Endothelial (dys)function: The target of physical exercise for prevention and treatment of cardiovascular disease

Journal of Sports Medicine and Physical Fitness

Volumn 51, Issue 2, 2011, Pages 260-267

  Pigozzi, F ^a   Rizzo, M ^a   Fagnani, F ^a   Parisi, A ^a   Spataro, A ^a   Casasco, M ^b   Borrione, P ^a  

^a UNIVERSITY OF ROME FORO ITALICO   (Italy)

^b Italian Federation of Sports Medicine   (Italy)

Author keywords

Endothelium; Exercise; Homocysteine; Nitric oxide

Indexed keywords

HOMOCYSTEINE; NITRIC OXIDE;

ARTICLE; BLOOD; CARDIOVASCULAR DISEASE; CASE CONTROL STUDY; EXERCISE; HUMAN; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

CARDIOVASCULAR DISEASES; CASE-CONTROL STUDIES; ENDOTHELIUM, VASCULAR; EXERCISE; HOMOCYSTEINE; HUMANS; NITRIC OXIDE;

EID: 80052476830     PISSN: 00224707     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (82)

1. Warburton DER, Nicol CW, Bredin SSD. Health benefits of physical activity: the evidence. CMAJ 2006;174:801-9.
2. Blair SN. Physical inactivity: the biggest public health problem of the 21st century. Br J Sports Med 2009;43:1-2.
3. Perez AB. Exercise as the cornestone of cardiovascular prevention. Rev Esp Cardiol 2008;61:514-28.
4. Green DJ, Maiorana A, O'Driscoll G, Taylor R. Nitric oxide, cardiovascular disease and physical exercise. J Physiol 2004;15;561(Pt l):l-25.
5. Einecke D. The athletic career, unfortunately not really atypical. From model athlete to infarct candidate. MMW Fortschc Med 2002;144:6-7.
6. Pipe A. The adverse effects of elite competition on health and wellbeing. Can J Appl Physiol 2001;26(Suppl):S192-201.(Pubitemid 33730871)
7. Furchgott RF, Vanhoutte PM. Endothelium- derived relaxing and contracting factors FASEB J 1989;3:2007-17.
8. Thijssen DHJ, Rongen GA, Smits P, Hopman MTE. Physical (in) activity and endothelium-derived constricting factors: overlooked adaptations. J Physiol 2008;586:319-24.
9. Endemann DH, Schiffrin EL. Endothelial dysfunction. J Am Soc Nephrol 2004; 1983-92.(Pubitemid 39031337)
10. Zago AS, Zanesco A. Nitric oxide, cardiovascular disease and physical exercise. Arq Bras Cardiol 2006;87:e-227-33.
11. Vanhoutte PM, Shimokawa H, Tang EHC, Feletou M. Endothelial dysfunction and vascular disease. Acta Physiol 2009;196:193-222.
12. Marietta MA. Nitric oxide: biosynthesis and biological significance. Trends Biochem Sci 1989;14:488-92.
13. Schini-Kerth VB, Vanhoutte PM. Nitric oxide synthases in vascular cells. Exp Physiol 1995;80:885-905.
14. Murad F, Forstermann U, Nakane M, Schmidt H, Pollock J, Sheng H et al. The nitric oxide-cyclic GMP signal transduction pathway in vascular smooth muscle preparations and other tissues. Jpn Pharmacol 1992;58:150-7.
15. Davies PF. Flow-mediated endothelial mechanotransduction. Physiol Rev 1995;75:519-60.
16. Fisher AB, Chien S, Barakat AL, Nerem RN. Endothelial cellular response to altered shear stress. Am J Physiol 2001;281:L529-L33.
17. Davies PF, Spaan JA, Krams R. Shear stress biology of the endothelium. Ann Biomed Eng 2005;33:1714-8.(Pubitemid 43037540)
18. Landmesser U, Horning B, Drexler H. Endothelial function: a critical determinant in atherosclerosis? Circulation 2004; 109:11-27-33.
19. Rosenfeld ME. Leukocyte recruitment into developing atherosclerotic lesions: the complex interaction between multiple molecules keeps getting more complex. Arterioscler Thromb Vase Biol 2002;22:361-3.(Pubitemid 34218739)
20. Hadi AR, Carr CS, Suwaidi JA. Endothelial dysfunction: cardiovascular risk factors, therapy, and outcome. Vascular Health and Risk Management 2005;I(3): 183-98.
21. Anderson TJ, Uehata A, Gerhard MD, Meredith IT, Knab S, Delagrange D et al. Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol 1995;26:1235-41.
