메뉴 건너뛰기




Volumn 6, Issue , 2011, Pages 13-21

Evidence-based assessment of potential use of fingolimod in treatment of relapsing multiple sclerosis

Author keywords

Fingolimod; FTY720; Multiple sclerosis; Oral treatment; S1P receptors

Indexed keywords

BETA1 INTERFERON; FINGOLIMOD;

EID: 80052756930     PISSN: 15551741     EISSN: None     Source Type: Journal    
DOI: 10.2147/CE.S10101     Document Type: Review
Times cited : (12)

References (56)
  • 1
    • 54149084585 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston A, Coles A. Multiple sclerosis. Lancet. 2008;372(9648): 1502-1517.
    • (2008) Lancet , vol.372 , Issue.9648 , pp. 1502-1517
    • Compston, A.1    Coles, A.2
  • 2
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
    • Lucchinetti C, Bruck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H. Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination. Ann Neurol. 2000;47(6):707-717.
    • (2000) Ann Neurol. , vol.47 , Issue.6 , pp. 707-717
    • Lucchinetti, C.1    Bruck, W.2    Parisi, J.3    Scheithauer, B.4    Rodriguez, M.5    Lassmann, H.6
  • 3
    • 5444240076 scopus 로고    scopus 로고
    • Recent neuropathological findings in multiple sclerosis - Implications for diagnosis and therapy
    • Lassmann H. Recent neuropathological findings in multiple sclerosis - implications for diagnosis and therapy. J Neurol. 2004;251 Suppl 4: IV2-IV5.
    • (2004) J Neurol. , vol.251 , Issue.SUPPL. 4
    • Lassmann, H.1
  • 4
    • 56349150992 scopus 로고    scopus 로고
    • Basic and escalating immunomodulatory treatments in multiple sclerosis: Current therapeutic recommendations
    • Wiendl H, Toyka KV, Rieckmann P, Gold R, Hartung HP, Hohlfeld R. Basic and escalating immunomodulatory treatments in multiple sclerosis: Current therapeutic recommendations. J Neurol. 2008;255(10): 1449-1463.
    • (2008) J Neurol. , vol.255 , Issue.10 , pp. 1449-1463
    • Wiendl, H.1    Toyka, K.V.2    Rieckmann, P.3    Gold, R.4    Hartung, H.P.5    Hohlfeld, R.6
  • 5
    • 0027418515 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial
    • The IFNB Multiple Sclerosis Study Group
    • The IFNB Multiple Sclerosis Study Group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology. 1993;43(4):655-661.
    • (1993) Neurology , vol.43 , Issue.4 , pp. 655-661
  • 6
    • 0008678962 scopus 로고    scopus 로고
    • Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG)
    • Jacobs LD, Cookfair DL, Rudick RA, et al. Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. The Multiple Sclerosis Collaborative Research Group (MSCRG). Ann Neurol. 1996;39(3):285-294.
    • (1996) Ann Neurol. , vol.39 , Issue.3 , pp. 285-294
    • Jacobs, L.D.1    Cookfair, D.L.2    Rudick, R.A.3
  • 7
    • 0345601517 scopus 로고    scopus 로고
    • Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis
    • PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group
    • PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group. Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. Lancet. 1998;352(9139):1498-1504.
    • (1998) Lancet , vol.352 , Issue.9139 , pp. 1498-1504
  • 8
    • 0029082566 scopus 로고
    • Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: Results of a phase III multicenter, double-blind placebo-controlled trial. The Copolymer 1 Multiple Sclerosis Study Group
    • Johnson KP, Brooks BR, Cohen JA, et al. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: Results of a phase III multicenter, double-blind placebo-controlled trial. The Copolymer 1 Multiple Sclerosis Study Group. Neurology. 1995; 45(7):1268-1276.
    • (1995) Neurology , vol.45 , Issue.7 , pp. 1268-1276
    • Johnson, K.P.1    Brooks, B.R.2    Cohen, J.A.3
  • 9
    • 54049087015 scopus 로고    scopus 로고
    • Assessment: The use of natalizumab (Tysabri) for the treatment of multiple sclerosis (an evidence-based review): Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
    • Goodin DS, Cohen BA, O'Connor P, Kappos L, Stevens JC. Assessment: The use of natalizumab (Tysabri) for the treatment of multiple sclerosis (an evidence-based review): Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology. 2008;71(10):766-773.
