Targeted disruption of the murine junD gene results in multiple defects in male reproductive function

Development

Volumn 127, Issue 1, 2000, Pages 143-153

  Thépot, Dominique ^a,b   Weitzman, Jonathan B ^b   Barra, Jacqueline ^b   Segretain, Dominique ^c   Stinnakre, Marie Georges ^a   Babinet, Charles ^b   Yaniv, Moshe ^b  

^a CEMAGREF   (France)

^b INSTITUT PASTEUR   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

AP 1; Growth; Infertility; JunD; Mouse; Spermatogenesis

Indexed keywords

ACTIN; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MESSENGER RNA; PROTAMINE; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL LINEAGE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENDOCRINE DISEASE; FEMALE; GENE DISRUPTION; GENE INACTIVATION; GENE TARGETING; MALE; MALE GENITAL SYSTEM; MOUSE; NONHUMAN; NORTHERN BLOTTING; ONCOGENE C JUN; POSTNATAL GROWTH; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPERMATOGENESIS; TISSUE DISTRIBUTION;

ANIMALS; CELL LINE; FEMALE; GENE EXPRESSION; GENE TARGETING; INFERTILITY, MALE; LAC OPERON; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MUTAGENESIS; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-JUN; SPERMATOGENESIS; SPERMATOZOA;

ANIMALIA; BACTERIA (MICROORGANISMS); MAMMALIA; MURINAE;

