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Volumn 116, Issue 26, 2010, Pages 6046-6053

Heparin modifies the immunogenicity of positively charged proteins

Author keywords

[No Author keywords available]

Indexed keywords

HEPARIN; INTERLEUKIN 12; LYSOZYME; PROTAMINE; THROMBOCYTE FACTOR 4;

EID: 78650644854     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-06-292938     Document Type: Article
Times cited : (48)

References (46)
  • 1
    • 0019192750 scopus 로고
    • The multiple complexes formed by the interaction of platelet factor 4 with heparin
    • Bock PE, Luscombe M, Marshall SE, Pepper DS, Holbrook JJ. The multiple complexes formed by the interaction of platelet factor 4 with heparin. Biochem J. 1980;191(3):769-776.
    • (1980) Biochem. J. , vol.191 , Issue.3 , pp. 769-776
    • Bock, P.E.1    Luscombe, M.2    Marshall, S.E.3    Pepper, D.S.4    Holbrook, J.J.5
  • 2
    • 0028014541 scopus 로고
    • Heparin-associated thrombocytopenia: Isolation of the antibody and characterization of a multimolecular PF4-heparin complex as the major antigen
    • Greinacher A, Potzsch B, Amiral J, Dummel V, Eichner A, Mueller-Eckhardt C. Heparin-associated thrombocytopenia: isolation of the antibody and characterization of a multimolecular PF4-heparin complex as the major antigen. Thromb Haemost. 1994;71(2):247-251.
    • (1994) Thromb. Haemost. , vol.71 , Issue.2 , pp. 247-251
    • Greinacher, A.1    Potzsch, B.2    Amiral, J.3    Dummel, V.4    Eichner, A.5    Mueller-Eckhardt, C.6
  • 3
    • 11144238284 scopus 로고    scopus 로고
    • Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia
    • Rauova L, Poncz M, McKenzie SE, et al. Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia. Blood. 2005;105(1):131-138.
    • (2005) Blood , vol.105 , Issue.1 , pp. 131-138
    • Rauova, L.1    Poncz, M.2    McKenzie, S.E.3
  • 4
    • 33749059398 scopus 로고    scopus 로고
    • Close approximation of two platelet factor 4 tetramers by charge neutralization forms the antigens recognized by HIT antibodies
    • Greinacher A, Gopinadhan M, Gunther J-U, et al. Close approximation of two platelet factor 4 tetramers by charge neutralization forms the antigens recognized by HIT antibodies. Arterioscler Thromb Vasc Biol. 2006;26(10):2386-2393.
    • (2006) Arterioscler Thromb. Vasc. Biol. , vol.26 , Issue.10 , pp. 2386-2393
    • Greinacher, A.1    Gopinadhan, M.2    Gunther, J.-U.3
  • 5
    • 39649122158 scopus 로고    scopus 로고
    • Determinants of PF4/heparin immunogenicity
    • Suvarna S, Espinasse B, Qi R, et al. Determinants of PF4/heparin immunogenicity. Blood. 2007;110(13):4253-4260.
    • (2007) Blood , vol.110 , Issue.13 , pp. 4253-4260
    • Suvarna, S.1    Espinasse, B.2    Qi, R.3
  • 6
    • 65349173974 scopus 로고    scopus 로고
    • Optimization of a murine immunization model for study of PF4/heparin antibodies
    • Suvarna S, Qi R, Arepally G. Optimization of a murine immunization model for study of PF4/heparin antibodies. J Thromb Haemost. 2009;7(5):857-864.
    • (2009) J. Thromb. Haemost. , vol.7 , Issue.5 , pp. 857-864
    • Suvarna, S.1    Qi, R.2    Arepally, G.3
  • 8
    • 0035443891 scopus 로고    scopus 로고
    • Order out of complexity-protein structures that interact with heparin
    • Mulloy B, Linhardt RJ. Order out of complexity-protein structures that interact with heparin. Curr Opin Struct Biol. 2001;11(5):623-628.
