CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons

Genes and Development

Volumn 24, Issue 20, 2010, Pages 2330-2342

  Oury, Franck ^a   Yadav, Vijay K ^a   Wang, Ying ^a   Zhou, Bin ^b   Liu, X Sherry ^b   Guo, X Edward ^b   Tecott, Laurence H ^c   Schutz, Günther ^d   Means, Anthony R ^e   Karsenty, Gerard ^a  

^a Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

^b Fu Foundation School of Engineering and Applied Science   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Bone mass accrual; Brain derived serotonin; CAM kinases; CREB; Hypothalamus

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE BETA; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE IV; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; CALMODULIN; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; SERINE DERIVATIVE; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MASS; CALMODULIN KINASE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SPECIFICITY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENE INACTIVATION; HISTOPATHOLOGY; HORMONAL REGULATION; HYPOTHALAMUS; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; MORPHOMETRICS; MOUSE; NERVE CELL; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; SEROTONIN BRAIN LEVEL; SIGNAL TRANSDUCTION; SYMPATHETIC TONE;

ANIMALS; BONE AND BONES; BRAIN; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; CELL LINE, TUMOR; CLUSTER ANALYSIS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HYPOTHALAMUS; ISOENZYMES; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; NEURONS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOBLASTS; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEROTONIN;

EID: 77958523915     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1977210     Document Type: Article

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