Developmental biology of glomerular basement membrane components

Current Opinion in Nephrology and Hypertension

Volumn 7, Issue 1, 1998, Pages 13-19

  Miner, Jeffrey H ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 4; ENTACTIN; LAMININ; PROTEOGLYCAN;

BLOOD FILTRATION; CONGENITAL NEPHROTIC SYNDROME; GLOMERULUS BASEMENT MEMBRANE; HUMAN; KIDNEY BLOOD FLOW; KIDNEY DEVELOPMENT; MEMBRANE COMPONENT; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; ULTRAFILTRATION;

ANIMALS; BASEMENT MEMBRANE; HUMANS; KIDNEY GLOMERULUS; NEPHRONS;

EID: 0031963693     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-199801000-00003     Document Type: Review

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55. ••] describe the production of knockout mice with a targeted mutation in Col4a3, which causes a disease with many similarities to human Alport syndrome, including absence of the collagen α3-α5(IV) chains in kidney. Both studies make use of the ability to look at renal structure and various GBM components before and during the onset of disease, which is rarely possible in humans. RNA analyses show that the α4 and α5(IV) mRNAs are not down-regulated as they are in the dog model.
56. ••].
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