Pregnancy and fetal outcomes after interferon-β exposure in multiple sclerosis

Neurology

Volumn 75, Issue 20, 2010, Pages 1794-1802

  Amato, M P ^a   Portaccio, E ^a   Ghezzi, A ^b   Hakiki, B ^a   Zipoli, V ^a   Martinelli, V ^c   Moiola, L ^c   Patti, F ^d   La Mantia, L ^e   Mancardi, G L ^f   Solaro, C ^g   Tola, M R ^h   Pozzilli, C ⁱ   De Giglio, L ^i,p   Totaro, R ^j   Lugaresi, A ^k   Di Tommaso, V ^k,p   Paolicelli, D ^l   Marrosu, M G ^m   Comi, G ^c   Pellegrini, F ^n,o   Trojano, M ^l   Siracusa, G ^p   Rizzo, A ^p   Zaffaroni, M ^p   Radaelli, M ^p   Milanese, C ^p   Protti, A ^p   Spreafico, C ^p   Marazzi, R ^p   Cavalla, P ^p   Masera, S ^p   Bergamaschi, R ^p   Capello, E ^p   Molinari, F ^p   Caniatti, L ^p   Granella, F ^p   Immovilli, P ^p   Annunziata, P ^p   De Santi, L ^p   Plewnia, K ^p   Guidi, L ^p   Bartolozzi, M L ^p   Mazzoni, M ^p   De Luca, Giovanna ^p   Carrozzo, A ^p   D'Onghia, M ^p   Musu, L ^p   Cavallaro, T ^p   more..

^a UNIVERSITY OF FLORENCE   (Italy)

^b ASST Valle Olona   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d UNIVERSITY OF CATANIA   (Italy)

^e DEPARTMENT OF NEUROSURGERY   (Italy)

^f UNIVERSITY OF GENOA   (Italy)

^g ASL 3 Genovese   (Italy)

^h UNIVERSITY OF FERRARA   (Italy)

ⁱ SAPIENZA UNIVERSITY OF ROME   (Italy)

^j UNIVERSITY OF L'AQUILA   (Italy)

^k UNIVERSITY OF CHIETI   (Italy)

^l UNIVERSITY OF BARI   (Italy)

^m UNIVERSITY OF CAGLIARI   (Italy)

ⁿ Consorzio Mario Negri Sud ^*  (Italy)

^o CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^p NONE

more..

Author keywords

[No Author keywords available]

Indexed keywords

BETA1A INTERFERON;

ADULT; ARTICLE; COHORT ANALYSIS; CONCEPTION; CONFIDENCE INTERVAL; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; FEMALE; FETUS MALFORMATION; FETUS OUTCOME; FOLLOW UP; HUMAN; LOW BIRTH WEIGHT; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PREDICTION; PREGNANCY OUTCOME; PREMATURE LABOR; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; SEMI STRUCTURED INTERVIEW; SPONTANEOUS ABORTION;

EID: 78650016412     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3181fd62bb     Document Type: Article

References (32)

