Intracellular zinc release-activated ERK-dependent GSK-3Β-p53 and Noxa-Mcl-1 signaling are both involved in cardiac ischemic-reperfusion injury

Cell Death and Differentiation

Volumn 18, Issue 10, 2011, Pages 1651-1663

  Lin, C L ^a,b   Tseng, H C ^a   Chen, W P ^b   Su, M J ^a   Fang, K M ^a   Chen, R F ^c   Wu, M L ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

flavonoids; GSK 3 ; I R injury; Noxa; TPEN; zinc

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; FLAVONOID; GLYCOGEN SYNTHASE KINASE 3BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N,N,N',N' TETRAKIS(2 PYRIDYLMETHYL)ETHYLENEDIAMINE; POTASSIUM; PROTEIN MCL 1; PROTEIN NOXA; PROTEIN P53; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; ZINC ION;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSOL; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRION; NEWBORN; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TIME LAPSE IMAGING;

ANIMALS; APOPTOSIS; BUTADIENES; CELL NUCLEUS; CELLS, CULTURED; GLYCOGEN SYNTHASE KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; NITRILES; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; TUMOR SUPPRESSOR PROTEIN P53; ZINC;

EID: 80052736659     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2011.80     Document Type: Article

References (30)

1. Maret W, Vallee BL. Thiolate ligands in metallothionein confor redox activity on Zn2+ chelators. Proc Natl Acad Sci 1998; 95: 3478-3482. (Pubitemid 28173153)
2. Bozym RA, Thompson RB, Stoddard AK, Fierke CA. Measuring picomolar intracellular exchangeable zinc in PC-12 cells using a ratiometric fluorescence biosensor. ACS Chem Biol 2006; 1: 103-111.
3. Cheung P-Y, Wang W, Schulz R. Glutathione protects against myocardial ischemiareperfusion injury by detoxifying peroxynitrite. J Mol Cell Cardiol 2000; 32: 1669-1678.
4. Juhaszova M, Zorov DB, Kim S-H, Pepe S, Fu Q, Fishbein KW et al. Glycogen synthase kinase-3b mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore. J Clin Invest 2004; 113: 1535-1549. (Pubitemid 39071677)
5. Yellon DM, Hausenloy DJ. Myocardial Reperfusion Injury. N Engl J Med 2007; 357: 1121-1135.
6. Kang YJ, Li G, Saari JT. Metallothionein inhibits ischemia-reperfusion injury in mouse heart. Am J Physiol 1999; 26: H993-H997. (Pubitemid 29157473)
7. Bossy-Wetzel E, Talantova MV, Lee WD, Schö lzke MN, Harrop A, Mathews E et al. Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels. Neuron 2004; 41: 351-365. (Pubitemid 38221040)
8. Zhang Y, Wang H, Li J, Dong L, Xu P, Chen W et al. Intracellular zinc release and ERK phosphorylation are required upstream of 12-lipoxygenease activation in peroxynitrite toxicity to mature rat oligodendrocytes. J Biol Chem 2006; 281: 9460-9470. (Pubitemid 43864663)
9. Mclntosh R, Lee SY, Ghio AJ, Xi J, Zhu M, Shen X et al. The critical role of intracellular zinc in adenosine A2 receptor activation induced cardioprotection against reperfusion injury. J Mol Cell Cardiol 2010; 49: 41-47.
10. Karagulova G, Yue Y, Moreyra A, Boutjdir M, Korichneva I. Protective role of intracellular zinc in myocardial ischemia/reperfusion is associated with preservation of protein kinase C isoforms. JPET 2007; 321: 517-525. (Pubitemid 46624490)
11. Sensi SL, Ton-That D, Sullivan PG, Jonas EA, Gee KR, Kaczmarek LK et al. Modulation of mitochondrial function by endogenous Zn2+ pools. Proc Natl Acad Sci 2003; 100: 6157-6162. (Pubitemid 36576947)
