Toll-like receptor 7 stimulation promotes autoimmune diabetes in the NOD mouse

Diabetologia

Volumn 54, Issue 6, 2011, Pages 1407-1416

  Lee, A S ^a   Ghoreishi, M ^a   Cheng, W K ^a   Chang, T Y E ^a   Zhang, Y Q ^a   Dutz, J P ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

8.3 NOD mice; Autoimmune diabetes; BMDC; CD40 agonist; CD8 + T cell activation; CL097; IFN ; IRS661; TLR7

Indexed keywords

ALPHA INTERFERON; ANTIDIABETIC AGENT; CD40 AGONIST; CL 097; GAMMA INTERFERON; IMIQUIMOD; IRS 661; TOLL LIKE RECEPTOR 7; UNCLASSIFIED DRUG; CD40 ANTIGEN; CL097 COMPOUND; CYTOKINE; IMIDAZOLE DERIVATIVE; MEMBRANE PROTEIN; QUINOLINE DERIVATIVE; TLR7 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ARTICLE; AUTOIMMUNE DIABETES MELLITUS; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY TEST; DENDRITIC CELL; DIABETES MELLITUS; DRUG EFFICACY; DRUG MECHANISM; IMMUNOREGULATION; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE ACTIVATION; TREATMENT RESPONSE; ANIMAL; BONE MARROW CELL; CYTOLOGY; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; GENETICS; IMMUNOLOGY; METABOLISM; NONOBESE DIABETIC MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD40; AUTOIMMUNE DISEASES; BONE MARROW CELLS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; DENDRITIC CELLS; DIABETES MELLITUS; DISEASE MODELS, ANIMAL; IMIDAZOLES; INTERFERON-ALPHA; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED NOD; MICE, TRANSGENIC; QUINOLINES; TOLL-LIKE RECEPTOR 7;

EID: 80052521583     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2083-y     Document Type: Article

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