메뉴 건너뛰기




Volumn 6, Issue 9, 2011, Pages

The locus coeruleus is directly implicated in l-Dopa-Induced dyskinesia in parkinsonian rats: An electrophysiological and behavioural study

Author keywords

[No Author keywords available]

Indexed keywords

2 BROMO N (2 CHLOROETHYL) N ETHYLBENZYLAMINE; IBOTENIC ACID; LEVODOPA; AMPHETAMINE;

EID: 80052567233     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024679     Document Type: Article
Times cited : (47)

References (89)
  • 2
    • 0023874410 scopus 로고
    • Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implications
    • Kish SJ, Shannak K, Hornykiewicz O, (1988) Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implications. N Engl J Med 318: 876-880.
    • (1988) N Engl J Med , vol.318 , pp. 876-880
    • Kish, S.J.1    Shannak, K.2    Hornykiewicz, O.3
  • 3
    • 0035353725 scopus 로고    scopus 로고
    • Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature
    • Ahlskog JE, Muenter MD, (2001) Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature. Mov Disord 16: 448-458.
    • (2001) Mov Disord , vol.16 , pp. 448-458
    • Ahlskog, J.E.1    Muenter, M.D.2
  • 4
    • 72649085036 scopus 로고    scopus 로고
    • Dopamine receptors and L-dopa-induced dyskinesia
    • Berthet A, Bezard E, (2009) Dopamine receptors and L-dopa-induced dyskinesia. Parkinsonism Relat Disord 15 (Suppl 4): S8-12.
    • (2009) Parkinsonism Relat Disord , vol.15 , Issue.SUPPL. 4 , pp. 8-12
    • Berthet, A.1    Bezard, E.2
  • 5
    • 77955380256 scopus 로고    scopus 로고
    • Maladaptive striatal plasticity in L-DOPA-induced dyskinesia
    • Cenci MA, Konradi C, (2010) Maladaptive striatal plasticity in L-DOPA-induced dyskinesia. Prog Brain Res 183: 209-233.
    • (2010) Prog Brain Res , vol.183 , pp. 209-233
    • Cenci, M.A.1    Konradi, C.2
  • 6
    • 0033695441 scopus 로고    scopus 로고
    • Levodopa motor complications in Parkinson's disease
    • Obeso JA, Olanow CW, Nutt JG, (2000) Levodopa motor complications in Parkinson's disease. Trends Neurosci 23: S2-7.
    • (2000) Trends Neurosci , vol.23 , pp. 2-7
    • Obeso, J.A.1    Olanow, C.W.2    Nutt, J.G.3
  • 7
    • 40749157838 scopus 로고    scopus 로고
    • Advances in understanding L-DOPA-induced dyskinesia
    • Cenci MA, Lindgren HS, (2007) Advances in understanding L-DOPA-induced dyskinesia. Curr Opin Neurobiol 17: 665-671.
    • (2007) Curr Opin Neurobiol , vol.17 , pp. 665-671
    • Cenci, M.A.1    Lindgren, H.S.2
  • 8
    • 20544476874 scopus 로고    scopus 로고
    • The 'magic' of L-dopa: why is it the gold standard Parkinson's disease therapy?
    • Mercuri NB, Bernardi G, (2005) The 'magic' of L-dopa: why is it the gold standard Parkinson's disease therapy? Trends Pharmacol Sci 26: 341-344.
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 341-344
    • Mercuri, N.B.1    Bernardi, G.2
  • 9
    • 77953358302 scopus 로고    scopus 로고
    • Binding of dopamine and 3-methoxytyramine as l-DOPA metabolites to human alpha(2)-adrenergic and dopaminergic receptors
    • Alachkar A, Brotchie JM, Jones OT, (2010) Binding of dopamine and 3-methoxytyramine as l-DOPA metabolites to human alpha(2)-adrenergic and dopaminergic receptors. Neurosci Res 67: 245-249.
    • (2010) Neurosci Res , vol.67 , pp. 245-249
    • Alachkar, A.1    Brotchie, J.M.2    Jones, O.T.3
  • 10
    • 0037337815 scopus 로고    scopus 로고
    • Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases
    • Zarow C, Lyness SA, Mortimer JA, Chui HC, (2003) Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases. Arch Neurol 60: 337-341.
    • (2003) Arch Neurol , vol.60 , pp. 337-341
    • Zarow, C.1    Lyness, S.A.2    Mortimer, J.A.3    Chui, H.C.4
  • 11
    • 58349087872 scopus 로고    scopus 로고
    • The neuropathological basis for depression in Parkinson's disease
    • Frisina PG, Haroutunian V, Libow LS, (2009) The neuropathological basis for depression in Parkinson's disease. Parkinsonism Relat Disord 15: 144-148.
    • (2009) Parkinsonism Relat Disord , vol.15 , pp. 144-148
    • Frisina, P.G.1    Haroutunian, V.2    Libow, L.S.3
  • 13
    • 0031682676 scopus 로고    scopus 로고
    • Biochemical aspects of Parkinson's disease
    • Hornykiewicz O, (1998) Biochemical aspects of Parkinson's disease. Neurology 51: S2-9.
    • (1998) Neurology , vol.51 , pp. 2-9
    • Hornykiewicz, O.1
  • 14
    • 20444477480 scopus 로고    scopus 로고
    • Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system
    • Remy P, Doder M, Lees A, Turjanski N, Brooks D, (2005) Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system. Brain 128: 1314-1322.
    • (2005) Brain , vol.128 , pp. 1314-1322
    • Remy, P.1    Doder, M.2    Lees, A.3    Turjanski, N.4    Brooks, D.5
  • 15
    • 33947302427 scopus 로고    scopus 로고
    • Modulation of L-DOPA-induced abnormal involuntary movements by clinically tested compounds: further validation of the rat dyskinesia model
    • Dekundy A, Lundblad M, Danysz W, Cenci MA, (2007) Modulation of L-DOPA-induced abnormal involuntary movements by clinically tested compounds: further validation of the rat dyskinesia model. Behav Brain Res 179: 76-89.
