메뉴 건너뛰기




Volumn 238, Issue 3, 1996, Pages 653-660

A recombinant insect-specific α-toxin of Buthus occitanus tunetanus scorpion confers protection against homologous mammal toxins

Author keywords

cDNA; expression in Escherichia coli; scorpion toxin

Indexed keywords

ALPHA TOXIN; ANTISERUM; SCORPION VENOM;

EID: 8944239876     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.1996.0653w.x     Document Type: Article
Times cited : (48)

References (63)
  • 1
    • 0024844960 scopus 로고
    • Precursors of Androctonus australis scorpion neurotoxins: Structures of precursors, processing outcomes and expression of a functional recombinant toxin II
    • Bougis, P., Rochat, H. & Smith, L. A. (1989) Precursors of Androctonus australis scorpion neurotoxins: structures of precursors, processing outcomes and expression of a functional recombinant toxin II, J. Biol. Chem. 264, 19259-19265.
    • (1989) J. Biol. Chem. , vol.264 , pp. 19259-19265
    • Bougis, P.1    Rochat, H.2    Smith, L.A.3
  • 2
    • 8944234898 scopus 로고    scopus 로고
    • Construction et caractérisation d'une banque d'ADNc spécifique des toxines du scorpion Buthus occitanus tunetanus
    • in the press
    • Bouhaouala-Zahar, B., El Ayeb, M. & Karoui, H. (1996) Construction et caractérisation d'une banque d'ADNc spécifique des toxines du scorpion Buthus occitanus tunetanus, Biologia (Tunis), in the press.
    • (1996) Biologia (Tunis)
    • Bouhaouala-Zahar, B.1    El Ayeb, M.2    Karoui, H.3
  • 3
    • 0014674485 scopus 로고
    • A complementation analysis of the restriction and modification of DNA in Escherichia coli
    • Boyer, H. W. & Roulland-Dussoix, D. (1969) A complementation analysis of the restriction and modification of DNA in Escherichia coli, J. Mol. Biol. 41, 459.
    • (1969) J. Mol. Biol. , vol.41 , pp. 459
    • Boyer, H.W.1    Roulland-Dussoix, D.2
  • 4
    • 0025371585 scopus 로고
    • A recombinant snake neurotoxin generated by chemical cleavage of a hybrid protein recovers full biological properties
    • Boyot, P., Pillet, L., Ducancel, F., Boulain, J.-C., Trémeau, O. & Ménez, A. (1990) A recombinant snake neurotoxin generated by chemical cleavage of a hybrid protein recovers full biological properties, FEBS Lett. 266, 87-90.
    • (1990) FEBS Lett. , vol.266 , pp. 87-90
    • Boyot, P.1    Pillet, L.2    Ducancel, F.3    Boulain, J.-C.4    Trémeau, O.5    Ménez, A.6
  • 5
    • 0024235420 scopus 로고
    • Synthesis of a gene coding for an insect-specific scorpion neurotoxin and attemps to express it using baculovirus vectors
    • Carbonell, L. F., Hodge, M. R., Tomalski, M. D. & Miller, L. K. (1988) Synthesis of a gene coding for an insect-specific scorpion neurotoxin and attemps to express it using baculovirus vectors, Gene (Amst.) 73, 409-418.
    • (1988) Gene (Amst.) , vol.73 , pp. 409-418
    • Carbonell, L.F.1    Hodge, M.R.2    Tomalski, M.D.3    Miller, L.K.4
  • 6
    • 0017067617 scopus 로고
    • Membrane potential dependent binding of scorpion toxin to action potential sodium ionophore
    • Catterall, W. A., Ray, R. & Morow, C. S. (1976) Membrane potential dependent binding of scorpion toxin to action potential sodium ionophore, Proc. Natl Acad. Sci. USA 73, 2683-2686.
