-
1
-
-
20044366163
-
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
-
Stupp R, Mason W, van den Bent M, Weller M, Fisher B, Taphoom M, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005; 352: 987-996.
-
(2005)
N Engl J Med
, vol.352
, pp. 987-996
-
-
Stupp, R.1
Mason, W.2
van den Bent, M.3
Weller, M.4
Fisher, B.5
Taphoom, M.6
-
2
-
-
0021932240
-
Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin
-
Libermann T, Nusbaum H, Razon N, Kris R, Lax I, Soreq H, et al. Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature 1985; 313: 144-147.
-
(1985)
Nature
, vol.313
, pp. 144-147
-
-
Libermann, T.1
Nusbaum, H.2
Razon, N.3
Kris, R.4
Lax, I.5
Soreq, H.6
-
3
-
-
0025790916
-
Genes for epidermal growth factor receptor, transforming growth factor alpha and epidermal growth factor and their expression in human gliomas in vivo
-
Ekstrand A, James C, Cavanee W, Seliger B, Pettersson R, Collins V. Genes for epidermal growth factor receptor, transforming growth factor alpha and epidermal growth factor and their expression in human gliomas in vivo. Cancer Res 1991; 51: 2164-2172.
-
(1991)
Cancer Res
, vol.51
, pp. 2164-2172
-
-
Ekstrand, A.1
James, C.2
Cavanee, W.3
Seliger, B.4
Pettersson, R.5
Collins, V.6
-
4
-
-
67651154339
-
Therapeutic inhibition of the epidermal growth factor receptor in high-grade gliomas - where do we stand?
-
Karpel-Massler G, Schmidt U, Unterberg A, Halatsch M. Therapeutic inhibition of the epidermal growth factor receptor in high-grade gliomas - where do we stand? Mol Cancer Res 2009; 7: 1000-1012.
-
(2009)
Mol Cancer Res
, vol.7
, pp. 1000-1012
-
-
Karpel-Massler, G.1
Schmidt, U.2
Unterberg, A.3
Halatsch, M.4
-
6
-
-
0034629485
-
Reversible G1 arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27KIP1 independent of MAPK activity
-
Busse D, Doughty R, Ramsey T, Russell W, Price J, Flanagan W, et al. Reversible G1 arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27KIP1 independent of MAPK activity. J Biol Chem 2000; 275: 6987-6995.
-
(2000)
J Biol Chem
, vol.275
, pp. 6987-6995
-
-
Busse, D.1
Doughty, R.2
Ramsey, T.3
Russell, W.4
Price, J.5
Flanagan, W.6
-
7
-
-
0035884231
-
The epidermal growth factor receptor: From mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia
-
Arteaga C. The epidermal growth factor receptor: From mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia. J Clin Oncol 2001; 19: 32S-40S.
-
(2001)
J Clin Oncol
, vol.19
-
-
Arteaga, C.1
-
8
-
-
0030787340
-
Receptor dimerization is not a factor in the signaling activity of a transforming variant epidermal growth factor receptor (EGFRvIII)
-
Chu C, Everiss K, Wikstrand C, Batra S, Kung H, Bigner D. Receptor dimerization is not a factor in the signaling activity of a transforming variant epidermal growth factor receptor (EGFRvIII). Biochem J 1997; 324: 855-861.
-
(1997)
Biochem J
, vol.324
, pp. 855-861
-
-
Chu, C.1
Everiss, K.2
Wikstrand, C.3
Batra, S.4
Kung, H.5
Bigner, D.6
-
9
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch T, Bell D, Sordella R, Gurubhagavatula S, Okimoto R, Brannigan B, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004; 350: 2129-2139.
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.1
Bell, D.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.5
Brannigan, B.6
-
10
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez J, Jänne P, Lee J, Tracy S, Greulich H, Gabriel S, et al. EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 2004; 304: 1497-1500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.1
Jänne, P.2
Lee, J.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
-
11
-
-
0037096945
-
Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion
-
Lal A, Glazer C, Martinson H, Friedman H, Archer G, Sampson J, et al. Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion. Cancer Res 2002; 62: 3335-3339.
-
(2002)
Cancer Res
, vol.62
, pp. 3335-3339
-
-
Lal, A.1
Glazer, C.2
Martinson, H.3
Friedman, H.4
Archer, G.5
Sampson, J.6
-
12
-
-
10744229118
-
Inverse correlation of epidermal growth factor receptor messenger RNA induction and suppression of anchorageindependent growth by OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in glioblastoma multiforme cell lines
-
Halatsch M-E, Gehrke E, Vougioukas V, Bötefür I, Efferth T, Gebhardt E, et al. Inverse correlation of epidermal growth factor receptor messenger RNA induction and suppression of anchorageindependent growth by OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in glioblastoma multiforme cell lines. J Neurosurg 2004; 100: 523-533.
-
(2004)
J Neurosurg
, vol.100
, pp. 523-533
-
-
Halatsch, M.-E.1
Gehrke, E.2
Vougioukas, V.3
Bötefür, I.4
Efferth, T.5
Gebhardt, E.6
-
13
-
-
75749122223
-
A phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy
-
Raizer J, Abrey L, Lassman A, Chang S, Lamborn K, Kuhn J, et al. A phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy. Neurooncol 2010; 12: 95-103.
-
(2010)
Neurooncol
, vol.12
, pp. 95-103
-
-
Raizer, J.1
Abrey, L.2
Lassman, A.3
Chang, S.4
Lamborn, K.5
Kuhn, J.6
-
14
-
-
62449150719
-
Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034
-
van den Bent M, Brandes A, Rampling R, Kouwenhoven M, Kros J, Carpentier A, et al. Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034. J Clin Oncol 2009; 27: 1268-1274.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1268-1274
-
-
van den Bent, M.1
Brandes, A.2
Rampling, R.3
Kouwenhoven, M.4
Kros, J.5
Carpentier, A.6
-
15
-
-
57149118473
-
Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177
-
Brown P, Krishnan S, Sarkaria J, Wu W, Jaeckle K, Uhm J, et al. Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177. J Clin Oncol 2008; 26: 5603-5609.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5603-5609
-
-
Brown, P.1
Krishnan, S.2
Sarkaria, J.3
Wu, W.4
Jaeckle, K.5
Uhm, J.6
-
16
-
-
59149086517
-
Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma
-
Prados M, Chang S, Butowski N, DeBoer R, Parvataneni R, Carliner H, et al. Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma. J Clin Oncol 2009; 27: 579-584.