    • (2001) Curr. Opin. Struct Biol. , vol.11 , Issue.5 , pp. 623-628
    • Mulloy, B.1    Linhardt, R.J.2
  • 9
    • 17644419346 scopus 로고    scopus 로고
    • Complex coacervation of lysozyme and heparin: Complex characterization and protein stability
    • van de Weert M, Andersen MB, Frokjaer S. Complex coacervation of lysozyme and heparin: complex characterization and protein stability. Pharm Res. 2004;21(12):2354-2359.
    • (2004) Pharm. Res. , vol.21 , Issue.12 , pp. 2354-2359
    • Van De Weert, M.1    Andersen, M.B.2    Frokjaer, S.3
  • 10
    • 0019979024 scopus 로고
    • Protamine-heparin aggregates. Their fine structure, histochemistry, and renal deposition
    • Rossmann P, Matousovic K, Horacek V. Protamine-heparin aggregates. Their fine structure, histochemistry, and renal deposition. Virchows Arch B Cell Pathol. 1982;40(1):81-98.
    • (1982) Virchows Arch. B Cell. Pathol. , vol.40 , Issue.1 , pp. 81-98
    • Rossmann, P.1    Matousovic, K.2    Horacek, V.3
  • 11
    • 0018225978 scopus 로고
    • Formation of complexes of heparin with proteins and its physiological role. II
    • Lyapina LA, Ul'yanov AM. Formation of complexes of heparin with proteins and its physiological role. II. Hum Physiol. 1979;4(2):239-248.
    • (1979) Hum Physiol. , vol.4 , Issue.2 , pp. 239-248
    • Lyapina, L.A.1    Ul'yanov, A.M.2
  • 12
    • 0019478658 scopus 로고
    • Study of the molecular interaction between lysozyme and heparin and application in affinity chromatography
    • Boschetti E, Girot P, Secheresse JP, Saint Blancard J. Study of the molecular interaction between lysozyme and heparin and application in affinity chromatography. J Chromatogr. 1981;210:469-475.
    • (1981) J. Chromatogr , vol.210 , pp. 469-475
    • Boschetti, E.1    Girot, P.2    Secheresse, J.P.3    Blancard, J.S.4
  • 13
    • 0034653434 scopus 로고    scopus 로고
    • CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen
    • Vremec D, Pooley J, Hochrein H, Wu L, Shortman K. CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen. J Immunol. 2000;164(3):2978-2986.
    • (2000) J. Immunol. , vol.164 , Issue.3 , pp. 2978-2986
    • Vremec, D.1    Pooley, J.2    Hochrein, H.3    Wu, L.4    Shortman, K.5
  • 14
    • 33746383559 scopus 로고
    • Die Bindung von Heparin an Eiweiss
    • Fischer A. Die Bindung von Heparin an Eiweiss. Biochem Z. 1935;278:133.
    • (1935) Biochem. Z , vol.278 , pp. 133
    • Fischer, A.1
  • 15
    • 0017335813 scopus 로고
    • Evidence for a heparin-induced conformational change on antithrombin III
    • Villanueva GB, Danishefsky I. Evidence for a heparin-induced conformational change on antithrombin III. Biochem Biophys Res Commun. 1977;74(2):803-809.
    • (1977) Biochem. Biophys. Res. Commun. , vol.74 , Issue.2 , pp. 803-809
    • Villanueva, G.B.1    Danishefsky, I.2
  • 16
    • 0027313186 scopus 로고
    • Physical stabilization of acidic fibroblast growth factor by polyanions
    • Volkin DB, Tsai PK, Dabora JM, et al. Physical stabilization of acidic fibroblast growth factor by polyanions. Arch Biochem Biophys. 1993;300(1):30-41.
    • (1993) Arch. Biochem. Biophys. , vol.300 , Issue.1 , pp. 30-41
    • Volkin, D.B.1    Tsai, P.K.2    Dabora, J.M.3
  • 17
    • 0029809050 scopus 로고    scopus 로고
    • Interaction of lipoprotein lipase with heparin fragments and with heparan sulfate: Stoichiometry, stabilization, and kinetics
    • Lookene A, Chevreuil O, Ostergaard P, Olivecrona G. Interaction of lipoprotein lipase with heparin fragments and with heparan sulfate: stoichiometry, stabilization, and kinetics. Biochemistry. 1996;35(37):12155- 12163.