1. Confavreux C, Hutchinson M, Hours MM, Cortinovis-Tourniaire P, Moreau T. Rate of pregnancy-related relapse in multiple sclerosis: Pregnancy in Multiple Sclerosis Group. N Engl J Med 1998;339:285-291.
2. Roullet E, Verdier-Taillefer MH, Amarenco P, Gharbi G, Alperovitch A, Marteau R. Pregnancy and multiple sclerosis: A longitudinal study of 125 remittent patients. J Neurol Neurosurg Psychiatry 1993;56:1062-1065.
3. Vukusic S, Confavreux C. Pregnancy and multiple sclerosis: The children of PRIMS. Clin Neurol Neurosurg 2006; 108:266-270.
4. Biogen. Avonex (interferon-α 1a): Product monograph. Biogen; 1998.
5. Coyle PK, Christie S, Fodor P, et al. Multiple sclerosis gender issues: Clinical practices of women neurologists. Mult Scler 2004;10:582-588.
6. McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001;50:121-127.
7. ISTAT. Dimissioni dagli istituti di cura per aborto spontaneo in Italia. Available at: Http://www.istat.it/dati/dataset/ 20080415-01/. Accessed June 15, 2009.
8. Salute MD. Certificato di assistenza al parto (CeDAP) Analisi dell'evento nascite: Anno 2005. Available at: Www. ministerosalute.it/imgs/C-17- pubblicazioni-819-allegato. pdf. Accessed August 4, 2009.
9. Boskovic R, Wide R, Wolpin J, Bauer DJ, Koren G. The reproductive effects of beta interferon therapy in pregnancy: A longitudinal cohort. Neurology 2005;65:807-811.
10. Sandberg-Wollheim M, Frank D, Goodwin TM, et al. Pregnancy outcomes during treatment with interferon beta-1a in patients with multiple sclerosis. Neurology 2005;65:802-806.
11. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology 1983;33:1444-1452.
12. D'Agostino RB Jr. Propensity score methods for bias reduction in the comparison of a treatment to a nonrandomized control group. Stat Med 1998;17:2265-2281.
13. Yanovitzky I, Zanutto E, Hornik R. Estimating causal effects of public health education campaigns using propensity score methodology. Eval Program Plann 2005:209-220.
14. Rubin DB. Estimating causal effects from large data sets using propensity scores. Ann Intern Med 1997;127:757-763.
15. Fernandez Liguori N, Klajn D, Acion L, et al. Epidemiological characteristics of pregnancy, delivery, and birth outcome in women with multiple sclerosis in Argentina (EMEMAR study). Mult Scler 2009;15:555-562.
16. Weber-Schoendorfer C, Schaefer C. Multiple sclerosis, immunomodulators, and pregnancy outcome: A prospective observational study. Mult Scler 2009;15:1037-1042.
17. Lin DY, Psaty BM, Kronmal RA. Assessing the sensitivity of regression results to unmeasured confounders in observational studies. Biometrics 1998;54:948-963.
18. Trojano M. Is it time to use observational data to estimate treatment effectiveness in multiple sclerosis? Neurology 2007;69:1478-1479.
19. Stenestrand U, Wallentin L. Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 2001;285:430-436.
20. Gum PA, Thamilarasan M, Watanabe J, Blackstone EH, Lauer MS. Aspirin use and all-cause mortality among patients being evaluated for known or suspected coronary artery disease: A propensity analysis. JAMA 2001;286: 1187-1194.
21. Trojano M, Pellegrini F, Fuiani A, et al. New natural history of interferon-beta-treated relapsing multiple sclerosis. Ann Neurol 2007;61:300-306.
22. Dahl J, Myhr KM, Daltveit AK, Gilhus NE. Pregnancy, delivery and birth outcome in different stages of maternal multiple sclerosis. J Neurol 2008;255:623-627.
23. Chen YH, Lin HL, Lin HC. Does multiple sclerosis increase risk of adverse pregnancy outcomes? A populationbased study. Mult Scler 2009;15:606-612.
24. Kelly VM, Nelson LM, Chakravarty EF. Obstetric outcomes in women with multiple sclerosis and epilepsy. Neurology 2009;73:1831-1836.
25. Metzger BE, Lowe LP, Dyer AR, et al. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 2008;358: 1991-2002.
26. Nohr EA, Timpson NJ, Andersen CS, Davey Smith G, Olsen J, Sorensen TI. Severe obesity in young women and reproductive health: The Danish National Birth Cohort. PLoS One 2009;4:e8444.
27. McCowan L, Horgan RP. Risk factors for small for gestational age infants. Best Pract Res Clin Obstet Gynaecol 2009;23:779-793.
28. Raghupathy R, Kalinka J. Cytokine imbalance in pregnancy complications and its modulation. Front Biosci 2008;13:985-994.
29. Challier JC, Guerre-Millo M, Nandakumaran M, Gerbaut L, d'Athis P. Clearance of compounds of different molecular size in the human placenta in vitro. Biol Neonate 1985; 48:143-148.
30. Waysbort A, Giroux M, Mansat V, Teixeira M, Dumas JC, Puel J. Experimental study of transplacental passage of alpha interferon by two assay techniques. Antimicrob Agents Chemother 1993;37:1232-1237.
31. Chard T. Interferon in pregnancy. J Dev Physiol 1989;11: 271-276.
32. Duc-Goiran P, Robert-Galliot B, Lopez J, Chany C. Unusual apparently constitutive interferons and antagonists in human placental blood. Proc Natl Acad Sci USA 1985;82: 5010-5014.