22. Celermajer DS, Sorensen KE, Bull C, Robinson J, Deanfield JE. Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol 1994;24:1468-74.(Pubitemid 24344241)
23. Heitzer T, Schlinzig T, Krohn K, Meinertz T, Munzel T. Endothelial dysfunction, oxidative stress and risk of cardiovascular events in patients with coronary artery disease. Circulation 2001;104:2673-8.(Pubitemid 33108132)
24. Miller VM, Vanhoutte PM. Enhanced release of endotheliumderived factors by chronic increases in blood flow. Am J Physiol 1988;255:H446-H51.
25. Rubanyi GM, Romero JC, Vanhoutte PM. Flow-induced release of endothelium-derived relaxing factor. A J Physiol 1986;250:H 1145-H9.
26. Tronc F, Wassef M, Esposito B, Henrion D, Glagov S, Tedgui A. Role of NO in flow-induced remodelling of rabbit common carotid artery. Arterioscler Thromb Vase Biol 1996;16:1256-62.(Pubitemid 26339713)
27. Tuttle JL, Nachreiner RD, Bhuller AS, Condict KW, Connors BA, Herring BP. Shear level influences artery remodelling, wall dimensions, cell density and eNOS expression. Am J Physiol 2001;281:HI380-H9.
28. Muniyappa R, Iantorno M, Quon MJ. An integrated view of insulin resistance and endothelial dysfunction. Endocrinol Metab Clin North Am 2008;37:685.
29. Williams IL, Wheatcroft SB, Shah AM, Kearney MT. Obesity, atherosclerosis and the vascular endothelium: mechanisms of reduced nitric oxide bioavailability in obese humans. International Journal of Obesity 2002;26:754-64.(Pubitemid 34620866)
30. Seals DR, DeSouza CA, Donato AJ, Tanaka H. Habitual exercise and arterial aging. J Appl Physiol 2008;105:1323-32.
31. Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Cir Res 2000;87:840-4.
32. Landmesser U, Harrison DG. Oxidant stress as a marker for cardiovascular events: ox marks the spot. Circulation 2001;104:2638-41.
33. Kojda G, Harrison D. Interactions between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure. Cardiovasc Res 1999;43:562-71.(Pubitemid 29369255)
34. Looft-Wilson RC, Ashley BS, Billig JE, Wolfert MR, Ambrecht LA, Bearden SE. Chronic diet-induced hyperhomocysteinemia impairs eNOS regulation in mouse mesenteric arteries. Am J Physiol Regul Integr Comp Physiol 2008;295;R59-R66.
35. Liu Y, You Y, Song T, Wu S, Liu L. Impairment of endotheliumdependent relaxation of rat aortas by homocysteine thiolactone and attenuation by Captopril. J Cardiovasc Pharmacol 2007;50:155-61.(Pubitemid 47267740)
36. Stühlinger MC, Tsao PS, Her JH, Kimoto M, Balint RF, Cooke JP. Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine. Circulation 2001;104:2569-75.(Pubitemid 33104795)
37. hlinger MC, Oka RK, Graf EE, Schmölzer I, Upson BM, Kapoor O et al. Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine. Circulation 2003;108:933-8.
38. Booth FW, Gordon SE, Carlson CJ and Hamilton MT. Waging war on modern chronic diseases: primary prevention through exercise biology. J Appl Physiol 2000;88:774-87.(Pubitemid 30097126)
39. Maiorana A, O'Driscoll GJ, Taylor RR, Green DJ. Exercise and the nitric oxide vasodilator system. Sports Med 2003;33:1013-5.
40. Katz SD, Kram H, Kahn T, Knecht M. Exercise-induced vasodilatation in forearm circulation of normal subjects and patients with congestive heart failure: Role of endothelium-derived nitric oxide. J Am Coll Cardiol 1996;28:585-90.(Pubitemid 26288637)
41. Katz SD, Yuen J, Bijou R, Lejemtel TH. Training improves endothelium-dependent vasodilation in resistance vessels of patients with heart failure. J Appl Physiol 1997;82:1488-92.(Pubitemid 27203857)
42. Crimi E, Ignarro LJ, Cacciatore F, Napoli C. Mechanisms by which exercise training benefits patients with heart failure. Lavrenic A, Salobir BG, Keber I. Physical training improves flow-mediated dilation in patients with the polymetabolic syndrome. Arterioscler Thromb Vase Biol 2000;20:551-5.