    • (2007) Behav Brain Res , vol.179 , pp. 76-89
    • Dekundy, A.1    Lundblad, M.2    Danysz, W.3    Cenci, M.A.4
  • 16
    • 0027384928 scopus 로고
    • Effect of nondopaminergic drugs on L-dopa-induced dyskinesias in MPTP-treated monkeys
    • Gomez-Mancilla B, Bedard PJ, (1993) Effect of nondopaminergic drugs on L-dopa-induced dyskinesias in MPTP-treated monkeys. Clin Neuropharmacol 16: 418-427.
    • (1993) Clin Neuropharmacol , vol.16 , pp. 418-427
    • Gomez-Mancilla, B.1    Bedard, P.J.2
  • 17
    • 0042474326 scopus 로고    scopus 로고
    • Fipamezole (JP-1730) is a potent alpha2 adrenergic receptor antagonist that reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease
    • Savola JM, Hill M, Engstrom M, Merivuori H, Wurster S, et al. (2003) Fipamezole (JP-1730) is a potent alpha2 adrenergic receptor antagonist that reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease. Mov Disord 18: 872-883.
    • (2003) Mov Disord , vol.18 , pp. 872-883
    • Savola, J.M.1    Hill, M.2    Engstrom, M.3    Merivuori, H.4    Wurster, S.5
  • 18
    • 0032588996 scopus 로고    scopus 로고
    • The alpha2-adrenergic receptor antagonist idazoxan reduces dyskinesia and enhances anti-parkinsonian actions of L-dopa in the MPTP-lesioned primate model of Parkinson's disease
    • Henry B, Fox SH, Peggs D, Crossman AR, Brotchie JM, (1999) The alpha2-adrenergic receptor antagonist idazoxan reduces dyskinesia and enhances anti-parkinsonian actions of L-dopa in the MPTP-lesioned primate model of Parkinson's disease. Mov Disord 14: 744-753.
    • (1999) Mov Disord , vol.14 , pp. 744-753
    • Henry, B.1    Fox, S.H.2    Peggs, D.3    Crossman, A.R.4    Brotchie, J.M.5
  • 19
    • 0035412923 scopus 로고    scopus 로고
    • Neural mechanisms underlying peak-dose dyskinesia induced by levodopa and apomorphine are distinct: evidence from the effects of the alpha(2) adrenoceptor antagonist idazoxan
    • Fox SH, Henry B, Hill MP, Peggs D, Crossman AR, et al. (2001) Neural mechanisms underlying peak-dose dyskinesia induced by levodopa and apomorphine are distinct: evidence from the effects of the alpha(2) adrenoceptor antagonist idazoxan. Mov Disord 16: 642-650.
    • (2001) Mov Disord , vol.16 , pp. 642-650
    • Fox, S.H.1    Henry, B.2    Hill, M.P.3    Peggs, D.4    Crossman, A.R.5
  • 20
    • 0035412888 scopus 로고    scopus 로고
    • Idazoxan, an alpha-2 antagonist, and L-DOPA-induced dyskinesias in patients with Parkinson's disease
    • Rascol O, Arnulf I, Peyro-Saint Paul H, Brefel-Courbon C, Vidailhet M, et al. (2001) Idazoxan, an alpha-2 antagonist, and L-DOPA-induced dyskinesias in patients with Parkinson's disease. Mov Disord 16: 708-713.
    • (2001) Mov Disord , vol.16 , pp. 708-713
    • Rascol, O.1    Arnulf, I.2    Peyro-Saint Paul, H.3    Brefel-Courbon, C.4    Vidailhet, M.5
  • 21
    • 59149087458 scopus 로고    scopus 로고
    • Alpha1-adrenoceptors mediate dihydroxyphenylalanine-induced activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaques
    • Visanji NP, Fox SH, Johnston TH, Millan MJ, Brotchie JM, (2009) Alpha1-adrenoceptors mediate dihydroxyphenylalanine-induced activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaques. J Pharmacol Exp Ther 328: 276-283.
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 276-283
    • Visanji, N.P.1    Fox, S.H.2    Johnston, T.H.3    Millan, M.J.4    Brotchie, J.M.5
  • 23
    • 0033050159 scopus 로고    scopus 로고
    • Dependence of serotonin release in the locus coeruleus on dorsal raphe neuronal activity
    • Kaehler ST, Singewald N, Philippu A, (1999) Dependence of serotonin release in the locus coeruleus on dorsal raphe neuronal activity. Naunyn Schmiedebergs Arch Pharmacol 359: 386-393.
    • (1999) Naunyn Schmiedebergs Arch Pharmacol , vol.359 , pp. 386-393
    • Kaehler, S.T.1    Singewald, N.2    Philippu, A.3
  • 24
    • 0032693049 scopus 로고    scopus 로고
    • The release of catecholamines in hypothalamus and locus coeruleus is modulated by peripheral chemoreceptors
    • Kaehler ST, Singewald N, Philippu A, (1999) The release of catecholamines in hypothalamus and locus coeruleus is modulated by peripheral chemoreceptors. Naunyn Schmiedebergs Arch Pharmacol 360: 428-434.
    • (1999) Naunyn Schmiedebergs Arch Pharmacol , vol.360 , pp. 428-434
    • Kaehler, S.T.1    Singewald, N.2    Philippu, A.3
  • 25
    • 44849137636 scopus 로고    scopus 로고
    • Possible dopaminergic stimulation of locus coeruleus alpha1-adrenoceptors involved in behavioral activation
    • Lin Y, Quartermain D, Dunn AJ, Weinshenker D, Stone EA, (2008) Possible dopaminergic stimulation of locus coeruleus alpha1-adrenoceptors involved in behavioral activation. Synapse 62: 516-523.
