Glutathione protects against myocardial ischemia-reperfusion injury by detoxifying peroxynitrite

Journal of Molecular and Cellular Cardiology

Volumn 32, Issue 9, 2000, Pages 1669-1678

  Cheung, Po Yin ^a   Wang, Wenjie ^a   Schulz, Richard ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

5' guanosine monophosphate; Cyclic 3'; Isolated rat heart; Thiols

Indexed keywords

GLUTATHIONE PEROXIDASE; PEROXYNITRITE;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; HEART MUSCLE ISCHEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

EID: 0033794758     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.2000.1203     Document Type: Article

References (37)

1. Glutathione
2. Function of glutathione peroxidase in decomposition of hydrogen peroxide in isolated liver and heart cells
3. Protection of myocytes against free radical-induced damage by accelerated turnover of the glutathione redox cycle
4. Myocardial sulfhydryl pool alterations occur during reperfusion after brief and prolonged myocardial ischemia in vivo
5. Depletion of myocardial glutathione: Its effects on heart function and metabolism during ischaemia and reperfusion
6. Exogenous glutathione attenuates stunning following intermittent hypoxia in isolated rat hearts
7. 2+, and function in reperfused rat hearts
8. Glutathione causes coronary vasodilation via a nitric oxide- and soluble guanylate cyclase-dependent mechanism
9. S-Nitroglutathione, a product of the reaction between peroxynitrite and glutathione that generates nitric oxide
10. A new pathway of nitric oxide/cyclic GMP signaling involving S-nitrosoglutathione
11. Peroxynitrite-induced accumulation of cyclic GMP in endothelial cells and stimulation of purified soluble guanylate cyclase
12. Measurement of nitric oxide and peroxynitrite generation in the postischemic heart. Evidence for peroxynitrite-mediated reperfusion injury
13. Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts
14. Paradoxical fate and biological action of peroxynitrite on human platelets
15. Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation
16. Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species
17. Involvement of nitric oxide and nitrosothiols in relaxation of pulmonary arteries to peroxynitrite
18. Dityrosine, a specific marker of oxidation is synthesized by the myeloperoxidase-hydrogen peroxide system of human neutrophils and macrophages
19. Dityrosine and tyrosine oxidation products are endogenous markers for the selective proteolysis of oxidatively modified red cell hemoglobin by (the 19S) proteasome
20. Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite
21. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
22. Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury
23. Cell permeable superoxide dismutase mimetic protects from myocardial ischemia-reperfusion
24. Peroxynitrite aggravates myocardial reperfusion injury in the isolated perfused rat heart
25. Thiols protect the inhibition of myocardial aconitase by peroxynitrite
26. Myocardial protective actions of nitric oxide donors after myocardial ischemia and reperfusion
27. S-nitrosoglutathione improves functional recovery in the isolated rat heart after cardioplegic ischemic arrest - Evidence for a cardioprotective effect of nitric oxide
28. 2+ responsiveness and altered diastolic function in intact ventricular muscle
29. 2+ in intact cardiac myocytes
30. Peroxynitrite reduces myocardial infarct size and preserves coronary endothelium after ischemia and reperfusion in cats
31. Mechanism of cardioprotection by peroxynitrite in myocardial ischemia and reperfusion injury
32. Glutathione redox cycle is an important defense system of endothelial cells against chronic hyperoxia
33. The addition of glutathione (YM737) to a crystalloid cardioplegic solution enhances myocardial protection
34. Endothelial function following ischemia
35. Agonist-induced peroxynitrite production from endothelial cells
36. The role of glutathione in the transport and catabolism of nitric oxide
37. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor