AP-1 transcription factor JunD confers protection from accelerated nephrotoxic nephritis and control podocyte-specific Vegfa expression

American Journal of Pathology

Volumn 179, Issue 1, 2011, Pages 134-140

  Cook, H Terence ^a   Tarzi, Ruth ^a   D'Souza, Zelpha ^a   Laurent, Gaelle ^b   Lin, Wei Chou ^a   Aitman, Timothy J ^a   Mechta Grigoriou, Fatima ^b   Behmoaras, Jacques ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b INSTITUT CURIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CHEMOKINE RECEPTOR CXCR4; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN G; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR JUND; UREA; VASCULOTROPIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL IMMORTALIZATION; CELL INFILTRATION; CELL PROLIFERATION; CELL SPECIFICITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; GENETIC SUSCEPTIBILITY; GLOMERULUS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; JUND DEFICIENCY; KIDNEY FUNCTION; KIDNEY INJURY; MACROPHAGE; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; OXIDATIVE STRESS; PODOCYTE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS; REPORTER GENE; SHEEP; SPLEEN CELL; UREA BLOOD LEVEL;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GLOMERULONEPHRITIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOENZYME TECHNIQUES; IMMUNOGLOBULIN G; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PODOCYTES; PROTO-ONCOGENE PROTEINS C-JUN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SHEEP; TRANSCRIPTION FACTOR AP-1; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 80052498525     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.03.006     Document Type: Article

References (60)