    • (1996) Biochemistry , vol.35 , Issue.37 , pp. 12155-12163
    • Lookene, A.1    Chevreuil, O.2    Ostergaard, P.3    Olivecrona, G.4
  • 18
    • 34247610845 scopus 로고    scopus 로고
    • Heparan sulphate proteoglycans fine-tune mammalian physiology
    • Bishop JR, Schuksz M, Esko JD. Heparan sulphate proteoglycans fine-tune mammalian physiology. Nature. 2007;446(7139):1030-1037.
    • (2007) Nature , vol.446 , Issue.7139 , pp. 1030-1037
    • Bishop, J.R.1    Schuksz, M.2    Esko, J.D.3
  • 19
    • 47649113597 scopus 로고    scopus 로고
    • Platelet Factor 4 (PF4)-Heparin complexes Trigger Immune Responses independently of the MyD88 Pathway
    • Suvarna S, Qi R, Hollingsworth JW, Arepally GM. Platelet Factor 4 (PF4)-Heparin complexes Trigger Immune Responses independently of the MyD88 Pathway. Br J Haematol. 2008;142(4):671-673.
    • (2008) Br. J. Haematol , vol.142 , Issue.4 , pp. 671-673
    • Suvarna, S.1    Qi, R.2    Hollingsworth, J.W.3    Arepally, G.M.4
  • 20
    • 23044486252 scopus 로고    scopus 로고
    • PF4/heparin complexes are T cell-dependent antigens
    • Suvarna S, Rauova L, McCracken EKE, et al. PF4/heparin complexes are T cell-dependent antigens. Blood. 2005;106(3):929-931.
    • (2005) Blood , vol.106 , Issue.3 , pp. 929-931
    • Suvarna, S.1    Rauova, L.2    McCracken, E.K.E.3
  • 21
    • 44049104999 scopus 로고    scopus 로고
    • The protamine family of sperm nuclear proteins
    • Balhorn R. The protamine family of sperm nuclear proteins. Genome Biol. 2007;8(9):227.
    • (2007) Genome Biol. , vol.8 , Issue.9 , pp. 227
    • Balhorn, R.1
  • 22
    • 0029986463 scopus 로고    scopus 로고
    • Staphylococci bind heparin-binding host growth factors
    • Pascu C, Ljungh A, Wadstrom T. Staphylococci bind heparin-binding host growth factors. Curr Microbiol. 1996;32(4):201-207.
    • (1996) Curr. Microbiol. , vol.32 , Issue.4 , pp. 201-207
    • Pascu, C.1    Ljungh, A.2    Wadstrom, T.3
  • 23
    • 0013852463 scopus 로고
    • Structure of hen egg-white lysozyme. A three-dimensional Fourier synthesis at 2 Angstrom resolution
    • Blake CC, Koenig DF, Mair GA, North AC, Phillips DC, Sarma VR. Structure of hen egg-white lysozyme. A three-dimensional Fourier synthesis at 2 Angstrom resolution. Nature. 1965;206(986):757-761.
    • (1965) Nature , vol.206 , Issue.986 , pp. 757-761
    • Blake, C.C.1    Koenig, D.F.2    Mair, G.A.3    North, A.C.4    Phillips, D.C.5    Sarma, V.R.6
  • 24
    • 36048962961 scopus 로고    scopus 로고
    • How do adjuvants work? Important considerations for new generation adjuvants
    • McKee AS, Munks MW, Marrack P. How do adjuvants work? Important considerations for new generation adjuvants. Immunity. 2007;27(5):687-690.
