Development of Cys38 knock-out and humanized version of NbAahII10 nanobody with improved neutralization of AahII Scorpion toxin

Protein Engineering, Design and Selection

Volumn 24, Issue 9, 2011, Pages 727-735

  Ben Abderrazek, Rahma ^a   Vincke, Cécile ^b,c   Hmila, Issam ^a   Saerens, Dirk ^b,c   Abidi, Naima ^a   El Ayeb, Mohamed ^a   Muyldermans, Serge ^b,c   Bouhaouala Zahar, Balkiss ^a,d  

^a PASTEUR INSTITUTE OF TUNIS   (Tunisia)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^d UNIVERSITY OF TUNIS EL MANAR   (Tunisia)

Author keywords

anti venom; humanization; nanobody; scorpion toxin; single domain antibody

Indexed keywords

ANTI-VENOM; HUMANIZATION; NANOBODY; SCORPION TOXIN; SINGLE DOMAINS;

ANTIBODIES; ANTIGENS; MAMMALS; MEDICAL PROBLEMS; NIOBIUM COMPOUNDS;

TOXIC MATERIALS;

ANDROCTONUS AUSTRALIS HECTOR II TOXIN; ANTIBODY; CYSTEINE; NANOBODY; SCORPION VENOM; UNCLASSIFIED DRUG;

ANTIBODY AFFINITY; ANTIGEN BINDING; ARTICLE; COMPLEMENTARITY DETERMINING REGION; DIMERIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIBODIES, NEUTRALIZING; ANTIBODY AFFINITY; CAMELS; CHROMATOGRAPHY, GEL; CYSTEINE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN HEAVY CHAINS; LETHAL DOSE 50; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; PROTEIN MULTIMERIZATION; RECOMBINANT PROTEINS; SCORPION VENOMS;

MUS; SCORPIONES;

EID: 80052329487     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzr037     Document Type: Article

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