp. 623-627
    • Liu, A.M.1    Poon, R.T.2    Luk, J.M.3
  • 107
    • 57749122174 scopus 로고    scopus 로고
    • YAP regulates neural progenitor cell number via the TEA domain transcription factor
    • Cao X, Pfaff SL, Gage FH. YAP regulates neural progenitor cell number via the TEA domain transcription factor. Genes Dev 2008;22:3320-3334
    • (2008) Genes Dev , vol.22 , pp. 3320-3334
    • Cao, X.1    Pfaff, S.L.2    Gage, F.H.3
  • 108
    • 60849138138 scopus 로고    scopus 로고
    • Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling
    • Ota M, Sasaki H. Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. Development 2008;135:4059-4069
    • (2008) Development , vol.135 , pp. 4059-4069
    • Ota, M.1    Sasaki, H.2
  • 109
    • 77952116604 scopus 로고    scopus 로고
    • Structural and functional analysis of the YAP-binding domain of human TEAD2
    • Tian W, Yu J, Tomchick DR, et al. Structural and functional analysis of the YAP-binding domain of human TEAD2. Proc Natl Acad Sci USA 2010;107:7293-7298
    • Proc Natl Acad Sci USA , vol.2010 , Issue.107 , pp. 7293-7298
    • Tian, W.1    Yu, J.2    Tomchick, D.R.3
  • 110
    • 67649412006 scopus 로고    scopus 로고
    • TEAD Transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition
    • Zhang H, Liu CY, Zha ZY, et al. TEAD Transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem 2009;284:13355-13362
    • (2009) J Biol Chem , vol.284 , pp. 13355-13362
    • Zhang, H.1    Liu, C.Y.2    Zha, Z.Y.3
  • 111
    • 65949093307 scopus 로고    scopus 로고
    • Connective tissue growth factor confers drug resistance in breast cancer through concomitant up-regulation of Bcl-xL and cIAP1
    • Wang MY, Chen PS, Prakash E, et al. Connective tissue growth factor confers drug resistance in breast cancer through concomitant up-regulation of Bcl-xL and cIAP1. Cancer Res 2009;69:3482-3491
    • (2009) Cancer Res , vol.69 , pp. 3482-3491
    • Wang, M.Y.1    Chen, P.S.2    Prakash, E.3
  • 112
    • 0035893738 scopus 로고    scopus 로고
    • Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features
    • Xie D, Nakachi K, Wang H, et al. Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features. Cancer Res 2001;61:8917-8923
    • (2001) Cancer Res , vol.61 , pp. 8917-8923
    • Xie, D.1    Nakachi, K.2    Wang, H.3
  • 113
    • 33745247375 scopus 로고    scopus 로고
    • Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis
    • Dornhofer N, Spong S, Bennewith K, et al. Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis. Cancer Res 2006;66:5816-5827
    • (2006) Cancer Res , vol.66 , pp. 5816-5827
    • Dornhofer, N.1    Spong, S.2    Bennewith, K.3
  • 114
    • 37549035044 scopus 로고    scopus 로고
    • Connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through beta-catenin-T-cell factor/Lef signaling
    • Deng YZ, Chen PP, Wang Y, et al. Connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through beta-catenin-T-cell factor/Lef signaling. J Biol Chem 2007;282:36571-36581
    • (2007) J Biol Chem , vol.282 , pp. 36571-36581
    • Deng, Y.Z.1    Chen, P.P.2    Wang, Y.3
  • 115
    • 34248562252 scopus 로고    scopus 로고
    • Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL
    • Lay JD, Hong CC, Huang JS, et al. Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL. Cancer Res 2007;67:3878-3887
    • (2007) Cancer Res , vol.67 , pp. 3878-3887
    • Lay, J.D.1    Hong, C.C.2    Huang, J.S.3
  • 116
    • 40949156351 scopus 로고    scopus 로고
    • AXL is a potential target for therapeutic intervention in breast cancer progression
    • Zhang YX, Knyazev PG, Cheburkin YV, et al. AXL is a potential target for therapeutic intervention in breast cancer progression. Cancer Res 2008;68:1905-1915
    • (2008) Cancer Res , vol.68 , pp. 1905-1915