-
(2009)
J Clin Oncol
, vol.27
, pp. 579-584
-
-
Prados, M.1
Chang, S.2
Butowski, N.3
Deboer, R.4
Parvataneni, R.5
Carliner, H.6
-
17
-
-
77953617053
-
Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiforme
-
Peereboom D, Shepard D, Ahluwalia M, Brewer C, Agarwal N, Stevens G, et al. Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiforme. J Neurooncol 2010; 98: 93-99.
-
(2010)
J Neurooncol
, vol.98
, pp. 93-99
-
-
Peereboom, D.1
Shepard, D.2
Ahluwalia, M.3
Brewer, C.4
Agarwal, N.5
Stevens, G.6
-
18
-
-
33748058820
-
Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTENdeficient and PTEN-intact glioblastoma cells
-
Wang M, Lu K, Zhu S, Dia E, Vivanco I, Shackleford G, et al. Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTENdeficient and PTEN-intact glioblastoma cells. Cancer Res 2006; 66: 7864-7869.
-
(2006)
Cancer Res
, vol.66
, pp. 7864-7869
-
-
Wang, M.1
Lu, K.2
Zhu, S.3
Dia, E.4
Vivanco, I.5
Shackleford, G.6
-
19
-
-
34548596728
-
A dual phosphoinositide-3-kinase anti/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma
-
Fan Q-W, Cheng C, Nicolaides T, Hackett C, Knight Z, Shokat K, et al. A dual phosphoinositide-3-kinase anti/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma. Cancer Res 2007; 67: 7960-7965.
-
(2007)
Cancer Res
, vol.67
, pp. 7960-7965
-
-
Fan, Q.-W.1
Cheng, C.2
Nicolaides, T.3
Hackett, C.4
Knight, Z.5
Shokat, K.6
-
20
-
-
33746807790
-
Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas
-
Doherty L, Gigas D, Kesari S, Drappatz J, Kim R, Zimmermann J, et al. Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas. Neurology 2006; 67: 156-158.
-
(2006)
Neurology
, vol.67
, pp. 156-158
-
-
Doherty, L.1
Gigas, D.2
Kesari, S.3
Drappatz, J.4
Kim, R.5
Zimmermann, J.6
-
21
-
-
75049084471
-
Phase II trial of erlotinib plus sirolimus in adults with recurrent glioblastoma
-
Reardon D, Desjardins A, Vredenburgh J, Gururangan S, Friedman A, Herndon II J, et al. Phase II trial of erlotinib plus sirolimus in adults with recurrent glioblastoma. J Neurooncol 2010; 96: 219-230.
-
(2010)
J Neurooncol
, vol.96
, pp. 219-230
-
-
Reardon, D.1
Desjardins, A.2
Vredenburgh, J.3
Gururangan, S.4
Friedman, A.5
Herndon, J.6
-
22
-
-
78650102866
-
Phase II trial of bevacizumab and erlotinib in patients with recurrent malignant glioma
-
Sathornsumetee S, Desjardins A, Vredenburgh J, McLendon R, Marcello J, Herndon II J, et al. Phase II trial of bevacizumab and erlotinib in patients with recurrent malignant glioma. Neurooncol 2010; 12: 1300-1310.
-
(2010)
Neurooncol
, vol.12
, pp. 1300-1310
-
-
Sathornsumetee, S.1
Desjardins, A.2
Vredenburgh, J.3
McLendon, R.4
Marcello, J.5
Herndon, J.6
-
23
-
-
33745183568
-
Phase I trial of erlotinib with radiation therapy in patients with glioblastoma multiforme: Results of North Central Cancer Treatment Group protocol N0177
-
Krishnan S, Brown P, Ballmann K, Fiveash J, Uhm J, Giannini C, et al. Phase I trial of erlotinib with radiation therapy in patients with glioblastoma multiforme: results of North Central Cancer Treatment Group protocol N0177. Int J Radiat Oncol Biol Phys 2006; 65: 1192-1199.
-
(2006)
Int J Radiat Oncol Biol Phys
, vol.65
, pp. 1192-1199
-
-
Krishnan, S.1
Brown, P.2
Ballmann, K.3
Fiveash, J.4
Uhm, J.5
Giannini, C.6
-
24
-
-
31544474851
-
Phase I study of erlotinib HCl alone and combined with temozolomide in patients with stable or recurrent malignant glioma
-
Prados M, Lamborn K, Chang S, Burton E, Butowski N, Malec M, et al. Phase I study of erlotinib HCl alone and combined with temozolomide in patients with stable or recurrent malignant glioma. Neurooncol 2006; 8: 67-78.
-
(2006)
Neurooncol
, vol.8
, pp. 67-78
-
-
Prados, M.1
Lamborn, K.2
Chang, S.3
Burton, E.4
Butowski, N.5
Malec, M.6
-
25
-
-
73949128107
-
Histone deacetylase inhibitors in cancer therapy
-
Lane AA, Chabner BA. Histone deacetylase inhibitors in cancer therapy. J Clin Oncol 2009; 27: 5459-5468.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5459-5468
-
-
Lane, A.A.1
Chabner, B.A.2
-
26
-
-
49249116407
-
A work in progress: The clinical development of histone deacetylase inhibitors
-
Marsoni S, Damia G, Camboni G. A work in progress: The clinical development of histone deacetylase inhibitors. Epigenetics 2008; 3: 164-171.
