Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion

Circulation

Volumn 124, Issue 11 SUPPL. 1, 2011, Pages

  Itoh, Satoshi ^a   Kimura, Naoyuki ^a   Axtell, Robert C ^a   Velotta, Jeffrey B ^a   Gong, Yongquan ^a   Wang, Xi ^a   Kajiwara, Naoki ^b,c   Nambu, Aya ^b,d   Shimura, Eri ^b   Adachi, Hideo ^d,g   Iwakura, Yoichiro ^e   Saito, Hirohisa ^c   Okumura, Ko ^b   Sudo, Katsuko ^h   Steinman, Lawrence ^h   Robbins, Robert C ^a   Nakae, Susumu ^f   Fischbein, Michael P ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JUNTENDO UNIVERSITY   (Japan)

^c NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^d Laboratory of Systems Biology   (Japan)

^e Laboratory of Molecular Pathogenesis   (Japan)

^f UNIVERSITY OF TOKYO   (Japan)

^g JICHI MEDICAL UNIVERSITY   (Japan)

^h TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

; acute allograft rejection; IL 17; regulatory T cell; T cell

Indexed keywords

INTERLEUKIN 17; RAG2 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIAC GRAFT REJECTION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GAMMA DELTA T LYMPHOCYTE; GRAFT RECIPIENT; GRAFT SURVIVAL; HEART TRANSPLANTATION; HETEROTOPIC TRANSPLANTATION; INFLAMMATION; INFLAMMATORY CELL; MALE; MOUSE; NONHUMAN; ORGAN DONOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T CELL DEPLETION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; GRAFT REJECTION; HEART TRANSPLANTATION; INTERLEUKIN-17; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, ANIMAL; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; TRANSPLANTATION, HOMOLOGOUS;

EID: 80052734905     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.110.014852     Document Type: Article

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