    • (2008) Synapse , vol.62 , pp. 516-523
    • Lin, Y.1    Quartermain, D.2    Dunn, A.J.3    Weinshenker, D.4    Stone, E.A.5
  • 26
    • 0017741055 scopus 로고
    • Catecholamine receptors on locus coeruleus neurons: pharmacological characterization
    • Cedarbaum JM, Aghajanian GK, (1977) Catecholamine receptors on locus coeruleus neurons: pharmacological characterization. Eur J Pharmacol 44: 375-385.
    • (1977) Eur J Pharmacol , vol.44 , pp. 375-385
    • Cedarbaum, J.M.1    Aghajanian, G.K.2
  • 27
    • 0022478763 scopus 로고
    • Electrophysiological effects of the enantiomers of 3-PPP on neurons in the locus coeruleus of the rat
    • Elam M, Clark D, Svensson TH, (1986) Electrophysiological effects of the enantiomers of 3-PPP on neurons in the locus coeruleus of the rat. Neuropharmacology 25: 1003-1008.
    • (1986) Neuropharmacology , vol.25 , pp. 1003-1008
    • Elam, M.1    Clark, D.2    Svensson, T.H.3
  • 28
    • 79952769776 scopus 로고    scopus 로고
    • Locus coeruleus and dorsal raphe neuron activity and response to acute antidepressant administration in a rat model of Parkinson's disease
    • Miguelez C, Grandoso L, Ugedo L, (2010) Locus coeruleus and dorsal raphe neuron activity and response to acute antidepressant administration in a rat model of Parkinson's disease. Int J Neuropsychopharmacol pp. 1-14.
    • (2010) Int J Neuropsychopharmacol , pp. 1-14
    • Miguelez, C.1    Grandoso, L.2    Ugedo, L.3
  • 29
    • 35448979969 scopus 로고    scopus 로고
    • Noradrenaline in Parkinson's disease: from disease progression to current therapeutics
    • Fornai F, di Poggio AB, Pellegrini A, Ruggieri S, Paparelli A, (2007) Noradrenaline in Parkinson's disease: from disease progression to current therapeutics. Curr Med Chem 14: 2330-2334.
    • (2007) Curr Med Chem , vol.14 , pp. 2330-2334
    • Fornai, F.1    Di Poggio, A.B.2    Pellegrini, A.3    Ruggieri, S.4    Paparelli, A.5
  • 30
    • 33846646618 scopus 로고    scopus 로고
    • Abnormal involuntary movements (AIMs) following pulsatile dopaminergic stimulation: severe deterioration and morphological correlates following the loss of locus coeruleus neurons
    • Fulceri F, Biagioni F, Ferrucci M, Lazzeri G, Bartalucci A, et al. (2007) Abnormal involuntary movements (AIMs) following pulsatile dopaminergic stimulation: severe deterioration and morphological correlates following the loss of locus coeruleus neurons. Brain Res 1135: 219-229.
    • (2007) Brain Res , vol.1135 , pp. 219-229
    • Fulceri, F.1    Biagioni, F.2    Ferrucci, M.3    Lazzeri, G.4    Bartalucci, A.5
  • 31
    • 35348916611 scopus 로고    scopus 로고
    • Modulation of the motor response to dopaminergic drugs in a parkinsonian model of combined dopaminergic and noradrenergic degeneration
    • Perez V, Sosti V, Rubio A, Barbanoj M, Rodriguez-Alvarez J, et al. (2007) Modulation of the motor response to dopaminergic drugs in a parkinsonian model of combined dopaminergic and noradrenergic degeneration. Eur J Pharmacol 576: 83-90.
    • (2007) Eur J Pharmacol , vol.576 , pp. 83-90
    • Perez, V.1    Sosti, V.2    Rubio, A.3    Barbanoj, M.4    Rodriguez-Alvarez, J.5
  • 32
    • 49749111104 scopus 로고    scopus 로고
    • Effect of locus coeruleus denervation on levodopa-induced motor fluctuations in hemiparkinsonian rats
    • Marin C, Aguilar E, Bonastre M, (2008) Effect of locus coeruleus denervation on levodopa-induced motor fluctuations in hemiparkinsonian rats. J Neural Transm.
    • (2008) J Neural Transm
    • Marin, C.1    Aguilar, E.2    Bonastre, M.3
  • 33
    • 0031925945 scopus 로고    scopus 로고
    • L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA
    • Cenci MA, Lee CS, Bjorklund A, (1998) L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA. Eur J Neurosci 10: 2694-2706.
    • (1998) Eur J Neurosci , vol.10 , pp. 2694-2706
    • Cenci, M.A.1    Lee, C.S.2    Bjorklund, A.3
  • 34
    • 74449090187 scopus 로고    scopus 로고
    • A comprehensive analysis of the effect of DSP4 on the locus coeruleus noradrenergic system in the rat
    • Szot P, Miguelez C, White SS, Franklin A, Sikkema C, et al. (2010) A comprehensive analysis of the effect of DSP4 on the locus coeruleus noradrenergic system in the rat. Neuroscience 166: 279-291.
    • (2010) Neuroscience , vol.166 , pp. 279-291
    • Szot, P.1    Miguelez, C.2    White, S.S.3    Franklin, A.4    Sikkema, C.5
  • 36
    • 33644813224 scopus 로고    scopus 로고
    • Role of striatal L-DOPA in the production of dyskinesia in 6-hydroxydopamine lesioned rats
    • Carta M, Lindgren HS, Lundblad M, Stancampiano R, Fadda F, et al. (2006) Role of striatal L-DOPA in the production of dyskinesia in 6-hydroxydopamine lesioned rats. J Neurochem 96: 1718-1727.
