[3H]ifenprodil binding to NMDA receptors in porcine hippocampal brain membranes

European Journal of Pharmacology

Volumn 394, Issue 2-3, 2000, Pages 211-219

  Höfner, Georg ^a   Wanner, Klaus T ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Hippocampal brain membrane porcine; NMDA receptor; 3H Ifenprodil; 3H MK 801; site

Indexed keywords

1 (4 AZIDO 2 METHYLPHENYL) 3 (2 METHYLPHENYL)GUANIDINE; 1-(4-AZIDO-2-METHYLPHENYL)-3-(2-METHYLPHENYL)GUANIDINE; AMINO ACID RECEPTOR BLOCKING AGENT; AZIDE; DIZOCILPINE MALEATE; GUANIDINE DERIVATIVE; IFENPRODIL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PIPERIDINE DERIVATIVE; SIGMA OPIATE RECEPTOR; 1,10 DECANEDIAMINE; 1,3 BIS(2 METHYLPHENYL)GUANIDINE; 2 AMINO 5 PHOSPHONOVALERIC ACID; 4 (3 PHOSPHONOPROPYL) 2 PIPERAZINECARBOXYLIC ACID; 5,7 DICHLOROKYNURENIC ACID; 6,7 DINITRO 2,3 QUINOXALINEDIONE; ARCAINE; BUPHENINE; CATION; DEXTRO SERINE; DIETHYLENETRIAMINE; DIZOCILPINE; ELIPRODIL; GLUTAMIC ACID; GLYCINE; HALOPERIDOL; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEOMYCIN; PENTAMIDINE; PHENCYCLIDINE; POLYAMINE; PRECLAMOL; RECEPTOR SUBUNIT; SIGMA RECEPTOR LIGAND; SPERMIDINE; SPERMINE; TRITIUM; VANOXERINE;

ANIMAL; ARTICLE; BINDING COMPETITION; CELL FRACTIONATION; DRUG ANTAGONISM; DRUG EFFECT; HIPPOCAMPUS; IN VITRO STUDY; KINETICS; MEMBRANE; METABOLISM; PROTEIN BINDING; SWINE; ANIMAL TISSUE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; BRAIN MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG INHIBITION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; IC 50; MODEL; NONHUMAN; PRIORITY JOURNAL; SUCROSE DENSITY GRADIENT CENTRIFUGATION; TEMPERATURE;

ANIMALS; AZIDES; BINDING, COMPETITIVE; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; GUANIDINES; HIPPOCAMPUS; KINETICS; MEMBRANES; PIPERIDINES; PROTEIN BINDING; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, SIGMA; SUBCELLULAR FRACTIONS; SWINE;

EID: 0034646484     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00084-4     Document Type: Article

References (37)

