Chemokine receptor CXCR4 expression in hepatocellular carcinoma patients increases the risk of bone metastases and poor survival

BMC Cancer

Volumn 9, Issue , 2009, Pages

  Xiang, Zuo Lin ^a   Zeng, Zhao Chong ^a   Tang, Zhao You ^a   Fan, Jia ^a   Zhuang, Peng Yuan ^a   Liang, Ying ^a   Tan, Yun Shan ^a   He, Jian ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CXCR4 PROTEIN, HUMAN;

ADOLESCENT; ADULT; AGED; ARTICLE; BONE METASTASIS; CANCER PATIENT; CANCER RISK; CANCER SURVIVAL; CHILD; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PROGNOSIS; PROTEIN EXPRESSION; RISK FACTOR; SCHOOL CHILD; TISSUE MICROARRAY; BIOSYNTHESIS; BONE TUMOR; LIVER TUMOR; METABOLISM; METASTASIS; METHODOLOGY; MICROARRAY ANALYSIS; MIDDLE AGED; PATHOLOGY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BONE NEOPLASMS; CARCINOMA, HEPATOCELLULAR; CHILD; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MALE; MICROARRAY ANALYSIS; MIDDLE AGED; RECEPTORS, CXCR4; RISK FACTORS; YOUNG ADULT;

EID: 67650246591     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-9-176     Document Type: Article

References (30)