    • (1976) Proc. Natl Acad. Sci. USA , vol.73 , pp. 2683-2686
    • Catterall, W.A.1    Ray, R.2    Morow, C.S.3
  • 7
    • 0021330126 scopus 로고
    • The molecular basis of neuronal excitability
    • Catterall, W. A. (1984) The molecular basis of neuronal excitability, Science 223, 653-661.
    • (1984) Science , vol.223 , pp. 653-661
    • Catterall, W.A.1
  • 8
    • 0022555877 scopus 로고
    • Molecular properties of voltage-sensitive sodium channels
    • Catterall, W. A. (1986) Molecular properties of voltage-sensitive sodium channels, Annu. Rev. Biochem. 55, 953-985.
    • (1986) Annu. Rev. Biochem. , vol.55 , pp. 953-985
    • Catterall, W.A.1
  • 9
    • 0026050417 scopus 로고
    • In vivo protection against scorpion toxins by liposomal immunization
    • Chavez-Olortegui, C., Ait-Amara, D., Rochat, H., Diniz, C. & Granier, C. (1991) In vivo protection against scorpion toxins by liposomal immunization, Vaccine 9, 907-910.
    • (1991) Vaccine , vol.9 , pp. 907-910
    • Chavez-Olortegui, C.1    Ait-Amara, D.2    Rochat, H.3    Diniz, C.4    Granier, C.5
  • 10
    • 0020004059 scopus 로고
    • Two types of scorpion toxins receptors sites, one related to the activation of the action potential sodium channel
    • Couraud, F., Jover, E., Dubois, J. M. & Rochat, H. (1982) Two types of scorpion toxins receptors sites, one related to the activation of the action potential sodium channel, Toxicon 20, 9-16.
    • (1982) Toxicon , vol.20 , pp. 9-16
    • Couraud, F.1    Jover, E.2    Dubois, J.M.3    Rochat, H.4
  • 12
    • 0025921886 scopus 로고
    • 1H nuclear magnetic resonance study of AaHIT, an anti-insect toxin from the scorpion Androctonus australis hector. Sequential resonance assignements and folding of the polypeptide chain
    • 1H nuclear magnetic resonance study of AaHIT, an anti-insect toxin from the scorpion Androctonus australis hector. Sequential resonance assignements and folding of the polypeptide chain, Biochemistry 30, 1836-1845.
    • (1991) Biochemistry , vol.30 , pp. 1836-1845
    • Darbon, H.1    Weber, C.2    Braun, W.3
  • 13
    • 11944265666 scopus 로고
    • Expression and secretion of a functional scorpion insecticidal toxin in culture mouse cells
    • Dee, A., Belagaje, R. M., Ward, K., Chio, E. & Lai, M. T. (1990) Expression and secretion of a functional scorpion insecticidal toxin in culture mouse cells, Biotechnology (NY) 8, 339-342.
    • (1990) Biotechnology (NY) , vol.8 , pp. 339-342
    • Dee, A.1    Belagaje, R.M.2    Ward, K.3    Chio, E.4    Lai, M.T.5
  • 14
    • 0022547492 scopus 로고
    • Tityus serrulatus toxin VII bears pharmacological properties of both β toxin and insect toxin from scorpion venoms
    • De Lima, M. E., Martin, M. F., Diniz, C. R. & Rochat, H. (1986) Tityus serrulatus toxin VII bears pharmacological properties of both β toxin and insect toxin from scorpion venoms, Biochem. Biophys. Res. Commun. 139, 296-302.
    • (1986) Biochem. Biophys. Res. Commun. , vol.139 , pp. 296-302
    • De Lima, M.E.1    Martin, M.F.2    Diniz, C.R.3    Rochat, H.4
  • 15
    • 0019864267 scopus 로고
    • Scorpion venoms and neurotoxins: An immunological study
    • Delori, P., Van Rietschoten, J. & Rochat, H. (1981) Scorpion venoms and neurotoxins: an immunological study, Toxicon 19, 393-407.