43. Kingwell BA, Sherrard B, Jennings GL, Dart AM. Four weeks of cycle training increases basal production of nitric oxide from the forearm. Am J Physiol 1997;272:H1070-H7.
44. Fukai T, Siegfried MR, Ushio-Fukai M, Cheng Y, Kojda G, Harrison DG. Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training. J Clin Invest 2000; 105:1631 -9.
45. Maiorana A, O'Driscoll G, Dembo L, Cheetham C, Goodman C, Taylor R et al. Effect of aerobic and resistance exercise training on vascular function in heart failure. Am J Physiol 2000;279:H1999H2005.
46. Walsh JH, Bilsborough W, Maiorana A, Best M, O'Driscoll GJ, Taylor RR et al. Exercise improves conduit vessel endothelial function in CAD patients. J Appl Physiol 2003;285:20-5.(Pubitemid 36753779)
47. Walsh JH, Yong G, Cheetham C, Watts GF, O'Driscoll GJ, Taylor RR et al. Effect of exercise training on conduit and resistance vessel function in medicated and unmedicated hypercolesterolaemic patients. Eur Heart J 2003;24:1681-9.(Pubitemid 37174909)
48. Maiorana A, O'Driscoll G, Cheetham C, Dembo L, Stanton K, Goodman C et al. The effect of combined aerobic and resistance exercise training on vascular function in type 2 diabetes. J Am Coll Cardiol 2001;38:860-6.(Pubitemid 32835765)
49. Laufs U, Werner N, Link A, Endres M, Wassmann S, Jürgens K et al. Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation 2004;109:220-6.(Pubitemid 38114143)
50. Müller-Ehmsen J, Braun D, Schneider T, Pfister R, Worm N, Wielckens K et al. Decreased number of circulating progenitor cells in obesity: beneficial effects of weight reduction. Eur Heart J 2008;29:1560-8.(Pubitemid 351881989)
51. Sandri M, Adams V, Gielen S, Linke A, Lenk K, Kränkel N et al. Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studies. Circulation 2005;111:3391-9.(Pubitemid 40923392)
52. DeSouza CA, Shapiro LF, Clevenger CM, Dinenno FA, Monahan KD, Tanaka H et al. Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation 2000;102:1351-7.
53. Taddei S, Galetta F, Virdis A, Ghiadoni L, Salvetti G, Franzoni F et al. Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes. Circulation 2000;101:2896-901.(Pubitemid 30415878)
54. Blair SN, Kohl HW, Gordon NF, Paffenbarger RS Jr. How much physical activity is good for health? Annu Rev Public Health 1992;13:99-126.
55. Bembom O, van der Laan M, Haight T, Tager I. Leisure-time physical activity and all-cause mortality in an elderly cohort. Epidemiology 2009;20:424-30.
56. Manson JE, Greenland P, LaCroix AZ, Stefanick ML, Mouton CP, Oberman A et al. Walking compared with vigorous exercise for the prevention of cardiovascular events in women. N Engl J Med 2002;347:716-25.(Pubitemid 35203902)
57. Lynch J, Helmrich SP, Lakka TA, Kaplan GA, Cohen RD, Salonen R et al. Moderately intense physical activities and high levels of cardiorespiratory fitness reduce the risk of non-insulin- dependent diabetes mellitus in middle-aged men. Arch Intern Med 1996;156:1307-14.
58. Reid MB, Shoji T, Moody RM, Entmann MI. Reactive oxygen in skeletal muscle. II. Extracellular release of free radicals. J Appl Physiol 1992;73:1806-9.
59. Bergholm R, Mäkimattila S, Valkonen M, Liu ML, Lahdenperä S, Taskinen MR et al. Intense physical training decreases circulating antioxidants and endothelium-dependent vasodilation in vivo. Atherosclerosis 1999;145:141-9.
60. O C, Higashi Y, Kimura M, Noma K, Hara K, Nakagawa K et al. Effect of different intensities of exercise on endothelium-dependent vasodilation in humans. Role of endothelium-dependent nitric oxide and oxidative stress. Circulation 2003;108:530-5.
61. Tanasecu M, Leitzmann MF, Rimm EB et al. Exercise type and intensity in relation to coronary heart disease in men. JAMA 2002; 288:1994-2000.(Pubitemid 35204689)