    • Zhang, Y.X.1    Knyazev, P.G.2    Cheburkin, Y.V.3
  • 117
    • 4143074965 scopus 로고    scopus 로고
    • An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug-induced apoptosis
    • Alexia C, Fallot G, Lasfer M, et al. An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug-induced apoptosis. Biochem Pharmacol 2004;68:1003-1015
    • (2004) Biochem Pharmacol , vol.68 , pp. 1003-1015
    • Alexia, C.1    Fallot, G.2    Lasfer, M.3
  • 118
    • 47149111583 scopus 로고    scopus 로고
    • Autocrine insulin-like growth factor-II stimulation of tumor cell migration is a progression step in human hepatocarcinogenesis
    • Nussbaum T, Samarin J, Ehemann V, et al. Autocrine insulin-like growth factor-II stimulation of tumor cell migration is a progression step in human hepatocarcinogenesis. Hepatology 2008;48:146-156
    • (2008) Hepatology , vol.48 , pp. 146-156
    • Nussbaum, T.1    Samarin, J.2    Ehemann, V.3
  • 119
    • 33746217612 scopus 로고    scopus 로고
    • Effect of blocking IGF-I receptor on growth of human hepatocellular carcinoma cells
    • Zhang YC, Wang XP, Zhang LY, et al. Effect of blocking IGF-I receptor on growth of human hepatocellular carcinoma cells. World J Gastroenterol 2006;12(25):3977-3982
    • (2006) World J Gastroenterol , vol.12 , Issue.25 , pp. 3977-3982
    • Zhang, Y.C.1    Wang, X.P.2    Zhang, L.Y.3
  • 120
    • 20144386856 scopus 로고    scopus 로고
    • Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751
    • Cohen BD, Baker DA, Soderstrom C, et al. Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871. Clin Cancer Res 2005;11:2063-2073
    • (2005) Clin Cancer Res , vol.871 , Issue.11 , pp. 2063-2073
    • Cohen, B.D.1    Baker, D.A.2    Soderstrom, C.3
  • 121
    • 70449556274 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and pharmacodynamics of the insulin-like growth factor type 1 receptor inhibitor figitumumab (CP-751,) in combination with paclitaxel and carboplatin
    • Karp DD, Pollak MN, Cohen RB, et al. Safety, pharmacokinetics, and pharmacodynamics of the insulin-like growth factor type 1 receptor inhibitor figitumumab (CP-751,871) in combination with paclitaxel and carboplatin. J Thorac Oncol 2009;4:1397-1403
    • (2009) J Thorac Oncol , vol.4 , pp. 1397-1403
    • Karp, D.D.1    Pollak, M.N.2    Cohen, R.B.3
  • 122
    • 66349091290 scopus 로고    scopus 로고
    • Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer
    • Karp DD, Paz-Ares LG, Novello S, et al. Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer. J Clin Oncol 2009;27:2516-2522
    • (2009) J Clin Oncol , vol.27 , pp. 2516-2522
    • Karp, D.D.1    Paz-Ares, L.G.2    Novello, S.3
  • 123
    • 38849088141 scopus 로고    scopus 로고
    • The emerging role of the insulin-like growth factor pathway as a therapeutic target in cancer
    • Ryan PD, Goss PE. The emerging role of the insulin-like growth factor pathway as a therapeutic target in cancer. Oncologist 2008;13:16-24
    • (2008) Oncologist , vol.13 , pp. 16-24
    • Ryan, P.D.1    Goss, P.E.2
  • 124
    • 73349128777 scopus 로고    scopus 로고
    • YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway
    • Zhang J, Ji J-Y, Yu M, et al. YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway. Nat Cell Biol 2009;11:1444-1450
    • (2009) Nat Cell Biol , vol.11 , pp. 1444-1450
    • Zhang, J.1    Ji, J.-Y.2    Yu, M.3
  • 125
    • 33745700212 scopus 로고    scopus 로고
    • Activation of sterile20-like kinase 1 in proteasome inhibitor bortezomib-induced apoptosis in oncogenic K-ras-transformed cells
    • Teraishi F, Guo W, Zhang L, et al. Activation of sterile20-like kinase 1 in proteasome inhibitor bortezomib-induced apoptosis in oncogenic K-ras-transformed cells. Cancer Res 2006;66:6072-6079