-
(2008)
Epigenetics
, vol.3
, pp. 164-171
-
-
Marsoni, S.1
Damia, G.2
Camboni, G.3
-
27
-
-
44449135127
-
HDAC inhibitors effectively induce cell type-specific differentiation in human glioblastoma cell lines of different origin
-
Svechnikova I, Almqvist PM, Ekstrom TJ. HDAC inhibitors effectively induce cell type-specific differentiation in human glioblastoma cell lines of different origin. Int J Oncol 2008; 32: 821-827.
-
(2008)
Int J Oncol
, vol.32
, pp. 821-827
-
-
Svechnikova, I.1
Almqvist, P.M.2
Ekstrom, T.J.3
-
28
-
-
33644856123
-
Epigenetic therapy of cancer: Past, present and future
-
Yoo CB, Jones PA. Epigenetic therapy of cancer: Past, present and future. Nat Rev Drug Discov 2006; 5: 37-50.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 37-50
-
-
Yoo, C.B.1
Jones, P.A.2
-
29
-
-
38449100788
-
Expression profile of class I histone deacetylases in human cancer tissues
-
Nakagawa M, Oda Y, Eguchi T, Aishima S, Yao T, Hosoi F, et al. Expression profile of class I histone deacetylases in human cancer tissues. Oncol Rep 2007; 18: 769-774.
-
(2007)
Oncol Rep
, vol.18
, pp. 769-774
-
-
Nakagawa, M.1
Oda, Y.2
Eguchi, T.3
Aishima, S.4
Yao, T.5
Hosoi, F.6
-
30
-
-
13444274622
-
Inhibitors of histone deacetylases induce tumorselective apoptosis through activation of the death receptor pathway
-
Insinga A, Monestiroli S, Ronzoni S, Gelmetti V, Marchesi F, Viale A, et al. Inhibitors of histone deacetylases induce tumorselective apoptosis through activation of the death receptor pathway. Nat Med 2005; 11: 71-76.
-
(2005)
Nat Med
, vol.11
, pp. 71-76
-
-
Insinga, A.1
Monestiroli, S.2
Ronzoni, S.3
Gelmetti, V.4
Marchesi, F.5
Viale, A.6
-
31
-
-
13444306459
-
Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells
-
Nebbioso A, Clarke N, Voltz E, Germain E, Ambrosino C, Bontempo P, et al. Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells. Nat Med 2005; 11: 77-84.
-
(2005)
Nat Med
, vol.11
, pp. 77-84
-
-
Nebbioso, A.1
Clarke, N.2
Voltz, E.3
Germain, E.4
Ambrosino, C.5
Bontempo, P.6
-
32
-
-
31544466465
-
Bmf is a possible mediator in histone deacetylase inhibitors FK228 and CBHAinduced apoptosis
-
Zhang Y, Adachi M, Kawamura R, Imai K. Bmf is a possible mediator in histone deacetylase inhibitors FK228 and CBHAinduced apoptosis. Cell Death Differ 2006; 13: 129-140.
-
(2006)
Cell Death Differ
, vol.13
, pp. 129-140
-
-
Zhang, Y.1
Adachi, M.2
Kawamura, R.3
Imai, K.4
-
33
-
-
27644556419
-
Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim
-
Zhao Y, Tan J, Zhuang L, Jiang X, Liu ET, Yu Q. Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim. Proc Natl Acad Sci USA 2005; 102: 16090-16095.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 16090-16095
-
-
Zhao, Y.1
Tan, J.2
Zhuang, L.3
Jiang, X.4
Liu, E.T.5
Yu, Q.6
-
35
-
-
21144444486
-
HDAC6 regulates Hsp90 acetylation and chaperonedependent activation of glucocorticoid receptor
-
Kovacs JJ, Murphy PJ, Gaillard S, Zhao X, Wu JT, Nicchitta CV, et al. HDAC6 regulates Hsp90 acetylation and chaperonedependent activation of glucocorticoid receptor. Mol Cell 2005; 18: 601-607.
-
(2005)
Mol Cell
, vol.18
, pp. 601-607
-
-
Kovacs, J.J.1
Murphy, P.J.2
Gaillard, S.3
Zhao, X.4
Wu, J.T.5
Nicchitta, C.V.6
-
36
-
-
25844519550
-
Hsp90 and the chaperoning of cancer
-
Whitesell L, Lindquist SL. Hsp90 and the chaperoning of cancer. Nat Rev Cancer 2005; 5: 761-772.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 761-772
-
-
Whitesell, L.1
Lindquist, S.L.2
-
37
-
-
0034730127
-
Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation
-
Richon VM, Sandhoff TW, Rifkind RA, Marks PA. Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc Natl Acad Sci USA 2000; 97: 10014-10019.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10014-10019
-
-
Richon, V.M.1
Sandhoff, T.W.2
Rifkind, R.A.3
Marks, P.A.4
-
38
-
-
0033822112
-
P21-dependent g(1)arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228
-
Sandor V, Senderowicz A, Mertins S, Sackett D, Sausville E, Blagosklonny MV, et al. P21-dependent g(1)arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228. Br J Cancer 2000; 83: 817-825.
-
(2000)
Br J Cancer
, vol.83
, pp. 817-825
-
-
Sandor, V.1
Senderowicz, A.2
Mertins, S.3
Sackett, D.4
Sausville, E.5
Blagosklonny, M.V.6
-
39
-
-
0028258610
-
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity
-
Ueda H, Nakajima H, Hori Y, Fujita T, Nishimura M, Goto T, et al. FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity. J Antibiot (Tokyo) 1994; 47: 301-310.
-
(1994)
J Antibiot (Tokyo)
, vol.47
, pp. 301-310
-
-
Ueda, H.1
Nakajima, H.2
Hori, Y.3
Fujita, T.4
Nishimura, M.5
Goto, T.6
-
40
-
-
70449365376
-
Reactivation of DNA viruses in association with histone deacetylase inhibitor therapy: A case series report
-
Ritchie D, Piekarz RL, Blombery P, Karai LJ, Pittaluga S, Jaffe ES, et al. Reactivation of DNA viruses in association with histone deacetylase inhibitor therapy: A case series report. Haematologica 2009; 94: 1618-1622.