EID: 0033984696     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Agarwal, S. K., Guru, S. C., Heppner, C., Erdos, M. R., Collins, R. M., Park, S. Y., Saggar, S., Chandrasekharappa, S. C., Collins, F. S., Spiegel, A. M. et al. (1999). Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Cell 96, 143-152.
2. Albert, M. and Roussel, C. (1984). Strain differences in the concentration, motility and morphology of epididymal sperm in relation to puberty in mice. Int J Androl 7, 334-347.
3. Alcivar, A. A., Hake, L. E., Kwon, Y. K. and Hecht, N. B. (1991). JunD mRNA expression differs from c-jun and junB mRNA expression during male germinal cell differentiation. Mol. Reprod. Dev. 30, 187-193.
4. Angel, P., Allegretto, E. A., Okino, S. T., Hattori, K., Boyle, W. J., Hunter, T. and Karin, M. (1988). Oncogene jun encodes a sequence-specific trans-activator similar to AP-1. Nature 332, 166-171.
5. Angel, P. and Karin, M. (1991). The role of Jun, Fos und the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta 1072, 129-157.
6. Baum, M. J., Brown, J. J., Kica, E., Rubin, B. S., Johnson, R. S. and Papaioannou, V. E. (1994). Effect of a null mutation of the c-fos protooncogene on sexual behavior of male mice. Biol. Reprod. 50, 1040-1048.
7. Blendy, J. A., Kaestner, K. H., Weinbauer, G. F., Nieschlag, E. and Schutz, G. (1996). Severe impairment of spermatogenesis in mice lacking the CREM gene. Nature 380, 162-165.
8. Bohmann, D., Bos, T. J., Admon, A., Nishimura, T., Vogt, P. K. and Tjian, R. (1987). Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science 238, 1386-1392.
9. Bossy-Wetzel, E., Bakiri, L. and Yaniv, M. (1997). Induction of apoptosis by the transcription factor c-Jun. EMBO J. 16, 1695-1709.
10. Bradley, A. (1987). Production and analysis of chimearic mice. In Teratocarcinomas and Embryonic Stem cells; a Practical Approach. (ed. E. J. Robertson). pp. 113-151. Oxford: IRL Press.
11. Brown, J. R., Ye, H., Bronson, R. T., Dikkes, P. and Greenberg, M. E. (1996). A defect in nurturing in mice lacking the immediate early gene fosB. Cell 86, 297-309.
12. Camus, A., Kress, C., Babinet, C. and Barra, J. (1996) Unexpected behavior of a gene trap vector comprising a fusion between the Sh ble and the lacZ genes. Mol. Reprod. Dev. 45, 255-263.
13. Chiu, R., Angel, P. and Karin, M. (1989). Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun. Cell 59, 979-986.
14. Cohen, D. R., Vandermark, S. E., McGovern, J. D. and Bradley, M. P. (1993). Transcriptional regulation in the testis: a role for transcription factor AP-1 complexes at various stages of spermatogenesis. Oncogene 8, 443-455.
15. Colucci-Guyon, E., Portier, M. M., Dunia, I., Paulin, D., Pournin, S. and Babinet, C. (1994). Mice lacking vimentin develop and reproduce without an obvious phenotype. Cell 79, 679-694
16. Elliott, D. J. and Cooke, H. J. (1997). The molecular genetics of male infertility. BioEssays 19, 801-809.
17. Grigoriadis, A. E., Wang, Z. Q., Cecchini, M. G., Hofstetter, W., Felix, R., Fleisch, H. A. and Wagner, E. F. (1994). c-Fos: a key regulator of osteociast-macrophage lineage determination and bone remodeling. Science 266, 443-448.
18. Gruda, M. C., van Amsterdam, J., Rizzo, C. A., Durham, S. K., Lira, S. and Bravo, R. (1996). Expression of FosB during mouse development: normal development of FosB knockout mice. Oncogene 12, 2177-2185.
19. Hagaman, J. R., Moyer, J. S., Bachman, E. S., Sibony, M., Magyar, P. L., Welch, J. E., Smithies, O., Krege, J. H. and O'Brien, D. A. (1998). Angiotensin-converting enzyme and male fertility. Proc. Natl. Acad. Sci. USA 95, 2552-2557.
20. Hai, T. W., Liu, F., Coukos, W. J. and Green, M. R. (1989). Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Genes Dev. 3, 2083-2090.
21. Ham, J., Babij, C., Whitfield, J., Pfarr, C. M., Lallemand, D., Yaniv, M. and Rubin, L. L. (1995). A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 14, 927-939.
22. Hilberg, F., Aguzzi, A., Howells, N. and Wagner, E. F. (1993). c-jun is essential for normal mouse development and hepatogenesis. Nature 365, 179-181.
23. Hirai, S. I., Ryseck, R. P., Mechta, F., Bravo, R. and Yaniv, M. (1989) Characterization of junD: a new member of the jun proto-oncogene family. EMBO J. 8, 1433-1439.
24. Hummler, E., Cole, T. J., Blendy, J. A., Ganss, R., Aguzzi, A., Schmid, W., Beermann, F. and Schutz, G. (1994). Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors. Proc. Natl Acad. Sci. USA 91, 5647-5651.
25. Johnson, R., Spiegelman, B., Hanahan, D. and Wisdom, R. (1996). Cellular transformation and malignancy induced by ras require c-jun. Mol. Cell Biol. 16, 4504-4511
26. Johnson, R. S., Spiegelman, B. M. and Papaioannou, V. (1992). Pleiotropic effects of a null mutation in the c-fos proto-oncogene. Cell 71, 577-586.
27. Johnson, R. S., van Lingen, B., Papaioannou, V. E. and Spiegelman, B. M. (1993). A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. Genes Dev. 7, 1309-1317.
28. Kallunki, T., Deng, T., Hibi, M. and Karin, M. (1996). c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell 87, 929-939.
29. Karnovsky, M. (1971). Use of ferrocyanide-reduced osmium tetroxide in electron microscopy. J. Cell Biol. 51, 284.
30. Kastner, P., Mark, M., Leid, M., Gansmuller, A., Chin, W., Grondona, J. M., Decimo, D., Krezel, W., Dierich, A. and Chambon, P. (1996). Abnormal spermatogenesis in RXRβ mutant mice. Genex Dev. 10, 80-92.
31. Kouzarides, T. and Ziff, E. (1988). The role of the leucine zipper in the fos-jun interaction. Nature 336, 646-651.
