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Volumn 32, Issue 4, 2011, Pages 356-363

DNA fragmentation in morphologically normal spermatozoa: How much should we be concerned in the ICSI era?

Author keywords

Morphology; Pregnancy

Indexed keywords

CLINICAL DECISION MAKING; DNA DAMAGE; DNA FRAGMENTATION; EMBRYO DEVELOPMENT; HUMAN; HUMAN CELL; INTRACYTOPLASMIC SPERM INJECTION; MALE; MALE INFERTILITY; OOCYTE; PRIORITY JOURNAL; REVIEW; SPERMATOZOON; CONGENITAL MALFORMATION; DNA REPAIR; FEMALE; METHODOLOGY; NICK END LABELING; PREGNANCY; PREGNANCY OUTCOME; SPERMATOZOON MOTILITY;

EID: 80052616607     PISSN: 01963635     EISSN: 19394640     Source Type: Journal    
DOI: 10.2164/jandrol.110.012005     Document Type: Review
Times cited : (81)

References (69)
  • 1
    • 0032834290 scopus 로고    scopus 로고
    • Developmental capacity of damaged spermatozoa
    • Ahmadi A, Ng SC. Developmental capacity of damaged spermatozoa. Hum Reprod. 1999;14:2279-2285.
    • (1999) Hum Reprod , vol.14 , pp. 2279-2285
    • Ahmadi, A.1    Ng, S.C.2
  • 2
    • 25144504039 scopus 로고    scopus 로고
    • Development of a novel electrophoretic system for the isolation of human spermatozoa
    • Ainsworth C, Nixon B, Aitken RJ. Development of a novel electrophoretic system for the isolation of human spermatozoa. Hum Reprod. 2005;20:2261-2270.
    • (2005) Hum Reprod , vol.20 , pp. 2261-2270
    • Ainsworth, C.1    Nixon, B.2    Aitken, R.J.3
  • 3
    • 34250747441 scopus 로고    scopus 로고
    • Origins and consequences of DNA damage in male germ cells
    • Aitken RJ, De Iuliis GN. Origins and consequences of DNA damage in male germ cells. Reprod Biomed Online. 2007;14:727-733.
    • (2007) Reprod Biomed Online , vol.14 , pp. 727-733
    • Aitken, R.J.1    De Iuliis, G.N.2
  • 4
    • 77649219526 scopus 로고    scopus 로고
    • On the possible origins of DNA damage in human spermatozoa
    • Aitken RJ, De Iuliis GN. On the possible origins of DNA damage in human spermatozoa. Mol Hum Reprod. 2010;16:3-13.
    • (2010) Mol Hum Reprod , vol.16 , pp. 3-13
    • Aitken, R.J.1    De Iuliis, G.N.2
  • 5
    • 58149289746 scopus 로고    scopus 로고
    • Biological and clinical significance of DNA damage in the male germ line
    • Aitken RJ, De Iuliis GN, McLachlan RI. Biological and clinical significance of DNA damage in the male germ line. Int J Androl. 2009;32:46-56.
    • (2009) Int J Androl , vol.32 , pp. 46-56
    • Aitken, R.J.1    De Iuliis, G.N.2    McLachlan, R.I.3
  • 6
    • 25144453511 scopus 로고    scopus 로고
    • The predictive value of sperm chromatin structure assay
    • Alvarez JG. The predictive value of sperm chromatin structure assay. Hum Reprod. 2005;20:2365-2367.
    • (2005) Hum Reprod , vol.20 , pp. 2365-2367
    • Alvarez, J.G.1
  • 7
    • 77953705043 scopus 로고    scopus 로고
    • DNA fragmentation of normal spermatozoa negatively impacts embryo quality and intracytoplasmic sperm injection outcome
    • Avendaño C, Franchi A, Duran H, Oehninger S. DNA fragmentation of normal spermatozoa negatively impacts embryo quality and intracytoplasmic sperm injection outcome. Fertil Steril. 2010;94: 549-557.
    • (2010) Fertil Steril , vol.94 , pp. 549-557
    • Avendano, C.1    Franchi, A.2    Duran, H.3    Oehninger, S.4
  • 10
    • 0038060337 scopus 로고    scopus 로고
    • Sperm DNA fragmentation decreases the pregnancy rate in an assisted reproductive technique
    • Benchaib M, Braun V, Lornage J, Hadj S, Salle B, Lejeune H, Guerin JF. Sperm DNA fragmentation decreases the pregnancy rate in an assisted reproductive technique. Hum Reprod. 2003;18:1023-1028.