-
(2009)
Haematologica
, vol.94
, pp. 1618-1622
-
-
Ritchie, D.1
Piekarz, R.L.2
Blombery, P.3
Karai, L.J.4
Pittaluga, S.5
Jaffe, E.S.6
-
42
-
-
19944432566
-
A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia
-
Byrd J, Marcucci G, Parthun M, Xiao J, Klisovic R, Moran M, et al. A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia. Blood 2005; 105: 959-967.
-
(2005)
Blood
, vol.105
, pp. 959-967
-
-
Byrd, J.1
Marcucci, G.2
Parthun, M.3
Xiao, J.4
Klisovic, R.5
Moran, M.6
-
43
-
-
58149235277
-
Histone deacetylase inhibitor romidepsin has differential activity in core binding factor acute myeloid leukemia
-
Odenike O, Alkan S, Sher D, Godwin J, Huo D, Brandt S, et al. Histone deacetylase inhibitor romidepsin has differential activity in core binding factor acute myeloid leukemia. Clin Cancer Res 2008; 14: 7095-7101.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7095-7101
-
-
Odenike, O.1
Alkan, S.2
Sher, D.3
Godwin, J.4
Huo, D.5
Brandt, S.6
-
44
-
-
73949149251
-
Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous Tcell lymphoma
-
Piekarz R, Frye R, Turner M, Wright J, Allen S, Kirschbaum M, et al. Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous Tcell lymphoma. J Clin Oncol 2009; 27: 5410-5417.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5410-5417
-
-
Piekarz, R.1
Frye, R.2
Turner, M.3
Wright, J.4
Allen, S.5
Kirschbaum, M.6
-
45
-
-
77954879663
-
Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphoma
-
Whittaker S, Demierre M-F, Kim E, Rook A, Lerner A, Duvic M, et al. Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphoma. J Clin Oncol 2010; 28: 4485-4491.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4485-4491
-
-
Whittaker, S.1
Demierre, M.-F.2
Kim, E.3
Rook, A.4
Lerner, A.5
Duvic, M.6
-
46
-
-
14044250159
-
Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid
-
Camphausen K, Cerna D, Scott T, Sproull M, Burgan W, Cerra M, et al. Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid. Int J Cancer 2005; 114: 380-386.
-
(2005)
Int J Cancer
, vol.114
, pp. 380-386
-
-
Camphausen, K.1
Cerna, D.2
Scott, T.3
Sproull, M.4
Burgan, W.5
Cerra, M.6
-
47
-
-
34147206651
-
In vivo efficacy of a novel histone deacetylase inhibitor in combination with radiation for the treatment of gliomas
-
Entin-Meer M, Yang X, Van den Berg S, Lamborn K, Nudelman A, Rephaeli A, et al. In vivo efficacy of a novel histone deacetylase inhibitor in combination with radiation for the treatment of gliomas. Neurooncol 2007; 9: 82-88.
-
(2007)
Neurooncol
, vol.9
, pp. 82-88
-
-
Entin-Meer, M.1
Yang, X.2
van den Berg, S.3
Lamborn, K.4
Nudelman, A.5
Rephaeli, A.6
-
48
-
-
52249090461
-
Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: Class II and IV are hypoexpressed in glioblastomas
-
Lucio-Eterovic AK, Cortez MA, Valera ET, Motta FJ, Queiroz RG, Machado HR, et al. Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: Class II and IV are hypoexpressed in glioblastomas. BMC Cancer 2008; 8: 243.
-
(2008)
BMC Cancer
, vol.8
, pp. 243
-
-
Lucio-Eterovic, A.K.1
Cortez, M.A.2
Valera, E.T.3
Motta, F.J.4
Queiroz, R.G.5
Machado, H.R.6
-
49
-
-
2942685013
-
Histone deacetylase inhibitor, FK228, induces apoptosis and suppresses cell proliferation of human glioblastoma cells in vitro and in vivo
-
Sawa H, Murakami H, Kumagai M, Nakasato M, Yamauchi S, Matsuyama N, et al. Histone deacetylase inhibitor, FK228, induces apoptosis and suppresses cell proliferation of human glioblastoma cells in vitro and in vivo. Acta Neuropathol 2004; 107: 523-531.
-
(2004)
Acta Neuropathol
, vol.107
, pp. 523-531
-
-
Sawa, H.1
Murakami, H.2
Kumagai, M.3
Nakasato, M.4
Yamauchi, S.5
Matsuyama, N.6
-
51
-
-
0037087531
-
Inhibition of KIT tyrosine kinase activity: A novel molecular approach to the treatment of KIT-positive malignancies
-
Heinrich MC, Blanke CD, Druker BJ, Corless CL. Inhibition of KIT tyrosine kinase activity: A novel molecular approach to the treatment of KIT-positive malignancies. J Clin Oncol 2002; 20: 1692-703.
-
(2002)
J Clin Oncol
, vol.20
, pp. 1692-1703
-
-
Heinrich, M.C.1
Blanke, C.D.2
Druker, B.J.3
Corless, C.L.4
-
52
-
-
2742529418
-
Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand
-
Yarden Y, Kuang W-J, Yang-Feng T, Coussens L, Munemitsu S, Dull T, et al. Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 1987; 11: 3341-3351.
-
(1987)
EMBO J
, vol.11
, pp. 3341-3351
-
-
Yarden, Y.1
Kuang, W.-J.2
Yang-Feng, T.3
Coussens, L.4
Munemitsu, S.5
Dull, T.6
-
53
-
-
0025160956
-
Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors
-
Nocka K, Buck J, Levi E, Besmer P. Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors. EMBO J 1990; 9: 3287-3294.
-
(1990)
EMBO J
, vol.9
, pp. 3287-3294
-
-
Nocka, K.1
Buck, J.2
Levi, E.3
Besmer, P.4
-
54
-
-
2542520755
-
Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs)
-
Duensing A, Medeiros F, McConarty B, Joseph NE, Panigrahy D, Singer S, et al. Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs). Oncogene 2004; 23: 3999-4006.