    • (2006) J Neurochem , vol.96 , pp. 1718-1727
    • Carta, M.1    Lindgren, H.S.2    Lundblad, M.3    Stancampiano, R.4    Fadda, F.5
  • 37
    • 0036070538 scopus 로고    scopus 로고
    • L-DOPA-induced dyskinesia in the intrastriatal 6-hydroxydopamine model of parkinson's disease: relation to motor and cellular parameters of nigrostriatal function
    • Winkler C, Kirik D, Bjorklund A, Cenci MA, (2002) L-DOPA-induced dyskinesia in the intrastriatal 6-hydroxydopamine model of parkinson's disease: relation to motor and cellular parameters of nigrostriatal function. Neurobiol Dis 10: 165-186.
    • (2002) Neurobiol Dis , vol.10 , pp. 165-186
    • Winkler, C.1    Kirik, D.2    Bjorklund, A.3    Cenci, M.A.4
  • 38
    • 0036459952 scopus 로고    scopus 로고
    • Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease
    • Lundblad M, Andersson M, Winkler C, Kirik D, Wierup N, et al. (2002) Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease. Eur J Neurosci 15: 120-132.
    • (2002) Eur J Neurosci , vol.15 , pp. 120-132
    • Lundblad, M.1    Andersson, M.2    Winkler, C.3    Kirik, D.4    Wierup, N.5
  • 39
    • 44049103762 scopus 로고    scopus 로고
    • Ratings of L-DOPA-induced dyskinesia in the unilateral 6-OHDA lesion model of Parkinson's disease in rats and mice
    • Chapter 9: Unit 9
    • Cenci MA, Lundblad M, (2007) Ratings of L-DOPA-induced dyskinesia in the unilateral 6-OHDA lesion model of Parkinson's disease in rats and mice. Curr Protoc Neurosci Chapter 9: Unit 9 25.
    • (2007) Curr Protoc Neurosci , vol.25
    • Cenci, M.A.1    Lundblad, M.2
  • 40
    • 15044365742 scopus 로고    scopus 로고
    • Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors
    • Carlsson T, Winkler C, Burger C, Muzyczka N, Mandel RJ, et al. (2005) Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors. Brain 128: 559-569.
    • (2005) Brain , vol.128 , pp. 559-569
    • Carlsson, T.1    Winkler, C.2    Burger, C.3    Muzyczka, N.4    Mandel, R.J.5
  • 41
    • 0033932460 scopus 로고    scopus 로고
    • Embryonic ventral mesencephalic grafts improve levodopa-induced dyskinesia in a rat model of Parkinson's disease
    • Lee CS, Cenci MA, Schulzer M, Bjorklund A, (2000) Embryonic ventral mesencephalic grafts improve levodopa-induced dyskinesia in a rat model of Parkinson's disease. Brain 123 (Pt7): 1365-1379.
    • (2000) Brain , vol.123 , Issue.Pt7 , pp. 1365-1379
    • Lee, C.S.1    Cenci, M.A.2    Schulzer, M.3    Bjorklund, A.4
  • 42
    • 77349086589 scopus 로고    scopus 로고
    • L-DOPA-induced dopamine efflux in the striatum and the substantia nigra in a rat model of Parkinson's disease: temporal and quantitative relationship to the expression of dyskinesia
    • Lindgren HS, Andersson DR, Lagerkvist S, Nissbrandt H, Cenci MA, (2010) L-DOPA-induced dopamine efflux in the striatum and the substantia nigra in a rat model of Parkinson's disease: temporal and quantitative relationship to the expression of dyskinesia. J Neurochem 112: 1465-1476.
    • (2010) J Neurochem , vol.112 , pp. 1465-1476
    • Lindgren, H.S.1    Andersson, D.R.2    Lagerkvist, S.3    Nissbrandt, H.4    Cenci, M.A.5
  • 43
    • 33845976016 scopus 로고    scopus 로고
    • The "motor complication syndrome" in rats with 6-OHDA lesions treated chronically with L-DOPA: relation to dose and route of administration
    • Lindgren HS, Rylander D, Ohlin KE, Lundblad M, Cenci MA, (2007) The "motor complication syndrome" in rats with 6-OHDA lesions treated chronically with L-DOPA: relation to dose and route of administration. Behav Brain Res 177: 150-159.
    • (2007) Behav Brain Res , vol.177 , pp. 150-159
    • Lindgren, H.S.1    Rylander, D.2    Ohlin, K.E.3    Lundblad, M.4    Cenci, M.A.5
  • 44
    • 67349239317 scopus 로고    scopus 로고
    • alpha(2)-Adrenoceptors mediate the acute inhibitory effect of fluoxetine on locus coeruleus noradrenergic neurons
    • Miguelez C, Fernandez-Aedo I, Torrecilla M, Grandoso L, Ugedo L, (2009) alpha(2)-Adrenoceptors mediate the acute inhibitory effect of fluoxetine on locus coeruleus noradrenergic neurons. Neuropharmacology 56: 1068-1073.
    • (2009) Neuropharmacology , vol.56 , pp. 1068-1073
    • Miguelez, C.1    Fernandez-Aedo, I.2    Torrecilla, M.3    Grandoso, L.4    Ugedo, L.5
  • 45
    • 0021718376 scopus 로고
    • The control of firing pattern in nigral dopamine neurons: burst firing
    • Grace AA, Bunney BS, (1984) The control of firing pattern in nigral dopamine neurons: burst firing. J Neurosci 4: 2877-2890.
    • (1984) J Neurosci , vol.4 , pp. 2877-2890
    • Grace, A.A.1    Bunney, B.S.2
  • 46
    • 0017164341 scopus 로고
    • Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the alpha-antagonist piperoxane
    • Cedarbaum JM, Aghajanian GK, (1976) Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the alpha-antagonist piperoxane. Brain Res 112: 413-419.
    • (1976) Brain Res , vol.112 , pp. 413-419
    • Cedarbaum, J.M.1    Aghajanian, G.K.2
  • 47
    • 0035477920 scopus 로고    scopus 로고
    • Olanzapine activates the rat locus coeruleus: in vivo electrophysiology and c-Fos immunoreactivity
    • Dawe GS, Huff KD, Vandergriff JL, Sharp T, O'Neill MJ, et al. (2001) Olanzapine activates the rat locus coeruleus: in vivo electrophysiology and c-Fos immunoreactivity. Biol Psychiatry 50: 510-520.