62. Davies KJ, Quintaniha AT, Brooks GA, Packer L. Free radicals and tissue damage produced by exercise. Biochem Biophys Res Commun 1982; 107:1198-1205(Pubitemid 13222413)
63. Cadroy Y, Pillard F, Sakariassen S, et al. Strenous but not moderate exercise increases the thrombotic tendency in healthy sedentary male volunteers. J Appl Physiol 2002;93:829-833.(Pubitemid 34919651)
64. Ikarugi H, Taka T, Nakajima S, et al. Norepinephrine, but not epinephrine, enhances platelet reactivity and coagulation after exercise in humans. J Appl Physiol 1999;86:133-138(Pubitemid 29046950)
65. Mockel M, Ulrich NV, Heller G, et al. Platelet activation through triathlon competition in ultra-endurance trained athletes: impact of thrombin and plasmin generation and catecholamine release. Int J Sports Med 2001;22:337-343.(Pubitemid 32678776)
66. Wang JS. Intense exercise increases shear-induced platelet aggregation in men through enhancement of von Willbrand factor binding, glycoprotein Ilb/IIIa activation, and P-selectin expression on platelets. Eur J Appl Physiol 2004;91:741-747
67. Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999; 19:217246.
68. Stanger O, Weger M. Interactions of homocysteine, nitric oxide, folate and radicals in the progressively damaged endothelium. Clin ChemLab 1997;272:17012-17017
69. Clarke R, Daly L, Robinson K et al. Hyperomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 1991; 324:1149-1155.
70. McCully KS. Homocysteine and vascular disease. Nat Med 1996; 2:386-389(Pubitemid 26191904)
71. Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 2002; 288:2015-2022.
72. Den Heijer M, Lewington S, Clarke R. Homocysteine, MTHFR and risk of venous thrombosis: a meta-analysis of published epidemiological studies. J Thromb Haemost 2005; 3:292-299.(Pubitemid 41623617)
73. Stampfer MJ, Malinow MR, Willett WC et al. A prospective study of plasma homocysteine and risk of myocardial infarction in US physicians. JAMA 1992; 268:877-881.
74. Eridimanne VER, Woo CWH, Siow YL et al. Homocysteine stimulates NADPH oxidase-mediated superoxide production leading to endothelial dysfunction in rats. Can J Physiol Pharmacol 2007; 85:1236-1247.(Pubitemid 351222389)
75. Carluccio MA, Ancora MA, Massaro M, et al. Homocysteine induces VCAM-1 gene expression through NF-kB and NAD(P)H oxidase activation: protective role of Mediterranean diet polyphenols antioxidants. Am J Physiol Heart Circ Physiol 2007; 293:H2344-H2354(Pubitemid 47605880)
76. Wang G, Siow YL,and O K. Homocysteine stimulates nuclear factor kappaB activity and monocyte chemoattractant rotein-1 expression by activating NF-kappa inTHP-I macrophages. Am J Physiol Heart Circ Physiol 2001; 280:H2840-H2847.
77. Weiss N, Keller C, Hoffmann U and Loscalzo J. Endothelial dysfunction and atherothrombosis in mild hyperhomocysteinemia. Vase Med 2002; 7:227-239.(Pubitemid 36104324)
78. Lentz SR. Mechanisms of homocysteine-induced athero-thrombosis. J Thromb Haemost 2005; 3:1646-1654.
79. Boger RH, Lentz SR, Bode-Boger SM, Knapp HR, Haynes WG. Elevation of asymmetrical dimethylarginine may mediate endothelial dysfunction during experimental hyperhomocist(e)inemia in humans. Clin Sci 2001; 100:161-7.
80. Borrionc P, Pigozzi F, Massazza G, et al. Hyperhomocysteinemia in winter elite athletes: a longitudinal study. J Endocrinol Invest 2007; 30:367-375.(Pubitemid 47098231)
81. Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med 1998;338:1042-50.(Pubitemid 128753793)
82. Reeser JC, Verhagen E, Briner WW, Askeland TI, Bahr R. Sportrelated hyperhomocysteinaemia: a putative marker of muscular demand to be noted for cardiovascular risk. Br J Sports Med 2008;42:594-600.