-
(2004)
Oncogene
, vol.23
, pp. 3999-4006
-
-
Duensing, A.1
Medeiros, F.2
McConarty, B.3
Joseph, N.E.4
Panigrahy, D.5
Singer, S.6
-
55
-
-
0042357240
-
Structure of a c-kit product complex reveals the basis for kinase transactivation
-
Mol CD, Lim KB, Sridhar V, Zou H, Chien EY, Sang BC, et al. Structure of a c-kit product complex reveals the basis for kinase transactivation. J Biol Chem 2003; 278: 31461-31464.
-
(2003)
J Biol Chem
, vol.278
, pp. 31461-31464
-
-
Mol, C.D.1
Lim, K.B.2
Sridhar, V.3
Zou, H.4
Chien, E.Y.5
Sang, B.C.6
-
56
-
-
0030986854
-
Ultrastructural identification of the c-kit-expressing interstitial cells in the rat stomach: A comparison of control and Ws/Ws mutant rats
-
Ishikawa K, Komuro T, Hirota S, Kitamura Y. Ultrastructural identification of the c-kit-expressing interstitial cells in the rat stomach: A comparison of control and Ws/Ws mutant rats. Cell Tissue Res 1997; 289: 137-143.
-
(1997)
Cell Tissue Res
, vol.289
, pp. 137-143
-
-
Ishikawa, K.1
Komuro, T.2
Hirota, S.3
Kitamura, Y.4
-
57
-
-
0026475653
-
Expression of c-kit receptor in normal and transformed human nonlymphoid tissues
-
Natali PG, Nicotra MR, Sures I, Santoro E, Bigotti A, Ullrich A. Expression of c-kit receptor in normal and transformed human nonlymphoid tissues. Cancer Res 1992; 52: 6139-6143.
-
(1992)
Cancer Res
, vol.52
, pp. 6139-6143
-
-
Natali, P.G.1
Nicotra, M.R.2
Sures, I.3
Santoro, E.4
Bigotti, A.5
Ullrich, A.6
-
58
-
-
0024687135
-
Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice - evidence for an impaired c-kit kinase in mutant mice
-
Nocka K, Majumder S, Chabot B, Ray P, Cervone M, Bernstein A, et al. Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice - evidence for an impaired c-kit kinase in mutant mice. Genes Dev 1989; 3: 816-826.
-
(1989)
Genes Dev
, vol.3
, pp. 816-826
-
-
Nocka, K.1
Majumder, S.2
Chabot, B.3
Ray, P.4
Cervone, M.5
Bernstein, A.6
-
59
-
-
0026642099
-
Nonhematopoietic tumor cell lines express stem cell factor and display c-kit receptors
-
Turner AM, Zsebo KM, Martin F, Jacobsen FW, Bennett LG, Broudy VC. Nonhematopoietic tumor cell lines express stem cell factor and display c-kit receptors. Blood 1992; 80: 374-381.
-
(1992)
Blood
, vol.80
, pp. 374-381
-
-
Turner, A.M.1
Zsebo, K.M.2
Martin, F.3
Jacobsen, F.W.4
Bennett, L.G.5
Broudy, V.C.6
-
60
-
-
77954213847
-
Targeted therapies of gastrointestinal stromal tumors (GIST) - the next frontiers
-
Duensing S, Duensing A. Targeted therapies of gastrointestinal stromal tumors (GIST) - the next frontiers. Biochem Pharmacol 2010; 80: 575-583.
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 575-583
-
-
Duensing, S.1
Duensing, A.2
-
61
-
-
77954216079
-
Targeting KIT in melanoma: A paradigm of molecular medicine and targeted therapeutics
-
Woodman SE, Davies MA. Targeting KIT in melanoma: A paradigm of molecular medicine and targeted therapeutics. Biochem Pharmacol 2010; 80: 568-574.
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 568-574
-
-
Woodman, S.E.1
Davies, M.A.2
-
63
-
-
26044467362
-
Amplification of genes encoding KIT, PDGFRalpha and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme
-
Joensuu H, Puputti M, Sihto H, Tynninen O, Nupponen NN. Amplification of genes encoding KIT, PDGFRalpha and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme. J Pathol 2005; 207: 224-231.
-
(2005)
J Pathol
, vol.207
, pp. 224-231
-
-
Joensuu, H.1
Puputti, M.2
Sihto, H.3
Tynninen, O.4
Nupponen, N.N.5
-
64
-
-
33846292596
-
Amplification of KIT, PDGFRA, VEGFR2, and EGFR in gliomas
-
Puputti M, Tynninen O, Sihto H, Blom T, Maenpaa H, Isola J, et al. Amplification of KIT, PDGFRA, VEGFR2, and EGFR in gliomas. Mol Cancer Res 2006; 4: 927-934.
-
(2006)
Mol Cancer Res
, vol.4
, pp. 927-934
-
-
Puputti, M.1
Tynninen, O.2
Sihto, H.3
Blom, T.4
Maenpaa, H.5
Isola, J.6
-
65
-
-
39149123549
-
Long-term results from a randomized phase II trial of standard-versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT
-
Blanke CD, Demetri GD, von Mehren M, Heinrich MC, Eisenberg B, Fletcher JA, et al. Long-term results from a randomized phase II trial of standard-versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT. J Clin Oncol 2008; 26: 620-625.
-
(2008)
J Clin Oncol
, vol.26
, pp. 620-625
-
-
Blanke, C.D.1
Demetri, G.D.2
von Mehren, M.3
Heinrich, M.C.4
Eisenberg, B.5
Fletcher, J.A.6
-
66
-
-
39149127634
-
Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033
-
Blanke CD, Rankin C, Demetri GD, Ryan CW, von Mehren M, Benjamin RS, et al. Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033. J Clin Oncol 2008; 26: 626-632.
-
(2008)
J Clin Oncol
, vol.26
, pp. 626-632
-
-
Blanke, C.D.1
Rankin, C.2
Demetri, G.D.3
Ryan, C.W.4
von Mehren, M.5
Benjamin, R.S.6
-
67
-
-
33845648143
-
Outcome of metastatic GIST in the era before tyrosine kinase inhibitors
-
Gold JS, van der Zwan SM, Gonen M, Maki RG, Singer S, Brennan MF, et al. Outcome of metastatic GIST in the era before tyrosine kinase inhibitors. Ann Surg Oncol 2007; 14: 134-142.
