C-terminal Substitution of MDM2 interacting peptides modulates binding affinity by distinctive mechanisms

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Brown, Christopher J ^b   Dastidar, Shubhra G ^b   Quah, Soo T ^b   Lim, Annie ^c   Chia, Brian ^c   Verma, Chandra S ^a,d,e  

^a BIOINFORMATICS INSTITUTE   (Singapore)

^b AGENCY FOR SCIENCE   (Singapore)

^c Agency for Science   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MDM2; PROTEIN P53; PEPTIDE;

ALPHA HELIX; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; COMPLEX FORMATION; COMPUTER SIMULATION; CONTROLLED STUDY; MOLECULAR DYNAMICS; PROTEIN PROTEIN INTERACTION; THERMODYNAMICS; TRANSACTIVATION; AMINO ACID SEQUENCE; CALORIMETRY; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; CALORIMETRY; CIRCULAR DICHROISM; COMPUTER SIMULATION; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MDM2; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR SUPPRESSOR PROTEIN P53;

EID: 80052319750     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024122     Document Type: Article

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