    • (1981) Toxicon , vol.19 , pp. 393-407
    • Delori, P.1    Van Rietschoten, J.2    Rochat, H.3
  • 16
    • 0024784407 scopus 로고
    • Direct expression in E. coli of a functionally active protein A-snake toxin fusion protein
    • Ducancel, F., Boulain, J. C., Tremeau, O. & Menez, A. (1989) Direct expression in E. coli of a functionally active protein A-snake toxin fusion protein, Protein Eng. 3, 139-143.
    • (1989) Protein Eng. , vol.3 , pp. 139-143
    • Ducancel, F.1    Boulain, J.C.2    Tremeau, O.3    Menez, A.4
  • 17
    • 0025303099 scopus 로고
    • A scorpion venom neurotoxin paralytic to insects that affects sodium current inactivation: Purification, primary structure and mode of action
    • Eitan, M., Fowler, E., Herrmann, R., Duval, A., Pelhate, M. & Zlotkin, E. (1990) A scorpion venom neurotoxin paralytic to insects that affects sodium current inactivation: purification, primary structure and mode of action, Biochemistry 29, 5941-5947.
    • (1990) Biochemistry , vol.29 , pp. 5941-5947
    • Eitan, M.1    Fowler, E.2    Herrmann, R.3    Duval, A.4    Pelhate, M.5    Zlotkin, E.6
  • 18
    • 0021020227 scopus 로고
    • Immunochemistry of alpha toxins: Antigenic homologies checked with radioimmunoassays
    • El Ayeb, M., Delori, P. & Rochat, H. (1983a) Immunochemistry of alpha toxins: antigenic homologies checked with radioimmunoassays, Toxicon 21, 709-716.
    • (1983) Toxicon , vol.21 , pp. 709-716
    • El Ayeb, M.1    Delori, P.2    Rochat, H.3
  • 19
    • 0020523715 scopus 로고
    • Immunochemistry of scorpion α-neurotoxins. Determination of the antigenic site number and isolation of highly enriched antibody specific to a single antigenic site of toxin II of Androctonus australis Hector
    • El Ayeb, M., Martin, M., Delori, P., Bechis, G. & Rochat, H. (1983b) Immunochemistry of scorpion α-neurotoxins. Determination of the antigenic site number and isolation of highly enriched antibody specific to a single antigenic site of toxin II of Androctonus australis Hector, Mol. Immun. 20, 697-708.
    • (1983) Mol. Immun. , vol.20 , pp. 697-708
    • El Ayeb, M.1    Martin, M.2    Delori, P.3    Bechis, G.4    Rochat, H.5
  • 20
    • 0022239908 scopus 로고
    • Polymorphism and quantitative variations of toxins in the venom of the scorpion Androctonus australis Hector
    • El Ayeb, M. & Rochat, H. (1985) Polymorphism and quantitative variations of toxins in the venom of the scorpion Androctonus australis Hector, Toxicon 23, 755-760.
    • (1985) Toxicon , vol.23 , pp. 755-760
    • El Ayeb, M.1    Rochat, H.2
  • 21
    • 0022447357 scopus 로고
    • Differential effects of defined chemical modifications on antigenic and pharmacological activities of scorpion α and β toxins
    • El Ayeb, M., Darbon, H., Bahraoui, E. M., Vargas, O. & Rochat, H. (1986) Differential effects of defined chemical modifications on antigenic and pharmacological activities of scorpion α and β toxins, Eur. J. Biochem. 155, 289-294.
    • (1986) Eur. J. Biochem. , vol.155 , pp. 289-294
    • El Ayeb, M.1    Darbon, H.2    Bahraoui, E.M.3    Vargas, O.4    Rochat, H.5
  • 22
    • 0344434140 scopus 로고
    • Three-dimensional structure of a protein from scorpion venom: A new structural class of neurotoxins
    • Fontecilla-Camps, J. C., Almassy, R. J., Suddath, F. L., Watt, D. D. & Bugg, C. E. (1980) Three-dimensional structure of a protein from scorpion venom: A new structural class of neurotoxins, Proc. Natl Acad. Sci. USA 77, 6496-6500.
