Synthesis of a series of γ-amino alcohols comprising an N-methyl isoindoline moiety and their evaluation as NMDA receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 19, 2011, Pages 5795-5799

  Müller, Andreas ^a   Höfner, Georg ^a   Renukappa Gutke, Thejavathi ^a   Parsons, Chris G ^b   Wanner, Klaus T ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b MERZ PHARMACEUTICALS GMBH   (Germany)

Author keywords

Amino alcohol; Biological activity; Ifenprodil; Isoindoline; NMDA

Indexed keywords

AMINOALCOHOL; DIZOCILPINE; ELIPRODIL; IFENPRODIL; ISOINDOLE DERIVATIVE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; POTASSIUM CHANNEL HERG;

ARTICLE; BINDING AFFINITY; BINDING SITE; BIOLOGICAL ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; STEREOCHEMISTRY; STEREOISOMERISM;

AMINO ALCOHOLS; BINDING SITES; DIZOCILPINE MALEATE; DRUG DESIGN; ETHER-A-GO-GO POTASSIUM CHANNELS; EXCITATORY AMINO ACID ANTAGONISTS; INHIBITORY CONCENTRATION 50; LIGANDS; MOLECULAR STRUCTURE; MOLECULAR TARGETED THERAPY; N-METHYLASPARTATE; NEUROPROTECTIVE AGENTS; PIPERIDINES; RECEPTORS, N-METHYL-D-ASPARTATE; STEREOISOMERISM;

EID: 80052601854     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.07.119     Document Type: Article

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