    • (2003) Hum Reprod , vol.18 , pp. 1023-1028
    • Benchaib, M.1    Braun, V.2    Lornage, J.3    Hadj, S.4    Salle, B.5    Lejeune, H.6    Guerin, J.F.7
  • 11
    • 12444318663 scopus 로고    scopus 로고
    • The morphological normalcy of the sperm nucleus and pregnancy rate of intracytoplasmic injection with morphologically selected sperm
    • Berkovitz A, Eltes F, Yaari S, Katz N, Barr I, Fishman A, Bartoov B. The morphological normalcy of the sperm nucleus and pregnancy rate of intracytoplasmic injection with morphologically selected sperm. Hum Reprod. 2005;20:185-190.
    • (2005) Hum Reprod , vol.20 , pp. 185-190
    • Berkovitz, A.1    Eltes, F.2    Yaari, S.3    Katz, N.4    Barr, I.5    Fishman, A.6    Bartoov, B.7
  • 12
    • 0036798423 scopus 로고    scopus 로고
    • Prenatal testing in ICSI pregnancies: incidence of chromosomal anomalies in 1586 karyotypes and relation to sperm parameters
    • Bonduelle M, Van Assche E, Joris H, Keymolen K, Devroey P, Van Steirteghem A, Liebaers I. Prenatal testing in ICSI pregnancies: incidence of chromosomal anomalies in 1586 karyotypes and relation to sperm parameters. Hum Reprod. 2002;17:2600-2614.
    • (2002) Hum Reprod , vol.17 , pp. 2600-2614
    • Bonduelle, M.1    Van Assche, E.2    Joris, H.3    Keymolen, K.4    Devroey, P.5    Van Steirteghem, A.6    Liebaers, I.7
  • 13
    • 33749993552 scopus 로고    scopus 로고
    • Sperm DNA fragmentation: paternal effect on early post-implantation embryo development in ART
    • Borini A, Tarozzi N, Bizzaro D, Bonu MA, Fava L, Flamigni C, Coticchio G. Sperm DNA fragmentation: paternal effect on early post-implantation embryo development in ART. Hum Reprod. 2006;21:2876-2881.
    • (2006) Hum Reprod , vol.21 , pp. 2876-2881
    • Borini, A.1    Tarozzi, N.2    Bizzaro, D.3    Bonu, M.A.4    Fava, L.5    Flamigni, C.6    Coticchio, G.7
  • 15
    • 2642527705 scopus 로고    scopus 로고
    • Cellular maturity and apoptosis in human sperm: creatine kinase, caspase-3 and Bcl-XL levels in mature and diminished maturity sperm
    • Cayli S, Sakkas D, Vigue L, Demir R, Huszar G. Cellular maturity and apoptosis in human sperm: creatine kinase, caspase-3 and Bcl-XL levels in mature and diminished maturity sperm. Mol Hum Reprod. 2004;10:365-372.
    • (2004) Mol Hum Reprod , vol.10 , pp. 365-372
    • Cayli, S.1    Sakkas, D.2    Vigue, L.3    Demir, R.4    Huszar, G.5
  • 16
    • 4544324523 scopus 로고    scopus 로고
    • Sperm selection for ICSI: shape properties do not predict the absence or presence of numerical chromosomal aberrations
    • Celik-Ozenci C, Jakab A, Kovacs T, Catalanotti J, Demir R, Bray-Ward P, Ward D, Huszar G. Sperm selection for ICSI: shape properties do not predict the absence or presence of numerical chromosomal aberrations. Hum Reprod. 2004;19:2052-2059.
    • (2004) Hum Reprod , vol.19 , pp. 2052-2059
    • Celik-Ozenci, C.1    Jakab, A.2    Kovacs, T.3    Catalanotti, J.4    Demir, R.5    Bray-Ward, P.6    Ward, D.7    Huszar, G.8
  • 17
    • 33748624192 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention. 2007Atlanta GA: US Department of Health and Human Services
    • Centers for Disease Control and Prevention. 2007 Assisted Reproductive Technology Success Rates. Atlanta, GA: US Department of Health and Human Services; 2009.
    • (2009) Assisted Reproductive Technology Success, Rates
  • 18
    • 41749087618 scopus 로고    scopus 로고
    • Do sperm DNA integrity tests predict pregnancy with in vitro fertilization?
