The role of surface PF4:glycosaminoglycan complexes in the pathogenesis of heparin-induced thrombocytopenia (HIT)

Pathophysiology of Haemostasis and Thrombosis

Volumn 35, Issue 1-2, 2006, Pages

  Poncz, Mortimer ^a   Rauova, Lubica ^a   Cines, Douglas B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHONDROITIN SULFATE; DERMATAN SULFATE; GLYCOSAMINOGLYCAN; HEPARAN SULFATE; HEPARIN; PROTAMINE SULFATE; THROMBOCYTE FACTOR 4;

ANTIBODY PRODUCTION; BINDING AFFINITY; COMPLEX FORMATION; CONFERENCE PAPER; DIAGNOSTIC TEST; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; HEPARIN INDUCED THROMBOCYTOPENIA; HEPARINIZATION; HUMAN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; THROMBOCYTE ACTIVATION; THROMBUS;

EID: 33748473052     PISSN: 14248832     EISSN: None     Source Type: Journal    
DOI: 10.1159/000093543     Document Type: Conference Paper

References (3)

1. Rauova L, Kowalska MA, Arepally GA, Cines DB, Poncz M. Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: Diagnostic and therapeutic implications. Blood 2006;107:2346-2353.
2. Rauova l, Poncz M, McKenzie, Reilly MP, Arepally G, Weisel JW, Nagaswami C, Cines DB, Sachais BS. Ultralarge complexes of heparin and PF4 are central to the pathogenesis of heparin-induced thrombocytopenia. Blood 2005;105:131-138.
3. Reilly MP, Taylor SM, Hartman NK, Arepally GM, Cines DB, Poncz M, McKenzie SE. Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through Fc□RIIA. Blood 2001;98:2442-2447.