32. Kovary, K. and Bravo, R. (1991). Expression of different Jun and Fos proteins during the G0-to-G1 transition in mouse fibroblasts: in vitro and in vivo associations. Mol. Cell Biol. 11, 2451-2459.
33. Kress, C., Vandormael, P. S., Baldacci, P., Cohen, T. M. and Babinet, C. (1998). Nonpermissiveness for mouse embryonic stem (ES) cell derivation circumvented by a single backcross to 129/Sv strain: establishment of ES cell lines bearing the omd conditional lethal mutation. Mamm. Genome 9, 998-1001
34. Lallemand, D., Spyrou, G., Yaniv, M. and Pfarr, C. M. (1997). Variations in Jun and Fos protein expression and AP-1 activity in cycling, resting and stimulated fibroblasts. Oncogene 14, 819-830.
35. Landschulz, W. H., Johnson, P. F. and McKnight, S. L. (1988). The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science 240, 1759-1764.
36. Lee, M. H., Williams, B. O., Mulligan, G., Mukai, S., Bronson, R. T., Dyson, N., Harlow, E. and Jacks, T. (1996). Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev. 10, 1621-1632.
37. Mansour, S. L., Goddard, J. M. and Capecchi, M. R. (1993). Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. Development 117, 13-28.
38. Martin-Blanco, E. (1997). Regulation of cell differentiation by the Drosophila Jun kinase cascade. Curr. Opin. Genet. Dev. 7, 666-671.
39. Mechta, F., Lallemand, D., Pfarr, C. M. and Yaniv, M. (1997). Transformation by ras modifies API composition and activity. Oncogene 14, 837-847.
40. Nakabeppu, Y., Ryder, K. and Nathans, D. (1988). DNA binding activities of three murine Jun proteins: stimulation by Fos. Cell 55, 907-915.
41. Nantel, F., Monaco, L., Foulkes, N. S., Masquilier, D., LeMeur, M., Henriksen, K., Dierich, A., Parvinen, M. and Sassone-Corsi, P. (1996). Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice. Nature 380, 159-162.
42. Paylor, R., Johnson, R. S., Papaioannou, V., Spiegelman, B. M. and Wehner, J. M. (1994). Behavioral assessment of c-fos mutant mice. Brain Res. 651, 275-282.
43. Pearse, R. n., Drolet, D. W., Kalla, K. A., Hooshmand, F., Bermingham, J. J. and Rosenfeld, M. G. (1997). Reduced fertility in mice deficient for the POU protein sperm-1. Proc. Natl Acad Sci. USA 94, 7555-7560.
44. Pfarr, C. M., Mechta, F., Spyrou, G., Lallemand, D., Carillo, S. and Yaniv, M. (1994). Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras. Cell 76, 747-760.
45. Reijo, R., Lee, T. Y., Salo, P., Alagappan, R., Brown, L. G., Rosenberg, M., Rozen, S., Jaffe, T., Straus, D., Hovatta, O. et al. (1995). Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene. Nat. Genet. 10, 383-393.
46. Reimold, A. M., Grusby, M. J., Kosaras, B., Fries, J. W., Mori, R., Maniwa, S., Clauss, I. M., Collins, T., Sidman, R. L., Glimcher, M. J. et al. (1996). Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice. Nature 379, 262-265.
47. Rudnicki, M. A., Schnegelsberg, P. N., Stead, R. H., Braun, T., Arnold, H. H. and Jaenisch, R. (1993). MyoD or Myf-5 is required for the formation of skeletal muscle. Cell 75, 1351-1359.
48. Rutberg, S. E., Saez, E., Glick, A., Dlugosz, A. A., Spiegelman, B. M. and Yuspa, S. H. (1996). Differentiation of mouse keratinocytes is accompanied by PKC-dependent changes in AP-1 proteins. Oncogene 13, 167-176.
49. Ryder, K., Lanahan, A., Perez, A. E. and Nathans, D. (1989). jun-D: a third member of the jun gene family. Proc. Natl Acad. Sci. USA 86, 1500-1503.
50. Ryseck, R. P., Hirai, S. I., Yaniv, M. and Bravo, R. (1988). Transcriplional activation of c-jun during the G0/G1 transition in mouse fibroblasts. Nature 334, 535-537.
51. Sah, V. P., Attardi, L. D., Mulligan, G. J., Williams, B. O., Bronson, R. T. and Jacks, T. (1995). A subset of p53-deficient embryos exhibit exencephaly. Nat. Genet. 10, 175-180.
52. Sassone-Corsi, P., Ransone, L. J., Lamph, W. W. and Verma, I. M. (1988). Direct interaction between fos and jun nuclear oncoproteins: role of the 'leucine zipper' domain. Nature 336, 692-695.
53. Schorpp-Kistner, M., Wang, Z.-Q., Angel, P. and Wagner, E. F. (1999). JunB is essential for mammalian placentation. EMBO J. 18, 934-948.
54. Schultz, R., Penttila, T. L., Parvinen, M., Persson, H., Hokfelt, T. and Pelto-Huikko, M. (1995). Expression of immediate early genes in tubular cells of rat testis. Biol. Reprod. 52, 1215-1226.
55. Sicinski, P., Donaher, J. L., Parker, S. B., Li, T., Fazeli, A., Gardner, H., Haslam, S. Z., Bronson, R. T., Elledge, S. J. and Weinberg, R. A. (1995) Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 82, 621-630.
56. Smeal, T., Binetruy, B., Mercola, D. A., Birrer, M. and Karin, M. (1991) Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature 354, 494-496.
57. Supp, D. M., Witte, D. P., Branford, W. W., Smith, E. P. and Potter, S. S. (1996). Sp4, a member of the Sp1-family of zinc finger transcription factors. is required for normal murine growth, viability, and male fertility. Dev. Biol. 176, 284-299.
58. Ting, X. and Spradling, A. (1998). decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary, Cell 94, 251-260.
59. Wang, Z. Q., Ovitt, C., Grigoriadis, A. E., Mohle, S. U., Ruther, U. and Wagner, E. F. (1992). Bone and haematopoietic defects in mice lacking c-fos. Nature 360, 741-745.
60. Wilkinson, D. G., Bhatt, S., Ryseck, R. P. and Bravo, R. (1989). Tissue-specific expression of c-jun and junB during organogenesis in the mouse. Development 106, 465-471.
61. Zhao, G. Q., Deng, K., Labosky, P. A., Liaw, L. and Hogan, B. L. (1996) The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse. Genes Dev. 10, 1657-1669.
62. Zhao, G. Q., Liaw, L. and Hogan, B. L. (1998). Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. Development 125, 1103-1112.