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Volumn 19, Issue 18, 2011, Pages 5612-5627
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De novo design, synthesis and biological evaluation of 1,4-dihydroquinolin- 4-ones and 1,2,3,4-tetrahydroquinazolin-4-ones as potent kinesin spindle protein (KSP) inhibitors
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Author keywords
1,2,3,4 Tetrahydroquinazolin 4 one; 1,4 Dihydroquinolin 4 one; Anti proliferation; Apoptosis inducer; Inhibitor; Kinesin spindle protein
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Indexed keywords
1,2,3,4 TETRAHYDROQUINAZOLIN 4 ONE DERIVATIVE;
1,4 DIHYDROQUINOLIN 4 ONE DERIVATIVE;
2 (3' HYDROXYPHENYL) 3 BENZYL 6 (MORPHILIN 4 YL) 1,4 DIHYDROQUINOLINE 4 ONE;
2 (3' HYDROXYPHENYL) 3 BENZYL 6 (PIPERIDIN 1 YL) 1,2,3,4 TETRAHYDRO 1H QUINOLIN 4 ONE;
2 (3' HYDROXYPHENYL) 3 BENZYL 6 (PIPERIDIN 1 YL) 1,4 DIHYDROQUINOLINE 4 ONE;
2 (3' HYDROXYPHENYL) 3 BENZYL 6 (PYRROLIDIN 1 YL) 1,2,3,4 TETRAHYDRO 1H QUINOLIN 4 ONE;
2 (3' HYDROXYPHENYL) 3 METHYL 6 (4 METHYLPIPERAZIN 1 YL) 1,4 DIHYDROQUINOLINE 4 ONE;
2 (3' HYDROXYPHENYL) 3 METHYL 6 (MORPHILIN 4 YL) 1,4 DIHYDROQUINOLINE 4 ONE;
2 (3' HYDROXYPHENYL) 3 METHYL 6 (PIPERIDIN 1 YL) 1,4 DIHYDROQUINOLINE 4 ONE;
2 (3' HYDROXYPHENYL) 3 METHYL 6 (PYRROLIDIN 1 YL) 1,2,3,4 TETRAHYDRO 1H QUINAZOLIN 4 ONE;
2 (4' HYDROXYPHENYL) 3 BENZYL 6 (PIPERIDIN 1 YL) 1,2,3,4 TETRAHYDRO 1H QUINOLIN 4 ONE;
2 (4' HYDROXYPHENYL) 3 BENZYL 6 (PIPERIDIN 1 YL) 1,4 DIHYDROQUINOLINE 4 ONE;
2 (4' HYDROXYPHENYL) 3 BENZYL 6 (PYRROLIDIN 1 YL) 1,2,3,4 TETRAHYDRO 1H QUINOLIN 4 ONE;
2 (4' HYDROXYPHENYL) 3 METHYL 6 (4 METHYLPIPERAZIN 1 YL) 1,4 DIHYDROQUINOLINE 4 ONE;
2 (4' HYDROXYPHENYL) 3 METHYL 6 (MORPHILIN 4 YL) 1,2,3,4 TETRAHYDRO 1H QUINAZOLIN 4 ONE;
2 (4' HYDROXYPHENYL) 3 METHYL 6 (PIPERIDIN 1 YL) 1,2,3,4 TETRAHYDRO 1H QUINAZOLIN 4 ONE;
2 (4' HYDROXYPHENYL) 3 METHYL 6 (PIPERIDIN 1 YL) 1,4 DIHYDROQUINOLINE 4 ONE;
2 (4' HYDROXYPHENYL) 3 METHYL 6 (PYRROLIDIN 1 YL) 1,2,3,4 TETRAHYDRO 1H QUINAZOLIN 4 ONE;
2 PHENYL 3 BENZYL 6 (PIPERIDIN 1 YL) 1,2,3,4 TETRAHYDRO 1H QUINAZOLIN 4 ONE;
2 PHENYL 3 METHYL 6 (4 METHYLPIPERAZIN 1 YL) 1,4 DIHYDROQUINOLINE 4 ONE;
2 PHENYL 3 METHYL 6 (MORPHILIN 4 YL) 1,2,3,4 TETRAHYDRO 1H QUINAZOLIN 4 ONE;
2 PHENYL 3 METHYL 6 (MORPHILIN 4 YL) 1,4 DIHYDROQUINOLINE 4 ONE;
2 PHENYL 3 METHYL 6 (PIPERIDIN 1 YL) 1,4 DIHYDROQUINOLINE 4 ONE;
2 PHENYL 3 METHYL 6 (PYRROLIDIN 1 YL) 1,2,3,4 TETRAHYDRO 1H QUINAZOLIN 4 ONE;
5 CHLORO 2 NITROACETOPHENONE;
CK 0106023;
KINESIN SPINDLE PROTEIN INHIBITOR;
MONASTROL;
PROTEIN INHIBITOR;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
ANIMAL CELL;
ANIMAL EXPERIMENT;
ANIMAL MODEL;
ANTINEOPLASTIC ACTIVITY;
APOPTOSIS;
ARTICLE;
CANCER INHIBITION;
CELL CYCLE ARREST;
CELL CYCLE G2 PHASE;
CELL CYCLE M PHASE;
CELL DEATH;
CELL PROLIFERATION;
CONTROLLED STUDY;
DRUG CYTOTOXICITY;
DRUG DESIGN;
DRUG POTENCY;
DRUG PROTEIN BINDING;
DRUG STRUCTURE;
DRUG SYNTHESIS;
DRUG TOLERABILITY;
HUMAN;
HUMAN CELL;
IC 50;
IN VITRO STUDY;
IN VIVO STUDY;
MITOSIS SPINDLE;
MOUSE;
NONHUMAN;
SARCOMA;
ANIMALS;
ANTINEOPLASTIC AGENTS;
CELL CYCLE;
CELL DEATH;
CELL LINE, TUMOR;
CELL PROLIFERATION;
DOSE-RESPONSE RELATIONSHIP, DRUG;
DRUG DESIGN;
HUMANS;
KINESIN;
MICE;
MICE, INBRED ICR;
MODELS, MOLECULAR;
MOLECULAR STRUCTURE;
QUINOLONES;
SARCOMA 180;
STEREOISOMERISM;
STRUCTURE-ACTIVITY RELATIONSHIP;
TETRAHYDRONAPHTHALENES;
XENOGRAFT MODEL ANTITUMOR ASSAYS;
MUS;
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EID: 80052576062
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2011.07.029 Document Type: Article |
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Times cited : (25)
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References (25)
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