    • (2007) Immunity , vol.27 , Issue.5 , pp. 687-690
    • McKee, A.S.1    Munks, M.W.2    Marrack, P.3
  • 25
    • 45949086068 scopus 로고    scopus 로고
    • Parenteral anticoagulants: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition)
    • DOI 10.1378/chest.08-0689
    • Hirsh J, Bauer KA, Donati MB, Gould M, Samama MM, Weitz JI. Parenteral Anticoagulants: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133(6 Suppl): 141S-159S. (Pubitemid 351892966)
    • (2008) Chest , vol.133 , Issue.6 SUPPL. 6
    • Hirsh, J.1    Bauer, K.A.2    Donati, M.B.3    Gould, M.4    Samama, M.M.5    Weitz, J.I.6
  • 26
    • 0030703541 scopus 로고    scopus 로고
    • Differences in specificity of heparin-dependent antibodies developed in heparin-induced thrombocytopenia and consequences on cross-reactivity with danaparoid sodium
    • Pouplard C, Amiral J, Borg JY, Vissac AM, Delahousse B, Gruel Y. Differences in specificity of heparin-dependent antibodies developed in heparin-induced thrombocytopenia and consequences on cross-reactivity with danaparoid sodium. Br J Haematol. 1997;99(2):273-280.
    • (1997) Br. J. Haematol , vol.99 , Issue.2 , pp. 273-280
    • Pouplard, C.1    Amiral, J.2    Borg, J.Y.3    Vissac, A.M.4    Delahousse, B.5    Gruel, Y.6
  • 27
    • 54949152657 scopus 로고    scopus 로고
    • Confirmatory procedure and other maneuvers to assess pathogenicity of platelet factor 4 (PF4)-dependent antibodies-distinguishing "signal" from "noise."
    • Warkentin TE. Confirmatory procedure and other maneuvers to assess pathogenicity of platelet factor 4 (PF4)-dependent antibodies-distinguishing "signal" from "noise." Thromb Haemost. 2008;100(4):523-524.
    • (2008) Thromb. Haemost. , vol.100 , Issue.4 , pp. 523-524
    • Warkentin, T.E.1
  • 28
    • 54949085747 scopus 로고    scopus 로고
    • Anti-heparin/platelet factor 4 antibody optical density values and the confirmatory procedure in the diagnosis of heparin-induced thrombocytopenia
    • Whitlatch NL, Perry SL, Ortel TL. Anti-heparin/platelet factor 4 antibody optical density values and the confirmatory procedure in the diagnosis of heparin-induced thrombocytopenia. Thromb Haemost. 2008;100(4):678-684.
    • (2008) Thromb. Haemost. , vol.100 , Issue.4 , pp. 678-684
    • Whitlatch, N.L.1    Perry, S.L.2    Ortel, T.L.3
  • 29
    • 77956593113 scopus 로고    scopus 로고
    • Validation of the high-heparin confirmatory step for the diagnosis of heparin-induced thrombocytopenia
    • Whitlatch NL, Kong DF, Metjian AD, Arepally GM, Ortel TL. Validation of the high-heparin confirmatory step for the diagnosis of heparin-induced thrombocytopenia. Blood. 2010:116 (10):1761-1766.
    • (2010) Blood , vol.116 , Issue.10 , pp. 1761-1766
    • Whitlatch, N.L.1    Kong, D.F.2    Metjian, A.D.3    Arepally, G.M.4    Ortel, T.L.5
  • 30
    • 0033151915 scopus 로고    scopus 로고
    • Analysis of adjuvant function by direct visualization of antigen presentation in vivo: Endotoxin promotes accumulation of antigen-bearing dendritic cells in the T-cell areas of lymphoid tissue
    • Reis e Sousa C, Germain RN. Analysis of adjuvant function by direct visualization of antigen presentation in vivo: endotoxin promotes accumulation of antigen-bearing dendritic cells in the T-cell areas of lymphoid tissue. J Immunol. 1999;162(11):6552-6561.
    • (1999) J. Immunol. , vol.162 , Issue.11 , pp. 6552-6561
    • Reis E Sousa, C.1    Germain, R.N.2
  • 31
    • 0033168323 scopus 로고    scopus 로고
    • Complexes of heparin and platelet factor 4 specifically stimulate T cells from patients with heparin-induced thrombocytopenia/thrombosis
    • Bacsi S, De Palma R, Visentin GP, Gorski J, Aster RH. Complexes of heparin and platelet factor 4 specifically stimulate T cells from patients with heparin-induced thrombocytopenia/thrombosis. Blood. 1999;94(1):208-215.