    • (2008) Neurology , vol.71 , Issue.10 , pp. 766-773
    • Goodin, D.S.1    Cohen, B.A.2    O'connor, P.3    Kappos, L.4    Stevens, J.C.5
  • 10
    • 69949098534 scopus 로고    scopus 로고
    • 250 microg or 500 microg interferon beta-1b versus 20 mg glatiramer acetate in relapsing-remitting multiple sclerosis: A prospective, randomised, multicentre study
    • O'Connor P, Filippi M, Arnason B, et al. 250 microg or 500 microg interferon beta-1b versus 20 mg glatiramer acetate in relapsing-remitting multiple sclerosis: A prospective, randomised, multicentre study. Lancet Neurol. 2009;8(10):889-897.
    • (2009) Lancet Neurol. , vol.8 , Issue.10 , pp. 889-897
    • O'connor, P.1    Filippi, M.2    Arnason, B.3
  • 11
    • 51449101000 scopus 로고    scopus 로고
    • Comparison of subcutaneous interferon beta-1a with glatiramer acetate in patients with relapsing multiple sclerosis (the REbif vs Glatiramer Acetate in Relapsing MS Disease [REGARD] study): A multicentre, randomised, parallel, open-label trial
    • Mikol DD, Barkhof F, Chang P, et al. Comparison of subcutaneous interferon beta-1a with glatiramer acetate in patients with relapsing multiple sclerosis (the REbif vs Glatiramer Acetate in Relapsing MS Disease [REGARD] study): A multicentre, randomised, parallel, open-label trial. Lancet Neurol. 2008;7(10): 903-914.
    • (2008) Lancet Neurol. , vol.7 , Issue.10 , pp. 903-914
    • Mikol, D.D.1    Barkhof, F.2    Chang, P.3
  • 12
    • 77951828930 scopus 로고    scopus 로고
    • Evidence report: The efficacy and safety of mitoxantrone (Novantrone) in the treatment of multiple sclerosis: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
    • Marriott JJ, Miyasaki JM, Gronseth G, O'Connor PW. Evidence report: The efficacy and safety of mitoxantrone (Novantrone) in the treatment of multiple sclerosis: Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology. 2010;74(18):1463-1470.
    • (2010) Neurology , vol.74 , Issue.18 , pp. 1463-1470
    • Marriott, J.J.1    Miyasaki, J.M.2    Gronseth, G.3    O'connor, P.W.4
  • 13
    • 53649106228 scopus 로고    scopus 로고
    • Natalizumab: A country-based surveillance program
    • Mancardi GL, Amato MP, D'Alessandro R, et al. Natalizumab: A country-based surveillance program. Neurol Sci. 2008;29 Suppl 2: S235-S237.
    • (2008) Neurol Sci. , vol.29 , Issue.SUPPL. 2
    • Mancardi, G.L.1    Amato, M.P.2    D'alessandro, R.3
  • 14
    • 74049140476 scopus 로고    scopus 로고
    • The pharmacovigilance program on natalizumab in Italy: 2 years of experience
    • Tedeschi G, Amato MP, D'Alessandro R, et al. The pharmacovigilance program on natalizumab in Italy: 2 years of experience. Neurol Sci. 2009;30 Suppl 2:S163-S165.
    • (2009) Neurol Sci. , vol.30 , Issue.SUPPL. 2
    • Tedeschi, G.1    Amato, M.P.2    D'alessandro, R.3
  • 15
    • 82455185180 scopus 로고    scopus 로고
    • Three years of experience: The Italian registry and safety data update
    • Jul 20. [Epub ahead of print]
    • Mancardi GL, Tedeschi G, Amato MP, et al. Three years of experience: The Italian registry and safety data update. Neurol Sci. 2010 Jul 20. [Epub ahead of print].
    • (2010) Neurol Sci.
    • Mancardi, G.L.1    Tedeschi, G.2    Amato, M.P.3
  • 16
    • 66749154882 scopus 로고    scopus 로고
    • Improving compliance with interferon-beta therapy in patients with multiple sclerosis
    • Portaccio E, Amato MP. Improving compliance with interferon-beta therapy in patients with multiple sclerosis. CNS Drugs. 2009;23(6): 453-462.