    • (1980) Proc. Natl Acad. Sci. USA , vol.77 , pp. 6496-6500
    • Fontecilla-Camps, J.C.1    Almassy, R.J.2    Suddath, F.L.3    Watt, D.D.4    Bugg, C.E.5
  • 23
    • 0024094439 scopus 로고
    • Orthorhombic crystals and three dimensional structure of the potent toxin II from the scorpion Androctonus australis australis
    • Fontecilla-Camps, J. C., Habersetze-Rochat, C. & Rochat, H. (1988) Orthorhombic crystals and three dimensional structure of the potent toxin II from the scorpion Androctonus australis australis, Proc. Natl Acad. Sci. USA 85, 7443-7447.
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 7443-7447
    • Fontecilla-Camps, J.C.1    Habersetze-Rochat, C.2    Rochat, H.3
  • 24
    • 0021682684 scopus 로고
    • The binding of insect selective neurotoxin (AaHIT) from the scorpion venom to locust synaptosomal membranes
    • Gordon, D., Jover, E., Couraud, F. & Zlotkin, E. (1984) The binding of insect selective neurotoxin (AaHIT) from the scorpion venom to locust synaptosomal membranes, Biochem. Biophys. Acta 778, 349-358.
    • (1984) Biochem. Biophys. Acta , vol.778 , pp. 349-358
    • Gordon, D.1    Jover, E.2    Couraud, F.3    Zlotkin, E.4
  • 25
    • 0027441481 scopus 로고
    • Binding of a scorpion toxin to insect sodium channels is not dependent on membrane potentiel
    • Gordon, D. & Zlotkin, E. (1993) Binding of a scorpion toxin to insect sodium channels is not dependent on membrane potentiel. FEBS Letts 315, 125-128.
    • (1993) FEBS Letts , vol.315 , pp. 125-128
    • Gordon, D.1    Zlotkin, E.2
  • 26
    • 0020622419 scopus 로고
    • Covalent structure of toxin I and II from the scorpion
    • Grégoire, J. & Rochat, H. (1983) Covalent structure of toxin I and II from the scorpion, Toxicon 21, 153-162.
    • (1983) Toxicon , vol.21 , pp. 153-162
    • Grégoire, J.1    Rochat, H.2
  • 27
    • 0020959710 scopus 로고
    • Studies on transformation of Escherichia coli with plasmids
    • Hanahan, D. (1983) Studies on transformation of Escherichia coli with plasmids, J. Mol. Biol. 166, 557-580.
    • (1983) J. Mol. Biol. , vol.166 , pp. 557-580
    • Hanahan, D.1
  • 30
    • 0019181273 scopus 로고
    • Two types of scorpion neurotoxin characterized by their binding to two separate receptor sites on rat brain synaptosomes
    • Jover, E., Couraud, F. & Rochat, H. (1980) Two types of scorpion neurotoxin characterized by their binding to two separate receptor sites on rat brain synaptosomes, Biochem. Biophys. Res. Commun 95, 1607-1614.
    • (1980) Biochem. Biophys. Res. Commun , vol.95 , pp. 1607-1614
    • Jover, E.1    Couraud, F.2    Rochat, H.3
  • 31
  • 32
    • 0027250861 scopus 로고
    • Characterization of toxin III of the scorpion Leirus quinquestriatus quinquestriatus: A new type of toxin highly toxic both to mammals and insects
    • Kopeyan, C., Mansuelle, P., Martin-Eauclaire, M. F., Rochat, H. & Miranda, F. (1993) Characterization of toxin III of the scorpion Leirus quinquestriatus quinquestriatus: a new type of toxin highly toxic both to mammals and insects, Nat. Toxins 1, 308-312.
    • (1993) Nat. Toxins , vol.1 , pp. 308-312
    • Kopeyan, C.1    Mansuelle, P.2    Martin-Eauclaire, M.F.3    Rochat, H.4    Miranda, F.5
  • 33
    • 0021770224 scopus 로고
    • Compilation and analysis of sequences upstream from the translation start site in eucaryotic mRNAs
    • Kozak, M. (1984) Compilation and analysis of sequences upstream from the translation start site in eucaryotic mRNAs, Nucleic Acids Res. 12, 857-872.