    • Collins JA, Barnhart KT, Schlegel PN. Do sperm DNA integrity tests predict pregnancy with in vitro fertilization? Fertil Steril. 2008; 89:823-831.
    • (2008) Fertil Steril , vol.89 , pp. 823-831
    • Collins, J.A.1    Barnhart, K.T.2    Schlegel, P.N.3
  • 19
    • 34548085071 scopus 로고    scopus 로고
    • Motile human normozoospermic and oligozoospermic semen samples show a difference in double-strand DNA break incidence
    • Derijck AA, van der Heijden GW, Ramos L, Giele M, Kremer JA, de Boer P. Motile human normozoospermic and oligozoospermic semen samples show a difference in double-strand DNA break incidence. Hum Reprod. 2007;22:2368-2376.
    • (2007) Hum Reprod , vol.22 , pp. 2368-2376
    • Derijck, A.A.1    van der Heijden, G.W.2    Ramos, L.3    Giele, M.4    Kremer, J.A.5    de Boer, P.6
  • 20
    • 0019296108 scopus 로고
    • Relation of mammalian sperm chromatin heterogeneity to fertility
    • Evenson DP, Darzynkiewicz Z, Melamed MR. Relation of mammalian sperm chromatin heterogeneity to fertility. Science. 1980;210: 1131-1133.
    • (1980) Science , vol.210 , pp. 1131-1133
    • Evenson, D.P.1    Darzynkiewicz, Z.2    Melamed, M.R.3
  • 22
    • 26244454147 scopus 로고    scopus 로고
    • Comparison of the Halosperm test kit with the sperm chromatin structure assay (SCSA) infertility test in relation to patient diagnosis and prognosis
    • Evenson DP, Wixon R. Comparison of the Halosperm test kit with the sperm chromatin structure assay (SCSA) infertility test in relation to patient diagnosis and prognosis. Fertil Steril. 2005;84:846-849.
    • (2005) Fertil Steril , vol.84 , pp. 846-849
    • Evenson, D.P.1    Wixon, R.2
  • 23
    • 0043080560 scopus 로고    scopus 로고
    • The sperm chromatin dispersion test: a simple method for the determination of sperm DNA fragmentation
    • Fernández JL, Muriel L, Rivero MT, Goyanes V, Vazquez R, Alvarez JG. The sperm chromatin dispersion test: a simple method for the determination of sperm DNA fragmentation. J Androl. 2003;24(1): 59-66.
    • (2003) J Androl , vol.24 , Issue.1 , pp. 59-66
    • Fernández, J.L.1    Muriel, L.2    Rivero, M.T.3    Goyanes, V.4    Vazquez, R.5    Alvarez, J.G.6
  • 26
    • 77049091416 scopus 로고    scopus 로고
    • Does severe teratozoospermia affect blastocyst formation, live birth rate, and other clinical outcome parameters in ICSI cycles?
    • French DB, Sabanegh ES Jr, Goldfarb J, Desai N. Does severe teratozoospermia affect blastocyst formation, live birth rate, and other clinical outcome parameters in ICSI cycles? Fertil Steril. 2010;93:1097-1103.
    • (2010) Fertil Steril , vol.93 , pp. 1097-1103
    • French, D.B.1    Sabanegh Jr., E.S.2    Goldfarb, J.3    Desai, N.4
  • 28
    • 75749108954 scopus 로고    scopus 로고
    • Birefringence characteristics in sperm heads allow for the selection of reacted spermatozoa for intracytoplasmic sperm injection
    • Gianaroli L, Magli MC, Ferraretti AP, Crippa A, Lappi M, Capitani S, Baccetti B. Birefringence characteristics in sperm heads allow for the selection of reacted spermatozoa for intracytoplasmic sperm injection. Fertil Steril. 2010;93:807-813.
    • (2010) Fertil Steril , vol.93 , pp. 807-813
    • Gianaroli, L.1    Magli, M.C.2    Ferraretti, A.P.3    Crippa, A.4    Lappi, M.5    Capitani, S.6    Baccetti, B.7
  • 29
    • 0027217458 scopus 로고
    • Presence of DNA strand breaks and increased sensitivity of DNA in situ to denaturation in abnormal human sperm cells: analogy to apoptosis of somatic cells
    • Gorczyca W, Traganos F, Jesionowska H, Darzynkiewicz Z. Presence of DNA strand breaks and increased sensitivity of DNA in situ to denaturation in abnormal human sperm cells: analogy to apoptosis of somatic cells. Exp Cell Res. 1993;207:202-205.