-
(2007)
Ann Surg Oncol
, vol.14
, pp. 134-142
-
-
Gold, J.S.1
van der Zwan, S.M.2
Gonen, M.3
Maki, R.G.4
Singer, S.5
Brennan, M.F.6
-
68
-
-
20844433223
-
Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: Randomised trial
-
Verweij J, Casali PG, Zalcberg J, LeCesne A, Reichardt P, Blay JY, et al. Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: Randomised trial. Lancet 2004; 364: 1127-1134.
-
(2004)
Lancet
, vol.364
, pp. 1127-1134
-
-
Verweij, J.1
Casali, P.G.2
Zalcberg, J.3
Lecesne, A.4
Reichardt, P.5
Blay, J.Y.6
-
69
-
-
33746919951
-
Characterization of an imatinib-sensitive subset of high-grade human glioma cultures
-
Hagerstrand D, Hesselager G, Achterberg S. Characterization of an imatinib-sensitive subset of high-grade human glioma cultures. Oncogene 2006; 25: 4913-4922.
-
(2006)
Oncogene
, vol.25
, pp. 4913-4922
-
-
Hagerstrand, D.1
Hesselager, G.2
Achterberg, S.3
-
70
-
-
33745792563
-
Human glioblastoma and carcinoma xenograft tumors treated by combined radiation and imatinib (Gleevec®)
-
Oertel S, Krempien R, Lindel K, Zabel A, Milker-Zabel S, Bischof M, et al. Human glioblastoma and carcinoma xenograft tumors treated by combined radiation and imatinib (Gleevec®). Strahlenther Onkol 2006; 7: 400-407.
-
(2006)
Strahlenther Onkol
, vol.7
, pp. 400-407
-
-
Oertel, S.1
Krempien, R.2
Lindel, K.3
Zabel, A.4
Milker-Zabel, S.5
Bischof, M.6
-
71
-
-
70349694368
-
Phase II study of neoadjuvant imatinib in glioblastoma: Evaluation of clinical and molecular effects of the treatment
-
Razis E, Selviaridis P, Labropoulos S, Norris JL, Zhu MJ, Song DD, et al. Phase II study of neoadjuvant imatinib in glioblastoma: Evaluation of clinical and molecular effects of the treatment. Clin Cancer Res 2009; 15: 6258-6266.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6258-6266
-
-
Razis, E.1
Selviaridis, P.2
Labropoulos, S.3
Norris, J.L.4
Zhu, M.J.5
Song, D.D.6
-
72
-
-
33748376520
-
Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American BrainTumor Consortium Study 99-08
-
Wen P, Yung W, Lamborn K, Dahia P, Wang Y, Peng B, et al. Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American BrainTumor Consortium Study 99-08. Clin Cancer Res 2006; 12: 4899-4907.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4899-4907
-
-
Wen, P.1
Yung, W.2
Lamborn, K.3
Dahia, P.4
Wang, Y.5
Peng, B.6
-
74
-
-
31544481378
-
OSI-930: A novel selective inhibitor of Kit and kinase insert domain receptor tyrosine kinases with antitumor activity in mouse xenograft models
-
Garton AJ, Crew AP, Franklin M, Cooke AR, Wynne GM, Castaldo L, et al. OSI-930: A novel selective inhibitor of Kit and kinase insert domain receptor tyrosine kinases with antitumor activity in mouse xenograft models. Cancer Res 2006; 66: 1015-1024.
-
(2006)
Cancer Res
, vol.66
, pp. 1015-1024
-
-
Garton, A.J.1
Crew, A.P.2
Franklin, M.3
Cooke, A.R.4
Wynne, G.M.5
Castaldo, L.6
-
75
-
-
33644830094
-
Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme
-
Reardon D, Egorin M, Quinn J, Rich Sr J, Gururangan I, Vredenburgh J, et al. Phase II study of imatinib mesylate plus hydroxyurea in adults with recurrent glioblastoma multiforme. J Clin Oncol 2005; 23: 9359-9368.
-
(2005)
J Clin Oncol
, vol.23
, pp. 9359-9368
-
-
Reardon, D.1
Egorin, M.2
Quinn, J.3
Rich, J.4
Gururangan, I.5
Vredenburgh, J.6
-
76
-
-
33748908563
-
Pralatrexate: An emerging new agent with activity in T-cell lymphomas
-
O'Connor OA. Pralatrexate: An emerging new agent with activity in T-cell lymphomas. Curr Opin Oncol 2006; 18: 591-597.
-
(2006)
Curr Opin Oncol
, vol.18
, pp. 591-597
-
-
O'Connor, O.A.1
-
77
-
-
69049101976
-
Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers
-
Izbicka E, Diaz A, Streeper R, Wick M, Campos D, Steffen R, et al. Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers. Cancer Chemother Pharmacol 2009; 64: 993-999.
-
(2009)
Cancer Chemother Pharmacol
, vol.64
, pp. 993-999
-
-
Izbicka, E.1
Diaz, A.2
Streeper, R.3
Wick, M.4
Campos, D.5
Steffen, R.6
-
78
-
-
0037409795
-
Activity of a novel anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against human lymphoma is superior to methotrexate and correlates with tumor RFC-1 gene expression
-
Wang E, O'Connor O, She Y, Zelenetz A, Sirotnak F, Moore M. Activity of a novel anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against human lymphoma is superior to methotrexate and correlates with tumor RFC-1 gene expression. Leuk Lymphoma 2003; 44: 1027-1035.
-
(2003)
Leuk Lymphoma
, vol.44
, pp. 1027-1035
-
-
Wang, E.1
O'Connor, O.2
She, Y.3
Zelenetz, A.4
Sirotnak, F.5
Moore, M.6
-
79
-
-
0031851925
-
A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice
-
Sirotnak FM, DeGraw JI, Colwell WT, Piper JR. A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice. Cancer Chemother Pharmacol 1998; 42: 313-318.
