A novel compound C12 inhibits inflammatory cytokine production and protects from inflammatory injury in vivo

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Wang, Yi ^a   Yu, Congcong ^a   Pan, Yong ^a   Li, Jianling ^a   Zhang, Yali ^b   Ye, Faqing ^a   Yang, Shulin ^b   Zhang, Hui ^a   Li, Xiaokun ^a,c   Liang, Guang ^a,b  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c Basic Medical College   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2,6 BIS[4 [3 (DIMETHYLAMINO)PROPOXY]BENZYLIDENE]CYCLOHEXANONE; ANTIINFLAMMATORY AGENT; DEXAMETHASONE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; 2,6 BIS(4 (3 (DIMETHYLAMINO)PROPOXY)BENZYLIDENE)CYCLOHEXANONE; 2,6 BIS(BENZYLIDENE)CYCLOHEXANONE; 2,6-BIS(4-(3-(DIMETHYLAMINO)PROPOXY)BENZYLIDENE)CYCLOHEXANONE; 2,6-BIS(BENZYLIDENE)CYCLOHEXANONE; AUTACOID; BENZYLIDENE DERIVATIVE; CYCLOHEXANONE DERIVATIVE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; NITRIC OXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYCLOOXYGENASE 2 GENE; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; ENZYME PHOSPHORYLATION; GENE; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; INDUCIBLE NITRIC OXIDE SYNTHASE GENE; INTERLEUKIN 1BETA GENE; INTERLEUKIN 6 GENE; LUNG INJURY; MALE; MOUSE; NONHUMAN; PAW EDEMA; PERITONEUM MACROPHAGE; PROSTAGLANDIN E SYNTHASE GENE; PROTEIN BLOOD LEVEL; PROTEIN SYNTHESIS INHIBITION; SURVIVAL TIME; TUMOR NECROSIS FACTOR ALPHA GENE; ACUTE DISEASE; ANIMAL; BIOSYNTHESIS; BLOOD; CHEMISTRY; DISEASE MODEL; EDEMA; ENZYMOLOGY; GENETICS; INFLAMMATION; LIVER; LUNG; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SURVIVAL;

MUS;

ACUTE DISEASE; ANIMALS; BENZYLIDENE COMPOUNDS; CYCLOHEXANONES; CYTOKINES; DISEASE MODELS, ANIMAL; EDEMA; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; INFLAMMATION; INFLAMMATION MEDIATORS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; LIVER; LUNG; MACROPHAGES, PERITONEAL; MALE; MICE; NF-KAPPA B; NITRIC OXIDE; PHOSPHORYLATION; RNA, MESSENGER; SURVIVAL ANALYSIS;

EID: 80052546669     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024377     Document Type: Article

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