SCOPUS 정보 검색 플랫폼

Volumn 19, Issue 18, 2011, Pages 5372-5382

SAR studies of acidic dual γ-secretase/PPARγ modulators

(8) Hieke, Martina a,e Ness, Julia b Steri, Ramona a Greiner, Christine c Werz, Oliver d Schubert Zsilavecz, Manfred a Weggen, Sascha b Zettl, Heiko a,e

a GOETHE UNIVERSITY (Germany)

b HEINRICH HEINE UNIVERSITY (Germany)

c UNIVERSITY OF TÜBINGEN (Germany)

d FRIEDRICH SCHILLER UNIVERSITY JENA (Germany)

e BROWN UNIVERSITY (United States)

Author keywords

Secretase modulators; Alzheimer's disease; Carboxylic acids; PPAR agonists; SAR

Indexed keywords

2 (3,5 DIPHENETHOXYBENZYLIDENE)HEXANOIC ACID; 2 (3,5 DIPHENETHOXYPHENOXY)HEXANOIC ACID; 2 [(3,5 DIPHENETHOXYPHENYL)THIO]HEXANOIC ACID; 2 [3,4 BIS(2 CYCLOHEXYLETHOXY)BENZYL]HEXANOIC ACID; 2 [4 (2 CYCLOHEXYLETHOXY) 3 PHENETHOXYBENZYL]HEXANOIC ACID; 2 [4 [2 [3 CYCLOHEXYL 1 (4 CYCLOHEXYLBUTYL)UREIDO]ETHYL]PHENYLTHIO] 2 METHYLPROPIONIC ACID; 2 BENZYLIDENE HEXANOIC ACID DERIVATIVE; 3 (2 CYCLOHEXYLETHOXY) 4 PHENETHOXYBENZALDEHYDE; 3 HYDROXY 4 (2 CYCLOHEXYLETHOXY)BENZALDEHYDE; 3 HYDROXY 4 PHENETHOXYBENZALDEHYDE; 3,4 BIS(2 CYCLOHEXYLETHOXY)BENZALDEHYDE; 4 (2 CYCLOHEXYLETHOXY) 3 PHENETHOXYBENZALDEHYDE; 4 [4 [3 (4 ACETYL 3 HYDROXY 2 PROPYLPHENOXY)PROPOXY]PHENOXY]ACETIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ETHYL 2 [3 (2 CYCLOHEXYLETHOXY) 4 PHENETHOXYBENZYL]HEXANOATE; ETHYL 2 [3 (2 CYCLOHEXYLETHOXY) 4 PHENETHOXYBENZYL]HEXANOIC ACID; ETHYL 2 [3 (2 CYCLOHEXYLETHOXY) 4 PHENETHOXYBENZYLIDENE]HEXANOATE; ETHYL 2 [3,4 BIS(2 CYCLOHEXYLETHOXY)BENZYL]HEXANOATE; ETHYL 2 [3,4 BIS(2 CYCLOHEXYLETHOXY)BENZYLIDENE]HEXANOATE; ETHYL 2 [4 (2 CYCLOHEXYLETHOXY) 3 PHENETHOXYBENZYL]HEXANOATE; ETHYL 2 [4 (2 CYCLOHEXYLETHOXY) 3 PHENETHOXYBENZYLIDENE]HEXANOATE; GAMMA SECRETASE MODULATOR; HORMONE RECEPTOR STIMULATING AGENT; NOTCH RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HYDROGENATION; IC 50; IN VITRO STUDY; NONHUMAN; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CRICETINAE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEXANOIC ACIDS; HUMANS; MOLECULAR CONFORMATION; PPAR GAMMA; RECOMBINANT PROTEINS; SHEEP; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 80052576382 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2011.08.003 Document Type: Article

Times cited : (16)

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