Atomoxetine facilitates attentional set shifting in adolescent rats

Developmental Cognitive Neuroscience

Volumn 1, Issue 4, 2011, Pages 552-559

  Cain, Rachel E ^a   Wasserman, Michelle C ^a   Waterhouse, Barry D ^b   McGaughy, Jill A ^a  

^a UNIVERSITY OF NEW HAMPSHIRE   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Executive function; Norepinephrine; Prefrontal cortex; Reversals; Set shifting

Indexed keywords

ATOMOXETINE; NORADRENALIN; NORADRENALIN TRANSPORTER;

ADOLESCENT; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; ATTENTIONAL SET SHIFTING TASK; CONCENTRATION RESPONSE; DISCRIMINATION LEARNING; DRUG DOSE COMPARISON; DRUG MECHANISM; EXECUTIVE FUNCTION; LOW DRUG DOSE; MALE; NONHUMAN; NORADRENALIN BRAIN LEVEL; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TARGETING; RAT; REINFORCEMENT; RIGIDITY; TASK PERFORMANCE;

ADRENERGIC UPTAKE INHIBITORS; AGE FACTORS; ANIMALS; ATTENTION; DISCRIMINATION LEARNING; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; PROPYLAMINES; RATS; RATS, LONG-EVANS; REACTION TIME;

EID: 80052725198     PISSN: 18789293     EISSN: 18789307     Source Type: Journal    
DOI: 10.1016/j.dcn.2011.04.003     Document Type: Article

References (97)

