Alteration of xylose reductase coenzyme preference to improve ethanol production by Saccharomyces cerevisiae from high xylose concentrations

Bioresource Technology

Volumn 102, Issue 19, 2011, Pages 9206-9215

  Xiong, Mingyong ^a,b   Chen, Guohua ^a,b   Barford, John ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Ethanol; Redox imbalance; Saccharomyces cerevisiae; Xylose; Xylose reductase

Indexed keywords

GLUCOSE; SUGAR SUBSTITUTES; XYLOSE; YEAST;

CONSUMPTION RATES; DIFFERENT SUBSTRATES; ETHANOL PRODUCTION; ETHANOL PRODUCTIVITY; ETHANOL YIELD; REDOX IMBALANCE; THEORETICAL YIELD; XYLOSE REDUCTASE;

ETHANOL;

ALCOHOL; GLUCOSE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; XYLITOL; XYLOSE;

BACTERIUM; ENZYME ACTIVITY; ETHANOL; EXPERIMENTAL STUDY; FERMENTATION; GLUCOSE; MUTATION; REDOX CONDITIONS; SUBSTRATE; THEORETICAL STUDY;

ALCOHOL PRODUCTION; ARTICLE; COENZYME; FERMENTATION; FUNGAL STRAIN; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SPECIES COMPARISON; THEORY; WILD TYPE;

SACCHAROMYCES CEREVISIAE;

EID: 80052377729     PISSN: 09608524     EISSN: 18732976     Source Type: Journal    
DOI: 10.1016/j.biortech.2011.06.058     Document Type: Article

References (36)

