Dendritic cell status modulates the outcome of hiv-related b cell disease progression

PLoS Pathogens

Volumn 7, Issue 8, 2011, Pages

  Poudrier, Johanne ^a,b   Roger, Michel ^a,b  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

B CELL ACTIVATING FACTOR; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G;

ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DISEASE; CD4+ T LYMPHOCYTE; DENDRITIC CELL; DISEASE COURSE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DYSREGULATION; IMMUNOREGULATION; INFECTION CONTROL; LEUKOCYTE DISORDER; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA; NONHUMAN; PROTEIN EXPRESSION; VIRUS IMMUNITY; ANIMAL; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE; TRANSGENIC MOUSE;

ANIMALS; B-CELL ACTIVATING FACTOR; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; DISEASE PROGRESSION; HIV INFECTIONS; HUMANS; MICE; MICE, TRANSGENIC;

EID: 80052308361     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002154     Document Type: Article

References (51)

1. Moir S, Fauci AS, (2009) B cells in HIV infection and disease. Nat Rev Immunol 9: 235-245.
2. Fontaine J, Chagon-Choquet J, Valcke HS, Poudrier J, Roger M, (2011) High expression levels of B Lymphocyte Stimulator (BLyS) by dendritic cells correlate with HIV-related B cell disease progression in humans. Blood 117: 145-155.
3. Jacobson MA, Khayam-Bashi H, Martin JN, Black D, Ng V, (2002) Effect of long-term highly antiretroviral therapy in restoring HIV-induced abnormal B-lymphocyte function. J Acquir Immune Defic Syndr 31: 472-477.
4. Calabrese LH, Kirchner E, Shrestha R, (2005) Rheumatic complications of human immunodeficiency virus infection in the era of highly active antiretroviral therapy: emergence of a new syndrome of immune reconstitution and changing patterns of disease. Semin Arthritis Rheum 35: 166-174.
5. Bekker V, Scherpbier H, Pajkrt D, Jurriaans S, Zaaijer H, et al. (2006) Persistent humoral immune defect in highly active antiretroviral therapy-treated children with HIV-1 infection: loss of specific antibodies against attenuated vaccine strains and natural viral infection. Pediatrics 118: e315-e322.
6. Batista FD, Harwood NE, (2009) The who, how and where of antigen presentation to B cells. Nat Rev Immunol 9: 15-27.
7. Macpherson G, Kushnir N, Wykes M, (1999) Dendritic cells, B cells and the regulation of antibody synthesis. Immunol Rev 172: 325-334.
8. Cerutti A, Rescigno M, (2008) The biology of intestinal immunoglobulin A responses. Immunity 28: 740-750.
9. Lekkerkerker AN, van Kooyk Y, Geijtenbeek TB, (2006) Viral piracy: HIV-1 targets dendritic cells for transmission. Curr HIV Res 4: 169-176.
10. Hanna Z, Kay DG, Rebai N, Guimond A, Jothy S, et al. (1998) Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice. Cell 95: 163-175.
11. Poudrier J, Weng X, Kay DG, Paré G, Calvo EL, et al. (2001) The AIDS disease of CD4C/HIV transgenic mice shows impaired germinal centers and auto-antibodies and develops in the absence of IFN-gamma and IL-6. Immunity 15: 173-185.
12. Poudrier J, Weng X, Kay DG, Hanna Z, Jolicoeur P, (2003) The AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with accumulation of immature CD11bHi dendritic cells. J Virol 77: 11733-11744.
13. Mackay F, Figgett WA, Saulep D, Lepage M, Hibbs ML, (2010) B-cell stage and context-dependent requirements for survival signals from BAFF and the B-cell receptor. Immunol Rev 237: 205-225.
14. Hässler S, Ramsey C, Karlsson MC, Larsson D, Herrmann B, et al. (2006) AIRE-deficient mice develop haematopoietic irregularities and marginal zone B-cell lymphoma. Blood 108: 1941-1948.
15. Lindh E, Lind SM, Lindmark E, Hässler S, Perheentupa J, et al. (2008) AIRE regulates T-cell-independent B-cell responses through BAFF. Proc Natl Acad Sci USA 105: 18466-18471.
16. Federico M, Percario Z, Olivetta E, Fiorucci G, Muratori C, et al. (2001) HIV-1 Nef activates STAT1 in human monocytes/macrophages through the release of soluble factors. Blood 98: 2752-2761.
17. Mangino G, Percario ZA, Fiorucci G, Vaccari G, Manrique S, et al. (2007) In vitro treatment of human monocytes/macrophages with myristoylated recombinant NEF of human immunodeficiency virus type 1 leads to the activation of mitogen-activated protein kinases, IkappaB kinases, and interferon regulatory factor 3 and to the release of beta interferon. J Virol 81: 2777-2791.
18. Quaranta MG, Tritarelli E, Giordani L, Viora M, (2002) HIV-1 Nef induces dendritic cell differentiation: a possible mechanism of uninfected CD4 (+) T cell activation. Exp Cell Res 275: 243-254.
19. He B, Qiao X, Klasse PJ, Chiu A, Chadburn A, et al. (2006) HIV-1 envelope triggers polyclonal Ig class switch recombination through a CD40-independent mechanism involving BAFF and C-type lectin receptors. J Immunol 176: 3931-3941.
20. Yu H, Liu Y, Han J, Yang Z, Sheng W, et al. (2011) TLR7 regulates dendritic cell-dependent B cell responses through BLyS in immune thrombocytopenic purpura. Eur J Haematol 86: 67-74.