    • (1999) Blood , vol.94 , Issue.1 , pp. 208-215
    • Bacsi, S.1    De Palma, R.2    Visentin, G.P.3    Gorski, J.4    Aster, R.H.5
  • 32
    • 0035113216 scopus 로고    scopus 로고
    • Identification of T cells responding to a self-protein modified by an external agent
    • Bacsi S, Geoffrey R, Visentin G, De Palma R, Aster R, Gorski J. Identification of T cells responding to a self-protein modified by an external agent. Hum Immunol. 2001;62(2):113-124.
    • (2001) Hum Immunol. , vol.62 , Issue.2 , pp. 113-124
    • Bacsi, S.1    Geoffrey, R.2    Visentin, G.3    De Palma, R.4    Aster, R.5    Gorski, J.6
  • 33
    • 73649129229 scopus 로고    scopus 로고
    • Studies of the anti-platelet factor 4/heparin immune response: Adapting the enzyme-linked immunosorbent spot assay for detection of memory B cells against complex antigens
    • Selleng K, Schutt A, Selleng S, Warkentin TE, Greinacher A. Studies of the anti-platelet factor 4/heparin immune response: adapting the enzyme-linked immunosorbent spot assay for detection of memory B cells against complex antigens. Transfusion. 2010;50(1):32-39.
    • (2010) Transfusion , vol.50 , Issue.1 , pp. 32-39
    • Selleng, K.1    Schutt, A.2    Selleng, S.3    Warkentin, T.E.4    Greinacher, A.5
  • 34
    • 65349122236 scopus 로고    scopus 로고
    • Studies of the immune response in heparin-induced thrombocytopenia
    • Warkentin TE, Sheppard J-AI, Moore JC, Cook RJ, Kelton JG. Studies of the immune response in heparin-induced thrombocytopenia. Blood. 2009;113(20):4963-4969.
    • (2009) Blood , vol.113 , Issue.20 , pp. 4963-4969
    • Warkentin, T.E.1    Sheppard, J.-A.I.2    Moore, J.C.3    Cook, R.J.4    Kelton, J.G.5
  • 36
    • 68549133389 scopus 로고    scopus 로고
    • The relationship between heparin level and activated clotting time in the adult cardiac surgery population
    • Fitzgerald DJ, Patel A, Body SC, Garvin S. The relationship between heparin level and activated clotting time in the adult cardiac surgery population. Perfusion. 2009;24(2):93-96.
    • (2009) Perfusion , vol.24 , Issue.2 , pp. 93-96
    • Fitzgerald, D.J.1    Patel, A.2    Body, S.C.3    Garvin, S.4
  • 37
    • 0036841228 scopus 로고    scopus 로고
    • Rapid disappearance of protamine in adults undergoing cardiac operation with cardiopulmonary bypass
    • Butterworth J, Lin YA, Prielipp RC, Bennett J, Hammon JW, James RL. Rapid disappearance of protamine in adults undergoing cardiac operation with cardiopulmonary bypass. Ann Thorac Surg. 2002;74(3):1589-1595.
    • (2002) Ann. Thorac. Surg. , vol.74 , Issue.3 , pp. 1589-1595
    • Butterworth, J.1    Lin, Y.A.2    Prielipp, R.C.3    Bennett, J.4    Hammon, J.W.5    James, R.L.6
  • 38
    • 33646086738 scopus 로고    scopus 로고
    • Comparison of the inflammatory response between miniaturized and standard CPB circuits in aortic valve surgery
    • Bical OM, Fromes Y, Gaillard D, et al. Comparison of the inflammatory response between miniaturized and standard CPB circuits in aortic valve surgery. Eur J Cardiothorac Surg. 2006;29(5):699-702.
    • (2006) Eur. J. Cardiothorac Surg. , vol.29 , Issue.5 , pp. 699-702
    • Bical, O.M.1    Fromes, Y.2    Gaillard, D.3
  • 39
    • 13244297062 scopus 로고    scopus 로고
    • Hemodynamic changes after protamine administration: Association with mortality after coronary artery bypass surgery
    • Welsby IJ, Newman MF, Phillips-Bute B, Messier RH, Kakkis ED, Stafford-Smith M. Hemodynamic changes after protamine administration: association with mortality after coronary artery bypass surgery. Anesthesiol. 2005;102(2):308-314.
