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Volumn 37, Issue 6, 1998, Pages 812-814

Silanediols: A new class of potent protease inhibitors

Author keywords

Angiotensin converting enzyme; Enzyme inhibitors; Peptidomimetics; Silanols; Structure activity relationships

Indexed keywords


EID: 0031901524     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3773(19980403)37:6<812::AID-ANIE812>3.0.CO;2-I     Document Type: Article
Times cited : (116)

References (26)
  • 1
    • 84942740884 scopus 로고
    • Eds.: G. Wilkinson, F. G. A. Stone, E. W. Abel, Pergamon, New York
    • F. O. Stark, J. R. Falender, A. P. Wright in Comprehensive Organometallic Chemistry, Vol. 2 (Eds.: G. Wilkinson, F. G. A. Stone, E. W. Abel), Pergamon, New York, 1982, pp. 305-363; S. S. Brown, T. C. Kendrick, J. McVie, D. R. Thomas in Comprehensive Organometallic Chemistry II, Vol. 2 (Eds.: E. W. Abel, F. G. A. Stone, G. Wilkinson), Pergamon, New York, 1995, pp. 111-135.
    • (1982) Comprehensive Organometallic Chemistry , vol.2 , pp. 305-363
    • Stark, F.O.1    Falender, J.R.2    Wright, A.P.3
  • 2
    • 0000274533 scopus 로고
    • Eds.: E. W. Abel, F. G. A. Stone, G. Wilkinson, Pergamon, New York
    • F. O. Stark, J. R. Falender, A. P. Wright in Comprehensive Organometallic Chemistry, Vol. 2 (Eds.: G. Wilkinson, F. G. A. Stone, E. W. Abel), Pergamon, New York, 1982, pp. 305-363; S. S. Brown, T. C. Kendrick, J. McVie, D. R. Thomas in Comprehensive Organometallic Chemistry II, Vol. 2 (Eds.: E. W. Abel, F. G. A. Stone, G. Wilkinson), Pergamon, New York, 1995, pp. 111-135.
    • (1995) Comprehensive Organometallic Chemistry II , vol.2 , pp. 111-135
    • Brown, S.S.1    Kendrick, T.C.2    McVie, J.3    Thomas, D.R.4
  • 6
    • 1542576034 scopus 로고    scopus 로고
    • Eds.: S. C. DeVito, R. L. Garrett, American Chemical Society, Washington, DC
    • S. McN. Sieburth in Designing Safer Chemicals (Eds.: S. C. DeVito, R. L. Garrett), American Chemical Society, Washington, DC, 1996, pp. 74-83.
    • (1996) Designing Safer Chemicals , pp. 74-83
    • Sieburth, S.McN.1
  • 7
    • 0344533433 scopus 로고    scopus 로고
    • note
    • Diphenylsilanediol is the only silanediol that has been found to be biologically active. For an excellent review, see ref. [4].
  • 14
    • 0345395751 scopus 로고    scopus 로고
    • note
    • Initial attempts to prepare 7 with a benzyl group rather than an isobutyl group failed.
  • 15
    • 0001228546 scopus 로고
    • Eds.: S. Udenfriend, J. Meienhofer, Academic Press, New York
    • J. P. Tam, R. B. Merrifield in The Peptides. Vol. 9 (Eds.: S. Udenfriend, J. Meienhofer), Academic Press, New York, 1987, pp. 185-248.
    • (1987) The Peptides , vol.9 , pp. 185-248
    • Tam, J.P.1    Merrifield, R.B.2
  • 18
    • 37049149848 scopus 로고
    • H. J. Emeléus, C. J. Wilkins, J. Chem. Soc. 1944, 454-456; C. Eaborn, J. Chem. Soc. 1952, 2846-2849.
    • (1952) J. Chem. Soc. , pp. 2846-2849
    • Eaborn, C.1
  • 19
    • 0344964414 scopus 로고    scopus 로고
    • note
    • 1H NMR spectroscopy; 7a and 15a are 1:1 mixtures of diastereomers, and 7b, 14, and 15b are approximately 1:1:1:1 mixtures. Full experimental details will be reported elsewhere.
  • 21
    • 0001493148 scopus 로고    scopus 로고
    • W. Uhlig, Chem. Ber. 1996, 129, 733-739.
    • (1996) Chem. Ber. , vol.129 , pp. 733-739
    • Uhlig, W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.