1. W. Adriani, D. Leo, D. Greco, M. Rea, U. di Porzio, and G. Laviola Methylphenidate administration to adolescent rats determines plastic changes on reward-related behavior and striatal gene expression Neuropsychopharmacology 31 2006 1946 1956
2. S.L. Andersen Trajectories of brain developnment: point of vulnerability or window of opportunity? Neurosci. Biobehav. Rev. 27 2008 3 18 (Pubitemid 36535387)
3. A.F.T. Arnsten Catecholamine modulation of prefrontal cortical cognitive function Trends Cogn. Neurosci. 2 1998 436 447 (Pubitemid 28518356)
4. A.F.T. Arnsten Fundamentals of attention-deficit/hyperactivity disorder: circuits and pathways J. Clin. Psychiatry 67 2006 4 9
5. A.F.T. Arnsten Stimulants: therapeutic actions in ADHD Neuropsychopharmacology 31 2006 2376 2383 (Pubitemid 44607054)
6. G. Aston-Jones, S. Chen, Y. Zhu, and M.L. Oshinsky A neural circuit for circadian regulation of arousal Nat. Neurosci. 4 2001 732 738 (Pubitemid 32595412)
7. G. Aston-Jones, and J.D. Cohen An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance Annu. Rev. Neurosci. 28 2005 403 450 (Pubitemid 41098911)
8. G. Aston-Jones, J. Rajkowski, and J. Cohen Locus coeruleus and regulation of behavioral flexibility and attention Prog. Brain Res. 126 2000 165 182 (Pubitemid 35461288)
9. R.A. Barkley Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD Psychol. Bull. 121 1997 65 94 (Pubitemid 127705285)
10. M. Baxter, D. Bucci, L. Gorman, R. Wiley, and M. Gallagher Selective immunotoxic lesions of basal forebrain cholinergic cells: effects on learning and memory in rats Behav. Neurosci. 109 1995 714 722
11. J. Berke, and S.E. Hyman Addiction, dopamine and the molecular mechanisms of memory Neuron 25 2000 515 532
12. C. Berridge, and B. Waterhouse The locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processes Brain Res. Rev. 42 2003 33 84 (Pubitemid 36369264)
13. C.W. Berridge, D.M. Devilbiss, M.E. Andrzejewski, A.F. Arnsten, A.E. Kelley, and B. Schmeichel Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function Biol. Psychiatry 60 2006 1111 1120 (Pubitemid 44647216)
14. J. Biederman, J.H. Heiligenstein, D.E. Faries, N. Galil, R. Dittman, and G.J. Emslie Efficacy of atomoxetine versus placebo in school-age girls with attention-deficit/hyperactivity disorder Pediatrics 110 2002 e75
15. J. Birrell, and V. Brown Medial frontal cortex mediates perceptual attentional set shifting in the rat J. Neurosci. 20 11 2000 4320 4324 (Pubitemid 30365702)
16. Y.D. Black, F.R. Maclaren, A.V. Naydenov, W.A.J. Carlezon, M. Baxter, and C. Konradi Altered attention and prefrontal cortex gene expression in rats after binge-like exposure to cocaine during adolescence J. Neurosci. 26 2006 9656 9665 (Pubitemid 44427704)
17. S. Bouret, and S.J. Sara Reward expectation, orientation of attention and locus coeruleus-medial frontal cortex interplay during learning Eur. J. Neurosci. 20 2004 791 802 (Pubitemid 39036939)
18. S. Bouret, and S.J. Sara Network reset: a simplified overarching theory of locus coeruleus noradrenaline function Trends Neurosci. 28 2005 574 582 (Pubitemid 41476687)
19. P.J. Boyce, and J.M. Finlay Extracellular dopamine and norepinephrine in the developing rat prefrontal cortex: transient effects of early partial loss of dopamine Brain Res Bull. 79 2 2009 104 110
20. H.C. Brenhouse, and S.L. Andersen Delayed extinction and stronger reinstatement of cocaine conditioned place preference in adolescent rats, compared to adults Behav. Neurosci. 122 2008 460 465 (Pubitemid 351672336)
21. H.C. Brenhouse, K.C. Sonntag, and S.L. Andersen Transient D1 dopamine receptor expression on prefrontal cortex projection neurons: relationship to enhanced motivational salience of drug cues in adolescence J. Neurosci. 28 10 2008 2375 2382 (Pubitemid 351348196)
22. L. Burns, B.J. Everitt, A.E. Kelley, and T.W. Robbins Glutamate-dopamine interactions in the ventral striatum: role in locomotor activity and responding with conditioned reinforcement Psychopharmacology (Berl) 115 1994 516 528 (Pubitemid 24248443)