    • (2005) Anesthesiol , vol.102 , Issue.2 , pp. 308-314
    • Welsby, I.J.1    Newman, M.F.2    Phillips-Bute, B.3    Messier, R.H.4    Kakkis, E.D.5    Stafford-Smith, M.6
  • 40
    • 0025312618 scopus 로고
    • Safety of protamine sulfate administration in vasectomized men
    • Vézina D, Sheridan P, Blain R, Roberts KD, Bleau G. Safety of protamine sulfate administration in vasectomized men. Contraception. 1990;41(6):605-616.
    • (1990) Contraception , vol.41 , Issue.6 , pp. 605-616
    • Vézina, D.1    Sheridan, P.2    Blain, R.3    Roberts, K.D.4    Bleau, G.5
  • 41
    • 0023832929 scopus 로고
    • Frequency and specificity of protamine antibodies in diabetic and control subjects
    • Nell LJ, Thomas JW. Frequency and specificity of protamine antibodies in diabetic and control subjects. Diabetes. 1988;37(2):172-176.
    • (1988) Diabetes , vol.37 , Issue.2 , pp. 172-176
    • Nell, L.J.1    Thomas, J.W.2
  • 42
    • 0024598118 scopus 로고
    • Association of protamine IgE and IgG antibodies with lifethreatening reactions to intravenous protamine
    • Weiss ME, Nyhan D, Peng ZK, et al. Association of protamine IgE and IgG antibodies with lifethreatening reactions to intravenous protamine. N Engl J Med. 1989;320(14):886-892.
    • (1989) N Engl. J. Med. , vol.320 , Issue.14 , pp. 886-892
    • Weiss, M.E.1    Nyhan, D.2    Peng, Z.K.3
  • 43
    • 0027474729 scopus 로고
    • High-titer protamine-specific IgG antibody associated with anaphylaxis: Report of a case and quantitative analysis of antibody in vasectomized men
    • Adourian U, Shampaine EL, Hirshman CA, Fuchs E, Adkinson NF Jr. High-titer protamine-specific IgG antibody associated with anaphylaxis: report of a case and quantitative analysis of antibody in vasectomized men. Anesthesiol. 1993;78(2):368-371.
    • (1993) Anesthesiol , vol.78 , Issue.2 , pp. 368-371
    • Adourian, U.1    Shampaine, E.L.2    Hirshman, C.A.3    Fuchs, E.4    Adkinson Jr., N.F.5
  • 44
    • 78650631847 scopus 로고    scopus 로고
    • Pseudo-HIT associated with antibodies to protamine sulfate
    • Abstract PP-MO-697
    • Amiral JJ, Vissac AM. Pseudo-HIT associated with antibodies to protamine sulfate. J Eur J Thromb Haemost. 2009;5(S2). Abstract PP-MO-697.
    • (2009) J. Eur. J. Thromb. Haemost. , vol.5 , Issue.S2
    • Amiral, J.J.1    Vissac, A.M.2
  • 45
    • 70350214787 scopus 로고    scopus 로고
    • Incidence and causes of heparin-induced skin lesions
    • Schindewolf M, Schwaner S, Wolter M, et al. Incidence and causes of heparin-induced skin lesions. Can Med Assoc J. 2009;181(8):477-481.
    • (2009) Can Med. Assoc. J. , vol.181 , Issue.8 , pp. 477-481
    • Schindewolf, M.1    Schwaner, S.2    Wolter, M.3
  • 46
    • 0032421581 scopus 로고    scopus 로고
    • Risk factors for clinically important adverse events after protamine administration following cardiopulmonary bypass
    • Kimmel SE, Sekeres MA, Berlin JA, Ellison N, DiSesa VJ, Strom BL. Risk factors for clinically important adverse events after protamine administration following cardiopulmonary bypass. J Am Coll Cardiol. 1998;32(7):1916-1922.
    • (1998) J. Am. Coll. Cardiol. , vol.32 , Issue.7 , pp. 1916-1922
    • Kimmel, S.E.1    Sekeres, M.A.2    Berlin, J.A.3    Ellison, N.4    DiSesa, V.J.5    Strom, B.L.6


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