Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat

Laboratory Investigation

Volumn 89, Issue 4, 2009, Pages 470-484

  Ma, Frank Y ^a   Flanc, Robert S ^a   Tesch, Greg H ^a   Bennett, Brydon L ^b   Friedman, Glenn C ^b   Nikolic Paterson, David J ^a,c  

^a MONASH UNIVERSITY   (Australia)

^b CELGENE CORPORATION   (United States)

^c MONASH MEDICAL CENTRE   (Australia)

Author keywords

Giant cell; JNK; Macrophage; MMP 12; Myofibroblast

Indexed keywords

CC 401; COLLAGEN TYPE 4; FIBRONECTIN; IMMUNOGLOBULIN G; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; MACROPHAGE ELASTASE; MESSENGER RNA; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; DISEASE SEVERITY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; FOCAL GLOMERULONEPHRITIS; GLOMERULONEPHRITIS; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; INFLAMMATION; INTERSTITIAL NEPHRITIS; KIDNEY DYSFUNCTION; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY TUBULE DAMAGE; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS; RAT; RENAL PROTECTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TREATMENT DURATION; UPREGULATION; WISTAR KYOTO RAT;

ANIMALS; ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE; ANTIBODY FORMATION; FEMALE; GENE EXPRESSION REGULATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KIDNEY GLOMERULUS; MACROPHAGES; PYRAZOLONES; RATS; RATS, INBRED WKY; SIGNAL TRANSDUCTION;

EID: 63449084230     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2009.2     Document Type: Article

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