23. F.P. Bymaster, J.S. Katner, D.L. Nelson, S.K. Hemrick-Luecke, P.G. Threlkeld, and J.H. Heiligenstein Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder Neuropsychopharmacology 27 2002 699 711 (Pubitemid 35335888)
24. F.X. Castellanos, and R. Tannock Neuroscience of attention deficit/hyperactivity disorder: the search for endophenotypes Neuroscience 3 2002 617 628 (Pubitemid 135706670)
25. S. Chamberlain, A. Hampshire, U. Müller, K. Rubia, N.D. Campo, and K. Craig Atomoxetine modulates right inferior frontal activation during inhibitory control: a pharmacological functional magnetic resonance imaging study Biol. Psychiatry 2009 65 2008 550 555
26. S.R. Chamberlain, N. del Campo, J. Dowson, U. Muller, L. Clark, and T.W. Robbins Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder Biol. Psychiatry 62 2007 977 984 (Pubitemid 47562368)
27. A.K. Christman, J.D. Fermo, and J.S. Markowitz Atomoxetine, a novel treatment for attention-deficit-hyperactivity disorder Pharmacotherapy 24 2004 1020 1036 (Pubitemid 39025202)
28. H.F. Clarke, J.W. Dalley, H.S. Crofts, T.W. Robbins, and A.C. Roberts Cognitive inflexibility after prefrontal serotonin depletion Science 204 2004 878 880 (Pubitemid 38620188)
29. H.F. Clarke, S.C. Walker, H.S. Crofts, J.W. Dalley, T.W. Robbins, and A.C. Roberts Prefrontal serotonin depletion affects reversal learning but not attentional set shifting J. Neurosci. 25 2005 532 538 (Pubitemid 40105626)
30. R. Cools, R.A. Barker, B.J. Sahakian, and T.W. Robbins Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands Cereb. Cortex 11 2001 1136 1143 (Pubitemid 33108240)
31. R. Cools, R.A. Barker, B.J. Sahakian, and T.W. Robbins Mechanisms of cognitive set flexibility in Parkinson's disease Brain 124 2001 2503 2512 (Pubitemid 33134938)
32. R. Cools, L. Clark, and T.W. Robbins Differential responses in human striatum and prefrontal cortex to changes in object and rule relevance J. Neurosci. 24 2004 1129 1135 (Pubitemid 38177020)
33. J.T. Coyle, and J. Axelrod Dopamine-β-hydroxylase in the rat brain: developmental characteristics J. Neurochem. 19 1972 449 459
34. J.W. Dalley, R.N. Cardinal, and T.W. Robbins Prefrontal executive functions in rodents: neural and neurochemical substrates Neurosci. Biobehav. Rev. 28 2004 771 784 (Pubitemid 39535871)
35. J.W. Dalley, J. McGaughy, M.T. O'Connell, R.N. Cardinal, L. Levita, and T.W. Robbins Distinct changes in cortical acetylcholine and noradrenaline efflux during contingent and non-contingent performance of a visual attentional task J. Neurosci. 21 2001 4908 4914 (Pubitemid 32565649)
36. M. Danet, S. Lapiz-Bluhm, and D.A. Morilak A cognitive deficit induced in rats by chronic intermittent cold stress is reversed by chronic antidepressant treatment Int. J. Psychopharmacol. 11 2010 1 13
37. D.M. Devilbiss, and C.W. Berridge Cognition-enhancing doses of methylphenidate preferentially increase prefrontal cortex neuronal responsiveness Biol. Psychiatry 64 2008 626 635
38. D.P. Dickstein, E.C. Finger, M.A. Brotman, B.A. Rich, D.S. Pine, and J.R. Blair Impaired probabilistic reversal learning in youths with mood and anxiety disorders Psychol. Med. 40 2009 1089 1100
39. D.L. Dow-Edwards, J.C. Weedon, and E. Hellman Methylphenidate improves performance on the radial arm in periadolescent rats Neurotoxicol. Teratol. 30 2008 419 427
40. M. Ernst, S.J. Grant, E.D. London, C.S. Contoreggi, A.S. Kimes, and L. Spurgeon Decision making in adolescents with behavior disorders and adults with substance abuse Am. J. Psychiatry 160 2003 33 40 (Pubitemid 36042424)
41. E.C. Finger, A.A. Marsh, D.G. Mitchell, M.E. Reid, C. Sims, and S. Budhani Abnormal ventromedial prefrontal cortex function in children with psychopathic traits during reversal learning Arch. Gen. Psychiatry 65 5 2008 586 594 (Pubitemid 351645054)