    • (1984) Nucleic Acids Res. , vol.12 , pp. 857-872
    • Kozak, M.1
  • 34
    • 0020073253 scopus 로고
    • Two insect toxins from the venom of the scorpion Buthus judaicus: Purification, characterization and mode of action
    • Lester, D., Lazarovici, P., Pelhate, M. & Zlotkin, E. (1982) Two insect toxins from the venom of the scorpion Buthus judaicus: purification, characterization and mode of action. Biochim. Biophys. Acta 701, 370-381.
    • (1982) Biochim. Biophys. Acta , vol.701 , pp. 370-381
    • Lester, D.1    Lazarovici, P.2    Pelhate, M.3    Zlotkin, E.4
  • 38
    • 0014884098 scopus 로고
    • Purification of animal neurotoxin. Isolation and characterization of eleven neurotoxins from the venoms of the scorpions Androctonus australis Hector, Buthus occitanus tunetanus and Leirus quinquestriatus quinquestriatus
    • Miranda, F., Kupeyan, C., Rochat, H., Rochat, C. & Lissitzky, S. (1970) Purification of animal neurotoxin. Isolation and characterization of eleven neurotoxins from the venoms of the scorpions Androctonus australis Hector, Buthus occitanus tunetanus and Leirus quinquestriatus quinquestriatus, Eur. J. Biochem. 16, 514-523.
    • (1970) Eur. J. Biochem. , vol.16 , pp. 514-523
    • Miranda, F.1    Kupeyan, C.2    Rochat, H.3    Rochat, C.4    Lissitzky, S.5
  • 40
    • 0020640836 scopus 로고
    • A cDNA cloning vector that permits expression of cDNA inserts in mammalian cell
    • Okayama, H. & Berg, P. (1983) A cDNA cloning vector that permits expression of cDNA inserts in mammalian cell, Mol. Cell. Biol. 3, 280-289.
    • (1983) Mol. Cell. Biol. , vol.3 , pp. 280-289
    • Okayama, H.1    Berg, P.2
  • 42
    • 0016113075 scopus 로고
    • Selective inhibition of potassium current in the giant axon of the cockroach
    • Pelhate, M. & Pichon, Y. (1974) Selective inhibition of potassium current in the giant axon of the cockroach, J. Physiol. (Lond.) 242, 90-91.
    • (1974) J. Physiol. (Lond.) , vol.242 , pp. 90-91
    • Pelhate, M.1    Pichon, Y.2
  • 43
    • 0019488963 scopus 로고
    • + current in the cockroach giant axon induced by the scorpion venom 'insect toxin'
    • + current in the cockroach giant axon induced by the scorpion venom 'insect toxin', J. Physiol. (Lond.) 319, 30-31.
    • (1981) J. Physiol. (Lond.) , vol.319 , pp. 30-31
    • Pelhate, M.1    Zlotkin, E.2
  • 44
    • 0020124225 scopus 로고
    • Actions of insect toxin and other toxins derived from the venom of scorpion Androctonus australis on isolated giant axons of the cockroach Periplaneta americana
    • Pelhate, M. & Zlotkin, E. (1982) Actions of insect toxin and other toxins derived from the venom of scorpion Androctonus australis on isolated giant axons of the cockroach Periplaneta americana, J. Exp. Biol. 97, 66-77.
    • (1982) J. Exp. Biol. , vol.97 , pp. 66-77
    • Pelhate, M.1    Zlotkin, E.2
  • 45
    • 0001126633 scopus 로고
    • Pharmacological properties of insects axons: A review
    • Pelhate, M. & Sattelle, D. B. (1982) Pharmacological properties of insects axons: a review, J. Insect Physiol. 28, 889-903.