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2. F. Mechta-Grigoriou, D. Gerald, and M. Yaniv The mammalian Jun proteins: redundancy and specificity Oncogene 20 2001 2378 2389
3. D. Gerald, E. Berra, Y.M. Frapart, D.A. Chan, A.J. Giaccia, D. Mansuy, J. Pouyssegur, M. Yaniv, and F. Mechta-Grigoriou JunD reduces tumor angiogenesis by protecting cells from oxidative stress Cell 118 2004 781 794
4. A. Meixner, F. Karreth, L. Kenner, J.M. Penninger, and E.F. Wagner Jun and JunD-dependent functions in cell proliferation and stress response Cell Death Differ 17 2010 1409 1419
5. J. Pouyssegur, and F. Mechta-Grigoriou Redox regulation of the hypoxia-inducible factor Biol Chem 387 2006 1337 1346
6. G. Laurent, F. Solari, B. Mateescu, M. Karaca, J. Castel, B. Bourachot, C. Magnan, M. Billaud, and F. Mechta-Grigoriou Oxidative stress contributes to aging by enhancing pancreatic angiogenesis and insulin signaling Cell Metab 7 2008 113 124
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9. J. Behmoaras, G. Bhangal, J. Smith, K. McDonald, B. Mutch, P.C. Lai, J. Domin, L. Game, A. Salama, B.M. Foxwell, C.D. Pusey, H.T. Cook, and T.J. Aitman Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility Nat Genet 40 2008 553 559
10. J. Behmoaras, J. Smith, Z. D'Souza, G. Bhangal, R. Chawanasuntoropoj, F.W. Tam, C.D. Pusey, T.J. Aitman, and H.T. Cook Genetic loci modulate macrophage activity and glomerular damage in experimental glomerulonephritis J Am Soc Nephrol 21 2010 1136 1144
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16. R.M. Tarzi, H.T. Cook, I. Jackson, C.D. Pusey, and G.M. Lord Leptin-deficient mice are protected from accelerated nephrotoxic nephritis Am J Pathol 164 2004 385 390
17. D. Turnberg, M. Lewis, J. Moss, Y. Xu, M. Botto, and H.T. Cook Complement activation contributes to both glomerular and tubulointerstitial damage in adriamycin nephropathy in mice J Immunol 177 2006 4094 4102
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23. F.Y. Ma, R.S. Flanc, G.H. Tesch, B.L. Bennett, G.C. Friedman, and D.J. Nikolic-Paterson Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat Lab Invest 89 2009 470 484
24. P. Pflegerl, P. Vesely, B. Hantusch, M. Schlederer, R. Zenz, E. Janig, G. Steiner, A. Meixner, P. Petzelbauer, P. Wolf, A. Soleiman, G. Egger, R. Moriggl, T. Kishimoto, E.F. Wagner, and L. Kenner Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling Proc Natl Acad Sci U S A 106 2009 20423 20428
25. A. Meixner, F. Karreth, L. Kenner, and E.F. Wagner JunD regulates lymphocyte proliferation and T helper cell cytokine expression EMBO J 23 2004 1325 1335
26. V. Eremina, H.J. Baelde, and S.E. Quaggin Role of the VEGF-A signaling pathway in the glomerulus: evidence for crosstalk between components of the glomerular filtration barrier Nephron Physiol 106 2007 32 37
27. V. Eremina, M. Sood, J. Haigh, A. Nagy, G. Lajoie, N. Ferrara, H.P. Gerber, Y. Kikkawa, J.H. Miner, and S.E. Quaggin Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases J Clin Invest 111 2003 707 716
28. V. Eremina, J.A. Jefferson, J. Kowalewska, H. Hochster, M. Haas, J. Weisstuch, C. Richardson, J.B. Kopp, M.G. Kabir, P.H. Backx, H.P. Gerber, N. Ferrara, L. Barisoni, C.E. Alpers, and S.E. Quaggin VEGF inhibition and renal thrombotic microangiopathy N Engl J Med 358 2008 1129 1136
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31. J.M. Hernandez, D.H. Floyd, K.N. Weilbaecher, P.L. Green, and K. Boris-Lawrie Multiple facets of junD gene expression are atypical among AP-1 family members Oncogene 27 2008 4757 4767
32. F. Mechta-Grigoriou, D. Gerald, and M. Yaniv The mammalian Jun proteins: redundancy and specificity Oncogene 20 2001 2378 2389 (Pubitemid 32531296)
33. D. Gerald, E. Berra, Y.M. Frapart, D.A. Chan, A.J. Giaccia, D. Mansuy, J. Pouyssegur, M. Yaniv, and F. Mechta-Grigoriou JunD reduces tumor angiogenesis by protecting cells from oxidative stress Cell 118 2004 781 794 (Pubitemid 39221736)
34. A. Meixner, F. Karreth, L. Kenner, J.M. Penninger, and E.F. Wagner Jun and JunD-dependent functions in cell proliferation and stress response Cell Death Differ 17 2010 1409 1419
35. J. Pouyssegur, and F. Mechta-Grigoriou Redox regulation of the hypoxia-inducible factor Biol Chem 387 2006 1337 1346 (Pubitemid 44691412)
36. G. Laurent, F. Solari, B. Mateescu, M. Karaca, J. Castel, B. Bourachot, C. Magnan, M. Billaud, and F. Mechta-Grigoriou Oxidative stress contributes to aging by enhancing pancreatic angiogenesis and insulin signaling Cell Metab 7 2008 113 124 (Pubitemid 351181006)
37. A. Toullec, D. Gerald, G. Despouy, B. Bourachot, M. Cardon, S. Lefort, M. Richardson, G. Rigaill, M.C. Parrini, C. Lucchesi, D. Bellanger, M.H. Stern, T. Dubois, X. Sastre-Garau, O. Delattre, A. Vincent-Salomon, and F. Mechta-Grigoriou Oxidative stress promotes myofibroblast differentiation and tumour spreading EMBO Mol Med 2 2010 211 230
38. T.J. Aitman, R. Dong, T.J. Vyse, P.J. Norsworthy, M.D. Johnson, J. Smith, J. Mangion, C. Roberton-Lowe, A.J. Marshall, E. Petretto, M.D. Hodges, G. Bhangal, S.G. Patel, K. Sheehan-Rooney, M. Duda, P.R. Cook, D.J. Evans, J. Domin, J. Flint, J.J. Boyle, C.D. Pusey, and H.T. Cook Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans Nature 439 2006 851 855 (Pubitemid 43255703)