1. Kaifi JT Yekebas EF Schurr P Obonyo D Wachowiak R Busch P Heinecke A Pantel K Izbicki JR Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancer J Natl Cancer Inst 2005, 97(24):1840-1847. 16368946
2. Murphy PM Chemokines and the molecular basis of cancer metastasis N Engl J Med 2001, 345(11):833-835. 10.1056/NEJM200109133451113 11556308
3. Schimanski CC Bahre R Gockel I Müller A Frerichs K Hörner V Teufel A Simiantonaki N Biesterfeld S Wehler T et al. Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4 Br J Cancer 2006, 95(2):210-217. 10.1038/sj.bjc.6603251 16819541
4. Geminder H Sagi-Assif O Goldberg L Meshel T Rechavi G Witz IP Ben-Baruch A A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastoma J Immunol 2001, 167(8):4747-4757. 11591806
5. Taichman RS Cooper C Keller ET Pienta KJ Taichman NS McCauley LK Use of the stromal cell-derive factor-1/CXCR4 pathway in prostate cancer metastasis to bone Cancer Res 2002, 62(6):1832-1837. 11912162
6. Russell HV Hicks J Okcu MF Nuchtern JG CXCR4 expression in neuroblastoma primary tumors is associated with clinical presentation of bone and bone marrow metastases J Pediatr Surg 2004, 39(10):1506-1511. 10.1016/ j.jpedsurg.2004.06.019 15486895
7. Strahm B Durbin AD Sexsmith E Malkin D The CXCR4-SDF1 alpha axis is a critical mediator of rhabdomyosarcoma metastatic signaling induced by bone marrow stroma Clin Exp Metastasis 2008, 25(1):1-10. 10.1007/ s10585-007-9094-6 17768666
8. Burger JA Kipps TJ CXCR4: A key receptor in the crosstalk between tumor cells and their microenvironment Blood 2006, 107(5):1761-1767. 10.1182/ blood-2005-08-3182 16269611
9. Neiva K Sun YX Taichman RS The role of osteoblasts in regulating hematopoietic stem cell activity and tumor metastasis Braz J Med Biol Res 2005, 38(10):1449-1454. 10.1590/S0100-879X2005001000001 16172737
10. Sun YX Schneider A Jung Y Wang J Dai J Wang J Cook K Osman NI Koh-Paige AJ Shim H et al. Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo J Bone Miner Res 2005, 20(2):318-329. 10.1359/ JBMR.041109 15647826
11. Bian XW Yang SX Chen JH Ping YF Zhou XD Wang QL Jiang XF Gong W Xiao HL Du LL et al. Preferential expression of chemokine receptor CXCR4 by highly malignant human gliomas and its association with poor patient survival Neurosurgery 2007, 61(3):570-578. 10.1227/ 01.NEU.0000290905.53685.A2 17881971
12. Sohara Y Shimada H DeClerck YA Mechanisms of bone invasion and metastasis in human neuroblastoma Cancer Lett 2005, 228(1-2):203-209. 10.1016/j.canlet.2005.01.059 15975706
13. Ho CL Chen S Yeung DWC Cheng TK et al. Dual-tracer PET/CT imaging in evaluation of metastatic hepatocellular carcinoma J Nucl Med 2007, 48(6):902-909. 10.2967/jnumed.106.036673 17504862
14. Natsuizaka M Omura T Akaike T Kuwata Y Yamazaki K Sato T Karino Y Toyota J Suga T Asaka M Clinical features of hepatocellular carcinoma with extrahepatic metastases J Gastroenterol Hepatol 2005, 20(11):1781-1787. 10.1111/j.1440-1746.2005.03919.x 16246200
15. Kononen J Bubendorf L Kallioniemi A Barlund M Schraml P Leighton S Torhorst J Mihatsch MJ Sauter G Kallioniemi OP Tissue microarrays for high-throughput molecular profiling of tumor specimens Nat Med 1998, 4(7):844-847. 10.1038/nm0798-844 9662379
16. Shim H Lau SK Devi S Yoon Y Cho HT Liang Z Lower expression of CXCR4 in lymph node metastases than in primary breast cancers: Potential regulation by ligand-dependent degradation and HIF-1alpha Biochem Biophys Res Commun 2006, 346(1):252-258. 10.1016/j.bbrc.2006.05.110 16756955
17. Cappuzzo F Hirsch FR Rossi E Bartolini S Ceresoli GL Bemis L Haney J Witta S Danenberg K Domenichini I et al. Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer J Natl Cancer Inst 2005, 97(9):643-655. 15870435
18. Roodman GD Mechanisms of bone metastasis N Engl J Med 2004, 350(16):1655-1664. 10.1056/NEJMra030831 15084698
19. Kang Y Siegel PM Shu W Drobnjak M Kakonen SM Cordón-Cardo C Guise TA Massagué J A multigenic program mediating breast cancer metastasis to bone Cancer Cell 2003, 3(6):537-549. 10.1016/ S1535-6108(03)00132-6 12842083
20. Su L Zhang J Xu H Wang Y Chu Y Liu R Xiong S Differential expression of CXCR4 is associated with the metastatic potential of human non-small cell lung cancer cells Clin Cancer Res 2005, 11(23):8273-8280. 10.1158/ 1078-0432.CCR-05-0537 16322285
21. Hu J Deng X Bian X Li G Tong Y Li Y Wang Q Xin R He X Zhou G et al. The expression of functional chemokine receptor CXCR4 is associated with the metastatic potential of human nasopharyngeal carcinoma Clin Cancer Res 2005, 11(13):4658-4665. 10.1158/1078-0432.CCR-04-1798 16000558
22. Kucia M Reca R Miekus K Wanzeck J Wojakowski W Janowska-Wieczorek A Ratajczak J Ratajczak MZ Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: Pivotal role of the SDF-1-CXCR4 axis Stem Cells 2005, 23(7):879-894. 10.1634/ stemcells.2004-0342 15888687
23. Chinni SR Yamamoto H Dong Z Sabbota A Bonfil RD Cher ML CXCL12/CXCR4 transactivates HER2 in lipid rafts of prostate cancer cells and promotes growth of metastatic deposits in bone Mol Cancer Res 2008, 6(3):446-457. 10.1158/1541-7786.MCR-07-0117 18337451
24. Horak CE Steeg PS Metastasis gets site specific Cancer Cell 2005, 8(2):93-95. 10.1016/j.ccr.2005.07.013 16098461
25. Liu H Pan Z Li A Fu S Lei Y Sun H Wu M Zhou W Roles of chemokine receptor 4(CXCR4) and chemokine ligand 12 (CXCL12) in metastasis of hepatocellular carcinoma cells Cell Mol Immunol 2008, 5(5):373-378. 18954561
26. Zhang L Yeger H Das B Irwin MS Baruchel S Tissue xmicroenvironment modulates CXCR4 expression and tumor metastasis in neuroblastoma Neoplasia 2007, 9(1):36-46. 1803034 17325742 10.1593/neo.06670
27. Smith MC Luker KE Garbow JR Prior JL Jackson E Piwnica-Worms D Luker GD CXCR4 regulates growth of both primary and metastatic breast cancer Cancer Res 2004, 64(23):8604-8612. 10.1158/0008-5472.CAN-04-1844 15574767
28. Aapro M Abrahamsson PA Body JJ Coleman RE Colomer R Costa L Crinò L Dirix L Gnant M Gralow J et al. Guidance on the use of bisphosphonates in solid tumours: Recommendations of an international expert panel Ann Oncol 2008, 19(3):420-432. 10.1093/annonc/mdm442 17906299
29. Powles T Paterson S Kanis JA McCloskey E Ashley S Tidy A Rosenqvist K Smith I Ottestad L Legault S et al. Randomized, placebo-controlled trial of clodronate in patients with primary operable breast cancer J Clin Oncol 2002, 20(15):3219-3224. 10.1200/JCO.2002.11.080 12149294
30. Diel IJ Solomayer EF Costa SD Gollan C Goerner R Wallwiener D Kaufmann M Bastert G Reduction in new metastases in breast cancer with adjuvant clodronate treatment N Engl J Med 1998, 339(6):357-363. 10.1056/ NEJM199808063390601 9691101