Upstream molecular signaling pathways of p27(Kip1) expression in human breast cancer cells in vitro: Differential effects of 4-hydroxytamoxifen and deficiency of either D-(+)-glucose or L-leucine

Cancer Cell International

Volumn 11, Issue , 2011, Pages

  Eto, Isao ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFIMOXIFENE; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INITIATION FACTOR 4E BINDING PROTEIN 1; LEUCINE; LUCIFERASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOCHONDRIAL ATP SYNTHASE ALPHA CHAIN; MITOCHONDRIAL PROTEIN; PROTEIN P27; TAMOXIFEN; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CALORIC RESTRICTION; CANCER CELL; CANCER RISK; CELL STRAIN; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; IN VITRO STUDY; OBESITY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

EID: 80052585881     PISSN: None     EISSN: 14752867     Source Type: Journal    
DOI: 10.1186/1475-2867-11-31     Document Type: Article

References (40)

1. Eto I. Nutritional and chemopreventive anti-cancer agents up-regulate expression of p27Kip1, a cyclin-dependent kinase inhibitor, in mouse JB6 epidermal and human MCF7, MDA-MB-321 and AU565 breast cancer cells. Cancer Cell Int 2006, 6:20. (pp. 1-19), 10.1186/1475-2867-6-20, 1559648, 16899133.
2. Eto I. Upstream molecular signaling pathways of p27(Kip1) expression: Effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids. Cancer Cell Int 2010, 10:3. (pp. 1-19), 10.1186/1475-2867-10-3, 2841156, 20170512.
3. Eto I. G1 cell cycle regulatory proteins in chemically induced rat mammary adenocarcinomas in vivo and tumor promotion-sensitive, -resistant, and transformed mouse epidermal cells in vitro. Cell Cycle 2003, 2:149-156.
4. Goepfert U, Kullmann M, Hengst L. Cell cycle-dependent translation of p27 involves a responsive element in its 5'-UTR that overlaps with a uORF. Hum Mol Genet 2003, 12:1767-1779. 10.1093/hmg/ddg177, 12837699.
5. Agrawal D, Hauser P, McPherson F, Dong F, Garcia A, Pledger WJ. Repression of p27(kip1) synthesis by PDGF in balb/c 3T3 cells. Mol Cell Biol 1996, 16:4327-4336. 231431, 8754833.
6. Hengst L, Reed SI. Translational control of p27Kip1 accumulation during the cell cycle. Science 1996, 271:1861-1864. 10.1126/science.271.5257.1861, 8596954.
7. Millard SS, Yan JS, Nguyen H, Pagano M, Kiyokawa H, Koff A. Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest. J Biol Chem 1997, 272:7093-7098. 10.1074/jbc.272.11.7093, 9054402.
8. Kullmann M, Goepfert U, Siewe B, Hengst L. ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR. Genes Dev 2002, 16:3087-3099. 10.1101/gad.248902, 187493, 12464637.
9. Miskimins WK, Wang G, Hawkinson M, Miskimins R. Control of cyclin-dependent kinase inhibitor p27 expression by cap-independent translation. Mol Cell Biol 2001, 21:4960-4967. 10.1128/MCB.21.15.4960-4967.2001, 87223, 11438653.
10. Millard SS, Vidal A, Markus M, Koff A. A U-rich element in the 5' untranslated region is necessary for the translation of p27 mRNA. Mol Cell Biol 2000, 20:5947-5959. 10.1128/MCB.20.16.5947-5959.2000, 86072, 10913178.
11. Pagano M, Tam SW, Theodoras AM, Beer-Romero P, Del Sal G, Chau V, Yew PR, Draetta GF, Rolfe M. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 1995, 269:682-685. 10.1126/science.7624798, 7624798.