    • (1993) Exp Cell Res , vol.207 , pp. 202-205
    • Gorczyca, W.1    Traganos, F.2    Jesionowska, H.3    Darzynkiewicz, Z.4
  • 30
    • 69349099060 scopus 로고    scopus 로고
    • Assisted reproductive technology, epigenetics, and long-term health: a developmental time bomb still ticking
    • Grace KS, Sinclair KD. Assisted reproductive technology, epigenetics, and long-term health: a developmental time bomb still ticking. Semin Reprod Med. 2009;27:409-416.
    • (2009) Semin Reprod Med , vol.27 , pp. 409-416
    • Grace, K.S.1    Sinclair, K.D.2
  • 32
    • 0035761145 scopus 로고    scopus 로고
    • Enrichment of non-apoptotic human spermatozoa after cryopreservation by immunomagnetic cell sorting
    • Grunewald S, Paasch U, Glander HJ. Enrichment of non-apoptotic human spermatozoa after cryopreservation by immunomagnetic cell sorting. Cell Tissue Bank. 2001;2:127-133.
    • (2001) Cell Tissue Bank , vol.2 , pp. 127-133
    • Grunewald, S.1    Paasch, U.2    Glander, H.J.3
  • 34
    • 77349117050 scopus 로고    scopus 로고
    • Fernández-Gonzá lez R, Pintado B Gutiérrez-Adán A. Selection against spermatozoa with fragmented DNA after postovulatory mating depends on the type of damage
    • Hourcade JD, Pérez-Crespo M, Fernández-Gonzá lez R, Pintado B, Gutiérrez-Adán A. Selection against spermatozoa with fragmented DNA after postovulatory mating depends on the type of damage. Reprod Biol Endocrinol. 2010;8:9.
    • (2010) Reprod Biol Endocrinol , vol.8 , pp. 9
    • Hourcade, J.D.1    Pérez-Crespo, M.2
  • 35
    • 0030202411 scopus 로고    scopus 로고
    • A comparison of baseline and induced DNA damage in human spermatozoa from fertile and infertile men, using a modified comet assay
    • Hughes C, Lewis S, McKelvey-Martin V, Thompson W. A comparison of baseline and induced DNA damage in human spermatozoa from fertile and infertile men, using a modified comet assay. Mol Hum Reprod. 1996;2:613-619.
    • (1996) Mol Hum Reprod , vol.2 , pp. 613-619
    • Hughes, C.1    Lewis, S.2    McKelvey-Martin, V.3    Thompson, W.4
  • 36
    • 67249114256 scopus 로고    scopus 로고
    • Raman spectroscopy of DNA packaging in individual human sperm cells distinguishes normal from abnormal cells
    • Huser T, Orme CA, Hollars CW, Corzett MH, Balhorn R. Raman spectroscopy of DNA packaging in individual human sperm cells distinguishes normal from abnormal cells. J Biophotonics. 2009;2:322-332.
    • (2009) J Biophotonics , vol.2 , pp. 322-332
    • Huser, T.1    Orme, C.A.2    Hollars, C.W.3    Corzett, M.H.4    Balhorn, R.5
  • 37
    • 0028120752 scopus 로고
    • Creatine kinase immunocytochemistry of human sperm-hemizona complexes: selective binding of sperm with mature creatine kinase-staining pattern
    • Huszar G, Vigue L, Oehninger S. Creatine kinase immunocytochemistry of human sperm-hemizona complexes: selective binding of sperm with mature creatine kinase-staining pattern. Fertil Steril. 1994;61:136-142.
    • (1994) Fertil Steril , vol.61 , pp. 136-142
    • Huszar, G.1    Vigue, L.2    Oehninger, S.3
  • 39
    • 28944438420 scopus 로고    scopus 로고
    • Intracytoplasmic sperm injection: a novel selection method for sperm with normal frequency of chromosomal aneuploidies
    • Jakab A, Sakkas D, Delpiano E, Cayli S, Kovanci E, Ward D, Revelli A, Huszar G. Intracytoplasmic sperm injection: a novel selection method for sperm with normal frequency of chromosomal aneuploidies. Fertil Steril. 2005;84:1665-1673.