12. Cornell NW, Crivaro KE. Stability constant for the zinc-dithiothreitol complex. Analy Biochem 1972; 47: 203-208.
13. Das S, Wong R, Rajapakse N, Murphy E, Steenbergen C. Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltagedependent anion channel phosphorylation. Circ Res 2008; 103: 983-991.
14. Gross ER, Hsu AK, Gross GJ. Opioid-Induced cardioprotection occurs via glycogen synthase Kinase b inhibition during reperfusion in intact rat hearts. Circ Res 2004; 94: 960-966. (Pubitemid 38490074)
15. Gomez L, Paillard M, Thibault H, Derumeaux G, Ovize M. Inhibition of GSK-3b by postconditioning is required to prevent opening of the mitochondrial permeability transition pore during reperfusion. Circulation 2008; 117: 2761-2768. (Pubitemid 351770456)
16. Miura T, Miki T. GSK-3b, a therapeutic target for cardiomyocyte protection. Circ J 2009; 73: 1184-1192.
17. Yook JI, Li X-Y, Ota I, Hu C, Kim HS, Kim NH et al. A Wnt-Axin2-GSK3b cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol 2006; 8: 1398-1406. (Pubitemid 44835115)
18. Beurel E, Jope BS. The paradoxical pro-and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. Prog in Neurobiol 2006; 79: 173-189. (Pubitemid 44331500)
19. Lin T, Mak NK, Yang MS. MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: involvement of p53 phosphorylation and acetylation. Toxicology 2008; 247: 145-153.
20. Taylor RC, Cullen SP, Martin SJ. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 2008; 9: 231-241. (Pubitemid 351301823)
21. Sheridan C, Brumatti G, Elgendy M, Brunet M, Martin SJ. An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs. Oncogene 2010; 29: 6428-6441.
22. Aikawa T, Shinzawa K, Tanaka N, Tsujimoto Y. Noxa is necessary for hydrogen peroxideinduced caspase-dependent cell death. FEBS Letters 2010; 584: 681-688.
23. Chanoit G, Lee SR, Xi J, Zhu M, McIntosh RA, Mueller RA et al. Exogenous zinc protects cardiac cells from reperfusion injury by targeting mitochondrial permeability transition pore through inactivation of glycogen synthase kinase-3b. Am J Physiol 2008; 295: H1227-H1233.
24. Lee SY, Chanoit G, McIntosh R, Zvara DA, Xu Z. Molecular mechanism underlying Akt activation in zinc-induced cardioprotection. Am J Physiol 2009; 297: H569-H575.
25. Eom TY, Roth KA, Jope RS. Neural precursor cells are protected from apoptosis induced by trophic factor withdrawal or genotoxic stress by inhibitors of glycogen synthase kinase 3. J Biol Chem 2007; 282: 22856-22864. (Pubitemid 47267357)
26. Cagnol S, Chambard J-C. ERK and cell death: mechanisms of ERK-induced cell death-apoptosis, autophagy and senescence. FEBS J 2010; 277: 2-21.
27. Kohda Y, Matsunaga Y, Shiota R, Satoh T, Kishi Y, Kawai Y et al. Raf-1/Mek/ERK1/2 signaling pathway in zinc-induced injury in rat renal cortical slices. J Toxicol Sci 2006; 31: 207-217. (Pubitemid 44371853)
28. Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of Mcl-1. Mol Cell 2006; 21: 749-760. (Pubitemid 43376126)
29. Ding Q, He X, Hsu J-M, Xia W, Chen C-T, Li L-Y et al. Degradation of Mcl-1 by b-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. Mol Cell Biol 2007; 27: 4006-4017. (Pubitemid 47010998)
30. Frederickson CJ, Burdette SC, Frederickson CJ, Sensi SL, Weiss JH, Yin HZ et al. Method for identifying neuronal cells suffering zinc toxicity by use of a novel fluorescent sensor. J Neurosci Methods 2004; 139: 79-89. (Pubitemid 39194851)