Integrated transcriptional and proteomic analysis with in vitro biochemical assay reveal the important role of CYP3A46 in T-2 toxin hydroxylation in porcine primary hepatocytes

Molecular and Cellular Proteomics

Volumn 10, Issue 9, 2011, Pages

  Wang, Jianshe ^a   Jiang, Jun ^b   Zhang, Hongxia ^a   Wang, Junping ^b   Cai, Hua ^b   Li, Cheng ^c   Li, Kangbai ^b   Liu, Jing ^b   Guo, Xuejiang ^d   Zou, Guangxun ^a   Wang, Dazhi ^d   Deng, Yiqun ^b   Dai, Jiayin ^a,d  

^a INSTITUTE OF ZOOLOGY   (China)

^b SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

^c NANJING MEDICAL UNIVERSITY   (China)

^d XIAMEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLESTERASE; CARBOXYLESTERASE 1C4; CARBOXYLESTERASE 1C5; CYTOCHROME P450 3A; CYTOCHROME P450 3A39; CYTOCHROME P450 3A46; EPOXIDE HYDROLASE; RECOMBINANT PROTEIN; T 2 TOXIN; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BIOINFORMATICS; BIOTRANSFORMATION; CATALYSIS; CELL LEVEL; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOSKELETON; CYTOTOXICITY; DISORDERS OF LIPID AND LIPOPROTEIN METABOLISM; ELECTRON TRANSPORT; EPOXIDATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HYDROLYSIS; HYDROXYLATION; IN VITRO STUDY; LIPID METABOLISM; LIQUID CHROMATOGRAPHY; LIVER CELL; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METABOLITE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN MICROARRAY; PROTEIN PURIFICATION; PROTEOMICS; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; TRANSCRIPTOMICS; TWO DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS; XENOBIOTIC METABOLISM; ANIMAL; BIOASSAY; CHEMISTRY; CYTOLOGY; DNA MICROARRAY; DRUG EFFECT; FUSARIUM; GENETIC TRANSCRIPTION; GENETICS; LIVER; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; OXIDATION REDUCTION REACTION; PRIMARY CELL CULTURE; SWINE; TWO DIMENSIONAL GEL ELECTROPHORESIS;

ANIMALIA; SUS;

ANIMALS; APOPTOSIS; ARYL HYDROCARBON HYDROXYLASES; BIOLOGICAL ASSAY; CARBOXYLIC ESTER HYDROLASES; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; EPOXIDE HYDROLASES; FUSARIUM; HEPATOCYTES; HUMANS; HYDROXYLATION; LIPID METABOLISM; LIVER; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PRIMARY CELL CULTURE; PROTEOMICS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUS SCROFA; T-2 TOXIN; TRANSCRIPTION, GENETIC;

EID: 80052754650     PISSN: 15359476     EISSN: 15359484     Source Type: Journal    
DOI: 10.1074/mcp.M111.008748     Document Type: Article

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