    • (2001) Biol Psychiatry , vol.50 , pp. 510-520
    • Dawe, G.S.1    Huff, K.D.2    Vandergriff, J.L.3    Sharp, T.4    O'Neill, M.J.5
  • 48
    • 33646425853 scopus 로고    scopus 로고
    • Electrophysiological characterization of substantia nigra dopaminergic neurons in partially lesioned rats: effects of subthalamotomy and levodopa treatment
    • Bilbao G, Ruiz-Ortega JA, Miguens N, Ulibarri I, Linazasoro G, et al. (2006) Electrophysiological characterization of substantia nigra dopaminergic neurons in partially lesioned rats: effects of subthalamotomy and levodopa treatment. Brain Res 1084: 175-184.
    • (2006) Brain Res , vol.1084 , pp. 175-184
    • Bilbao, G.1    Ruiz-Ortega, J.A.2    Miguens, N.3    Ulibarri, I.4    Linazasoro, G.5
  • 49
    • 38749125491 scopus 로고    scopus 로고
    • Involvement of subthalamic nucleus in the stimulatory effect of Delta(9)-tetrahydrocannabinol on dopaminergic neurons
    • Morera-Herreras T, Ruiz-Ortega JA, Gomez-Urquijo S, Ugedo L, (2008) Involvement of subthalamic nucleus in the stimulatory effect of Delta(9)-tetrahydrocannabinol on dopaminergic neurons. Neuroscience 151: 817-823.
    • (2008) Neuroscience , vol.151 , pp. 817-823
    • Morera-Herreras, T.1    Ruiz-Ortega, J.A.2    Gomez-Urquijo, S.3    Ugedo, L.4
  • 50
    • 72449198035 scopus 로고    scopus 로고
    • Two opposite effects of Delta(9)-tetrahydrocannabinol on subthalamic nucleus neuron activity: involvement of GABAergic and glutamatergic neurotransmission
    • Morera-Herreras T, Ruiz-Ortega JA, Ugedo L, (2010) Two opposite effects of Delta(9)-tetrahydrocannabinol on subthalamic nucleus neuron activity: involvement of GABAergic and glutamatergic neurotransmission. Synapse 64: 20-29.
    • (2010) Synapse , vol.64 , pp. 20-29
    • Morera-Herreras, T.1    Ruiz-Ortega, J.A.2    Ugedo, L.3
  • 51
    • 0035104574 scopus 로고    scopus 로고
    • Dopamine agonist-induced dyskinesias are correlated to both firing pattern and frequency alterations of pallidal neurones in the MPTP-treated monkey
    • Boraud T, Bezard E, Bioulac B, Gross CE, (2001) Dopamine agonist-induced dyskinesias are correlated to both firing pattern and frequency alterations of pallidal neurones in the MPTP-treated monkey. Brain 124: 546-557.
    • (2001) Brain , vol.124 , pp. 546-557
    • Boraud, T.1    Bezard, E.2    Bioulac, B.3    Gross, C.E.4
  • 52
    • 33744811731 scopus 로고    scopus 로고
    • Increased slow oscillatory activity in substantia nigra pars reticulata triggers abnormal involuntary movements in the 6-OHDA-lesioned rat in the presence of excessive extracellular striatal dopamine
    • Meissner W, Ravenscroft P, Reese R, Harnack D, Morgenstern R, et al. (2006) Increased slow oscillatory activity in substantia nigra pars reticulata triggers abnormal involuntary movements in the 6-OHDA-lesioned rat in the presence of excessive extracellular striatal dopamine. Neurobiol Dis 22: 586-598.
    • (2006) Neurobiol Dis , vol.22 , pp. 586-598
    • Meissner, W.1    Ravenscroft, P.2    Reese, R.3    Harnack, D.4    Morgenstern, R.5
  • 53
    • 33750975077 scopus 로고    scopus 로고
    • Clinical correlates of levodopa-induced dopamine release in Parkinson disease: a PET study
    • Pavese N, Evans AH, Tai YF, Hotton G, Brooks DJ, et al. (2006) Clinical correlates of levodopa-induced dopamine release in Parkinson disease: a PET study. Neurology 67: 1612-1617.
    • (2006) Neurology , vol.67 , pp. 1612-1617
    • Pavese, N.1    Evans, A.H.2    Tai, Y.F.3    Hotton, G.4    Brooks, D.J.5
  • 54
    • 46749091342 scopus 로고    scopus 로고
    • Reuptake of L-DOPA-derived extracellular DA in the striatum of a rodent model of Parkinson's disease via norepinephrine transporter
    • Arai A, Tomiyama M, Kannari K, Kimura T, Suzuki C, et al. (2008) Reuptake of L-DOPA-derived extracellular DA in the striatum of a rodent model of Parkinson's disease via norepinephrine transporter. Synapse 62: 632-635.
    • (2008) Synapse , vol.62 , pp. 632-635
    • Arai, A.1    Tomiyama, M.2    Kannari, K.3    Kimura, T.4    Suzuki, C.5
  • 55
    • 84858863974 scopus 로고    scopus 로고
    • Changes in the mRNA Levels of alpha(2A) and alpha (2C) Adrenergic Receptors in Rat Models of Parkinson's Disease and L: -DOPA-Induced Dyskinesia
    • Alachkar A, Brotchie JM, Jones OT, (2011) Changes in the mRNA Levels of alpha(2A) and alpha (2C) Adrenergic Receptors in Rat Models of Parkinson's Disease and L:-DOPA-Induced Dyskinesia. J Mol Neurosci.
    • (2011) J Mol Neurosci
    • Alachkar, A.1    Brotchie, J.M.2    Jones, O.T.3
  • 57
    • 0028237781 scopus 로고
    • Subthalamic nucleus modulates burst firing of nigral dopamine neurones via NMDA receptors
    • Chergui K, Akaoka H, Charlety PJ, Saunier CF, Buda M, et al. (1994) Subthalamic nucleus modulates burst firing of nigral dopamine neurones via NMDA receptors. Neuroreport 5: 1185-1188.