    • (2006) Cancer Res , vol.66 , pp. 6072-6079
    • Teraishi, F.1    Guo, W.2    Zhang, L.3
  • 126
    • 77951154173 scopus 로고    scopus 로고
    • MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors
    • Liu X, Sempere LF, Ouyang H, et al. MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors. J Clin Invest 2010;120:1298-1309
    • J Clin Invest , vol.2010 , Issue.120 , pp. 1298-1309
    • Liu, X.1    Sempere, L.F.2    Ouyang, H.3
  • 127
    • 76649106069 scopus 로고    scopus 로고
    • Et al. miR-372 regulates cell cycle and apoptosis of ags human gastric cancer cell line through direct regulation of LATS2
    • Cho WJ, Shin JM, Kim JS, et al. miR-372 regulates cell cycle and apoptosis of ags human gastric cancer cell line through direct regulation of LATS2. Mol Cells 2009;28:521-527
    • (2009) Mol Cells , vol.28 , pp. 521-527
    • Cho, W.J.1    Shin, J.M.2    Kim, J.S.3
  • 128
    • 42349084868 scopus 로고    scopus 로고
    • Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway
    • Zhang J, Smolen GA, Haber DA. Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway. Cancer Res 2008;68:2789-2794
    • (2008) Cancer Res , vol.68 , pp. 2789-2794
    • Zhang, J.1    Smolen, G.A.2    Haber, D.A.3
  • 129
    • 21344467538 scopus 로고    scopus 로고
    • Taming the Hippo: Raf-1 controls apoptosis by suppressing MST2/Hippo
    • O'Neill E, Kolch W. Taming the Hippo: Raf-1 controls apoptosis by suppressing MST2/Hippo. Cell Cycle 2005;4:365-367
    • (2005) Cell Cycle , vol.4 , pp. 365-367
    • O'Neill, E.1    Kolch, W.2
  • 130
    • 11144267126 scopus 로고    scopus 로고
    • Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1
    • O'Neill E, Rushworth L, Baccarini M, Kolch W. Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1. Science 2004;306:2267-2270
    • (2004) Science , vol.306 , pp. 2267-2270
    • O'Neill, E.1    Rushworth, L.2    Baccarini, M.3    Kolch, W.4
  • 131
    • 12644268252 scopus 로고    scopus 로고
    • Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo
    • Monia BP, Sasmor H, Johnston JF, et al. Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo. Proc Natl Acad Sci USA 1996;93:15481-15484
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 15481-15484
    • Monia, B.P.1    Sasmor, H.2    Johnston, J.F.3
  • 133
    • 0036848796 scopus 로고    scopus 로고
    • Pharmacokinetics, toxicity, and efficacy of ends-modified raf antisense oligodeoxyribonucleotide encapsulated in a novel cationic liposome
    • Gokhale PC, Zhang C, Newsome JT, et al. Pharmacokinetics, toxicity, and efficacy of ends-modified raf antisense oligodeoxyribonucleotide encapsulated in a novel cationic liposome. Clin Cancer Res 2002;8:3611-3621
    • (2002) Clin Cancer Res , vol.8 , pp. 3611-3621
    • Gokhale, P.C.1    Zhang, C.2    Newsome, J.T.3
  • 134
    • 8444253256 scopus 로고    scopus 로고
    • Delivery of a liposomal c-raf-1 antisense oligonucleotide by weekly bolus dosing in patients with advanced solid tumors: A Phase i study
    • Rudin CM, Marshall JL, Huang CH, et al. Delivery of a liposomal c-raf-1 antisense oligonucleotide by weekly bolus dosing in patients with advanced solid tumors: A Phase I study. Clin Cancer Res 2004;10(21):7244-7251
    • (2004) Clin Cancer Res , vol.10 , Issue.21 , pp. 7244-7251
    • Rudin, C.M.1    Marshall, J.L.2    Huang, C.H.3
  • 135
    • 33644772211 scopus 로고    scopus 로고
    • Phase i study of liposome-encapsulated c-raf antisense oligodeoxyribonucleotide infusion in combination with radiation therapy in patients with advanced malignancies
    • Dritschilo A, Huang CH, Rudin CM, et al. Phase I study of liposome-encapsulated c-raf antisense oligodeoxyribonucleotide infusion in combination with radiation therapy in patients with advanced malignancies. Clin Cancer Res 2006;12:1251-1259