42. N.J. Gamo, M. Wang, and A.F.T. Arnsten Methylphenidate and atomoxetine enhance prefrontal function through α2-adrenergic and dopamine D1 receptors J. Am. Acad. Child Adolesc. Psychiatry 49 2010 1011 1029
43. D.E. Greydanus, H.D. Pratt, and D.R. Patel Attention deficit hyperactivity disorder across the lifespan: the child, adolescent, and adult Dis. Mon. 53 2007 70 131 (Pubitemid 46452595)
44. T.K. Harden, B.B. Wolfe, J.R. Sporn, J.P. Perkins, and P.B. Molinoff Ontogeny of B -adrenergic receptors in rat cerebral cortex Brain Res. 125 1977 99 108 (Pubitemid 8069487)
45. A.M. Himmelheber, M. Sarter, and J.P. Bruno Operant performance and cortical acetylcholine release: role of response rate, reward density, and non-contingent stimuli Cogn. Brain Res. 6 1997 23 36 (Pubitemid 27400479)
46. A.M. Himmelheber, M. Sarter, and J.P. Bruno Increases in cortical acetylcholine release during sustained attention performance in rats Cogn. Brain Res. 9 2000 313 325 (Pubitemid 30243116)
47. A.M. Himmelheber, M. Sarter, and J.P. Bruno The effects of manipulations of attentional demand on cortical acetylcholine release Cogn. Brain Res. 12 2001 353 370 (Pubitemid 33022690)
48. Y. Joung, C.-H. Kim, J. Moon, W.-S. Jang, J. Yang, and D. Shin Association studies of -3081(A/T) polymorphism of norepinephrine transporter gene with attention deficit/hyperactivity disorder in Korean population Am. J. Med. Genet. B Neuropsychitr. Genet. 153B 2009 691 694
49. C. Kieling, R.R.F. Goncalves, R. Tannock, and F.X. Castellanos Neurobiology of attention deficit hyperactivity disorder Child Adolesc. Psychiatr. Clin. N. Am. 17 2008 285 307 (Pubitemid 351258357)
50. C.J. Kratochvil, B.S. Vaughn, M.J. Harrington, and W.J. Burke Atomoxetine: a selective noradrenergic reuptake inhibitor for the treatment of attention-deficit/hyperactivity disorder Exp. Opin. Pharmacother. 4 2003 1165 1174 (Pubitemid 36857196)
51. C.J. Kratochvil, T.E. Wilens, L.L. Greenhill, H. Gao, K.D. Baker, and P.D. Feldman Effects of long-term atomoxetine treatment for young children with attention-deficit/hyperactivity disorder J. Am. Acad. Child Adolesc. Psychiatry 45 2006 919 927 (Pubitemid 44126866)
52. R. Kuczenski, and D.S. Segal Exposure of adolescent rats to oral methylphenidate: preferential effects on extracellular norepinephrine and absence of sensitization and cross-sensitization to methamphetamine J. Neurosci. 22 2002 7264 7271
53. F. Laboni, V.I. Douglas, and A.G. Baker Effects of reward and response costs on inhibition in ADHD children J. Abnorm. Psychol. 104 1995 232 240
54. E.K. Lambe, L.S. Krimer, and P.S. Goldman-Rakic Differential postnatal development of catecholamine and serotonin inputs to identified neurons in prefrontal cortex of rhesus monkey J. Neurosci. 20 2000 8780 8787
55. M.D. Lapiz-Bluhm, A.E. Soto-Piña, J.G. Hensler, and D.A. Morilak Chronic intermittent cold stress and serotonin depletion induce deficits of reversal learning in an attentional set-shifting test in rats Psychopharmacology (Berl) 202 2009 329 341
56. M.D.S. Lapiz, C.O. Bondi, and D. Morilak Chronic treatment with desipramine improves cognitive performance of rats in an attentional set-shifting test Neuropsychopharmacology 32 2007 1000 1010 (Pubitemid 46631988)
57. M.D.S. Lapiz, and D. Morilak Noradrenergic modulation of cognitive function in rat medial prefrontal cortex as measured by attentional set shifting capability Neuroscience 137 2006 1039 1049 (Pubitemid 43053965)
58. G. Laviola, W. Adriania, M. Livia-Terranova, and G. Gerra Psychobiological risk factors for vulnerability to psychostimulants in human adolescents and animal models Neurosci. Biobehav. Rev. 23 1999 993 1010 (Pubitemid 29502404)
59. P. Levitt, and R.Y. Moore Development of the noradrenergic innervation of the neocortex Brain Res. 162 1979 243 259
60. K.A. Loveland, J. Bachevalier, D.A. Pearson, and D.M. Lane Fronto-limbic functioning in children and adolescents with and without autism Neuropsychologia 46 2008 49 62
