Transgenic expression of human LAMA5 suppresses murine LAMA5 mRNA and laminin α5 protein deposition

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Steenhard, Brooke M ^a   Zelenchuk, Adrian ^a   Stroganova, Larysa ^a   Isom, Kathryn ^a   John, Patricia L ^a   Andrews, Glen K ^a,b   Peterson, Kenneth R ^a,b   Abrahamson, Dale R ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LAMININ; LAMININ 1ALPHA; LAMININ ALPHA5; LAMININ BETA1; LAMININ BETA2; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CONTROLLED STUDY; DEVELOPMENTAL STAGE; ENDOTHELIUM CELL; GENE; GENE EXPRESSION; GLOMERULAR DEVELOPMENT; GLOMERULUS; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS CAPILLARY; IMMUNOELECTRON MICROSCOPY; KIDNEY DEVELOPMENT; KIDNEY FUNCTION; KIDNEY TUBULE BASEMENT MEMBRANE; LAMININ ALPHA5 GENE; MOUSE; NONHUMAN; PODOCYTE; PROTEIN LOCALIZATION; TRANSGENE; TRANSGENIC MOUSE; ANIMAL; BASEMENT MEMBRANE; GENETICS; HEART MUSCLE; HUMAN; KIDNEY; LIVER; METABOLISM; SPLEEN;

BACTERIA (MICROORGANISMS); MURINAE; MUS; MUS MUSCULUS;

ANIMALS; BASEMENT MEMBRANE; HUMANS; KIDNEY; KIDNEY GLOMERULUS; LAMININ; LIVER; MICE; MICE, TRANSGENIC; MYOCARDIUM; SPLEEN;

EID: 80052541630     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023926     Document Type: Article

References (35)