39. J. Behmoaras, G. Bhangal, J. Smith, K. McDonald, B. Mutch, P.C. Lai, J. Domin, L. Game, A. Salama, B.M. Foxwell, C.D. Pusey, H.T. Cook, and T.J. Aitman Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility Nat Genet 40 2008 553 559 (Pubitemid 351601221)
40. J. Behmoaras, J. Smith, Z. D'Souza, G. Bhangal, R. Chawanasuntoropoj, F.W. Tam, C.D. Pusey, T.J. Aitman, and H.T. Cook Genetic loci modulate macrophage activity and glomerular damage in experimental glomerulonephritis J Am Soc Nephrol 21 2010 1136 1144
41. S.R. Holdsworth, A.R. Kitching, and P.G. Tipping Th1 and Th2 T helper cell subsets affect patterns of injury and outcomes in glomerulonephritis Kidney Int 55 1999 1198 1216 (Pubitemid 29157116)
42. K. Liu, Q.Z. Li, A.M. Delgado-Vega, A.K. Abelson, E. Sanchez, J.A. Kelly, L. Li, Y. Liu, J. Zhou, M. Yan, Q. Ye, S. Liu, C. Xie, X.J. Zhou, S.A. Chung, B. Pons-Estel, T. Witte, E. de Ramon, S.C. Bae, N. Barizzone, G.D. Sebastiani, J.T. Merrill, P.K. Gregersen, G.G. Gilkeson, R.P. Kimberly, T.J. Vyse, I. Kim, S. D'Alfonso, J. Martin, J.B. Harley, L.A. Criswell, E.K. Wakeland, M.E. Alarcon-Riquelme, and C. Mohan Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans J Clin Invest 119 2009 911 923
43. F.W. Tam, J. Smith, D. Morel, A.M. Karkar, E.M. Thompson, H.T. Cook, and C.D. Pusey Development of scarring and renal failure in a rat model of crescentic glomerulonephritis Nephrol Dial Transplant 14 1999 1658 1666 (Pubitemid 29313042)
44. J. Smith, P.C. Lai, J. Behmoaras, C. Roufosse, G. Bhangal, J.P. McDaid, T. Aitman, F.W. Tam, C.D. Pusey, and H.T. Cook Genes expressed by both mesangial cells and bone marrow-derived cells underlie genetic susceptibility to crescentic glomerulonephritis in the rat J Am Soc Nephrol 18 2007 1816 1823 (Pubitemid 46870318)
45. D. Thepot, J.B. Weitzman, J. Barra, D. Segretain, M.G. Stinnakre, C. Babinet, and M. Yaniv Targeted disruption of the murine junD gene results in multiple defects in male reproductive function Development 127 2000 143 153 (Pubitemid 30064396)
46. R.M. Tarzi, H.T. Cook, I. Jackson, C.D. Pusey, and G.M. Lord Leptin-deficient mice are protected from accelerated nephrotoxic nephritis Am J Pathol 164 2004 385 390 (Pubitemid 38364654)
47. D. Turnberg, M. Lewis, J. Moss, Y. Xu, M. Botto, and H.T. Cook Complement activation contributes to both glomerular and tubulointerstitial damage in adriamycin nephropathy in mice J Immunol 177 2006 4094 4102 (Pubitemid 44359944)
48. P.C. Lai, J. Smith, G. Bhangal, K.A. Chaudhry, A.N. Chaudhry, J.C. Keith Jr, F.W. Tam, C.D. Pusey, and H.T. Cook Interleukin-11 reduces renal injury and glomerular NF-kappa B activity in murine experimental glomerulonephritis Nephron Exp Nephrol 101 2005 e146 e154
49. M.A. Saleem, M.J. O'Hare, J. Reiser, R.J. Coward, C.D. Inward, T. Farren, C.Y. Xing, L. Ni, P.W. Mathieson, and P. Mundel A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression J Am Soc Nephrol 13 2002 630 638 (Pubitemid 34183927)
50. M.A. Hernández-Presa, C. Gómez-Guerrero, and J. Egido In situ non-radioactive detection of nuclear factors in paraffin sections by Southwestern histochemistry Kidney Int 55 1999 209 214 (Pubitemid 29004252)
51. S.A. Mezzano, M. Barria, M.A. Droguett, M.E. Burgos, L.G. Ardiles, C. Flores, and J. Egido Tubular NF-kappaB and AP-1 activation in human proteinuric renal disease Kidney Int 60 2001 1366 1377 (Pubitemid 32960030)
52. H. Sakurai, and T. Sugita c-Jun N-terminal kinase-mediated AP-1 activation in experimental glomerulonephritis in rats Biochem Mol Biol Int 45 1998 831 839 (Pubitemid 28393553)
53. F.Y. Ma, R.S. Flanc, G.H. Tesch, B.L. Bennett, G.C. Friedman, and D.J. Nikolic-Paterson Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat Lab Invest 89 2009 470 484
54. P. Pflegerl, P. Vesely, B. Hantusch, M. Schlederer, R. Zenz, E. Janig, G. Steiner, A. Meixner, P. Petzelbauer, P. Wolf, A. Soleiman, G. Egger, R. Moriggl, T. Kishimoto, E.F. Wagner, and L. Kenner Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling Proc Natl Acad Sci U S A 106 2009 20423 20428
55. A. Meixner, F. Karreth, L. Kenner, and E.F. Wagner JunD regulates lymphocyte proliferation and T helper cell cytokine expression EMBO J 23 2004 1325 1335 (Pubitemid 38525004)
56. V. Eremina, H.J. Baelde, and S.E. Quaggin Role of the VEGF-A signaling pathway in the glomerulus: evidence for crosstalk between components of the glomerular filtration barrier Nephron Physiol 106 2007 32 37
57. V. Eremina, M. Sood, J. Haigh, A. Nagy, G. Lajoie, N. Ferrara, H.P. Gerber, Y. Kikkawa, J.H. Miner, and S.E. Quaggin Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases J Clin Invest 111 2003 707 716 (Pubitemid 36278589)
58. V. Eremina, J.A. Jefferson, J. Kowalewska, H. Hochster, M. Haas, J. Weisstuch, C. Richardson, J.B. Kopp, M.G. Kabir, P.H. Backx, H.P. Gerber, N. Ferrara, L. Barisoni, C.E. Alpers, and S.E. Quaggin VEGF inhibition and renal thrombotic microangiopathy N Engl J Med 358 2008 1129 1136 (Pubitemid 351398487)
59. A. Köttgen, C. Pattaro, C.A. Boger, C. Fuchsberger, M. Olden, and N.L. Glazer New loci associated with kidney function and chronic kidney disease Nat Genet 42 2010 376 384
60. M. Ding, S. Cui, C. Li, S. Jothy, V. Haase, B.M. Steer, P.A. Marsden, J. Pippin, S. Shankland, M.P. Rastaldi, C.D. Cohen, M. Kretzler, and S.E. Quaggin Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice Nat Med 12 2006 1081 1087 (Pubitemid 44353390)