Functional inflammatory genotypes in ischemic stroke: Could we use them to predict age of onset and long-term outcome?

Stroke Research and Treatment

Volumn , Issue , 2011, Pages

  Marousi, Stella ^a   Antonacopoulou, Anna ^a   Kalofonos, Haralambos ^a   Papathanasopoulos, Panagiotis ^a   Karakantza, Marina ^a   Ellul, John ^a  

^a UNIVERSITY HOSPITAL OF PATRAS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; CYTOKINE; CYTOSINE; GUANINE; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 4; INTERLEUKIN 6; THYMINE; TUMOR NECROSIS FACTOR ALPHA;

ACUTE DISEASE; ADULT; ADVERSE OUTCOME; AGED; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; FEMALE; GENOTYPE; HUMAN; INFLAMMATION; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; REAL TIME POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 80052709812     PISSN: None     EISSN: 20420056     Source Type: Journal    
DOI: 10.4061/2011/792923     Document Type: Article

References (37)

1. Muir K. W., Tyrrell P., Sattar N., Warburton E., Inflammation and ischaemic stroke Current Opinion in Neurology 2007 20 3 334 342 (Pubitemid 46743118)
2. Hansson G. K., Immune mechanisms in atherosclerosis Arteriosclerosis, Thrombosis, and Vascular Biology 2001 21 12 1876 1890 (Pubitemid 34219736)
3. Engelmann M. D. M., Svendsen J. H., Inflammation in the genesis and perpetuation of atrial fibrillation European Heart Journal 2005 26 20 2083 2092 (Pubitemid 41408600)
4. Mergenthaler P., Dirnagl U., Meisel A., Pathophysiology of stroke: lessons from animal models Metabolic Brain Disease 2004 19 3-4 151 167 (Pubitemid 39361178)
5. Rodrguez-Yez M., Castillo J., Role of inflammatory markers in brain ischemia Current Opinion in Neurology 2008 21 3 353 357 (Pubitemid 351653988)
6. Cesari M., Penninx B. W. J. H., Newman A. B., Kritchevsky S. B., Nicklas B. J., Sutton-Tyrrell K., Rubin S. M., Ding J., Simonsick E. M., Harris T. B., Pahor M., Inflammatory markers and onset of cardiovascular events: results from the Health ABC study Circulation 2003 108 19 2317 2322 (Pubitemid 37413536)
7. Whiteley W., Jackson C., Lewis S., Lowe G., Rumley A., Sandercock P., Wardlaw J., Dennis M., Sudlow C., Inflammatory markers and poor outcome after stroke: a prospective cohort study and systematic review of interleukin-6 PLoS Medicine 2009 6 9
8. Sotgiu S., Zanda B., Marchetti B., Fois M. L., Arru G., Pes G. M., Salaris F. S., Arru A., Pirisi A., Rosati G., Inflammatory biomarkers in blood of patients with acute brain ischemia European Journal of Neurology 2006 13 5 505 513 (Pubitemid 43823367)
9. Trinchieri G., Interleukin-12 and the regulation of innate resistance and adaptive immunity Nature Reviews Immunology 2003 3 2 133 146 (Pubitemid 37328691)
10. Zaremba J., Losy J., Interleukin-12 in acute ischemic stroke patients Folia Neuropathologica 2006 44 1 59 66
11. Van Exel E., Gussekloo J., De Craen A. J. M., Bootsma-van Der Wiel A., Frlich M., Westendorp R. G. J., Inflammation and stroke: the Leiden 85-Plus Study Stroke 2002 33 4 1135 1138 (Pubitemid 34293603)
12. Perini F., Morra M., Alecci M., Galloni E., Marchi M., Toso V., Temporal profile of serum anti-inflammatory and pro-inflammatory interleukins in acute ischemic stroke patients Neurological Sciences 2001 22 4 289 296 (Pubitemid 34071562)
13. Vila N., Castillo J., Dvalos A., Esteve A., Planas A. M., Chamorro A., Levels of anti-inflammatory cytokines and neurological worsening in acute ischemic stroke Stroke 2003 34 3 671 675 (Pubitemid 36307391)
14. Brookes A. J., The essence of SNPs Gene 1999 234 2 177 186 (Pubitemid 29298180)
15. Marousi S., Ellul J., Karakantza M., Genetic polymorphisms of type-1 and type-2 inflammatory cytokines in ischaemic stroke Vascular Disease Prevention 2008 5 2 89 103 (Pubitemid 351632306)
16. Fishman D., Faulds G., Jeffey R., Mohamed-Ali V., Yudkin J. S., Humphries S., Woo P., The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic- onset juvenile chronic arthritis Journal of Clinical Investigation 1998 102 7 1369 1376 (Pubitemid 28467565)
17. Wilson A. G., Gordon C., Di Giovine F. S., De Vries N., Van De Putte L. B. A., Emery P., Duff G. W., A genetic association between systemic lupus erythematosus and tumor necrosis factor alpha European Journal of Immunology 1994 24 1 191 195 (Pubitemid 24014698)
18. Fei G. Z., Svenungsson E., Frostegrd J., Padyukov L., The A-1087IL-10 allele is associated with cardiovascular disease in SLE Atherosclerosis 2004 177 2 409 414 (Pubitemid 39505275)