1. Bengtsson O., Hahn-Hagerdal B., Gorwa-Grauslund M.F. Xylose reductase from Pichia stipitis with altered coenzyme preference improves ethanolic xylose fermentation by recombinant Saccharomyces cerevisiae. Biotechnol. Biofuels 2009, 2:9.
2. Brat D., Boles E., Wiedemann B. Functional expression of a bacterial xylose isomerase in Saccharomyces cerevisiae. Appl. Environ. Microbiol. 2009, 75(8):2304-2311.
3. Cao L., Zhang A., Kong Q., Xu X., Josine T.L., Chen X. Overexpression of GLT1 in fps1Delta gpdDelta mutant for optimum ethanol formation by Saccharomyces cerevisiae. Biomol. Eng. 2007, 24(6):638-642.
4. Dmytruk O.V., Voronovsky A.Y., Abbas C.A., Dmytruk K.V., Ishchuk O.P., Sibirny A.A. Overexpression of bacterial xylose isomerase and yeast host xylulokinase improves xylose alcoholic fermentation in the thermotolerant yeast Hansenula polymorpha. FEMS Yeast Res. 2008, 8(1):165-173.
5. Edelheit O., Hanukoglu A., Hanukoglu I. Simple and efficient site-directed mutagenesis using two single-primer reactions in parallel to generate mutants for protein structure-function studies. BMC Biotechnol. 2009, 9:61.
6. Eliasson A., Christensson C., Wahlbom C.F., Hahn-Hagerdal B. Anaerobic xylose fermentation by recombinant Saccharomyces cerevisiae carrying XYL1, XYL2, and XKS1 in mineral medium chemostat cultures. Appl. Environ. Microbiol. 2000, 66(8):3381-3386.
7. Guo Z.P., Zhang L., Ding Z.Y., Wang Z.X., Shi G.Y. Interruption of glycerol pathway in industrial alcoholic yeasts to improve the ethanol production. Appl. Microbiol. Biotechnol. 2009, 82(2):287-292.
8. Harhangi H.R., Akhmanova A.S., Emmens R., van der Drift C., de Laat W.T., van Dijken J.P., Jetten M.S., Pronk J.T., Op den Camp H.J. Xylose metabolism in the anaerobic fungus Piromyces sp. strain E2 follows the bacterial pathway. Arch. Microbiol. 2003, 180(2):134-141.
9. Ho N.W., Chen Z., Brainard A.P. Genetically engineered Saccharomyces yeast capable of effective cofermentation of glucose and xylose. Appl. Environ. Microbiol. 1998, 64(5):1852-1859.
10. Hou L. Novel methods of genome shuffling in Saccharomyces cerevisiae. Biotechnol. Lett. 2009, 31(5):671-677.
11. Hou J., Shen Y., Li X.P., Bao X.M. Effect of the reversal of coenzyme specificity by expression of mutated Pichia stipitis xylitol dehydrogenase in recombinant Saccharomyces cerevisiae. Lett. Appl. Microbiol. 2007, 45(2):184-189.
12. Jeffries T.W. Emerging technology for fermenting D-xylose. Trends Biotechnol. 1985, 3(8):208-212.
13. Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A., Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.S., Passoth V., Richardson P.M. Genome sequence of the lignocellulose-bioconverting and xylose-fermenting yeast Pichia stipitis. Nat. Biotechnol. 2007, 25(3):319-326.
14. Jeppsson H., Yu S., Hahn-Hagerdal B. Xylulose and glucose fermentation by Saccharomyces cerevisiae in chemostat culture. Appl. Environ. Microbiol. 1996, 62(5):1705-1709.
15. Johansson B., Christensson C., Hobley T., Hahn-Hagerdal B. Xylulokinase overexpression in two strains of Saccharomyces cerevisiae also expressing xylose reductase and xylitol dehydrogenase and its effect on fermentation of xylose and lignocellulosic hydrolysate. Appl. Environ. Microbiol. 2001, 67(9):4249-4255.
16. Karhumaa K., Hahn-Hagerdal B., Gorwa-Grauslund M.F. Investigation of limiting metabolic steps in the utilization of xylose by recombinant Saccharomyces cerevisiae using metabolic engineering. Yeast 2005, 22(5):359-368.
17. Karhumaa K., Garcia Sanchez R., Hahn-Hagerdal B., Gorwa-Grauslund M.F. Comparison of the xylose reductase-xylitol dehydrogenase and the xylose isomerase pathways for xylose fermentation by recombinant Saccharomyces cerevisiae. Microb. Cell Fact. 2007, 6:5.
18. Kong Q.X., Gu J.G., Cao L.M., Zhang A.L., Chen X., Zhao X.M. Improved production of ethanol by deleting FPS1 and over-expressing GLT1 in Saccharomyces cerevisiae. Biotechnol. Lett. 2006, 28(24):2033-2038.
19. Kong Q.X., Cao L.M., Zhang A.L., Chen X. Overexpressing GLT1 in gpd1Delta mutant to improve the production of ethanol of Saccharomyces cerevisiae. Appl. Microbiol. Biotechnol. 2007, 73(6):1382-1386.
20. Kong Q.X., Zhang A.L., Cao L.M., Chen X. Over-expressing GLT1 in a gpd2Delta mutant of Saccharomyces cerevisiae to improve ethanol production. Appl. Microbiol. Biotechnol. 2007, 75(6):1361-1366.
21. Kostrzynska M., Sopher C.R., Lee H. Mutational analysis of the role of the conserved lysine-270 in the Pichia stipitis xylose reductase. FEMS Microbiol. Lett. 1998, 159(1):107-112.
22. Kuyper M., Harhangi H.R., Stave A.K., Winkler A.A., Jetten M.S., de Laat W.T., den Ridder J.J., Op den Camp H.J., van Dijken J.P., Pronk J.T. High-level functional expression of a fungal xylose isomerase: the key to efficient ethanolic fermentation of xylose by Saccharomyces cerevisiae?. FEMS Yeast Res. 2003, 4(1):69-78.
23. Madhavan A., Tamalampudi S., Ushida K., Kanai D., Katahira S., Srivastava A., Fukuda H., Bisaria V.S., Kondo A. Xylose isomerase from polycentric fungus Orpinomyces: gene sequencing, cloning, and expression in Saccharomyces cerevisiae for bioconversion of xylose to ethanol. Appl. Microbiol. Biotechnol. 2009, 82(6):1067-1078.
24. Matsushika A., Sawayama S. Effect of initial cell concentration on ethanol production by flocculent Saccharomyces cerevisiae with xylose-fermenting ability. Appl. Biochem. Biotechnol. 2010.
25. Matsushika A., Watanabe S., Kodaki T., Makino K., Inoue H., Murakami K., Takimura O., Sawayama S. Expression of protein engineered NADP+-dependent xylitol dehydrogenase increases ethanol production from xylose in recombinant Saccharomyces cerevisiae. Appl. Microbiol. Biotechnol. 2008, 81(2):243-255.
26. Matsushika A., Inoue H., Kodaki T., Sawayama S. Ethanol production from xylose in engineered Saccharomyces cerevisiae strains: current state and perspectives. Appl. Microbiol. Biotechnol. 2009, 84(1):37-53.
27. Matsushika A., Inoue H., Murakami K., Takimura O., Sawayama S. Bioethanol production performance of five recombinant strains of laboratory and industrial xylose-fermenting Saccharomyces cerevisiae. Bioresour. Technol. 2009, 100(8):2392-2398.
28. Petschacher B., Nidetzky B. Altering the coenzyme preference of xylose reductase to favor utilization of NADH enhances ethanol yield from xylose in a metabolically engineered strain of Saccharomyces cerevisiae. Microb. Cell Fact. 2008, 7:9-20.
29. Salusjärvi L., Pitkänen J., Aristidou A., Ruohonen L., Penttilä M. Transcription analysis of recombinant Saccharomyces cerevisiae reveals novel responses to xylose. Appl. Biochem. Biotechnol. 2006, 128(3):237-261.
30. Sambrook J., Russell D. Molecular Cloning: A Laboratory Manual 2001, Cold Spring Harbor Laboratory Press. third ed.
31. Thomas B.J., Rothstein R. Elevated recombination rates in transcriptionally active DNA. Cell 1989, 56(4):619-630.
32. van Maris A.J., Winkler A.A., Kuyper M., de Laat W.T., van Dijken J.P., Pronk J.T. Development of efficient xylose fermentation in Saccharomyces cerevisiae: xylose isomerase as a key component. Adv. Biochem. Eng. Biotechnol. 2007, 108:179-204.
33. Watanabe S., Abu Saleh A., Pack S.P., Annaluru N., Kodaki T., Makino K. Ethanol production from xylose by recombinant Saccharomyces cerevisiae expressing protein-engineered NADH-preferring xylose reductase from Pichia stipitis. Microbiology 2007, 153(Pt 9):3044-3054.
34. Watanabe S., Pack S.P., Saleh A.A., Annaluru N., Kodaki T., Makino K. The positive effect of the decreased NADPH-preferring activity of xylose reductase from Pichia stipitis on ethanol production using xylose-fermenting recombinant Saccharomyces cerevisiae. Biosci. Biotechnol. Biochem. 2007, 71(5):1365-1369.
35. Watanabe S., Saleh A.A., Pack S.P., Annaluru N., Kodaki T., Makino K. Ethanol production from xylose by recombinant Saccharomyces cerevisiae expressing protein engineered NADP+-dependent xylitol dehydrogenase. J. Biotechnol. 2007, 130(3):316-319.
36. Zhang A., Kong Q., Cao L., Chen X. Effect of FPS1 deletion on the fermentation properties of Saccharomyces cerevisiae. Lett. Appl. Microbiol. 2007, 44(2):212-217.