21. Sabado RL, O'Brien M, Subedi A, Qin L, Hu N, et al. (2010) Evidence of dysregulation of dendritic cells in primary HIV infection. Blood 116: 3839-3852.
22. Fontaine J, Coutlée F, Tremblay C, Routy JP, Poudrier J, et al. (2009) HIV infection affects blood myeloid dendritic cells after successful therapy and despite nonprogressing clinical disease. J Infect Dis 199: 1007-1018.
23. Fontaine J, Poudrier J, Roger M, (2011) Persistence of high blood levels of the chemokines CCL2, CCL19 and CCL20 during the course of HIV infection. AIDS Res Hum Retroviruses 27: 655-657.
24. del Rio ML, Bernhardt G, Rodriguez-Barbosa JI, Förster R, (2010) Development and functional specialization of CD103+ dendritic cells. Immunol Rev 234: 268-281.
25. Weill JC, Weller S, Reynaud CA, (2009) Human Marginal Zone B cells. Annu Rev Immunol 27: 267-285.
26. Malaspina A, Moir S, Chaitt DG, Rehm CA, Kottilil S, et al. (2007) Idiopathic CD4+ T lymphocytopenia is associated with increases in immature/transitional B cells and serum levels of IL-7. Blood 109: 2086-2088.
27. Pantaleo G, Graziosi C, Demarest JF, Butini L, Montroni M, et al. (1993) HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362: 355-358.
28. Varin MM, Le Pottier L, Youinou P, Saulep D, Mackay F, et al. (2010) B-cell tolerance breakdown in Sjögren's syndrome: focus on BAFF. Autoimmun Rev 9 (9): 604-608.
29. Malaspina A, Moir S, Ho J, Wang W, Howell ML, et al. (2006) Appearance of immature/transitional B cells in HIV-infected individuals with advanced disease: correlation with increased IL-7. Proc Natl Acad Sci U S A 103: 2262-2267.
30. Cancro MP, D'Cruz DP, Khamashta MA, (2009) The role of B Lymphocyte Stimulator (BLyS) in systemic lupus erythematosus. J Clin Invest 119 (5): 1066-1073.
31. Cerutti A, (2008) The regulation of IgA class switching. Nat Rev Immunol 8: 421-434.
32. Lesley R, Xu Y, Kalled SL, Hess DM, Schwab SR, et al. (2004) Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity 20: 441-453.
33. Thien M, Phan TG, Gardam S, Amesbury M, Basten A, et al. (2004) Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches. Immunity 20: 785-798.
34. Stohl W, Cheema GS, Briggs WS, Xu D, Sosnovtseva S, et al. (2002) B lymphocyte stimulator protein-associated increase in circulating autoantibody levels may require CD4+ T cells: lessons from HIV-infected patients. Clin Immunol 104: 115-122.
35. Rodriguez B, Valdez H, Freimuth W, Butler T, Asaad R, et al. (2003) Plasma levels of B-lymphocyte stimulator increase with HIV disease progression. AIDS 17: 1983-2000.
36. Fagarasan S, Kawamoto S, Kanagawa O, Suzuki K, (2010) Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis. Annu Rev Immunol 28: 243-273.
37. Shacklett BL, (2010) Immune responses to HIV and SIV in mucosal tissues: 'location, location, location'. Curr Opin HIV AIDS 5: 128-134.
38. Tudor D, Derrien M, Diomede L, Drillet AS, Houimel M, et al. (2009) HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4(+) cell infection: an IgA gene and functional analysis. Mucosal Immunol 2: 412-426.
39. Bomsel M, Tudor D, Drillet AS, Alfsen A, Ganor Y, et al. (2011) Immunization with HIV-1 gp41 subunit virosomes induces mucosal antibodies protecting nonhuman primates against vaginal SHIV challenges. Immunity 34: 269-280.
40. Rescigno M, Disabatino A, (2009) Dendritic cells in intestinal homeostasis and disease. J Clin Invest 119: 2441-2450.
41. Xu W, He B, Chiu A, Chadburn A, Shan M, et al. (2007) Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI. Nature Immunol 8: 294-303.
42. Manicassamy S, Reizis B, Ravindran R, Nakaya H, Salazar-Gonzalez RM, et al. (2010) Activation of beta-catenin in dendritic cells regulates immunity versus tolerance in the intestine. Science 329: 849-853.
43. Sodora DL, Allan JS, Apetrei C, Brenchley JM, Douek DC, et al. (2009) Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts. Nat Med 15: 861-865.
44. Li Q, Estes JD, Schlievert PM, Duan L, Brosnahan AJ, et al. (2009) Glycerol monolaurate prevents mucosal SIV transmission. Nature 458: 1034-1038.
45. Mandl JN, Barry AP, Vanderford TH, Kozyr N, Chavan R, et al. (2008) Divergent TLR7 and TLR9 signalling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infection. Nat Med 14: 1077-1087.
46. Tezuka H, Abe Y, Asano J, Sato T, Liu J, et al. (2011) Prominent Role for Plasmacytoid Dendritic Cells in Mucosal T Cell-Independent IgA Induction. Immunity 34: 247-257.
47. Yang M, Sun L, Wang S, Ko KH, Xu H, et al. (2010) Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells. J Immunol 184 (7): 3321-3325.
48. Lund FE, Randall TD, (2010) Effector and regulatory B cells: modulators of CD4+ T cell immunity. Nat Rev Immunol 10: 236-247.
49. Gray D, Gray M, (2010) What are regulatory B cells? Eur J Immunol 40: 2677-2679.
50. Marino E, Villanueva J, Walters S, Liuwantara D, Mackay F, et al. (2009) CD4+ CD25+ T cells control autoimmunity in the absence of B cells. Diabetes 58: 1568-1577.
51. Lai Kwan Lam Q, King Hung Ko O, Zheng BJ, Lu L, (2008) Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis. Proc Natl Acad Sci U S A 105: 14993-14998.