1. Haraldsson B, Nystrom J, Deen WM, (2008) Properties of the glomerular barrier and mechanisms of proteinuria. Physiol Rev 88: 451-487.
2. Haraldsson B, Jeansson M, (2009) Glomerular filtration barrier. Curr Opin Nephrol Hypertens 18: 331-335.
3. Patrakka J, Tryggvason K, (2010) Molecular make-up of the glomerular filtration barrier. Biochem Biophys Res Commun 396: 164-169.
4. Jeansson M, Haraldsson B, (2006) Morphological and functional evidence for an important role of the endothelial cell glycocalyx in the glomerular barrier. Am J Physiol Renal Physiol 290: F111-F116.
5. Eremina V, Sood J, Haigh J, Nagy A, Lajoie G, et al. (2003) Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest 111: 707-716.
6. Eremina V, Jefferson JA, Kowalewska J, Hochster H, Haas M, et al. (2008) VEGF inhibition and renal thrombotic microangiopathy. New Engl J Med 358: 1129-1136.
7. Kestila M, Lenkkeri U, Mannikko M, Lamerdin J, McCready P, et al. (1998) Positionally cloned gene for a novel glomerular protein - nephrin- is mutated in congenital nephrotic syndrome. Mol Cell 1: 575-582.
8. Boute N, Gribouval O, Roselli S, Benessy F, Lee H, et al. (2000) NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat Genet 24: 349-354.
9. Schwarz K, Simons M, Reiser J, Saleem MA, Faul C, et al. (2001) Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin. J Clin Invest 108: 1621-1629.
10. Shih NY, Li J, Karpitskii V, Nguyen A, Dustin ML, et al. (1999) Congenital nephrotic syndrome in mice lacking CD2-associated protein. Science 286: 312-315.
11. Putaala H, Soininen R, Kilpelainen P, Wartiovaara J, Tryggvason K, (2001) The murine nephrin gene is specifically expressed in kidney, brain, and pancreas: inactivation of the gene leads to massive proteinuria and neonatal death. Hum Mol Genet 10: 1-8.
12. Roselli S, Heidet L, Sich M, Henger A, Kretzler M, et al. (2004) Early glomerular filtration defect and severe renal disease in podocin-deficient mice. Mol Cell Biol 24: 550-560.
13. Miner JH, (2011) Glomerular basement membrane composition and the filtration barrier. Pediatr Nephrol Feb 26 (9): 1413-1417 [Epub ahead of print.].
14. Miner JH, (1998) Developmental biology of glomerular basement membrane components. Curr Opin Nephrol Hypertens 7: 13-19.
15. Abrahamson DR, (2009) Development of kidney glomerular endothelial cells and their role in basement membrane assembly. Organogenesis 5: 275-287.
16. St John PL, Abrahamson DR, (2001) Glomerular endothelial cells and podocytes jointly synthesize laminin-1 and-11 chains. Kidney Int 60: 1037-1046.
17. Abrahamson DR, Hudson BG, Stroganova L, Borza DB, St John PL, (2009) Cellular origins of glomerular basement membrane type IV collagen networks. J Am Soc Nephrol 20: 1471-1479.
18. Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG, (2003) Alport's syndrome, Goodpasture's syndrome, and type IV collagen. N Engl J Med 348: 2543-2556.
19. Hudson BG, (2004) The molecular basis of Goodpasture and Alport syndrome: Beacons for the discovery of the collagen IV family. J Am Soc Nephrol 15: 2514-2527.
20. Cosgrove D, Meehan DT, Grunkemeyer JA, Kornak JM, Sayers R, et al. (1996) Collagen COL4A3 knockout: A mouse model for autosomal Alport syndrome. Genes Dev 10: 2981-2992.
21. Miner JH, Sanes JR, (1996) Molecular and functional defects in kidneys of mice lacking collagen alpha 3(IV): Implications for Alport syndrome. J Cell Biol 135: 1403-1413.
22. Lu W, Phillips CL, Killen PD, Hlaing T, Harrison WR, et al. (1999) Insertional mutation of the collagen genes Col4a3 and Col4a4 in a mouse model of Alport syndrome. Genomics 61: 113-124.
23. Heidet L, Borza DB, Jouin M, Sich M, Mattei MG, et al. (2003) A human-mouse chimera of the α3α4α5(IV) collagen protomer rescues the renal phenotype in Col4a3-/- Alport mice. Am J Pathol 163: 1633-1644.
24. Noakes PG, Miner JH, Gautam M, Cunningham JM, Sanes JR, et al. (1995) The renal glomerulus of mice lacking s-laminin/laminin β2: Nephrosis despite molecular compensation by laminin β1. Nat Genet 10: 400-406.
25. Miner JH, Go G, Cunningham J, Patton BL, Jarad G, (2006) Transgenic isolation of skeletal muscle and kidney defects in laminin beta 2 mutant mice: Implications for Pierson syndrome. Development 133: 967-975.
26. Miner JH, Cunningham J, Sanes JR, (1998) Roles for laminin in embryogenesis: Exencephaly, syndactyly, and placentopathy in mice lacking the laminin α5 chain. J Cell Biol 143: 1713-1723.
27. Miner JH, Li C, (2000) Defective glomerulogenesis in the absence of laminin α5 demonstrates a developmental role for the kidney glomerular basement membrane. Dev Biol 217: 278-289.
28. Abrahamson DR, St. John PL, Isom K, Robert B, Miner JH, (2007) Partial rescue of glomerular laminin α5 mutation by wildtype endothelial cells produce hybrid glomeruli. J Am Soc Nephrol 18: 2285-2297.
29. Goldberg S, Adair-Kirk TL, Senior RM, Miner JH, (2010) Maintenance of glomerular filtration barrier integrity requires laminin α5. J Am Soc Nephrol 21: 579-586.
30. Abrahamson DR, Isom K, Roach E, Stroganova L, Zelenchuk A, et al. (2007) Laminin compensation in collagen α3(IV) knockout (Alport) glomeruli contributes to permeability defects. J Am Soc Nephrol 18: 1465-1472.
31. Abrahamson DR, Irwin MH, St John PL, Perry EW, Accavitti MA, et al. (1989) Selective immunoreactivities of kidney basement membranes to monoclonal antibodies against laminin: Localization of the end of the long arm and the short arms to discrete microdomains. J Cell Biol 109: 3477-3491.
32. Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001 25 (4): 402-408.
33. Abrahamson DR, St John PL, (1992) Loss of laminin epitopes during glomerular basement membrane assembly in developing mouse kidneys. J Histochem Cytochem 40: 1943-1953.
34. Miner JH, (2005) Building the glomerulus: A matricentric view. J Am Soc Nephrol 16: 857-861.
35. Yurchenco PD, Quan Y, Colognato H, Mathus T, Harrison D, et al. (1997) The α chain of laminin-1 is independently secreted and drives secretion of its β- and γ-chain partners. Proc Natl Acad Sci USA 94: 10189-10194.