1. Avenet P., Leonardon J., Besnard F., Graham D., Frost J., Depoortere H., Langer S.Z., Scatton B. Antagonist properties of the stereoisomers of ifenprodil at NR1A/NR2A and NR1A/NR2B subtypes of the NMDA receptor expressed in Xenopus oocytes. Eur. J. Pharmacol. 296:1996;209-213.
2. Berger M.L. On the true affinity of glycine for ist binding site at the NMDA receptor complex. J. Pharmacol. Methods. 34:1995;79-88.
3. Bradford M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
4. Brimecombie J.C., Gallagher M.J., Lynch D.R., Aizenman E. An NR2B point mutation affecting haloperidol and CP101,606 sensitivity of single recombinant N-Methyl-D-Aspartate receptors. J. Pharmacol. Exp. Ther. 286:1998;627-634.
5. 3H](+)-Pentazocine binding to rat brain σ1-receptors. Eur. J. Pharmacol. 266:1994;131-138.
6. Carter C., Avenet P., Benavides J., Besnard F., Biton B., Cudennec A., Duverger D., Frost J., Giroux C., Graham D., Langer S.Z., Nowicki J.P., Oblin A., Perault G., Pigasse S., Rosen P., Sanger D., Schoemaker H., Thenot J.P., Scatton B. Ifenprodil and eliprodil: neuroprotective NMDA receptor antagonists and calcium channel blockers. Herling P.L. Excitatory Amino Acids-Clinical Results with Antagonists. 1997;57-151 Academic Press, San Diego.
7. Carter C.J., Minisclou C., Schoemaker H., Scatton B. Polyamine-directed non-competitive NMDA antagonists. Mol. Neuropharmacol. 2:1992;107-112.
8. Chazot P.L., Stephenson F.A. Molecular dissection of native mammalian forebrain NMDA receptors containing the NR1 C2 exon: direct demonstration of NMDA receptors comprising NR1, NR2A, and NR2B subunits within the same complex. J. Neurochem. 69:1997;2138-2144.
9. Chenard B.L., Bordner J., Butler T.W., Chambers L.K., Collins M.A., De Costa D.L., Ducat M.F., Dumont M.L., Fox C.B., Mena E.E., Menniti F.S., Nielsen J., Pagnozzi M.J., Richter K.E.G., Ronau R.T., Shalaby I.A., Stemple J.Z., White W.F. (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. J. Med. Chem. 38:1995;3138-3145.
10. 3H]ifenprodil binding in rat brain membranes. J. Pharmacol. Exp. Ther. 28:1997;584-592.
11. 3H]ifenprodil binding sites in the rat brain. Neurosci. Lett. 125:1991;45-48.
12. Gallagher M.J., Huang H., Lynch D.R. Modulation of the N-methyl-D-aspartate receptor by haloperidol: NR2B-specific interactions. J. Neurochem. 70:1998;2120-2128.
13. Gordon Weeks P.R. Isolation of synaptosomes, growth cones and their subcellular components. Turner A.J., Bachelard H.S. Neurochemistry a Practical Approach. 1987;1-26 IRL Press, Oxford.
14. 3H]ifenprodil binding to σ receptors in rat brain. Eur. J. Pharmacol. 236:1993;159-163.
15. 3H]ifenprodil binding in the rat brain. Eur. J. Pharmacol. 266:1994;67-77.
16. 2 receptors: characterisation by ligand binding and photoaffinity labeling. Eur. J. Pharmacol. 268:1994;9-18.
17. Hess S.D., Daggett L.P., Crona J., Deal C., Lu C.-C., Urrutia A., Chavez-Noriega L., Ellis S.B., Johnson E.C., Velicelebi G. Cloning and functional characterisation of human N-methyl-D-aspartate receptors. J. Pharmacol. Exp. Ther. 278:1996;808-816.
18. 3H]MK-801 binding and its cooperative modulation by pig brain membranes. J. Recept. Signal Transduction Res. 16:1996;297-313.
19. Ilyin V.I., Whittemore E.R., Guastella J., Weber E., Woodward R.M. Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol. Mol. Pharmacol. 50:1996;1541-1550.
20. Johnson T.D. Modulation of channel function by polyamines. Trends Pharmacol. Sci. 17:1996;22-27.
21. Kew J.N.C., Kemp J.A. An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurons. J. Physiol. 512:1998;17-28.
22. Knight A.R., Noble A., Wong E.H.F., Middlemiss D.N. The subcellular distribution and pharmacology of the sigma recognition site in the guinea-pig brain and liver. Mol. Neuropharmacol. 1:1991;71-75.
23. Muir K.W., Lees K.R. Clinical experience with excitatory amino acid antagonist drugs. Stroke. 26:1995;503-513.
24. 3H]ifenprodil sites in the rat brain: possible relationship to NMDAR2B receptors and calmodulin. J. Neurochem. 63:1994;2248-2258.
25. Reynolds I.J., Aizenman E. Pentamidine is an N-methyl-D-aspartate receptor antagonist and is neuroprotective in vitro. J. Neurosci. 12:1992;970-975.
26. Reynolds I.J., Miller R.J. Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines. Mol. Pharmacol. 36:1989;758-765.
27. Rock D.M., MacDonald R.L. The polyamine diaminodecane (DA10) produces a voltage-dependent flickery block of single NMDA receptor channels. Neurosci. Lett. 144:1992;111-115.
28. Scatton B., Avenet P., Benavides J., Carter C., Duverger D., Oblin A., Perault G., Sanger D., Schoemaker H. Neuroprotective potential of the polyamine site-directed NMDA receptor antagonists-ifenprodil and eliprodil. Palfreyman M.G., Reynolds I.J., Skolnick P. Direct and Allosteric Control of Glutamate Receptors. 1994;139-154 CRC Press, Boca Raton.
29. 3H]ifenprodil, a novel NMDA antagonist to a polyamine-sensitive site in the rat cerebral cortex. Eur. J. Pharmacol. 176:1990;249-250.
30. Segal J.A., Skolnick P. Polyamine like actions of aminoglycoside derivatives at NMDA receptors. Eur. J. Pharmacol. 347:1999;311-317.
31. Subramaniam S., Doneva S.D., Rogawski M.A. Hydrophobic interactions of n-alkyl diamines with the N-methyl-D-aspartate receptor: voltage dependent and -independent blocking sites. Mol. Pharmacol. 45:1992;117-124.
32. 3H]tolyl)guanidine: a selective ligand that labels σ-type receptors for psychotomimetic opiates and antipsychotic drugs. Proc. Natl. Acad. Sci. USA. 83:1986;8784-8788.
33. Whittemore E.R., Ilyin V.I., Konkoy C.S., Woodward R.M. Subtype-selective antagonism of NMDA receptors by nylidrin. Eur. J. Pharmacol. 337:1997;197-208.
34. Whittemore E.R., Ilyin V.I., Woodward R.M. Antagonism of N-methyl-D-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J. Pharmacol. Exp. Ther. 282:1997;326-338.
35. Williams K. Interactions of polyamines with ion channels. Biochem. J. 325:1997;289-297.
36. Williams K., Romano C., Dichter M.A., Molinoff P.B. Modulation of the NMDA receptor by polyamines. Life Sci. 48:1991;469-498.
37. Yamamoto H., Yamamoto T., Sagi N., Klenerova V., Goji K., Kawai N., Baba A., Takamori E., Moroji T. Sigma ligands indirectly modulate the NMDA receptor-ion channel complex on intact neuronal cells via σ1 site. J. Neurosci. 15:1995;731-736.