19. Morahan G., Huang D., Wu M., Holt B. J., White G. P., Kendall G. E., Sly P. D., Holt P. G., Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children Lancet 2002 360 9331 455 459 (Pubitemid 34880144)
20. Klein W., Tromm A., Griga T., Fricke H., Folwaczny C., Hocke M., Eitner K., Marx M., Duerig N., Epplen J. T., Interleukin-4 and interleukin-4 receptor gene polymorphisms in inflammatory bowel diseases Genes and Immunity 2001 2 5 287 289 (Pubitemid 33681715)
21. Wilson A. G., Di Giovine F. S., Blakemore A. I. F., Duff G. W., Single base polymorphism in the human tumour necrosis factor alpha (TNF ) gene detectable by NcoI restriction of PCR product Human Molecular Genetics 1992 1 5 353
22. Seegers D., Zwiers A., Strober W., Pea A. S., Bouma G., A TaqI polymorphism in the 3′ UTR of the IL-12 p40 gene correlates with increased IL-12 secretion Genes and Immunity 2002 3 7 419 423 (Pubitemid 41656541)
23. Rosenwasser L. J., Klemm D. J., Dresback J. K., Inamura H., Mascali J. J., Klinnert M., Borish L., Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy Clinical and Experimental Allergy, Supplement 1995 25 supplement 2 74 78
24. Rees L. E. N., Wood N. A. P., Gillespie K. M., Lai K. N., Gaston K., Mathieson P. W., The interleukin-101082 G/A polymorphism: allele frequency in different populations and functional significance Cellular and Molecular Life Sciences 2002 59 3 560 569 (Pubitemid 34267396)
25. Abraham L. J., Kroeger K. M., Impact of the -308 TNF promoter polymorphism on the transcriptional regulation of the TNF gene: relevance to disease Journal of Leukocyte Biology 1999 66 4 562 566 (Pubitemid 29489880)
26. Kube D., Platzer C., Von Knethen A., Straub H., Bohlen H., Hafner M., Tesch H., Isolation of the human interleukin 10 promoter. Characterization of the promoter activity in Burkitt's lymphoma cell lines Cytokine 1995 7 1 1 7
27. Adams Jr. H. P., Bendixen B. H., Kappelle L. J., Biller J., Love B. B., Gordon D. L., Marsh E. E. III, Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment Stroke 1993 24 1 35 41 (Pubitemid 23014379)
28. Mahoney F. I., Barthel D. W., Functional evaluation: the barthel index Maryland State Medical Journal 1965 14 61 65
29. Germer S., Higuchi R., Single-tube genotyping without oligonucleotide probes Genome Research 1999 9 1 72 78 (Pubitemid 29095150)
30. Revilla M., Obach V., Cervera., Dvalos A., Castillo J., Chamorro., A -174G/C polymorphism of the interleukin-6 gene in patients with lacunar infarction Neuroscience Letters 2002 324 1 29 32 (Pubitemid 34442670)
31. Harcos P., Laki J., Kiszel P., Széplaki Z., Szolnoki Z., Kovcs M., Melegh B., Széplaki G., Fst G., Blask B., Decreased frequency of the TNF2 allele of TNF- 308 Promoter polymorphism is associated with lacunar infarction Cytokine 2006 33 2 100 105
32. Trompet S., Pons D., De Craen A. J. M., Slagboom P., Shepherd J., Blauw G. J., Murphy M. B., Cobbe S. M., Bollen E. L. E. M., Buckley B. M., Ford I., Hyland M., Gaw A., Macfarlane P. W., Packard C. J., Norrie J., Perry I. J., Stott D. J., Sweeney B. J., Twomey C., Westendorp R. G. J., Jukema J. W., Genetic variation in the interleukin-10 gene promoter and risk of coronary and cerebrovascular events: the PROSPER study Annals of the New York Academy of Sciences 2007 1100 189 198 (Pubitemid 47092652)
33. Costeas P. A., Koumas L., Koumouli A., Kyriakou-Giantsiou A., Papaloizou A., Cytokine polymorphism frequencies in the Greek Cypriot population European Journal of Immunogenetics 2003 30 5 341 343 (Pubitemid 37340303)
34. Orozco G., Gonzlez-Gay M. A., Paco L., Lpez-Nevot M. A., Guzmn M., Pascual-Salcedo D., Balsa A., Martn J., Interleukin 12 (IL12B) and interleukin 12 receptor (IL12RB1) gene polymorphisms in rheumatoid arthritis Human Immunology 2005 66 6 710 714
35. Alvarez V., Mata I. F., Gonzlez P., Lahoz C. H., Martnez C., Pea J., Guisasola L. M., Coto E., Association between the TNF -308 A/G polymorphism and the onset-age of Alzheimer disease American Journal of Medical Genetics 2002 114 5 574 577 (Pubitemid 34680588)
36. Braun N., Michel U., Ernst B. P., Metzner R., Bitsch A., Weber F., Rieckmann P., Gene polymorphism at position -308 of the tumor-necrosis-factor- (TNF- ) in Multiple Sclerosis and its influence on the regulation of TNF- production Neuroscience Letters 1996 215 2 75 78 (Pubitemid 26313221)
37. DeGraba T. J., The role of inflammation after acute stroke: utility of pursuing anti- adhesion molecule therapy Neurology 1998 51 3 S62 S68