    • (2005) Fertil Steril , vol.84 , pp. 1665-1673
    • Jakab, A.1    Sakkas, D.2    Delpiano, E.3    Cayli, S.4    Kovanci, E.5    Ward, D.6    Revelli, A.7    Huszar, G.8
  • 40
    • 0028336649 scopus 로고
    • Evidence for a strong paternal effect on human preimplantation embryo development and blastocyst formation
    • Janny L, Menezo YJ. Evidence for a strong paternal effect on human preimplantation embryo development and blastocyst formation. Mol Reprod Dev. 1994;38:36-42.
    • (1994) Mol Reprod Dev , vol.38 , pp. 36-42
    • Janny, L.1    Menezo, Y.J.2
  • 41
    • 77949975818 scopus 로고    scopus 로고
    • Magnetic-activated cell sorting for sperm preparation reduces spermatozoa with apoptotic markers and improves the acrosome reaction in couples with unexplained infertility
    • Lee TH, Liu CH, Shih YT, Tsao HM, Huang CC, Chen HH, Lee MS. Magnetic-activated cell sorting for sperm preparation reduces spermatozoa with apoptotic markers and improves the acrosome reaction in couples with unexplained infertility. Hum Reprod. 2010;25:839-846.
    • (2010) Hum Reprod , vol.25 , pp. 839-846
    • Lee, T.H.1    Liu, C.H.2    Shih, Y.T.3    Tsao, H.M.4    Huang, C.C.5    Chen, H.H.6    Lee, M.S.7
  • 42
    • 0017161415 scopus 로고
    • A method for collecting motile spermatozoa from human semen
    • Lopata A, Patullo MJ, Chang A, James B. A method for collecting motile spermatozoa from human semen. Fertil Steril. 1976;27: 677-684.
    • (1976) Fertil Steril , vol.27 , pp. 677-684
    • Lopata, A.1    Patullo, M.J.2    Chang, A.3    James, B.4
  • 43
    • 0031895751 scopus 로고    scopus 로고
    • Sperm deoxyribonucleic acid fragmentation is increased in poor-quality semen samples and correlates with failed fertilization in intracytoplasmic sperm injection
    • Lopes S, Sun JG, Jurisicova A, Meriano J, Casper RF. Sperm deoxyribonucleic acid fragmentation is increased in poor-quality semen samples and correlates with failed fertilization in intracytoplasmic sperm injection. Fertil Steril. 1998;69:528-532.
    • (1998) Fertil Steril , vol.69 , pp. 528-532
    • Lopes, S.1    Sun, J.G.2    Jurisicova, A.3    Meriano, J.4    Casper, R.F.5
  • 44
    • 36749078665 scopus 로고    scopus 로고
    • Disruption of maternal DNA repair increases sperm-derived chromosomal aberrations
    • Marchetti F, Essers J, Kanaar R, Wyrobek AJ. Disruption of maternal DNA repair increases sperm-derived chromosomal aberrations. Proc Natl Acad Sci U S A. 2007;104:17725-17729.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 17725-17729
    • Marchetti, F.1    Essers, J.2    Kanaar, R.3    Wyrobek, A.J.4
  • 46
    • 70349445400 scopus 로고    scopus 로고
    • Sperm DNA damage: correlation to severity of semen abnormalities
    • Moskovtsev SI, Willis J, White J, Mullen JB. Sperm DNA damage: correlation to severity of semen abnormalities. Urology. 2009;74:789-793.
    • (2009) Urology , vol.74 , pp. 789-793
    • Moskovtsev, S.I.1    Willis, J.2    White, J.3    Mullen, J.B.4
  • 48
    • 43949146288 scopus 로고    scopus 로고
    • Sperm DNA fragmentation in subfertile men: the effect on the outcome of intracytoplasmic sperm injection and correlation with sperm variables
    • Nicopoullos JD, Gilling-Smith C, Almeida PA, Homa S, Norman-Taylor JQ, Ramsay JW. Sperm DNA fragmentation in subfertile men: the effect on the outcome of intracytoplasmic sperm injection and correlation with sperm variables. BJU Int. 2008;101: 1553-1560.
