HSulf-1 suppresses cell growth and down-regulates Hedgehog signaling in human gastric cancer cells

Oncology Letters

Volumn 2, Issue 6, 2011, Pages 1291-1295

  Ma, Hui Yan ^a   Zhang, Fang ^b   Li, Jie ^b   Mo, Min Li ^b   Chen, Zhao ^b   Liu, Lili ^a   Zhou, Hai Meng ^b   Sheng, Qing ^a,b  

^a ZHEJIANG SCI TECH UNIVERSITY   (China)

^b TSINGHUA UNIVERSITY   (China)

Author keywords

Gastric cancer; Hedgehog signaling; HSulf 1; Proliferation

Indexed keywords

MYC PROTEIN; PROTEIN; PROTEIN BCL 2; PROTEIN CCND1; PROTEIN HHIP; PROTEIN PATCHED 1; PROTEIN PATCHED 2; SONIC HEDGEHOG PROTEIN; SULFATASE; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG;

ARTICLE; CANCER GROWTH; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ANALYSIS; HUMAN; HUMAN CELL; PROTEIN ANALYSIS; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STOMACH CANCER; TRANSCRIPTION REGULATION;

EID: 80052782118     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2011.407     Document Type: Article

References (34)

1. Hartgrink HH, Jansen EP, van Grieken NC and van de Velde CJ: Gastric cancer. Lancet 374: 477-490, 2009.
2. Ding SZ, Goldberg JB and Hatakeyama M: Helicobacter pylori infection, oncogenic pathways and epigenetic mechanisms in gastric carcinogenesis. Future Oncol 6: 851-862, 2010.
3. Merchant JL, Saqui-Salces M and El-Zaatari M: Hedgehog signaling in gastric physiology and cancer. Prog Mol Biol Transl Sci 96: 133-156, 2010.
4. Martin J, Donnelly JM, Houghton J and Zavros Y: The role of sonic hedgehog reemergence during gastric cancer. Dig Dis Sci 55: 1516-1524, 2010.
5. Varjosalo M and Taipale J: Hedgehog: functions and mechanisms. Genes Dev 22: 2454-2472, 2008.
6. Yang L, Xie G, Fan Q and Xie J: Activation of the hedgehog-signaling pathway in human cancer and the clinical implications. Oncogene 29: 469-481, 2010.
7. Scales SJ and de Sauvage FJ: Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci 30: 303-312, 2009.
8. Ma X, Chen K, Huang S, et al: Frequent activation of the hedgehog pathway in advanced gastric adenocarcinomas. Carcinogenesis 26: 1698-1705, 2005.
9. Hooper JE and Scott MP: Communicating with Hedgehogs. Nat Rev Mol Cell Biol 6: 306-317, 2005.
10. Huangfu D and Anderson KV: Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development 133: 3-14, 2006.
11. Osterlund T and Kogerman P: Hedgehog signalling: how to get from Smo to Ci and Gli. Trends Cell Biol 16: 176-180, 2006.
12. Lin X: Functions of heparan sulfate proteoglycans in cell signaling during development. Development 131: 6009-6021, 2004.
13. Morimoto-Tomita M, Uchimura K, Werb Z, Hemmerich S and Rosen SD: Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. J Biol Chem 277: 49175-49185, 2002.
14. Bernfield M, Gotte M, Park PW, et al: Functions of cell surface heparan sulfate proteoglycans. Annu Rev Biochem 68: 729-777, 1999.
15. Lai J, Chien J, Staub J, et al: Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer. J Biol Chem 278: 23107-23117, 2003.
16. Lai JP, Chien JR, Moser DR, et al: hSulf1 Sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling. Gastroenterology 126: 231-248, 2004.
17. Lai JP, Sandhu DS, Shire AM and Roberts LR: The tumor suppressor function of human sulfatase 1 (SULF1) in carcinogenesis. J Gastrointest Cancer 39: 149-158, 2008.
18. Narita K, Staub J, Chien J, et al: HSulf-1 inhibits angiogenesis and tumorigenesis in vivo. Cancer Res 66: 6025-6032, 2006.
19. Dai Y, Yang Y, MacLeod V, et al: HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo. J Biol Chem 280: 40066-40073, 2005.
20. Lai JP, Chien J, Strome SE, et al: HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma. Oncogene 23: 1439-1447, 2004.
21. Lai JP, Sandhu DS, Moser CD, et al: Additive effect of apicidin and doxorubicin in sulfatase 1 expressing hepatocellular carcinoma in vitro and in vivo. J Hepatol 50: 1112-1121, 2009.
22. Chen Z, Fan JQ, Li J, et al: Promoter hypermethylation correlates with the Hsulf-1 silencing in human breast and gastric cancer. Int J Cancer 124: 739-744, 2009.
23. Li J, Kleeff J, Abiatari I, et al: Enhanced levels of Hsulf-1 interfere with heparin-binding growth factor signaling in pancreatic cancer. Mol Cancer 4: 14, 2005.
24. Abiatari I, Kleeff J, Li J, Felix K, Buchler MW and Friess H: Hsulf-1 regulates growth and invasion of pancreatic cancer cells. J Clin Pathol 59: 1052-1058, 2006.
25. Dhoot GK, Gustafsson MK, Ai X, Sun W, Standiford DM and Emerson CP, Jr.: Regulation of Wnt signaling and embryo patterning by an extracellular sulfatase. Science 293: 1663-1666, 2001.
26. Chuang PT, Kawcak T and McMahon AP: Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev 17: 342-347, 2003.
27. Chuang PT and McMahon AP: Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature 397: 617-621, 1999.
28. Katoh Y and Katoh M: Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. Curr Mol Med 9: 873-886, 2009.
29. Rao G, Pedone CA, Coffin CM, Holland EC and Fults DW: c-Myc enhances sonic hedgehog-induced medulloblastoma formation from nestin-expressing neural progenitors in mice. Neoplasia 5: 198-204, 2003.
30. Sherr CJ and Roberts JM: CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13: 1501-1512, 1999.
31. Bigelow RL, Chari NS, Unden AB, et al: Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1. J Biol Chem 279: 1197-1205, 2004.
32. Lai JP, Yu C, Moser CD, et al: SULF1 inhibits tumor growth and potentiates the effects of histone deacetylase inhibitors in hepatocellular carcinoma. Gastroenterology 130: 2130-2144, 2006.
33. Staub J, Chien J, Pan Y, et al: Epigenetic silencing of HSulf-1 in ovarian cancer:implications in chemoresistance. Oncogene 26: 4969-4978, 2007.
34. Lai JP, Thompson JR, Sandhu DS and Roberts LR: Heparin-degrading sulfatases in hepatocellular carcinoma: roles in pathogenesis and therapy targets. Future Oncol 4: 803-814, 2008.