    • (2006) Clin Cancer Res , vol.12 , pp. 1251-1259
    • Dritschilo, A.1    Huang, C.H.2    Rudin, C.M.3
  • 136
    • 0141634058 scopus 로고    scopus 로고
    • RAF antisense oligonucleotide as a tumor radiosensitizer
    • Kasid U, Dritschilo A. RAF antisense oligonucleotide as a tumor radiosensitizer. Oncogene 2003;22:5876-5884
    • (2003) Oncogene , vol.22 , pp. 5876-5884
    • Kasid, U.1    Dritschilo, A.2
  • 137
    • 17144373720 scopus 로고    scopus 로고
    • Inhibitors of the mammalian target of rapamycin
    • Dancey JE. Inhibitors of the mammalian target of rapamycin. Expert Opin Investig Drugs 2005;14:313-328
    • (2005) Expert Opin Investig Drugs , vol.14 , pp. 313-328
    • Dancey, J.E.1
  • 138
    • 35649014941 scopus 로고    scopus 로고
    • The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1
    • Cinar B, Fang PK, Lutchman M, et al. The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1. EMBO J 2007;26:4523-4534
    • (2007) EMBO J , vol.26 , pp. 4523-4534
    • Cinar, B.1    Fang, P.K.2    Lutchman, M.3
  • 139
    • 25844447107 scopus 로고    scopus 로고
    • Membrane organization and tumorigenesis-the NF2 tumor suppressor
    • McClatchey AI, Giovannini M. Membrane organization and tumorigenesis-the NF2 tumor suppressor, Merlin. Genes Dev 2005;19:2265-2277
    • (2005) Merlin. Genes Dev , vol.19 , pp. 2265-2277
    • McClatchey, A.I.1    Giovannini, M.2
  • 140
    • 42049107717 scopus 로고    scopus 로고
    • Down-regulation of mammalian sterile 20-like kinase 1 by heat shock protein 70 mediates cisplatin resistance in prostate cancer cells
    • Ren A, Yan G, You B, Sun J. Down-regulation of mammalian sterile 20-like kinase 1 by heat shock protein 70 mediates cisplatin resistance in prostate cancer cells. Cancer Res 2008;68:2266-2274
    • (2008) Cancer Res , vol.68 , pp. 2266-2274
    • Ren, A.1    Yan, G.2    You, B.3    Sun, J.4
  • 141
    • 0032522704 scopus 로고    scopus 로고
    • Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1
    • Graves JD, Gotoh Y, Draves KE, et al. Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. EMBO J 1998;17:2224-2234
    • (1998) EMBO J , vol.17 , pp. 2224-2234
    • Graves, J.D.1    Gotoh, Y.2    Draves, K.E.3
  • 142
    • 0035379556 scopus 로고    scopus 로고
    • MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation
    • Lee KK, Ohyama T, Yajima N, et al. MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. J Biol Chem 2001;276:19276-19285
    • (2001) J Biol Chem , vol.276 , pp. 19276-19285
    • Lee, K.K.1    Ohyama, T.2    Yajima, N.3
  • 143
    • 0041302154 scopus 로고    scopus 로고
    • Lats2, a putative tumor suppressor, inhibits G1/S transition
    • Li Y, Pei J, Xia H, et al. Lats2, a putative tumor suppressor, inhibits G1/S transition. Oncogene 2003;22:4398-4405
    • (2003) Oncogene , vol.22 , pp. 4398-4405
    • Li, Y.1    Pei, J.2    Xia, H.3
  • 144
    • 33845391172 scopus 로고    scopus 로고
    • Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity
    • Cantor JP, Iliopoulos D, Rao AS, et al. Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity. Int J Cancer 2007;120:24-31
    • (2007) Int J Cancer , vol.120 , pp. 24-31
    • Cantor, J.P.1    Iliopoulos, D.2    Rao, A.S.3
  • 145
    • 24744459073 scopus 로고    scopus 로고
    • Involvement of the RASSF1A tumor suppressor gene in controlling cell migration
    • Dallol A, Agathanggelou A, Tommasi S, et al. Involvement of the RASSF1A tumor suppressor gene in controlling cell migration. Cancer Res 2005;65:7653-7659
    • (2005) Cancer Res , vol.65 , pp. 7653-7659
    • Dallol, A.1    Agathanggelou, A.2    Tommasi, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.