    • (1994) Neuroreport , vol.5 , pp. 1185-1188
    • Chergui, K.1    Akaoka, H.2    Charlety, P.J.3    Saunier, C.F.4    Buda, M.5
  • 58
    • 0018657086 scopus 로고
    • Phasic firing enhances vasopressin release from the rat neurohypophysis
    • Dutton A, Dyball RE, (1979) Phasic firing enhances vasopressin release from the rat neurohypophysis. J Physiol 290: 433-440.
    • (1979) J Physiol , vol.290 , pp. 433-440
    • Dutton, A.1    Dyball, R.E.2
  • 59
    • 0022618750 scopus 로고
    • Frequency- and reserpine-dependent chemical coding of sympathetic transmission: differential release of noradrenaline and neuropeptide Y from pig spleen
    • Lundberg JM, Rudehill A, Sollevi A, Theodorsson-Norheim E, Hamberger B, (1986) Frequency- and reserpine-dependent chemical coding of sympathetic transmission: differential release of noradrenaline and neuropeptide Y from pig spleen. Neurosci Lett 63: 96-100.
    • (1986) Neurosci Lett , vol.63 , pp. 96-100
    • Lundberg, J.M.1    Rudehill, A.2    Sollevi, A.3    Theodorsson-Norheim, E.4    Hamberger, B.5
  • 60
    • 0023863123 scopus 로고
    • Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry
    • Gonon FG, (1988) Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry. Neuroscience 24: 19-28.
    • (1988) Neuroscience , vol.24 , pp. 19-28
    • Gonon, F.G.1
  • 61
    • 0032103897 scopus 로고    scopus 로고
    • Characterization of enhanced behavioral responses to L-DOPA following repeated administration in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease
    • Henry B, Crossman AR, Brotchie JM, (1998) Characterization of enhanced behavioral responses to L-DOPA following repeated administration in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease. Exp Neurol 151: 334-342.
    • (1998) Exp Neurol , vol.151 , pp. 334-342
    • Henry, B.1    Crossman, A.R.2    Brotchie, J.M.3
  • 62
    • 72849153132 scopus 로고    scopus 로고
    • The alpha(2) adrenoceptor antagonist idazoxan alleviates L-DOPA-induced dyskinesia by reduction of striatal dopamine levels: an in vivo microdialysis study in 6-hydroxydopamine-lesioned rats
    • Buck K, Voehringer P, Ferger B, (2010) The alpha(2) adrenoceptor antagonist idazoxan alleviates L-DOPA-induced dyskinesia by reduction of striatal dopamine levels: an in vivo microdialysis study in 6-hydroxydopamine-lesioned rats. J Neurochem 112: 444-452.
    • (2010) J Neurochem , vol.112 , pp. 444-452
    • Buck, K.1    Voehringer, P.2    Ferger, B.3
  • 64
    • 0030954423 scopus 로고    scopus 로고
    • Receptor reserve and turnover of alpha-2 adrenoceptors that mediate the clonidine-induced inhibition of rat locus coeruleus neurons in vivo
    • Pineda J, Ruiz-Ortega JA, Ugedo L, (1997) Receptor reserve and turnover of alpha-2 adrenoceptors that mediate the clonidine-induced inhibition of rat locus coeruleus neurons in vivo. J Pharmacol Exp Ther 281: 690-698.
    • (1997) J Pharmacol Exp Ther , vol.281 , pp. 690-698
    • Pineda, J.1    Ruiz-Ortega, J.A.2    Ugedo, L.3
  • 65
    • 0029146358 scopus 로고
    • The stimulatory effect of clonidine on locus coeruleus noradrenergic neurons through imidazoline receptors is modulated by excitatory amino acids
    • Pineda J, Ruiz-Ortega JA, Ugedo L, Garcia-Sevilla JA, (1995) The stimulatory effect of clonidine on locus coeruleus noradrenergic neurons through imidazoline receptors is modulated by excitatory amino acids. Ann N Y Acad Sci 763: 501-505.
    • (1995) Ann N Y Acad Sci , vol.763 , pp. 501-505
    • Pineda, J.1    Ruiz-Ortega, J.A.2    Ugedo, L.3    Garcia-Sevilla, J.A.4
  • 66
    • 0029112721 scopus 로고
    • The stimulatory effect of clonidine through imidazoline receptors on locus coeruleus noradrenergic neurones is mediated by excitatory amino acids and modulated by serotonin
    • Ruiz-Ortega JA, Ugedo L, Pineda J, Garcia-Sevilla JA, (1995) The stimulatory effect of clonidine through imidazoline receptors on locus coeruleus noradrenergic neurones is mediated by excitatory amino acids and modulated by serotonin. Naunyn Schmiedebergs Arch Pharmacol 352: 121-126.
    • (1995) Naunyn Schmiedebergs Arch Pharmacol , vol.352 , pp. 121-126
    • Ruiz-Ortega, J.A.1    Ugedo, L.2    Pineda, J.3    Garcia-Sevilla, J.A.4
  • 67
    • 0032589304 scopus 로고    scopus 로고
    • Adrenergic alpha2C-receptors reside in rat striatal GABAergic projection neurons: comparison of radioligand binding and immunohistochemistry
    • Holmberg M, Scheinin M, Kurose H, Miettinen R, (1999) Adrenergic alpha2C-receptors reside in rat striatal GABAergic projection neurons: comparison of radioligand binding and immunohistochemistry. Neuroscience 93: 1323-1333.