    • (2008) BJU Int , vol.101 , pp. 1553-1560
    • Nicopoullos, J.D.1    Gilling-Smith, C.2    Almeida, P.A.3    Homa, S.4    Norman-Taylor, J.Q.5    Ramsay, J.W.6
  • 49
    • 66249089816 scopus 로고    scopus 로고
    • Assisted reproductive technology and intrauterine inseminations in Europe 2005 results generated from European registers by ESHRE: ESHRE. The European IVF Monitoring Programme (EIM), for the European Society of Human Reproduction and Embryology (ESHRE)
    • Nyboe Andersen A, Goossens V, Bhattacharya S, Ferraretti AP, Kupka MS, de Mouzon J, Nygren KG. Assisted reproductive technology and intrauterine inseminations in Europe, 2005: results generated from European registers by ESHRE: ESHRE. The European IVF Monitoring Programme (EIM), for the European Society of Human Reproduction and Embryology (ESHRE). Hum Reprod. 2009;24:1267-1287.
    • (2009) Hum Reprod , vol.24 , pp. 1267-1287
    • Nyboe Andersen, A.1    Goossens, V.2    Bhattacharya, S.3    Ferraretti, A.P.4    Kupka, M.S.5    de Mouzon, J.6    Nygren, K.G.7
  • 50
    • 0035973294 scopus 로고    scopus 로고
    • Place of intracytoplasmic sperm injection in management of male infertility
    • Oehninger S. Place of intracytoplasmic sperm injection in management of male infertility. Lancet. 2001;357:2068-2069.
    • (2001) Lancet , vol.357 , pp. 2068-2069
    • Oehninger, S.1
  • 51
    • 0344875708 scopus 로고    scopus 로고
    • Pathophysiology of oligoasthenoteratozoospermia: are we improving in the diagnosis?
    • Oehninger S. Pathophysiology of oligoasthenoteratozoospermia: are we improving in the diagnosis? Reprod Biomed Online. 2003;7: 433-439.
    • (2003) Reprod Biomed Online , vol.7 , pp. 433-439
    • Oehninger, S.1
  • 52
    • 0036713167 scopus 로고    scopus 로고
    • Should ICSI be the treatment of choice for all cases of in-vitro conception? No, not in light of the scientific data
    • Oehninger S, Gosden RG. Should ICSI be the treatment of choice for all cases of in-vitro conception? No, not in light of the scientific data. Hum Reprod. 2002;17:2237-2242.
    • (2002) Hum Reprod , vol.17 , pp. 2237-2242
    • Oehninger, S.1    Gosden, R.G.2
  • 53
    • 0029018125 scopus 로고
    • The diagnosis of male infertility by semen quality Clinical significance of sperm morphology assessment
    • Oehninger S, Kruger T. The diagnosis of male infertility by semen quality. Clinical significance of sperm morphology assessment. Hum Reprod. 1995;10:1037-1038.
    • (1995) Hum Reprod , vol.10 , pp. 1037-1038
    • Oehninger, S.1    Kruger, T.2
  • 54
  • 55
    • 0028789044 scopus 로고
    • Intracytoplasmic sperm injection: achievement of high pregnancy rates in couples with severe male factor infertility is dependent primarily upon female and not male factors
    • Oehninger S, Veeck L, Lanzendorf S, Maloney M, Toner J, Muasher S. Intracytoplasmic sperm injection: achievement of high pregnancy rates in couples with severe male factor infertility is dependent primarily upon female and not male factors. Fertil Steril. 1995;64: 977-981.
    • (1995) Fertil Steril , vol.64 , pp. 977-981
    • Oehninger, S.1    Veeck, L.2    Lanzendorf, S.3    Maloney, M.4    Toner, J.5    Muasher, S.6
  • 56
    • 0026639854 scopus 로고
    • Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte
    • Palermo G, Joris H, Devroey P, Van Steirteghem AC. Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. Lancet. 1992;340:17-18.
    • (1992) Lancet , vol.340 , pp. 17-18
    • Palermo, G.1    Joris, H.2    Devroey, P.3    Van Steirteghem, A.C.4
  • 58
    • 0034621854 scopus 로고    scopus 로고
    • Frequent chromosomal translocations induced by DNA double-strand breaks
    • Richardson C, Jasin M. Frequent chromosomal translocations induced by DNA double-strand breaks. Nature. 2000;405:697-700.
    • (2000) Nature , vol.405 , pp. 697-700
    • Richardson, C.1    Jasin, M.2
  • 59
    • 77049084953 scopus 로고    scopus 로고
    • Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis
    • Sakkas D, Alvarez JG. Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis. Fertil Steril. 2010;93:1027-1036.