    • (2009) CNS Drugs. , vol.23 , Issue.6 , pp. 453-462
    • Portaccio, E.1    Amato, M.P.2
  • 17
    • 74249102004 scopus 로고    scopus 로고
    • Emerging multiple sclerosis oral therapies
    • Rammohan KW, Shoemaker J. Emerging multiple sclerosis oral therapies. Neurology. 2010;74 Suppl 1:S47-S53.
    • (2010) Neurology , vol.74 , Issue.SUPPL. 1
    • Rammohan, K.W.1    Shoemaker, J.2
  • 18
    • 76149083915 scopus 로고    scopus 로고
    • A placebo-controlled trial of oral cladribine for relapsing multiple sclerosis
    • Giovannoni G, Comi G, Cook S, et al. A placebo-controlled trial of oral cladribine for relapsing multiple sclerosis. N Engl J Med. 2010; 362(5):416-426.
    • (2010) N Engl J Med. , vol.362 , Issue.5 , pp. 416-426
    • Giovannoni, G.1    Comi, G.2    Cook, S.3
  • 19
    • 0037077308 scopus 로고    scopus 로고
    • The immune modulator FTY720 targets sphingosine 1-phosphate receptors
    • Brinkmann V, Davis MD, Heise CE, et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem. 2002; 277(24):21453-21457.
    • (2002) J Biol Chem. , vol.277 , Issue.24 , pp. 21453-21457
    • Brinkmann, V.1    Davis, M.D.2    Heise, C.E.3
  • 20
    • 84876261941 scopus 로고    scopus 로고
    • Accessed 2010 Oct 8
    • Gilenya label and approval history. Available from: http://www. accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search. Label-ApprovalHistory#apphist. Accessed 2010 Oct 8.
    • Gilenya Label and Approval History
  • 21
    • 0028372227 scopus 로고
    • Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite
    • Fujita T, Inoue K, Yamamoto S, et al. Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite. J Antibiot (Tokyo). 1994;47(2):208-215.
    • (1994) J Antibiot (Tokyo). , vol.47 , Issue.2 , pp. 208-215
    • Fujita, T.1    Inoue, K.2    Yamamoto, S.3
  • 22
    • 0346788900 scopus 로고    scopus 로고
    • Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways
    • Spiegel S, Milstien S. Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways. Biochem Soc Trans. 2003;31(Pt 6):1216-1219.
    • (2003) Biochem Soc Trans. , vol.31 , Issue.PART 6 , pp. 1216-1219
    • Spiegel, S.1    Milstien, S.2
  • 23
    • 0037067769 scopus 로고    scopus 로고
    • Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3
    • Ishii I, Ye X, Friedman B, et al. Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3. J Biol Chem. 2002;277(28):25152-25159.
    • (2002) J Biol Chem. , vol.277 , Issue.28 , pp. 25152-25159
    • Ishii, I.1    Ye, X.2    Friedman, B.3
  • 24
    • 34250832664 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology
    • Brinkmann V. Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology. Pharmacol Ther. 2007;115(1):84-105.
    • (2007) Pharmacol Ther. , vol.115 , Issue.1 , pp. 84-105
    • Brinkmann, V.1
  • 25
    • 1642580757 scopus 로고    scopus 로고
    • Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    • Matloubian M, Lo CG, Cinamon G, et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature. 2004;427(6972):355-360.
    • (2004) Nature , vol.427 , Issue.6972 , pp. 355-360
    • Matloubian, M.1    Lo, C.G.2    Cinamon, G.3
  • 26
    • 0037066466 scopus 로고    scopus 로고
    • Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
    • Mandala S, Hajdu R, Bergstrom J, et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science. 2002; 296(5566):346-349.
    • (2002) Science , vol.296 , Issue.5566 , pp. 346-349
    • Mandala, S.1    Hajdu, R.2    Bergstrom, J.3
  • 27
    • 0345578701 scopus 로고    scopus 로고
    • Edg-8 receptors are preferentially expressed in oligodendrocyte lineage cells of the rat central nervous system
    • Terai K, Soga T, Takahashi M, et al. Edg-8 receptors are preferentially expressed in oligodendrocyte lineage cells of the rat central nervous system. Neuroscience. 2003;116(4):1053-1062.
    • (2003) Neuroscience. , vol.116 , Issue.4 , pp. 1053-1062
    • Terai, K.1    Soga, T.2    Takahashi, M.3
  • 28
    • 0346024177 scopus 로고    scopus 로고
    • Characterization of lysophosphatidic acid and sphingosine-1-phosphate- mediated signal transduction in rat cortical oligodendrocytes
    • Yu N, Lariosa-Willingham KD, Lin FF, Webb M, Rao TS. Characterization of lysophosphatidic acid and sphingosine-1-phosphate-mediated signal transduction in rat cortical oligodendrocytes. Glia. 2004;45(1): 17-27.
