Dioscorealide B suppresses LPS-induced nitric oxide production and inflammatory cytokine expression in RAW 264.7 macrophages: The inhibition of NF-κB and ERK1/2 activation

Journal of Cellular Biochemistry

Volumn 109, Issue 5, 2010, Pages 1057-1063

  Hiransai, Poonsit ^a   Ratanachaiyavong, Suvina ^a   Itharat, Arunporn ^b   Graidist, Potchanapond ^a   Ruengrairatanaroj, Prasit ^a   Purintrapiban, Juntipa ^a  

^a PRINCE OF SONGKLA UNIVERSITY   (Thailand)

^b THAMMASAT UNIVERSITY   (Thailand)

Author keywords

Dioscorea membranacea; Inflammatory cytokines; Naphthofuranoxepin; Nitric oxide production; RAW 264.7 cells

Indexed keywords

CYTOKINE; DIOSCOREALIDE B; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LUCIFERASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; PHOSPHOTRANSFERASE; PLANT EXTRACT; REAGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL LINE; CONCENTRATION (PARAMETERS); DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; IC 50; INFLAMMATION; MACROPHAGE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RHIZOME; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

ANIMALS; CELL LINE; CYTOKINES; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; I-KAPPA B PROTEINS; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; LUCIFERASES; MACROPHAGES; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RNA, MESSENGER; TRANSFECTION;

DIOSCOREA MEMBRANACEA;

EID: 77950454178     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22535     Document Type: Article

References (24)

1. Avdiushko R, Hongo D, Lake-Bullock H, Kaplan A, Cohen D. 2001. IL-10 receptor dysfunction in macrophages during chronic inflammation. J Leukoc Biol 70:624-632.
2. Baldwin AS, Jr. 1996. The NF-kappa B and I kappa B proteins: New discoveries and insights. Annu Rev Immunol 14:649-683.
3. Carrigan SD, Scott G, Tabrizian M. 2004. Toward resolving the challenges of sepsis diagnosis. Clin Chem 50:1301-1314.
4. Chanteux H, Guisset AC, Pilette C, Sibille Y. 2007. LPS induces IL-10 production by human alveolar macrophages via MAPKinases- and Sp1-dependent mechanisms. Respir Res 8:71.
5. Davies SP, Reddy H, Caivano M, Cohen P. 2000. Specificity and mechanism of action of some commonly use protein kinase inhibitors. Biochem J 351:95-105.
6. Itharat A, Plubrukran A, Kongsaeree P, Buti T, Keawpradub N, Houghton PJ. 2003. Dioscorealides and dioscoreanone, novel cytotoxic napthofuranoxepins, and 1, 4- phenanthraquinone from Dioscorea membranacea, Pierre. Org Lett 5:2879-2882.
7. Itharat A, Houghton PJ, Eno-Amooquave E, Burke P, Sampson J, Raman A. 2004. In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer. J Ethnopharmacol 90:33-38.
8. Karin M, Ben-Neriah Y. 2000. Phosphorylation meets ubiquitination: The control of NF-kappa B activity. Annu Rev Immunol 18:621-663.
9. Knowles RG, Moncada S. 1994. Nitric oxide synthases in mammals. Biochem J 298(Pt2): 249-258.
10. Laskin DL, Pendino KJ. 1995. Macrophages and inflammatory mediators in tissue injury. Annu Rev Pharmacol Toxicol 35:655-677.
11. Lee Ms, Kim YJ. 2007. Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu Rev Biochem 76:447-480.
12. Li Q, Verma IM. 2002. NFkappa B regulation in the immune system. Nat Rev Immunol 2:725-734.
13. Nathan C, Xie QW. 1994. Regulation of biosynthesis of nitric oxide. J Biol Chem 269:13725-13728.
14. Ricciardolo FL, Sterk PJ, Gaston B, Folkerts B. 2004. Nitric oxide in health and disease of the respiratory system. Physiol Rev 84:731-765.
15. Richmond A. 2002. NF-kappa B, chemokine gene transcription and tumour growth. Nat Rev Immunol 2:664-674.
16. Robert L, McColl GJ. 2004. Tumour necrosis factor inhibitors: Risks and benefits in patients with rheumatoid arthritis. Intern Med J 34:687-693.
17. Siebenlist U, Franzoso G, Brown K. 1994. Structure, regulation and function of NF-kappa B. Annu Rev Cell Biol 10:405-455.
18. Takada Y, Mukhopadhyay A, Kundu GC, Mahabeleshwar GH, Singh S, Aggarwal BB. 2003. Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: Evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase. J Biol Chem 278:24233-24241.
19. Takeda K, Kaisho T, Akira S. 2003. Toll-like receptors. Annu Rev Immunol 21:335-376.
20. Tewtrakul S, Itharat A. 2007. Nitric oxide inhibitory substances from the rhizomes of Dioscorea membranacea. J Ethnopharmacol 109:412-416.
21. Tewtrakul S, Itharat A, Rattansuwan P. 2006. Anti-HIV-1 protease- and HIV-1 integrase activities of Thai medicinal plants known as Hua-Khao-Yen. J Ethnopharmacol 105:312-315.
22. Wang J, Fu YX. 2005. Tumor necrosis factor family members and inflammatory bowel disease. Immunol Rev 204:144-155.
23. West AP, Koblansky AA, Ghosh S. 2006. Recognition and signaling by toll-like receptors. Annu Rev Cell Dev Biol 22:409-437.
24. Whiteside ST, Israel A. 1997. I kappa B proteins: Structure, function and regulation. Semin Cancer Biol 8:75-82.