    • (1982) J. Insect Physiol. , vol.28 , pp. 889-903
    • Pelhate, M.1    Sattelle, D.B.2
  • 46
    • 0014143585 scopus 로고
    • Current-voltage relations in the isolated giant axons of the cockroach under voltage clamp conditions
    • Pichon, Y. & Boistel, J. (1967) Current-voltage relations in the isolated giant axons of the cockroach under voltage clamp conditions. J. Exp. Biol. 47, 343-355.
    • (1967) J. Exp. Biol. , vol.47 , pp. 343-355
    • Pichon, Y.1    Boistel, J.2
  • 48
    • 0027396750 scopus 로고
    • Genetic engineering of snake toxins: Role of invariant residues in the structural and functional properties of a curaremimetic toxin, as probed by site-directed mutagenesis
    • Pillet, L., Trémeau, O., Ducancel, F., Drevet, P., Zinn-Justin, S., Pinkasfeld, S., Boulain, J-C. & Ménez, A. (1993) Genetic engineering of snake toxins: role of invariant residues in the structural and functional properties of a curaremimetic toxin, as probed by site-directed mutagenesis. J. Biol . Chem. 268, 909-916.
    • (1993) J. Biol . Chem. , vol.268 , pp. 909-916
    • Pillet, L.1    Trémeau, O.2    Ducancel, F.3    Drevet, P.4    Zinn-Justin, S.5    Pinkasfeld, S.6    Boulain, J.-C.7    Ménez, A.8
  • 49
    • 0017089669 scopus 로고
    • 3′ Non-coding region sequences in eucaryolic messenger RNA
    • Proudfoot, N. J. & Brownlee, G. G. (1976) 3′ Non-coding region sequences in eucaryolic messenger RNA, Nature 263, 211-214.
    • (1976) Nature , vol.263 , pp. 211-214
    • Proudfoot, N.J.1    Brownlee, G.G.2
  • 50
    • 33745158157 scopus 로고
    • A simple method of estimating fifty percent end point
    • Reed, L. & Muench, H. (1938) A simple method of estimating fifty percent end point, Am. J. Hyg. 27, 493-497.
    • (1938) Am. J. Hyg. , vol.27 , pp. 493-497
    • Reed, L.1    Muench, H.2
  • 51
    • 0018400724 scopus 로고
    • Scorpion toxins: Chemistry and mode of action
    • Rochat, H., Bernard, P. & Couraud, F. (1979) Scorpion toxins: chemistry and mode of action, in Adv. cytopharmacol. 3, 325-330.
    • (1979) Adv. Cytopharmacol. , vol.3 , pp. 325-330
    • Rochat, H.1    Bernard, P.2    Couraud, F.3
  • 54
    • 0028934293 scopus 로고
    • Genetic engineering of snake toxins: The functional site of crabutoxinA, as delineated by site-directed mutagenesis, includes variant residues
    • Trémeau, O., Lemaire, C., Drevet, P., Pinkasfeld, S., Ducancel, F., Boulain, J.-C. & Ménez, A. (1995) Genetic engineering of snake toxins: the functional site of crabutoxinA, as delineated by site-directed mutagenesis, includes variant residues. J. Biol. chem. 270, 9362-9369.
    • (1995) J. Biol. Chem. , vol.270 , pp. 9362-9369
    • Trémeau, O.1    Lemaire, C.2    Drevet, P.3    Pinkasfeld, S.4    Ducancel, F.5    Boulain, J.-C.6    Ménez, A.7
  • 55
    • 0023641920 scopus 로고
    • Characterization of six toxins from the venom of the Moroccan scorpion Buthus occitanus mardochei
    • Vargas, O., Martin, M. F. & Rochat, H. (1987) Characterization of six toxins from the venom of the Moroccan scorpion Buthus occitanus mardochei, Eur. J. Biochem. 162, 589-599.
