Asymmetric synthesis and enantiospecificity of binding of 2-(1,2,3,4-tetrahydro-1-isoquinolyl)-ethanol derivatives to μ and κ receptors

Archiv der Pharmazie

Volumn 329, Issue 1, 1996, Pages 11-22

  Wanner, Klaus Th ^a   Praschak, Ilona ^a   Höfner, Georg ^a   Beer, Herbert ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

1,3 amino alcohols; asymmetric synthesis; biological enantioselectivity; opioid analgesics; tetrahydroisoquinolines

Indexed keywords

1 (4 CHLOROPHENYL) 2 (1,2,3,4 TETRAHYDRO 6,7 DIMETHOXY 2 METHYL 1 ISOQUINOLYL)ETHANOL; 1 (4 METHOXYPHENYL) 2 (1,2,3,4 TETRAHYDRO 6,7 DIMETHOXY 2 METHYL 1 ISOQUINOLYL)ETHANOL; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ISOQUINOLINE DERIVATIVE; KAPPA OPIATE RECEPTOR; MORPHINE; MU OPIATE RECEPTOR; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NALOXONE; TRAMADOL; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CATTLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

ANALGESICS; ANIMALS; CATTLE; CORPUS STRIATUM; ETHANOL; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030050245     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/ardp.19963290104     Document Type: Article

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