61. K. McAlonan, and V.J. Brown Orbital prefrontal cortex mediates reversal learning and not attentional set-shifting Behav. Brain Res. 146 2003 97 103 (Pubitemid 37476137)
62. J. McGaughy, J.W. Dalley, C.H. Morrison, B.J. Everitt, and T.W. Robbins Selective behavioral and neurochemical effects of cholinergic lesions produced by intrabasalis infusions of 192 IgG-saporin on attentional performance in a 5 choice serial reaction time task J. Neurosci. 22 2002 1905 1913 (Pubitemid 35386309)
63. J. McGaughy, T. Kaiser, and M. Sarter Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: selectivity of the behavioral impairment and relation to cortical AChE-positive fiber density Behav. Neurosci. 110 1996 247 265 (Pubitemid 26127571)
64. J. McGaughy, R.S. Ross, and H. Eichenbaum Noradrenergic, but not cholinergic, deafferentation of prefrontal cortex impairs attentional set-shifting Neuroscience 153 2008 63 71
65. M.A. Mehta, A.M. Owen, B.J. Sahakian, N. Mavaddat, J.D. Pickard, and T.W. Robbins Methylphenidate enhances working memory by modulating discrete frontal and parietal lobe regions in the human brain J. Neurosci. 20 2000 RC65
66. J.A. Milstein, O. Lehmann, D.E.H. Theobald, J.W. Dalley, and T.W. Robbins Selective depletion of cortical noradrenaline by anti-dopamine beta-hydroxylase impairs attentional function and enhances the effects of guanfacine in the rat Psychopharmacology (Berl) 190 2007 51 63 (Pubitemid 44885343)
67. G.H. Moll, C. Mehnert, M. Wicker, N. Bock, A. Rothenberger, and E. Rüther Age-associated changes in the densities of presynaptic monoamine transporters in different regions of the rat brain from early juvenile life to late adulthood Brain Res. Dev. Brain Res. 7 2000 251 257 (Pubitemid 30089816)
68. J.H. Morrison, M.E. Molliver, R. Grzanna, and J.T. Coyle Noradrenergic innervation patterns in three regions of medial cortex: an immunofluorescence characterization Brain Res. Bull. 4 1979 849 857 (Pubitemid 10137318)
69. F.C. Murphy, K.A. Smith, P.J. Cowen, T.W. Robbins, and B.J. Sahakian The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers Psychopharmacology (Berl) 163 2002 42 53
70. L.C. Murrin, J.D. Sanders, and D.B. Bylund Comparison of the maturation of the adrenergic and serotonergic neurotransmitter systems in the brain: implications for differential drug effects on juveniles and adults Biochem. Pharmacol. 73 2007 1225 1236 (Pubitemid 46413183)
71. J.H. Newcorn, C.J. Kratochvil, A.J. Allen, C.D. Casat, D.D. Ruff, and R.J. Moore Atomoxetine and osmotically released methylphenidate for the treatment of attention deficit hyperactivity disorder: acute comparison and differential response Am. J. Psychiatry 165 2008 721 730 (Pubitemid 351810541)
72. L.A. Newman, J. Darling, and J. McGaughy Atomoxetine reverses attentional deficits produced by noradrenergic deafferentation of medial prefrontal cortex Psychopharmacology (Berl) 200 2008 39 50
73. L.A. Newman, and J. McGaughy Adolescent rats show cognitive rigidity in a test of attentional set shifting Dev. Psychobiol. 53 4 2011 391 401
74. V. Parikh, R. Kozak, V. Martinez, and M. Sarter Prefrontal acetylcholine release controls cue detection on multiple time scales Neuron 56 2007 141 154 (Pubitemid 47484179)
75. K.J. Parker, K.L. Rainwater, C.L. Buckmaster, A.F. Schatzberg, S.E. Lindley, and D.M. Lyons Early life stress and novelty seeking behavior in adolescent monkeys Psychoneuroendocrinology 32 2007 785 792 (Pubitemid 47189730)
76. T.W. Robbins Chemical neuromodulation of frontal-executive functions in humans and other animals Exp. Brain Res. 133 2000 130 138 (Pubitemid 30411664)
77. T.W. Robbins, and B.J. Everitt Drug addiction: bad habits add up Nature 398 1999 567 570 (Pubitemid 29183674)
78. D. Romer, L. Betancourt, J.M. Giannetta, N.L. Brodsky, M. Farah, and H. Hurt Executive cognitive functions and impulsivity as correlates of risk taking and problem behavior in preadolescents Neuropsychologia 47 2009 2916 2926