12. Hara T, Kamura T, Nakayama K, Oshikawa K, Hatakeyama S. Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway. J Biol Chem 2001, 276:48937-48943. 10.1074/jbc.M107274200, 11682478.
13. Malek NP, Sundberg H, McGrew S, Nakayama K, Kyriakides TR, Roberts JM, Kyriakidis TR. A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase. Nature 2001, 413:323-327. 10.1038/35095083, 11565035.
14. Hengst L. A second RING to destroy p27Kip1. Nature Cell Biol 2004, 6:1153-1155. 10.1038/ncb1204-1153, 15573093.
15. Soos TJ, Kiyokawa H, Yan JS, Rubin MS, Giordano A, DeBlasio A, Bottega S, Wong B, Mendelsohn J, Koff A. Formation of p27-CDK complexes during the human mitotic cell cycle. Cell Growth Differ 1996, 7:135-146.
16. Rodier G, Montagnoli A, Di Marcotullio L, Coulombe P, Draetta GF, Pagano M, Meloche S. p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J 2001, 20:6672-6682. 10.1093/emboj/20.23.6672, 125773, 11726503.
17. Viglietto G, Motti ML, Bruni P, Melillo RM, D'Alessio A, Califano D, Vinci F, Chiappetta G, Tsichlis P, Bellacosa A, Fusco A, Santoro M. Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. Nat Med 2002, 8:1136-1144. 10.1038/nm762, 12244303.
18. Liang J, Zubovitz J, Petrocelli T, Kotchetkov R, Connor MK, Han K, Lee JH, Ciarallo S, Catzavelos C, Beniston R, Liang J, Zubovitz J, Petrocelli T, Kotchetkov R, Connor MK, Han K, Lee JH, Ciarallo S, Catzavelos C, Beniston R, Franssen E, Slingerland JM. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med 2002, 8:1153-1160. 10.1038/nm761, 12244302.
19. Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL. PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nat Med 2002, 8:1145-1152. 10.1038/nm759, 12244301.
20. Connor MK, Kotchetkov R, Cariou S, Resch A, Lupetti R, Beniston RG, Melchior F, Hengst L, Slingerland JM. CRM1/RAN-mediated nuclear export of p27Kip1 involves a nuclear export signal and links p27 export and proteolysis. Mol Biol Cell 2003, 14:201-213. 10.1091/mbc.E02-06-0319, 140238, 12529437.
21. Ciarallo S, Subramanian V, Hung W, Lee JH, Kotchetkov R, Sandhu C, Milic A, Slingerland JM. Altered p27Kip1 phosphorylation, localization, and function in human epithelial cells resistant to transforming growth factor β-mediated G1 arrest. Mol Cell Biol 2002, 22:2993-3002. 10.1128/MCB.22.9.2993-3002.2002, 133745, 11940657.
22. Chu I, Sun J, Arnaout A, Kahn H, Hanna W, Narod S, Sun P, Tan CK, Hengst L, Slingerland J. p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2. Cell 2007, 128:281-294. 10.1016/j.cell.2006.11.049, 1961623, 17254967.
23. Kazi A, Carie A, Blaskovich MA, Bucher C, Thai V, Moulder S, Peng H, Carrico D, Pusateri E, J Pledger WJ, Berndt N, Hamilton A, Sebti SM. Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: Implications for breast cancer therapy. Mol Cell Biol 2009, 29:2254-2263. 10.1128/MCB.01029-08, 2663293, 19204084.
24. Law IKM, Liu L, Xu A, Lam KSL, Vanhoutte PM, Che CM, Leung PTY, Wang Y. Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins. Proteomics 2009, 9:2444-2456. 10.1002/pmic.200800738, 19343720.
25. Laplante M, Sabatini DM. mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis. Proc Natl Acad Sci US 2010, 107:3281-3282.
26. Sengupta S, Peterson TR, Sabatini DM. Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress. Molecular Cell 2010, 40:310-322. 10.1016/j.molcel.2010.09.026, 2993060, 20965424.
27. Düvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S, Vander Heiden MG, MacKeigan JP, Finan PM, Clish CB, Murphy LO, Manning BD. Activation of a metabolic gene regulatory network downstream of mTOR complex. Molecular Cell 2010, 39:171-183. 10.1016/j.molcel.2010.06.022, 2946786, 20670887.
28. Porstmann T, Santos CR, Griffiths B, Cully M, Wu M, Leevers S, Griffiths JR, Chung YL, Schulze A. SREBP activity Is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab 2008, 8:224-236. 10.1016/j.cmet.2008.07.007, 2593919, 18762023.
29. Naidoo N, Zhang L, Romer M, Cater JR, Scharf MT, Raymond J Galante RJ, Pack AI. Changes in components of energy regulation in mouse cortex with Increases in wakefulness. SLEEP 2010, 33:889-900. 2894431, 20614849.
30. Finley LWS, Carracedo A, Lee J, Souza A, Egia A, Zhang J, Teruya-Feldstein J, Moreira PI, Cardoso SM, Clish CB, Pandolf PP, Haigis MC. SIRT3 opposes reprogramming of cancer cell metabolism through HIF1a destabilization. Cancer Cell 2011, 19:416-428. 10.1016/j.ccr.2011.02.014, 21397863.
31. Giralt A, Hondares E, Villena JA, Ribas F, Díaz-Delfín J, Giralt M, Iglesias R, Villarroya F. Peroxisome proliferator-activated receptor-γ coactivator-1α controls transcription of the Sirt3 gene, an essential component of the thermogenic brown adipocyte phenotype. J Biol Chem 2011, 286:16958-16966. 10.1074/jbc.M110.202390, 21454513.
32. Kim HS, Patel K, Muldoon-Jacobs K, Bisht KS, Aykin-Burns NA, Pennington JD, van der Meer R, Nguyen P, Savage J, Owens KM, Vassilopoulos A, Ozden O, Park SH, Singh KK, Sarki A Abdulkadir SA, Douglas R Spitz DR, Chu-Xia Deng CX, Gius D. SIRT3 Is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell 2010, 17:41-52. 10.1016/j.ccr.2009.11.023, 20129246.
33. Kong X, Wang R, Xue Y, Liu X, Zhang H, Chen Y, Fang F, Chang Y. Sirtuin 3, a new target of PGC-1a, plays an important role in the suppression of ROS and mitochondrial biogenesis. PLoS ONE 2010, 5:e11707. 10.1371/journal.pone.0011707, 2908542, 20661474.
34. Liu Y, Zhang D, Chen D. SIRT3: Striking at the heart of aging. Aging 2010, 12:914-923.
35. Choudhury M, Jonscher KR, Friedman JE. Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat. AGING 2011, 3:175-178. 3082013, 21386135.
36. Huang JY, Hirschey MD, Shimazu T, Ho L, Verdin E. Mitochondrial sirtuins. Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics 2010, 1804:1645-1651. 10.1016/j.bbapap.2009.12.021, 21907181.
37. Palacios OM, Carmona JJ, Michan S, Ke KY, Manabe Y, Ward III, Goodyear LJ, Tong Q. Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle. AGING 2009, 1:771-783. 2815736, 20157566.
38. Minami S, Ohtani-Fujita N, Igata E, Tamaki T, Sakai T. Molecular cloning and characterization of the human p27Kip1 gene promoter. FEBS Lett 1997, 411:1-6. 10.1016/S0014-5793(97)00660-1, 9247132.
39. Hsu TC, Nair R, Tulsian P, Camalier CE, Hegamyer GA, Young MR, Colburn NH. Transformation nonresponsive cells owe their resistance to lack of p65/nuclear factor-κB activation. Cancer Res 2001, 61:4160-4168.
40. Vidal A, S Millard S, Miller JP, Koff A. Rho activity can alter the translation of p27 mRNA and Is important for RasV12-induced transformation in a manner dependent on p27 status. J Biol Chem 2002, 277:16433-16440. 10.1074/jbc.M112090200, 11875067.