    • (2010) Fertil Steril , vol.93 , pp. 1027-1036
    • Sakkas, D.1    Alvarez, J.G.2
  • 61
    • 21244445743 scopus 로고    scopus 로고
    • Spermatozoal nuclear determinants of reproductive outcome: implications for ART
    • Seli E, Sakkas D. Spermatozoal nuclear determinants of reproductive outcome: implications for ART. Hum Reprod Update. 2005;11: 337-349.
    • (2005) Hum Reprod Update , vol.11 , pp. 337-349
    • Seli, E.1    Sakkas, D.2
  • 63
    • 74349102030 scopus 로고    scopus 로고
    • Aneuploidy and DNA fragmentation in morphologically abnormal sperm
    • Tang SS, Gao H, Zhao Y, Ma S. Aneuploidy and DNA fragmentation in morphologically abnormal sperm. Int J Androl. 2010;33: e163-e179.
    • (2010) Int J Androl , vol.33
    • Tang, S.S.1    Gao, H.2    Zhao, Y.3    Ma, S.4
  • 64
    • 1542711820 scopus 로고    scopus 로고
    • Late, but not early, paternal effect on human embryo development is related to sperm DNA fragmentation
    • Tesarik J, Greco E, Mendoza C. Late, but not early, paternal effect on human embryo development is related to sperm DNA fragmentation. Hum Reprod. 2004;19:611-615.
    • (2004) Hum Reprod , vol.19 , pp. 611-615
    • Tesarik, J.1    Greco, E.2    Mendoza, C.3
  • 65
    • 0034788876 scopus 로고    scopus 로고
    • Interrelationships between seminal parameters and sperm nuclear DNA damage before and after density gradient centrifugation: implications for assisted conception
    • Tomlinson MJ, Moffatt O, Manicardi GC, Bizzaro D, Afnan M, Sakkas D. Interrelationships between seminal parameters and sperm nuclear DNA damage before and after density gradient centrifugation: implications for assisted conception. Hum Reprod. 2001;16:2160-2165.
    • (2001) Hum Reprod , vol.16 , pp. 2160-2165
    • Tomlinson, M.J.1    Moffatt, O.2    Manicardi, G.C.3    Bizzaro, D.4    Afnan, M.5    Sakkas, D.6
  • 66
    • 0031822760 scopus 로고    scopus 로고
    • Oxidative damage to DNA in human spermatozoa does not preclude pronucleus formation at intracytoplasmic sperm injection
    • Twigg JP, Irvine DS, Aitken RJ. Oxidative damage to DNA in human spermatozoa does not preclude pronucleus formation at intracytoplasmic sperm injection. Hum Reprod. 1998;13:1864-1871.
    • (1998) Hum Reprod , vol.13 , pp. 1864-1871
    • Twigg, J.P.1    Irvine, D.S.2    Aitken, R.J.3
  • 67
    • 0025727849 scopus 로고
    • Sperm morphology and IVF pregnancy rate: comparison between Percoll gradient centrifugation and swim-up procedures
    • Van der Zwalmen P, Bertin-Segal G, Geerts L, Debauche C, Schoysman R. Sperm morphology and IVF pregnancy rate: comparison between Percoll gradient centrifugation and swim-up procedures. Hum Reprod. 1991;6(4):581-588.
    • (1991) Hum Reprod , vol.6 , Issue.4 , pp. 581-588
    • Van der Zwalmen, P.1    Bertin-Segal, G.2    Geerts, L.3    Debauche, C.4    Schoysman, R.5
  • 68
    • 33845604556 scopus 로고    scopus 로고
    • DNA double-strand break repair: all's well that ends well
    • Wyman C, Kanaar R. DNA double-strand break repair: all's well that ends well. Annu Rev Genet. 2006;40:363-383.
    • (2006) Annu Rev Genet , vol.40 , pp. 363-383
    • Wyman, C.1    Kanaar, R.2
  • 69
    • 0035062286 scopus 로고    scopus 로고
    • Correlations between two markers of sperm DNA integrity, DNA denaturation and DNA fragmentation, in fertile and infertile men
    • Zini A, Bielecki R, Phang D, Zenzes MT. Correlations between two markers of sperm DNA integrity, DNA denaturation and DNA fragmentation, in fertile and infertile men. Fertil Steril. 2001;75: 674-677.
    • (2001) Fertil Steril , vol.75 , pp. 674-677
    • Zini, A.1    Bielecki, R.2    Phang, D.3    Zenzes, M.T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.