    • (1999) Neuroscience , vol.93 , pp. 1323-1333
    • Holmberg, M.1    Scheinin, M.2    Kurose, H.3    Miettinen, R.4
  • 69
    • 0029847017 scopus 로고    scopus 로고
    • Distribution of alpha 2C-adrenergic receptor-like immunoreactivity in the rat central nervous system
    • Rosin DL, Talley EM, Lee A, Stornetta RL, Gaylinn BD, et al. (1996) Distribution of alpha 2C-adrenergic receptor-like immunoreactivity in the rat central nervous system. J Comp Neurol 372: 135-165.
    • (1996) J Comp Neurol , vol.372 , pp. 135-165
    • Rosin, D.L.1    Talley, E.M.2    Lee, A.3    Stornetta, R.L.4    Gaylinn, B.D.5
  • 70
    • 70349257159 scopus 로고    scopus 로고
    • Effect of the additional noradrenergic neurodegeneration to 6-OHDA-lesioned rats in levodopa-induced dyskinesias and in cognitive disturbances
    • Perez V, Marin C, Rubio A, Aguilar E, Barbanoj M, et al. (2009) Effect of the additional noradrenergic neurodegeneration to 6-OHDA-lesioned rats in levodopa-induced dyskinesias and in cognitive disturbances. J Neural Transm 116: 1257-1266.
    • (2009) J Neural Transm , vol.116 , pp. 1257-1266
    • Perez, V.1    Marin, C.2    Rubio, A.3    Aguilar, E.4    Barbanoj, M.5
  • 71
    • 0038684223 scopus 로고    scopus 로고
    • Potentiation of parkinsonian symptoms by depletion of locus coeruleus noradrenaline in 6-hydroxydopamine-induced partial degeneration of substantia nigra in rats
    • Srinivasan J, Schmidt WJ, (2003) Potentiation of parkinsonian symptoms by depletion of locus coeruleus noradrenaline in 6-hydroxydopamine-induced partial degeneration of substantia nigra in rats. Eur J Neurosci 17: 2586-2592.
    • (2003) Eur J Neurosci , vol.17 , pp. 2586-2592
    • Srinivasan, J.1    Schmidt, W.J.2
  • 72
    • 33747880216 scopus 로고    scopus 로고
    • Influence of noradrenaline denervation on MPTP-induced deficits in mice
    • Archer T, Fredriksson A, (2006) Influence of noradrenaline denervation on MPTP-induced deficits in mice. J Neural Transm 113: 1119-1129.
    • (2006) J Neural Transm , vol.113 , pp. 1119-1129
    • Archer, T.1    Fredriksson, A.2
  • 73
    • 73149094500 scopus 로고    scopus 로고
    • Noradrenergic lesion of the locus coeruleus increases apomorphine-induced circling behavior and the firing activity of substantia nigra pars reticulata neurons in a rat model of Parkinson's disease
    • Wang Y, Zhang QJ, Liu J, Ali U, Gui ZH, et al. (2010) Noradrenergic lesion of the locus coeruleus increases apomorphine-induced circling behavior and the firing activity of substantia nigra pars reticulata neurons in a rat model of Parkinson's disease. Brain Res 1310: 189-199.
    • (2010) Brain Res , vol.1310 , pp. 189-199
    • Wang, Y.1    Zhang, Q.J.2    Liu, J.3    Ali, U.4    Gui, Z.H.5
  • 74
    • 0024353437 scopus 로고
    • Immunohistochemical analysis of the neurotoxic effects of DSP-4 identifies two populations of noradrenergic axon terminals
    • Fritschy JM, Grzanna R, (1989) Immunohistochemical analysis of the neurotoxic effects of DSP-4 identifies two populations of noradrenergic axon terminals. Neuroscience 30: 181-197.
    • (1989) Neuroscience , vol.30 , pp. 181-197
    • Fritschy, J.M.1    Grzanna, R.2
  • 75
    • 0017177322 scopus 로고
    • Long-term effects of N-2-chlorethyl-N-ethyl-2-bromobenzylamine hydrochloride on noradrenergic neurones in the rat brain and heart
    • Ross SB, (1976) Long-term effects of N-2-chlorethyl-N-ethyl-2-bromobenzylamine hydrochloride on noradrenergic neurones in the rat brain and heart. Br J Pharmacol 58: 521-527.
    • (1976) Br J Pharmacol , vol.58 , pp. 521-527
    • Ross, S.B.1
  • 76
    • 0026085430 scopus 로고
    • Experimentally-induced neuron loss in the locus coeruleus of adult rats
    • Fritschy JM, Grzanna R, (1991) Experimentally-induced neuron loss in the locus coeruleus of adult rats. Exp Neurol 111: 123-127.
    • (1991) Exp Neurol , vol.111 , pp. 123-127
    • Fritschy, J.M.1    Grzanna, R.2
  • 77
    • 0024307175 scopus 로고
    • Partial injury to central noradrenergic neurons: reduction of tissue norepinephrine content is greater than reduction of extracellular norepinephrine measured by microdialysis
    • Abercrombie ED, Zigmond MJ, (1989) Partial injury to central noradrenergic neurons: reduction of tissue norepinephrine content is greater than reduction of extracellular norepinephrine measured by microdialysis. J Neurosci 9: 4062-4067.
    • (1989) J Neurosci , vol.9 , pp. 4062-4067
    • Abercrombie, E.D.1    Zigmond, M.J.2
  • 78
    • 0028024580 scopus 로고
    • Recovery of central noradrenergic neurons one year after the administration of the neurotoxin DSP4
    • Wolfman C, Abo V, Calvo D, Medina J, Dajas F, et al. (1994) Recovery of central noradrenergic neurons one year after the administration of the neurotoxin DSP4. Neurochem Int 25: 395-400.
    • (1994) Neurochem Int , vol.25 , pp. 395-400
    • Wolfman, C.1    Abo, V.2    Calvo, D.3    Medina, J.4    Dajas, F.5
  • 79
    • 0027494752 scopus 로고
    • Electrophysiological changes accompanying DSP-4 lesions of rat locus coeruleus neurons
    • Magnuson DS, Staines WA, Marshall KC, (1993) Electrophysiological changes accompanying DSP-4 lesions of rat locus coeruleus neurons. Brain Res 628: 317-320.
