Mutagenesis of the West Nile virus NS2B cofactor domain reveals two regions essential for protease activity

Journal of General Virology

Volumn 89, Issue 4, 2008, Pages 1010-1014

  Chappell, Keith J ^a   Stoermer, Martin J ^a   Fairlie, David P ^a   Young, Paul R ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; NONSTRUCTURAL PROTEIN 2; NONSTRUCTURAL PROTEIN 2B; NONSTRUCTURAL PROTEIN 3; PROTEINASE; NS2B PROTEIN, FLAVIVIRUS; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN TARGETING; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; VIRUS RECOMBINANT; WEST NILE FLAVIVIRUS; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; COENZYME; ENZYME ACTIVE SITE; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTAGENESIS; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; VIROLOGY; VIRUS INFECTION;

FLAVIVIRUS; WEST NILE VIRUS;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; COENZYMES; ENDOPEPTIDASES; FLAVIVIRUS INFECTIONS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS; WEST NILE FEVER; WEST NILE VIRUS;

EID: 45549101510     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.83447-0     Document Type: Article

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