A novel underuse model shows that inactivity but not ovariectomy determines the deteriorated material properties and geometry of cortical bone in the tibia of adult rats

Journal of Bone and Mineral Metabolism

Volumn 29, Issue 4, 2011, Pages 422-436

  Miyagawa, Kazuaki ^a,b   Kozai, Yusuke ^a   Ito, Yumi ^a   Furuhama, Takami ^a   Naruse, Kouji ^c   Nonaka, Kiichi ^d   Nagai, Yumiko ^e   Yamato, Hideyuki ^e   Kashima, Isamu ^a   Ohya, Keiichi ^f   Aoki, Kazuhiro ^f   Mikuni Takagaki, Yuko ^a  

^a KANAGAWA DENTAL COLLEGE   (Japan)

^b RESEARCH INSTITUTE FOR MATERNAL AND CHILD HEALTH   (Japan)

^c KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d Elk Corporation   (Japan)

^e KUREHA CORPORATION   (Japan)

^f TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Osteocyte; Osteoporosis; Raman spectroscopy and quality of bone; SOST sclerostin; Underuse

Indexed keywords

CARBOXY TERMINAL TELOPEPTIDE; ESTROGEN; OSTEOCALCIN; SCLEROSTIN;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE EXAMINATION; BONE LEVEL; BONE MINERALIZATION; BONE STRENGTH; BONE STRESS; BONE STRUCTURE; BONE TURNOVER; CANCELLOUS BONE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORTICAL BONE; DAILY LIFE ACTIVITY; FEMALE; FEMUR; HISTOLOGY; IMMOBILIZATION; LUMBAR VERTEBRA; MICROFOCUSED X RAY COMPUTED TOMOGRAPHY; MUSCULOSKELETAL SYSTEM PARAMETERS; NONHUMAN; OSSIFICATION; OSTEOLYSIS; OSTEOMETRY; PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAMAN SPECTROMETRY; RAT; THREE POINT BENDING TEST; TIBIA;

AGING; ANIMALS; BIOLOGICAL MARKERS; BIOMECHANICS; BODY WEIGHT; BONE DENSITY; BONE MATRIX; BONE MORPHOGENETIC PROTEINS; BONE REMODELING; EPIPHYSES; FEMALE; GENETIC MARKERS; IMMUNOHISTOCHEMISTRY; LUMBAR VERTEBRAE; MODELS, BIOLOGICAL; OSTEOCYTES; OVARIECTOMY; RATS; RATS, WISTAR; SPECTRUM ANALYSIS, RAMAN; TIBIA; WALKING; X-RAY MICROTOMOGRAPHY;

EID: 80052427051     PISSN: 09148779     EISSN: 14355604     Source Type: Journal    
DOI: 10.1007/s00774-010-0241-9     Document Type: Article

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