-
(1998)
Cancer Chemother Pharmacol
, vol.42
, pp. 313-318
-
-
Sirotnak, F.M.1
Degraw, J.I.2
Colwell, W.T.3
Piper, J.R.4
-
80
-
-
34247871454
-
Phase II trial of pralatrexate (10-propargyl-10-deazaaminopterin, PDX) in patients with unresectable malignant pleural mesothelioma
-
Krug LM, Heelan RT, Kris MG, Venkatraman E, Sirotnak FM. Phase II trial of pralatrexate (10-propargyl-10-deazaaminopterin, PDX) in patients with unresectable malignant pleural mesothelioma. J Thorac Oncol 2007; 2: 317-320.
-
(2007)
J Thorac Oncol
, vol.2
, pp. 317-320
-
-
Krug, L.M.1
Heelan, R.T.2
Kris, M.G.3
Venkatraman, E.4
Sirotnak, F.M.5
-
81
-
-
77954755959
-
Pralatrexate is synergistic with the proteasome inhibitor bortezomib in in vitro and in vivo models of T-cell lymphoid malignancies
-
Marchi E, Paoluzzi L, Scotto L, Seshan VE, Zain JM, Zinzani PL, et al. Pralatrexate is synergistic with the proteasome inhibitor bortezomib in in vitro and in vivo models of T-cell lymphoid malignancies. Clin Cancer Res 2010; 16: 3648-3658.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3648-3658
-
-
Marchi, E.1
Paoluzzi, L.2
Scotto, L.3
Seshan, V.E.4
Zain, J.M.5
Zinzani, P.L.6
-
82
-
-
0038176427
-
10-Propargyl-10-deazaaminopterin: An antifolate with activity in patients with previously treated non-small cell lung cancer
-
Krug LM, Azzoli CG, Kris MG, Miller VA, Khokhar NZ, Tong W, et al. 10-Propargyl-10-deazaaminopterin: An antifolate with activity in patients with previously treated non-small cell lung cancer. Clin Cancer Res 2003; 9: 2072-2078.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2072-2078
-
-
Krug, L.M.1
Azzoli, C.G.2
Kris, M.G.3
Miller, V.A.4
Khokhar, N.Z.5
Tong, W.6
-
83
-
-
34249066826
-
A phase 1 study of pralatrexate in combination with paclitaxel or docetaxel in patients with advanced solid tumors
-
Azzoli CG, Krug LM, Gomez J, Miller VA, Kris MG, Ginsberg MS, et al. A phase 1 study of pralatrexate in combination with paclitaxel or docetaxel in patients with advanced solid tumors. Clin Cancer Res 2007; 13: 2692-2698.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2692-2698
-
-
Azzoli, C.G.1
Krug, L.M.2
Gomez, J.3
Miller, V.A.4
Kris, M.G.5
Ginsberg, M.S.6
-
85
-
-
69349095364
-
Anticancer strategies involving the vasculature
-
Heath VL, Bicknell R. Anticancer strategies involving the vasculature. Nat Rev Clin Oncol 2009; 6: 395-404.
-
(2009)
Nat Rev Clin Oncol
, vol.6
, pp. 395-404
-
-
Heath, V.L.1
Bicknell, R.2
-
86
-
-
0033954292
-
Phase II trial of the antiangiogenic agent thalidomide in patients with recurrent high-grade gliomas
-
Fine HA, Figg WD, Jaeckle K, Wen PY, Kyritsis AP, Loeffler JS, et al. Phase II trial of the antiangiogenic agent thalidomide in patients with recurrent high-grade gliomas. J Clin Oncol 2000; 18: 708-715.
-
(2000)
J Clin Oncol
, vol.18
, pp. 708-715
-
-
Fine, H.A.1
Figg, W.D.2
Jaeckle, K.3
Wen, P.Y.4
Kyritsis, A.P.5
Loeffler, J.S.6
-
87
-
-
0037811745
-
Phase II trial of thalidomide and carmustine for patients with recurrent high-grade gliomas
-
Fine HA, Wen PY, Maher EA, Viscosi E, Batchelor T, Lakhani N, et al. Phase II trial of thalidomide and carmustine for patients with recurrent high-grade gliomas. J Clin Oncol 2003; 21: 2299-2304.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2299-2304
-
-
Fine, H.A.1
Wen, P.Y.2
Maher, E.A.3
Viscosi, E.4
Batchelor, T.5
Lakhani, N.6
-
88
-
-
4544289953
-
Phase II study of temozolomide and thalidomide with radiation therapy for newly diagnosed glioblastoma multiforme
-
Chang SM, Lamborn KR, Malec M, Larson D, Wara W, Sneed P, et al. Phase II study of temozolomide and thalidomide with radiation therapy for newly diagnosed glioblastoma multiforme. Int J Radiat Oncol Biol Phys 2004; 60: 353-357.
-
(2004)
Int J Radiat Oncol Biol Phys
, vol.60
, pp. 353-357
-
-
Chang, S.M.1
Lamborn, K.R.2
Malec, M.3
Larson, D.4
Wara, W.5
Sneed, P.6
-
89
-
-
36049037819
-
Bevacizumab plus irinotecan in recurrent glioblastoma multiforme
-
Vredenburgh JJ, Desjardins A, Herndon JE, 2nd, Marcello J, Reardon DA, Quinn JA, et al. Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J Clin Oncol 2007; 25: 4722-4729.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4722-4729
-
-
Vredenburgh, J.J.1
Desjardins, A.2
Herndon, J.E.3
Marcello, J.4
Reardon, D.A.5
Quinn, J.A.6
-
90
-
-
58149231546
-
Bevacizumab plus irinotecan in recurrent WHO grade III malignant gliomas
-
Desjardins A, Reardon DA, Herndon JE, 2nd, Marcello J, Quinn JA, Rich JN, et al. Bevacizumab plus irinotecan in recurrent WHO grade III malignant gliomas. Clin Cancer Res 2008; 14: 7068-7073.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7068-7073
-
-
Desjardins, A.1
Reardon, D.A.2
Herndon, J.E.3
Marcello, J.4
Quinn, J.A.5
Rich, J.N.6
-
91
-
-
70350461699
-
Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
-
Friedman H, Prados M, Wen P, Mikkelsen T, Schiff D, Abrey L, et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol 2009; 27: 4733-4740.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4733-4740
-
-
Friedman, H.1
Prados, M.2
Wen, P.3
Mikkelsen, T.4
Schiff, D.5
Abrey, L.6
-
92
-
-
36749043820
-
Tumour targeting by microtubuledepolymerizing vascular disrupting agents
-
Kanthou C, Tozer GM. Tumour targeting by microtubuledepolymerizing vascular disrupting agents. Expert Opin Ther Targets 2007; 11: 1443-1457.