    • (1993) Brain Res , vol.628 , pp. 317-320
    • Magnuson, D.S.1    Staines, W.A.2    Marshall, K.C.3
  • 80
    • 0020528723 scopus 로고
    • Decreased activity of locus coeruleus neurons in the rat after DSP-4 treatment
    • Olpe HR, Laszlo J, Dooley DJ, Heid J, Steinmann MW, (1983) Decreased activity of locus coeruleus neurons in the rat after DSP-4 treatment. Neurosci Lett 40: 81-84.
    • (1983) Neurosci Lett , vol.40 , pp. 81-84
    • Olpe, H.R.1    Laszlo, J.2    Dooley, D.J.3    Heid, J.4    Steinmann, M.W.5
  • 81
    • 0023911012 scopus 로고
    • Increase in mouse brain regional noradrenaline turnover after L-dopa administration
    • Gibson CJ, (1988) Increase in mouse brain regional noradrenaline turnover after L-dopa administration. J Pharm Pharmacol 40: 258-261.
    • (1988) J Pharm Pharmacol , vol.40 , pp. 258-261
    • Gibson, C.J.1
  • 82
    • 77955343996 scopus 로고    scopus 로고
    • Pathophysiology of L-DOPA-Induced Dyskinesia in Parkinson's Disease
    • In: Dunnett S, Iverson S, Iverson LL, editors, New York, NY, Oxford University Press
    • Cenci M, (2009) Pathophysiology of L-DOPA-Induced Dyskinesia in Parkinson's Disease. In: Dunnett S, Iverson S, Iverson LL, editors. Dopamine Handbook New York, NY Oxford University Press pp. 434-444.
    • (2009) Dopamine Handbook , pp. 434-444
    • Cenci, M.1
  • 83
    • 0032568898 scopus 로고    scopus 로고
    • Dopamine-degrading activity of monoamine oxidase in locus coeruleus and dorsal raphe nucleus neurons. A histochemical study in the rat
    • Arai R, Horiike K, Hasegawa Y, (1998) Dopamine-degrading activity of monoamine oxidase in locus coeruleus and dorsal raphe nucleus neurons. A histochemical study in the rat. Neurosci Lett 250: 41-44.
    • (1998) Neurosci Lett , vol.250 , pp. 41-44
    • Arai, R.1    Horiike, K.2    Hasegawa, Y.3
  • 84
    • 0032517856 scopus 로고    scopus 로고
    • Monoamine oxidase activity in noradrenaline neurons of the locus coeruleus of the rat. A double-labeling histochemical study
    • Hida T, Arai R, (1998) Monoamine oxidase activity in noradrenaline neurons of the locus coeruleus of the rat. A double-labeling histochemical study. Brain Res 814: 209-212.
    • (1998) Brain Res , vol.814 , pp. 209-212
    • Hida, T.1    Arai, R.2
  • 85
    • 34047186385 scopus 로고    scopus 로고
    • Antagonism of metabotropic glutamate receptor type 5 attenuates l-DOPA-induced dyskinesia and its molecular and neurochemical correlates in a rat model of Parkinson's disease
    • Mela F, Marti M, Dekundy A, Danysz W, Morari M, et al. (2007) Antagonism of metabotropic glutamate receptor type 5 attenuates l-DOPA-induced dyskinesia and its molecular and neurochemical correlates in a rat model of Parkinson's disease. J Neurochem 101: 483-497.
    • (2007) J Neurochem , vol.101 , pp. 483-497
    • Mela, F.1    Marti, M.2    Dekundy, A.3    Danysz, W.4    Morari, M.5
  • 86
    • 31944450238 scopus 로고    scopus 로고
    • alpha2-Adrenoceptor-mediated modulation of the release of GABA and noradrenaline in the rat substantia nigra pars reticulata
    • Alachkar A, Brotchie J, Jones OT, (2006) alpha2-Adrenoceptor-mediated modulation of the release of GABA and noradrenaline in the rat substantia nigra pars reticulata. Neurosci Lett 395: 138-142.
    • (2006) Neurosci Lett , vol.395 , pp. 138-142
    • Alachkar, A.1    Brotchie, J.2    Jones, O.T.3
  • 87
    • 0034123286 scopus 로고    scopus 로고
    • Alpha(1)-adrenoceptor-mediated excitation of substantia nigra pars reticulata neurons
    • Berretta N, Bernardi G, Mercuri NB, (2000) Alpha(1)-adrenoceptor-mediated excitation of substantia nigra pars reticulata neurons. Neuroscience 98: 599-604.
    • (2000) Neuroscience , vol.98 , pp. 599-604
    • Berretta, N.1    Bernardi, G.2    Mercuri, N.B.3
  • 88
    • 0027162344 scopus 로고
    • Localization of rat brain binding sites for [3H]tomoxetine, an enantiomerically pure ligand for norepinephrine reuptake sites
    • Gehlert DR, Gackenheimer SL, Robertson DW, (1993) Localization of rat brain binding sites for [3H]tomoxetine, an enantiomerically pure ligand for norepinephrine reuptake sites. Neurosci Lett 157: 203-206.
    • (1993) Neurosci Lett , vol.157 , pp. 203-206
    • Gehlert, D.R.1    Gackenheimer, S.L.2    Robertson, D.W.3
  • 89
    • 0028988546 scopus 로고
    • Comparison of (R)-[3H]tomoxetine and (R/S)-[3H]nisoxetine binding in rat brain
    • Gehlert DR, Schober DA, Gackenheimer SL, (1995) Comparison of (R)-[3H]tomoxetine and (R/S)-[3H]nisoxetine binding in rat brain. J Neurochem 64: 2792-2800.
    • (1995) J Neurochem , vol.64 , pp. 2792-2800
    • Gehlert, D.R.1    Schober, D.A.2    Gackenheimer, S.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.