    • (2004) Glia. , vol.45 , Issue.1 , pp. 17-27
    • Yu, N.1    Lariosa-Willingham, K.D.2    Lin, F.F.3    Webb, M.4    Rao, T.S.5
  • 29
    • 13844271705 scopus 로고    scopus 로고
    • Edg8/S1P5: An oligodendroglial receptor with dual function on process retraction and cell survival
    • Jaillard C, Harrison S, Stankoff B, et al. Edg8/S1P5: An oligodendroglial receptor with dual function on process retraction and cell survival. J Neurosci. 2005;25(6):1459-1469.
    • (2005) J Neurosci. , vol.25 , Issue.6 , pp. 1459-1469
    • Jaillard, C.1    Harrison, S.2    Stankoff, B.3
  • 30
    • 35348940243 scopus 로고    scopus 로고
    • Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells
    • Jung CG, Kim HJ, Miron VE, et al. Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells. Glia. 2007; 55(16):1656-1667.
    • (2007) Glia. , vol.55 , Issue.16 , pp. 1656-1667
    • Jung, C.G.1    Kim, H.J.2    Miron, V.E.3
  • 31
    • 33645283403 scopus 로고    scopus 로고
    • FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration
    • Kataoka H, Sugahara K, Shimano K, et al. FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration. Cell Mol Immunol. 2005;2(6):439-448.
    • (2005) Cell Mol Immunol. , vol.2 , Issue.6 , pp. 439-448
    • Kataoka, H.1    Sugahara, K.2    Shimano, K.3
  • 32
    • 34548443292 scopus 로고    scopus 로고
    • FTY720 sustains and restores neuronal function in the da rat model of MOG-induced experimental autoimmune encephalomyelitis
    • Balatoni B, Storch MK, Swoboda EM, et al. FTY720 sustains and restores neuronal function in the DA rat model of MOG-induced experimental autoimmune encephalomyelitis. Brain Res Bull. 2007; 74(5):307-316.
    • (2007) Brain Res Bull. , vol.74 , Issue.5 , pp. 307-316
    • Balatoni, B.1    Storch, M.K.2    Swoboda, E.M.3
  • 33
    • 76149093586 scopus 로고    scopus 로고
    • A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
    • Kappos L, Radue EW, O'Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med. 2010; 362(5):387-401.
    • (2010) N Engl J Med. , vol.362 , Issue.5 , pp. 387-401
    • Kappos, L.1    Radue, E.W.2    O'connor, P.3
  • 34
    • 76149140914 scopus 로고    scopus 로고
    • Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
    • Cohen JA, Barkhof F, Comi G, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med. 2010;362(5): 402-415.
    • (2010) N Engl J Med. , vol.362 , Issue.5 , pp. 402-415
    • Cohen, J.A.1    Barkhof, F.2    Comi, G.3
  • 35
    • 0037379202 scopus 로고    scopus 로고
    • Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment
    • Fujino M, Funeshima N, Kitazawa Y, et al. Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment. J. Pharmacol Exp Ther. 2003;305(1):70-77.
    • (2003) J. Pharmacol Exp Ther. , vol.305 , Issue.1 , pp. 70-77
    • Fujino, M.1    Funeshima, N.2    Kitazawa, Y.3
  • 36
    • 0142241216 scopus 로고    scopus 로고
    • Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes
    • Sorensen SD, Nicole O, Peavy RD, et al. Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes. Mol Pharmacol. 2003;64(5):1199-1209.
    • (2003) Mol Pharmacol. , vol.64 , Issue.5 , pp. 1199-1209
    • Sorensen, S.D.1    Nicole, O.2    Peavy, R.D.3
  • 37
    • 35348970884 scopus 로고    scopus 로고
    • Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: Consequences for mode of action in multiple sclerosis
    • Foster CA, Howard LM, Schweitzer A, et al. Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: Consequences for mode of action in multiple sclerosis. J Pharmacol Exp Ther. 2007;323(2):469-475.