-
(2007)
Expert Opin Ther Targets
, vol.11
, pp. 1443-1457
-
-
Kanthou, C.1
Tozer, G.M.2
-
93
-
-
0035417875
-
Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: Intravital microscopy and measurement of vascular permeability
-
Tozer GM, Prise VE, Wilson J, Cemazar M, Shan S, Dewhirst MW, et al. Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: Intravital microscopy and measurement of vascular permeability. Cancer Res 2001; 61: 6413-6422.
-
(2001)
Cancer Res
, vol.61
, pp. 6413-6422
-
-
Tozer, G.M.1
Prise, V.E.2
Wilson, J.3
Cemazar, M.4
Shan, S.5
Dewhirst, M.W.6
-
94
-
-
0030951899
-
Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature
-
Dark GG, Hill SA, Prise VE, Tozer GM, Pettit GR, Chaplin DJ. Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature. Cancer Res 1997; 57: 1829-1834.
-
(1997)
Cancer Res
, vol.57
, pp. 1829-1834
-
-
Dark, G.G.1
Hill, S.A.2
Prise, V.E.3
Tozer, G.M.4
Pettit, G.R.5
Chaplin, D.J.6
-
95
-
-
0033955698
-
The new tubulininhibitor combretastatin A-4 enhances thermal damage in the BT4An rat glioma
-
Eikesdal HP, Schem BC, Mella O, Dahl O. The new tubulininhibitor combretastatin A-4 enhances thermal damage in the BT4An rat glioma. Int J Radiat Oncol Biol Phys 2000; 46: 645-652.
-
(2000)
Int J Radiat Oncol Biol Phys
, vol.46
, pp. 645-652
-
-
Eikesdal, H.P.1
Schem, B.C.2
Mella, O.3
Dahl, O.4
-
96
-
-
0035204801
-
Tumor vasculature is targeted by the combination of combretastatin A-4 and hyperthermia
-
Eikesdal HP, Bjerkvig R, Raleigh JA, Mella O, Dahl O. Tumor vasculature is targeted by the combination of combretastatin A-4 and hyperthermia. Radiother Oncol 2001; 61: 313-320.
-
(2001)
Radiother Oncol
, vol.61
, pp. 313-320
-
-
Eikesdal, H.P.1
Bjerkvig, R.2
Raleigh, J.A.3
Mella, O.4
Dahl, O.5
-
97
-
-
0037096814
-
A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer
-
Dowlati A, Robertson K, Cooney M, Petros WP, Stratford M, Jesberger J, et al. A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer. Cancer Res 2002; 62: 3408-3416.
-
(2002)
Cancer Res
, vol.62
, pp. 3408-3416
-
-
Dowlati, A.1
Robertson, K.2
Cooney, M.3
Petros, W.P.4
Stratford, M.5
Jesberger, J.6
-
98
-
-
0042386700
-
Phase I clinical trial of weekly combretastatin A4 phosphate: Clinical and pharmacokinetic results
-
Rustin GJ, Galbraith SM, Anderson H, Stratford M, Folkes LK, Sena L, et al. Phase I clinical trial of weekly combretastatin A4 phosphate: Clinical and pharmacokinetic results. J Clin Oncol 2003; 21: 2815-2822.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2815-2822
-
-
Rustin, G.J.1
Galbraith, S.M.2
Anderson, H.3
Stratford, M.4
Folkes, L.K.5
Sena, L.6
-
99
-
-
0642307227
-
Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: Magnetic resonance imaging evidence for altered tumor blood flow
-
Stevenson JP, Rosen M, Sun W, Gallagher M, Haller DG, Vaughn D, et al. Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: Magnetic resonance imaging evidence for altered tumor blood flow. J Clin Oncol 2003; 21: 4428-4438.
-
(2003)
J Clin Oncol
, vol.21
, pp. 4428-4438
-
-
Stevenson, J.P.1
Rosen, M.2
Sun, W.3
Gallagher, M.4
Haller, D.G.5
Vaughn, D.6
-
100
-
-
33947504434
-
Tumor antivascular effects of radiotherapy combined with combretastatin A4 phosphate in human non-small-cell lung cancer
-
Ng Q-S, Goh V, Carnell D, Meer K, Padhani A, Saunders M, et al. Tumor antivascular effects of radiotherapy combined with combretastatin A4 phosphate in human non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 2007; 67: 1375-1380.
-
(2007)
Int J Radiat Oncol Biol Phys
, vol.67
, pp. 1375-1380
-
-
Ng, Q.-S.1
Goh, V.2
Carnell, D.3
Meer, K.4
Padhani, A.5
Saunders, M.6
-
101
-
-
77951667223
-
A Phase Ib trial of CA4P (combretastatin A-4 phosphate), carboplatin, and paclitaxel in patients with advanced cancer
-
Rustin GJ, Shreeves G, Nathan PD, Gaya A, Ganesan TS, Wang D, et al. A Phase Ib trial of CA4P (combretastatin A-4 phosphate), carboplatin, and paclitaxel in patients with advanced cancer. Br J Cancer 2010; 102: 1355-1360.
-
(2010)
Br J Cancer
, vol.102
, pp. 1355-1360
-
-
Rustin, G.J.1
Shreeves, G.2
Nathan, P.D.3
Gaya, A.4
Ganesan, T.S.5
Wang, D.6
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