    • (1987) Eur. J. Biochem. , vol.162 , pp. 589-599
    • Vargas, O.1    Martin, M.F.2    Rochat, H.3
  • 56
    • 0000083276 scopus 로고
    • Action of different toxins from Androctonus australis hector on a locust nerve muscle preparation
    • Walther, C., Zlotkin, E. & Rathmayer, W. (1976) Action of different toxins from Androctonus australis hector on a locust nerve muscle preparation, J. Insect Physiol. 22, 1187-1194.
    • (1976) J. Insect Physiol. , vol.22 , pp. 1187-1194
    • Walther, C.1    Zlotkin, E.2    Rathmayer, W.3
  • 57
    • 0002440731 scopus 로고
    • Screening of cDNA library
    • Woods, D. (1984) Screening of cDNA library, Focus (Idaho) 6, 3-4.
    • (1984) Focus (Idaho) , vol.6 , pp. 3-4
    • Woods, D.1
  • 59
    • 8944260449 scopus 로고
    • Expression of an active alpha scorpion neurotoxin using Expression coli, insect cells and Lepidopterous Larvas: Structure-activity relationship and future applications
    • Zilberberg, N., Gordon, D., Zlotkin, E., Pelhate, M., Chejanovsky, N. & Gurevitz, M. (1995) Expression of an active alpha scorpion neurotoxin using Expression coli, insect cells and Lepidopterous Larvas: structure-activity relationship and future applications, Toxicon 33, 269.
    • (1995) Toxicon , vol.33 , pp. 269
    • Zilberberg, N.1    Gordon, D.2    Zlotkin, E.3    Pelhate, M.4    Chejanovsky, N.5    Gurevitz, M.6
  • 60
    • 0014980110 scopus 로고
    • A new toxic protein in the venom of the scorpion Androctonus australis hector
    • Zlotkin, E., Miranda, F., Kopeyan, C. & Lissitzky, S. (1971 a) A new toxic protein in the venom of the scorpion Androctonus australis hector, Toxicon 9, 9-13.
    • (1971) Toxicon , vol.9 , pp. 9-13
    • Zlotkin, E.1    Miranda, F.2    Kopeyan, C.3    Lissitzky, S.4
  • 61
    • 0015197045 scopus 로고
    • Purification and properties of the insect toxin from the venom of the scorpion Androctonus australis hector
    • Zlotkin, E., Rochat, H., Kopeyan, C., Miranda, F. & Lisstzky, S. (1971 b) Purification and properties of the insect toxin from the venom of the scorpion Androctonus australis hector, Biochimic (Paris) 53, 1073-1078.
    • (1971) Biochimic (Paris) , vol.53 , pp. 1073-1078
    • Zlotkin, E.1    Rochat, H.2    Kopeyan, C.3    Miranda, F.4    Lisstzky, S.5
  • 62
    • 0022256583 scopus 로고
    • An excitatory and depressant insect toxins from scorpion venom-both affect sodium conductance and possess a common binding site
    • Zlotkin, E., Kadouri, D., Gordon, D., Pelhale, M., Martin, M. F. & Rochat, H. (1985) An excitatory and depressant insect toxins from scorpion venom-both affect sodium conductance and possess a common binding site, Arch. Biochem. Biophys. 240, 870-887.
    • (1985) Arch. Biochem. Biophys. , vol.240 , pp. 870-887
    • Zlotkin, E.1    Kadouri, D.2    Gordon, D.3    Pelhale, M.4    Martin, M.F.5    Rochat, H.6
  • 63
    • 0025784813 scopus 로고
    • Functional duality and structural uniqueness of depressant insect-selective neurotoxins
    • Zlotkin, E., Eitan, M., Bindokas, V. P., Adams, M. E., Moyer, M., Burkhart, W. & Fowler, E. (1991) Functional duality and structural uniqueness of depressant insect-selective neurotoxins, Biochemistry 30, 4814-4821.
    • (1991) Biochemistry , vol.30 , pp. 4814-4821
    • Zlotkin, E.1    Eitan, M.2    Bindokas, V.P.3    Adams, M.E.4    Moyer, M.5    Burkhart, W.6    Fowler, E.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.