    • (2007) J Pharmacol Exp Ther. , vol.323 , Issue.2 , pp. 469-475
    • Foster, C.A.1    Howard, L.M.2    Schweitzer, A.3
  • 38
    • 77953225859 scopus 로고    scopus 로고
    • Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices
    • Miron VE, Ludwin SK, Darlington PJ, et al. Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices. Am J Pathol. 2010;176(6):2682-2694.
    • (2010) Am J Pathol. , vol.176 , Issue.6 , pp. 2682-2694
    • Miron, V.E.1    Ludwin, S.K.2    Darlington, P.J.3
  • 39
    • 35548984947 scopus 로고    scopus 로고
    • The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors
    • Coelho RP, Payne SG, Bittman R, Spiegel S, Sato-Bigbee C. The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors. J Pharmacol Exp Ther. 2007;323(2): 26-635.
    • (2007) J Pharmacol Exp Ther. , vol.323 , Issue.2 , pp. 26-635
    • Coelho, R.P.1    Payne, S.G.2    Bittman, R.3    Spiegel, S.4    Sato-Bigbee, C.5
  • 40
    • 34247554847 scopus 로고    scopus 로고
    • Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration
    • Novgorodov AS, El-Alwani M, Bielawski J, Obeid LM, Gudz TI. Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration. FASEB J. 2007;21(7): 1503-1514.
    • (2007) FASEB J. , vol.21 , Issue.7 , pp. 1503-1514
    • Novgorodov, A.S.1    El-Alwani, M.2    Bielawski, J.3    Obeid, L.M.4    Gudz, T.I.5
  • 41
    • 34547431060 scopus 로고    scopus 로고
    • Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors
    • Mullershausen F, Craveiro LM, Shin Y, et al. Phosphorylated FTY720 promotes astrocyte migration through sphingosine-1-phosphate receptors. J Neurochem. 2007;102(4):1151-1161.
    • (2007) J Neurochem. , vol.102 , Issue.4 , pp. 1151-1161
    • Mullershausen, F.1    Craveiro, L.M.2    Shin, Y.3
  • 42
    • 0242411518 scopus 로고    scopus 로고
    • G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation
    • Allende ML, Yamashita T, Proia RL. G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation. Blood. 2003;102(10):3665-3667.
    • (2003) Blood. , vol.102 , Issue.10 , pp. 3665-3667
    • Allende, M.L.1    Yamashita, T.2    Proia, R.L.3
  • 43
    • 33644791607 scopus 로고    scopus 로고
    • The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo
    • Lan YY, de Creus A, Colvin BL, et al. The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo. Am J Transplant. 2005;5(11):2649-2659.
    • (2005) Am J Transplant. , vol.5 , Issue.11 , pp. 2649-2659
    • Lan, Y.Y.1    De Creus, A.2    Colvin, B.L.3
  • 44
  • 45
    • 0344443651 scopus 로고    scopus 로고
    • Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability
    • Sanchez T, Estrada-Hernandez T, Paik JH, et al. Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. J Biol Chem. 2003; 278(47):47281-47290.
    • (2003) J Biol Chem. , vol.278 , Issue.47 , pp. 47281-47290
    • Sanchez, T.1    Estrada-Hernandez, T.2    Paik, J.H.3
  • 46
    • 69949124388 scopus 로고    scopus 로고
    • Fingolimod and related compounds in a spontaneous autoimmune polyneuropathy
    • Kim HJ, Jung CG, Dukala D, et al. Fingolimod and related compounds in a spontaneous autoimmune polyneuropathy. J Neuroimmunol. 2009; 214(1-2):93-100.
    • (2009) J Neuroimmunol. , vol.214 , Issue.1-2 , pp. 93-100
    • Kim, H.J.1    Jung, C.G.2    Dukala, D.3
  • 47
    • 0142040141 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: A multicenter, randomized, placebo-controlled, phase i study
    • Kahan BD, Karlix JL, Ferguson RM, et al. Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: A multicenter, randomized, placebo-controlled, phase I study. Transplantation. 2003;76(7):1079-1084.
    • (2003) Transplantation , vol.76 , Issue.7 , pp. 1079-1084
    • Kahan, B.D.1    Karlix, J.L.2    Ferguson, R.M.3
  • 48
    • 58849124814 scopus 로고    scopus 로고
    • Ketoconazole increases fingolimod blood levels in a drug interaction via CYP4F2 inhibition
    • Kovarik JM, Dole K, Riviere GJ, et al. Ketoconazole increases fingolimod blood levels in a drug interaction via CYP4F2 inhibition. J Clin Pharmacol. 2009;49(2):212-218.