79. T. Sagvolden, and J. Sergeant Attention deficit/hyperactivity disorder-from branin dysfuncitons to behaviour Behav. Brain Res. 94 1998 1 10 (Pubitemid 28352459)
80. J.D. Sanders, H.K. Happer, D.B. Bylund, and L.C. Murrin Development of the norepinephrine transporter in the rat CNS Neuroscience 130 2005 107 117 (Pubitemid 39550419)
81. M. Sarter, M.E. Hasselmo, J.P. Bruno, and B. Givens Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection Brain Res. Brain Res. Rev. 48 2005 98 111 (Pubitemid 40215784)
82. K.P. Schulz, C.Y. Tang, J. Fan, D.J. Marks, A.M. Cheung, and J.H. Newcorn Differential prefrontal cortex activation during inhibitory control in adolescents with and without childhood attention-deficit/hyperactivity disorder Neuropsychology 19 2005 390 402 (Pubitemid 40727079)
83. E. Seu, A. Lang, R.J. Rivera, and J.D. Jentsch Inhibition of the norepinephrine transporter improves behavioral flexibility in rats and monkeys Psychopharmacology (Berl) 202 2008 505 519
84. K.M. Shafritz, K.E. Marchione, J.C. Gore, S.E. Shaywitz, and B.A. Shaywitz The effects of methylphenidate on neural systems of attention in attention deficit hyperactivity disorder Am. J. Psychiatry 161 2004 1990 1997 (Pubitemid 39441398)
85. M.V. Solanto Neuropharmacological basis of stimulant drug action in attention deficit disorder with hyperactivity: a review and synthesis Psychol. Bull. 95 1984 387 409
86. E.J.S. Sonuga-Barke, J.A. Sergeant, J. Nigg, and E. Willcutt Executive dysfunction and delay aversion in attention deficit hyperactivity disorder: nosologic and diagnostic implications Child Adolesc. Psychiatr. Clin. N. Am. 17 2008 367 384 (Pubitemid 351265398)
87. T. Spencer, J. Biederman, T.E. Wilens, J. Prince, M. Hatch, and J. Jones Effectiveness and tolerability of tomoxetine in adults with attention deficit hyperactivity disorder Am. J. Psychiatry 155 1998 93 95
88. D.S. Tait, V.J. Brown, A. Farovik, D.E. Theobald, J.W. Dalley, and T.W. Robbins Lesions of the dorsal noradrenergic bundle impair attentional set shifting in the rat Eur. J. Neurosci. 25 2007 3719 3724 (Pubitemid 47020451)
89. Y.K. Takahashi, M.R. Roesch, T.A. Stalnaker, R.Z. Haney, D.J. Calu, and A.R. Taylor The orbitofrontal cortex and ventral tegmental area are necessary for learning from unexpected outcomes Neuron 62 2009 269 280
90. E.T. Tzavara, F.P. Bymaster, C.D. Overshiner, R.J. Davis, K.W. Perry, and M. Wolff Procholinergic and memory enhancing properties of the selective norepinephrine uptake inhibitor atomoxetine Mol. Psychiatry 11 2007 187 195 (Pubitemid 43164620)
91. M. Usher, J.D. Cohen, D. Servan-Schreiber, J. Rajkowski, and G. Aston-Jones The role of locus coeruleus in the regulation of cognitive performance Science 283 1999 549 554
92. C. Verney Distribution of the catecholaminergic neurons in the central nervous system of human embryos and fetuses Microsc. Res. Tech. 46 1999 24 47 (Pubitemid 29319276)
93. D. Viggiano, D. Vallone, and A.G. Sadile Dysfunction in dopamine systems and ADHD: evidence from animals and modeling Neural Plast. 11 2004 97 114 (Pubitemid 39089574)
94. S. Wendlandt, T.J. Crow, and R.V. Stirling The involvement of the noradrenergic system arising from the locus coeruleus in the postnatal development of the cortex in rat brain Brain Res. 125 1977 1 9 (Pubitemid 8069480)
95. D.T. Wong, P.G. Threlkeld, K.L. Best, and F.P. Bymaster A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain J. Pharmacol. Exp. Ther. 222 1982 61 65 (Pubitemid 12096999)
96. X. Xu, Z. Hawi, K.J. Brookes, R. Anney, M. Bellgrove, and B. Franke Replication of a rare protective allele in the noradrenaline transporter gene and ADHD Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B 2008 1564 1567
97. A.J. Yu, and P. Dayan Uncertainty neuromodulation and attention Neuron 46 2005 681 692