    • (2009) J Clin Pharmacol. , vol.49 , Issue.2 , pp. 212-218
    • Kovarik, J.M.1    Dole, K.2    Riviere, G.J.3
  • 49
    • 1942508223 scopus 로고    scopus 로고
    • Multiple-dose FTY720: Tolerability, pharmacokinetics, and lymphocyte responses in healthy subjects
    • 200
    • Kovarik JM, Schmouder R, Barilla D, Riviere GJ, Wang Y, Hunt T. Multiple-dose FTY720: Tolerability, pharmacokinetics, and lymphocyte responses in healthy subjects. J Clin Pharmacol. 200;44(5):532-537.
    • J Clin Pharmacol. , vol.44 , Issue.5 , pp. 532-537
    • Kovarik, J.M.1    Schmouder, R.2    Barilla, D.3    Riviere, G.J.4    Wang, Y.5    Hunt, T.6
  • 50
    • 0037108378 scopus 로고    scopus 로고
    • Cutting edge: Suppression of T cell chemotaxis by sphingosine 1-phosphate
    • Graeler M, Shankar G, Goetzl EJ. Cutting edge: Suppression of T cell chemotaxis by sphingosine 1-phosphate. J Immunol. 2002;169(8): 4084-4087.
    • (2002) J Immunol. , vol.169 , Issue.8 , pp. 4084-4087
    • Graeler, M.1    Shankar, G.2    Goetzl, E.J.3
  • 51
    • 33751530065 scopus 로고    scopus 로고
    • Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism
    • Kabashima K, Haynes NM, Xu Y, et al. Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism. J Exp Med. 2006;203(12):2683-2690.
    • (2006) J Exp Med. , vol.203 , Issue.12 , pp. 2683-2690
    • Kabashima, K.1    Haynes, N.M.2    Xu, Y.3
  • 52
    • 2342634478 scopus 로고    scopus 로고
    • Single-dose FTY720 pharmacokinetics, food effect, and pharmacological responses in healthy subjects
    • Kovarik JM, Schmouder R, Barilla D, Wang Y, Kraus G. Single-dose FTY720 pharmacokinetics, food effect, and pharmacological responses in healthy subjects. Br J Clin Pharmacol. 2004;57(5):586-591.
    • (2004) Br J Clin Pharmacol. , vol.57 , Issue.5 , pp. 586-591
    • Kovarik, J.M.1    Schmouder, R.2    Barilla, D.3    Wang, Y.4    Kraus, G.5
  • 53
    • 54449099880 scopus 로고    scopus 로고
    • FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis
    • Mehling M, Brinkmann V, Antel J, et al. FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis. Neurology. 2008; 71(16):1261-1267.
    • (2008) Neurology , vol.71 , Issue.16 , pp. 1261-1267
    • Mehling, M.1    Brinkmann, V.2    Antel, J.3
  • 54
    • 10244246559 scopus 로고    scopus 로고
    • FTY720 suppresses humoral immunity by inhibiting germinal center reaction
    • Han S, Zhang X, Wang G, et al. FTY720 suppresses humoral immunity by inhibiting germinal center reaction. Blood. 2004;104(13): 4129-4133.
    • (2004) Blood. , vol.104 , Issue.13 , pp. 4129-4133
    • Han, S.1    Zhang, X.2    Wang, G.3
  • 55
    • 77955799815 scopus 로고    scopus 로고
    • Oral fingolimod (FTY720) for relapsing multiple sclerosis
    • Kappos L, Antel J, Comi G, et al. Oral fingolimod (FTY720) for relapsing multiple sclerosis. N Engl J Med. 2006;355(11):1124-1140.
    • (2006) N Engl J Med. , vol.355 , Issue.11 , pp. 1124-1140
    • Kappos, L.1    Antel, J.2    Comi, G.3
  • 56
    • 78650016412 scopus 로고    scopus 로고
    • Pregnancy and fetal outcomes after interferon-beta exposure in multiple sclerosis
    • Amato MP, Portaccio E, Ghezzi A, et al. Pregnancy and fetal outcomes after interferon-beta exposure in multiple sclerosis. Neurology. 2010; 75(20):1794-1802.
    • (2010) Neurology. , vol.75 , Issue.20 , pp. 1794-1802
    • Amato, M.P.1    Portaccio, E.2    Ghezzi, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.